WO2004046202A3 - Bio-degradable colloid particles, in particular for pulmonary applications - Google Patents

Bio-degradable colloid particles, in particular for pulmonary applications Download PDF

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Publication number
WO2004046202A3
WO2004046202A3 PCT/DE2003/003787 DE0303787W WO2004046202A3 WO 2004046202 A3 WO2004046202 A3 WO 2004046202A3 DE 0303787 W DE0303787 W DE 0303787W WO 2004046202 A3 WO2004046202 A3 WO 2004046202A3
Authority
WO
WIPO (PCT)
Prior art keywords
colloid particles
bio
amino groups
base
groups
Prior art date
Application number
PCT/DE2003/003787
Other languages
German (de)
French (fr)
Other versions
WO2004046202A2 (en
Inventor
Werner Seeger
Thomas Schmehl
Tobias Gessler
Lea Ann Dailey
Matthias Wittmar
Original Assignee
Transmit Technologietransfer
Univ Giessen Justus Liebig
Univ Marburg Philipps
Werner Seeger
Thomas Schmehl
Tobias Gessler
Lea Ann Dailey
Matthias Wittmar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transmit Technologietransfer, Univ Giessen Justus Liebig, Univ Marburg Philipps, Werner Seeger, Thomas Schmehl, Tobias Gessler, Lea Ann Dailey, Matthias Wittmar filed Critical Transmit Technologietransfer
Priority to ES03785518T priority Critical patent/ES2389471T3/en
Priority to AU2003294626A priority patent/AU2003294626A1/en
Priority to EP03785518A priority patent/EP1562559B1/en
Priority to US10/534,885 priority patent/US20060127485A1/en
Priority to DK03785518.6T priority patent/DK1562559T3/en
Priority to CA2545877A priority patent/CA2545877C/en
Publication of WO2004046202A2 publication Critical patent/WO2004046202A2/en
Publication of WO2004046202A3 publication Critical patent/WO2004046202A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/44—Preparation of metal salts or ammonium salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/08—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

The invention relates to a composition consisting of a bio-degradable, water-soluble comb polymer, based on a polyol backbone with side chains that carry amino groups and a stabiliser in the form of at least one negatively charged organic base, which can be a Lewis or Brönsted base, or a corresponding acid of said base, which can be a Lewis or Brönsted acid. There can be an excess or deficiency of the acidic groups of the stabilisers in relation to the primary, secondary or tertiary amino groups of the comb polymers or an excess or deficiency of the basic groups in relation to the quaternary amino groups of the comb polymers, in such a way that the colloid particles have a positive or negative zeta potential. Colloid particles of this type are particularly suitable for the pulmonary application of acidic or negatively charged pharmaceutical active agents.
PCT/DE2003/003787 2002-11-15 2003-11-14 Bio-degradable colloid particles, in particular for pulmonary applications WO2004046202A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES03785518T ES2389471T3 (en) 2002-11-15 2003-11-14 Biodegradable colloidal particles, especially for pulmonary applications
AU2003294626A AU2003294626A1 (en) 2002-11-15 2003-11-14 Bio-degradable colloid particles, in particular for pulmonary applications
EP03785518A EP1562559B1 (en) 2002-11-15 2003-11-14 Bio-degradable colloid particles, in particular for pulmonary applications
US10/534,885 US20060127485A1 (en) 2002-11-15 2003-11-14 Bio-degradable colloid particles, in particular for pulmonary applications
DK03785518.6T DK1562559T3 (en) 2002-11-15 2003-11-14 BIODEGRADABLE COLLOID PARTICLES, IN PARTICULAR FOR PULMONAL APPLICATIONS
CA2545877A CA2545877C (en) 2002-11-15 2003-11-14 Biodegradable colloidal particles for pulmonary applications in particular

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10253623A DE10253623B4 (en) 2002-11-15 2002-11-15 Biodegradable colloidal particles, especially for pulmonary applications
DE10253623.6 2002-11-15

Publications (2)

Publication Number Publication Date
WO2004046202A2 WO2004046202A2 (en) 2004-06-03
WO2004046202A3 true WO2004046202A3 (en) 2004-12-16

Family

ID=32240119

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2003/003787 WO2004046202A2 (en) 2002-11-15 2003-11-14 Bio-degradable colloid particles, in particular for pulmonary applications

Country Status (9)

Country Link
US (1) US20060127485A1 (en)
EP (1) EP1562559B1 (en)
AU (1) AU2003294626A1 (en)
CA (1) CA2545877C (en)
DE (1) DE10253623B4 (en)
DK (1) DK1562559T3 (en)
ES (1) ES2389471T3 (en)
PT (1) PT1562559E (en)
WO (1) WO2004046202A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
EP2407150A1 (en) * 2010-07-16 2012-01-18 Justus-Liebig-Universität Gießen Polymer nano and micro particles for the maintenance of the low surface tension in the lung and for the protection of the pulmonary surfactant
EP2526926A1 (en) * 2011-05-25 2012-11-28 Justus-Liebig-Universität Gießen Biocompatible nanopolymer particles with active agents for pulmonary application
EP2526927A1 (en) * 2011-05-25 2012-11-28 Justus-Liebig-Universität Gießen Biocompatible nano- and microparticles coated with stabilisers for pulmonary application
DE102012003730A1 (en) 2012-02-28 2013-08-29 Nanohale Ag Producing comb polymers involves providing polyols as backbone, and reacting polyol with amino, ammonium, carboxyl, sulfonyl, sulfonic acid and/or phosphate group-containing compound to form negatively and/or positively charged side chains
CN107903348B (en) * 2017-11-28 2020-06-26 常州大学 Preparation method of polyethylene glycol grafted polymethyl methacrylate amphiphilic graft copolymer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19839515A1 (en) * 1998-08-29 2000-03-09 Thomas Kissel Association of active agent with colloidal polymer, preferably new polymeric branched polyol ester, useful for controlled transmucosal administration of e.g. peptide, DNA construct or vaccine
EP1132416A1 (en) * 2000-03-08 2001-09-12 Aventis Research & Technologies GmbH & Co KG Colloidal nanoparticular carriers comprising loaded or non-loaded water soluble comb polymers and their use in mucosal applications
US20010047074A1 (en) * 2000-03-08 2001-11-29 Thomas Kissel Self-assembling colloidal carriers for protein delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3427797A1 (en) * 1984-07-25 1986-02-06 Schering AG, 1000 Berlin und 4709 Bergkamen Cytoprotective effect of prostacyclin derivatives on liver, pancreas gland and kidney
DE10104991A1 (en) * 2001-02-03 2002-08-08 Clariant Gmbh Microencapsulated biologically active ingredients containing a water-soluble or water-dispersible comb polymer
PT1443912E (en) * 2001-10-12 2007-11-28 Elan Pharma Int Ltd Compositions having a combination of immediate release and controlled release characteristics

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19839515A1 (en) * 1998-08-29 2000-03-09 Thomas Kissel Association of active agent with colloidal polymer, preferably new polymeric branched polyol ester, useful for controlled transmucosal administration of e.g. peptide, DNA construct or vaccine
EP1132416A1 (en) * 2000-03-08 2001-09-12 Aventis Research & Technologies GmbH & Co KG Colloidal nanoparticular carriers comprising loaded or non-loaded water soluble comb polymers and their use in mucosal applications
US20010047074A1 (en) * 2000-03-08 2001-11-29 Thomas Kissel Self-assembling colloidal carriers for protein delivery

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BEHRENS I ET AL.: "Self-assembling insulin-polymer complexes for peroral delivery: Interaction with Caco-2 cell monolayers, peptide transport and cytotoxicity", PROCEED. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., vol. 29, 2002, ISSN: 1022-0178, pages 881 - 882, XP008030038 *
KISSEL T ET AL.: "Protein delivery systems based on branched biodegradable polyesters", PROCEED. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., vol. 29, 2002, ISSN: 1022-0178, pages 286 - 287, XP008030039 *

Also Published As

Publication number Publication date
ES2389471T3 (en) 2012-10-26
DK1562559T3 (en) 2012-09-24
CA2545877A1 (en) 2004-06-03
DE10253623B4 (en) 2006-03-09
EP1562559A2 (en) 2005-08-17
PT1562559E (en) 2012-09-20
EP1562559B1 (en) 2012-06-20
US20060127485A1 (en) 2006-06-15
DE10253623A1 (en) 2004-06-03
AU2003294626A1 (en) 2004-06-15
WO2004046202A2 (en) 2004-06-03
CA2545877C (en) 2013-03-12
AU2003294626A8 (en) 2004-06-15

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