WO2004047925A3 - Therapeutic oxidation catalysts - Google Patents

Therapeutic oxidation catalysts Download PDF

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Publication number
WO2004047925A3
WO2004047925A3 PCT/GB2003/005095 GB0305095W WO2004047925A3 WO 2004047925 A3 WO2004047925 A3 WO 2004047925A3 GB 0305095 W GB0305095 W GB 0305095W WO 2004047925 A3 WO2004047925 A3 WO 2004047925A3
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic
oxidation catalysts
catalysts
organotellerium
organotelenium
Prior art date
Application number
PCT/GB2003/005095
Other languages
French (fr)
Other versions
WO2004047925A2 (en
Inventor
Claus Jacob
Gregory Giles
Fiona Fry
Original Assignee
Exeter Antioxidant Therapeutic
Claus Jacob
Gregory Giles
Fiona Fry
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exeter Antioxidant Therapeutic, Claus Jacob, Gregory Giles, Fiona Fry filed Critical Exeter Antioxidant Therapeutic
Priority to AU2003302365A priority Critical patent/AU2003302365A1/en
Publication of WO2004047925A2 publication Critical patent/WO2004047925A2/en
Publication of WO2004047925A3 publication Critical patent/WO2004047925A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C391/00—Compounds containing selenium
    • C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C395/00—Compounds containing tellurium

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)

Abstract

The present invention relates to the use of organotelenium and organotellerium GPx mimics for use as pro-oxidant catalysts and anti-oxidants.
PCT/GB2003/005095 2002-11-22 2003-11-24 Therapeutic oxidation catalysts WO2004047925A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003302365A AU2003302365A1 (en) 2002-11-22 2003-11-24 Therapeutic oxidation catalysts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0227348.0A GB0227348D0 (en) 2002-11-22 2002-11-22 Redox catalyst compositions
GB0227348.0 2002-11-22

Publications (2)

Publication Number Publication Date
WO2004047925A2 WO2004047925A2 (en) 2004-06-10
WO2004047925A3 true WO2004047925A3 (en) 2004-10-28

Family

ID=9948379

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/005095 WO2004047925A2 (en) 2002-11-22 2003-11-24 Therapeutic oxidation catalysts

Country Status (3)

Country Link
AU (1) AU2003302365A1 (en)
GB (1) GB0227348D0 (en)
WO (1) WO2004047925A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009144253A1 (en) * 2008-05-29 2009-12-03 Karolinska Institutet Innovations Ab Compounds comprising a 3-pyridinol or 5-pyrimidinol ring having an organoseleno or organotelluro substituent for use as antioxidants
CN103086935B (en) * 2011-10-28 2015-05-20 沈阳药科大学 Diphenyl selenide, diphenyl selenoxide, diphenyl selenone compounds and uses thereof
WO2017223160A1 (en) * 2016-06-21 2017-12-28 The University Of Toledo Substituted isoselenazolone anti-inflammatory, anti-cancer, cytoprotective, neuroprotective, and anti-oxidant agents
CN114057619B (en) * 2020-07-31 2024-03-22 深圳福山生物科技有限公司 Organic selenium compounds and therapeutic uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016993A1 (en) * 1992-02-20 1993-09-02 Aktiebolaget Astra Antioxidant diaryl tellurides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016993A1 (en) * 1992-02-20 1993-09-02 Aktiebolaget Astra Antioxidant diaryl tellurides

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
ANDREADOU, I. ET AL.: "Synthesis of Novel Se-SWubstituted Selenocysteine Derivatives as Potential Kidney Selective Prodrugs of Biologically Active Selenol Compounds", JOURNA OF MEDICINAL CHEMISTRY, vol. 39, no. 10, 1996, pages 2040 - 2046 *
BACK, T. G. ET AL.: "Concise, Improved Procedure for the Synthesis of Brassinolide and Some Novel Side-Chain Analogues", JOURNAL OF ORGANIC CHEMISTRY, vol. 62, 1997, pages 1179 - 1182, XP002282839 *
BARBOSA, N. B. V. ET AL.: "Effect of Organic Forms of Selenium on gamma-Aminolevulinate Dehydratase from Liver, Kidney and Brain of Adult Rats", TOXICOLOGY AND APPLIED PHARMACOLOGY, vol. 149, 9 January 1998 (1998-01-09), pages 243 - 253, XP002282834 *
DATABASE CAOLD CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285553, retrieved from STN Database accession no. 90:137408 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285546, retrieved from STN Database accession no. 1994:483501 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285547, retrieved from STN Database accession no. 1999:583580 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285548, retrieved from STN Database accession no. 1972:128839 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285549, retrieved from STN Database accession no. 1987:18122 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285550, retrieved from STN Database accession no. 1983:215600 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285551, retrieved from STN Database accession no. 1995:994310 *
DATABASE CAPLUS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002285552, retrieved from STN Database accession no. 1996:241974 *
ENGMAN, L. ET AL.: "Diaryl Chalcogenides as Selective Inhibitors of Thioredoxin Reductase and Potential Antitumor Agents", ANTICANCER RESEARCH, vol. 17, 1997, pages 4599 - 4606, XP008030901 *
FAN, W. ET AL.: "Some 1,4-benzoquinones and 1,4-naphthoquinones with aryl- or alkyltelluro substituents", YOUJI HUAXUE, vol. 13, no. 6, 1993, pages 612 - 615 *
GILES N M ET AL: "Redox catalysts as sensitisers towards oxidative stress", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 535, 9 January 2003 (2003-01-09), pages 179 - 182, XP002272681, ISSN: 0014-5793 *
GILES, G. I. ET AL.: "Electrochemistry of chalcogen compounds: prediction of antioxidant activity", CHEMICAL COMMUNICATIONS, vol. 23, 15 November 2001 (2001-11-15), pages 2490 - 2491, XP002282835 *
KAUR, R. ET AL.: "Synthesis and Characterisation of Hybrid Bi- and Multidentate Tellurium LIgands Derived from N,N-Dimethylbenzylamine", ORGANOMETALLICS, vol. 14, 1995, pages 4755 - 4763, XP002282840 *
KEMMITT, T. ET AL.: "Synthesis and Multinuclear NMR Studies of [M{o- C6H4(TeMe)2}X2] (M = Pd, Pt; X = Cl, Br, I). The Presence of a Characteristic Ring Contribution to Te NMR Chemical Shifts", INORGANIC CHEMISTRY, vol. 29, 1990, pages 731 - 735, XP002282837 *
MAKSIMENKO, A. ET AL.: "Reduction of diaryl tellurium oxides", ZHURNAL ORGANICHESKOI KHIMII, vol. 14, no. 12, 1978, pages 2621 - 2622 *
SAKAKIBARA, M. ET AL.: "New Selenenylation Method. Synthesis of Selenonaphthoquinones and Selenoquinolinequinones Mediated by Phenyl Selenide Ion", JOURNAL OF CHEMICAL SOCIETY, 1991, pages 1231 - 1234, XP001189497 *
SINGH, A. K. ET AL.: "Ditelluroether ligand bis(4-methoxyphenyltelluro) methane- synthesis, reaction with iodine and its ruthenium(II) complexes", INORGANICA CHIMICA ACTA, vol. 304, 2000, pages 45 - 51, XP002282838 *
VASIL'EV, A. A. ET AL.: "Preparation of Unsymmetrical Diaryl Selenides via SNAr Reactions in eta 6-Cloroarene Transition Metal Complexes", ORGANOMETTALICS, vol. 18, no. 7, 1999, pages 1318 - 1325, XP002282836 *
WILSON, S.R. ET AL.: "Development of Synthetic Compounds with Glutathione Peroxidase Activity", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 111, 1989, pages 5936 - 5939, XP002039295 *

Also Published As

Publication number Publication date
AU2003302365A1 (en) 2004-06-18
WO2004047925A2 (en) 2004-06-10
GB0227348D0 (en) 2002-12-31

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