WO2004046112A2 - 3-amino-piperidine derivatives and processes for their preparation - Google Patents
3-amino-piperidine derivatives and processes for their preparation Download PDFInfo
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- WO2004046112A2 WO2004046112A2 PCT/IB2003/005151 IB0305151W WO2004046112A2 WO 2004046112 A2 WO2004046112 A2 WO 2004046112A2 IB 0305151 W IB0305151 W IB 0305151W WO 2004046112 A2 WO2004046112 A2 WO 2004046112A2
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- 0 *C(CCCN1*)C1[Os] Chemical compound *C(CCCN1*)C1[Os] 0.000 description 4
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4462—Non condensed piperidines, e.g. piperocaine only substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Definitions
- This invention relates to 3-amino-piperadine derivatives, their intermediates, and methods of manufacture.
- Pyrrolo[2,3-d]pyrimidine compounds are inhibitors of protein kinases, such as the enzyme Janus Kinase 3 (JAK3) and are therefore useful therapy as immunosuppressive agents for organ transplants, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, Leukemia and other indications where immunosuppression would be desirable.
- the pyrrolo[2,3-d]pyrimidine compounds, pharmaceutical compositions thereof and methods of use are described in co- pending application serial no. 09/732669, filed December 8, 2000, and assigned to the assignee of the present invention, which is incorporated herein by reference for all purposes.
- this invention in one aspect, relates to methods of making compounds of the formula (la)
- Ri is carboxy, cyano, deuterium, (C C 6 )alkyl, (d-C 6 )alkoxy, (C C 6 )acyl, (C C 6 )alkylamino, amino(C 1 -C 6 )alkyl, (C C 6 )alkoxy-CO-NH, (C r C 6 )alkylamino-CO-, (C 2 -C 6 )alkenyl, (C 2 -C 6 ) alkynyl, (d-C 6 )alkylamino, amino(C ⁇ - C 6 )alkyl, (C 1 -C 6 )alkoxy(C 1 -C 6 )alkyl, (CrC 6 )acyloxy(C ⁇ -C 6 )alkyl, nitro, cyano(C C 6 )alkyl, nitro(d-C 6 )alkyl, trifluoromethyl, trifluoromethy d-CeJalkyl,
- R 3 is hydrogen, (d-C 6 )alkyl, (C 3 -C 10 )cycloalkyl, (C 2 -C 6 )alkenyl, or (C 2 - C 6 )alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, halogen, trifluoromethyl, (C C )alkoxy, (d-C 6 )acyloxy, (d- C 6 )alkylamino, (d-C 6 )acylamino, ((d-C 6 )alkyl) 2 amino, (C 2 -C 6 )alkenyl, (C 2 - C 6 )alkynyl, cyano, cyano(d-C 6 )alkyl, trifluoromethyl(d-C 6 )alkyl, nitro, or nitro(C C 6 )alkyl ; R is (C C 6 )alkyl, (
- R7, Re. R9, R 10 and Rn are each independently hydrogen or (C r C 6 )alkyl optionally substituted by deuterium, hydroxy, trifluoromethyl, (d-C 6 )acyloxy, (d- C 6 )acylamino, (CrC 6 )alkylamino, ((CrC 6 )alkyl) 2 amino, cyano, cyano(C C 6 )alkyl, trifluoromethy d-C ⁇ Jalkyl, nitro, nitro(d-C 6 )alkyl or (C r C 6 )acylamino;
- R ⁇ 2 is carboxy, cyano, amino, oxo, deuterium, hydroxy, trifluoromethyl, (d-C 6 )alkyl, trifluoromethy d-CeJalkyl, (d-C 6 )alkoxy, (C C 6 )acyl, (C ⁇ -C 6 )alkylamino,
- R 15 and R 16 are each independently hydrogen or (C C 6 )alkyl
- Y is S(O) p or carbonyl
- Z is S(O) p , carbonyl, C(O)O-, or C(O)NR-; a is 0, 1 , 2, 3 or 4; b, c, e, f and g are each independently 0 or 1 ; d is 0, 1 , 2, or 3; m is 0, 1 or 2; n is 1 , 2, 3, or 4; p is 0, 1 or 2; and wherein the method comprises reacting NHR 2 R 3 , N(CH 3 )R 2 H, or N(CH 2 CH 3 )R 2 H with a compound of formula (lla)
- the reducing agent is a borohydride.
- the present invention relates to formation of the compound of the formula (lla) by reacting a compound having the formula r ⁇ OH, water, or R t Nhb and a compound of the formula (Ilia) wherein R 5 is CO(C ⁇ -C 6 )alkyl.
- the present invention further relates to formation of the compound of the formula (Ilia) by heating a compound having the formula (IVa)
- the present invention relates to formation of the compound of the formula (IVa) by oxidizing a compound having the formula (Va)
- the oxidizing conditions are an electrochemical oxidation.
- the present invention also relates to formation of the compound of the formula (Va) by reacting a compound having the formula WCO 2 R 4 and a compound having the formula (Via)
- a second aspect of the present invention relates to methods of making a compound having the formula (lb)
- R 13 is (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, (C 6 -C 10 )aryl, (C C 6 )carboalkoxy, (C 5 - C 9 )heteroaryl, (d-doJary d-CeJalkyl, or (C 5 -C 9 )heteroaryl(d-C 6 )alkyl wherein the R 13 group is optionally substituted by deuterium, hydroxy, amino, trifluoromethyl,, (C r C 6 )alkyl, (C C 4 )alkoxy, (d-C 6 )alkylamino, ((CrC 6 )alkyl) 2 amino, (C 2 -C 6 )alkenyl, (C 2 - C 6 )alkynyl, trifluoromethy ⁇ d-CeJalkyl, nitro, or nitro(C C 6 ); and wherein the
- R 1 is (C C 6 )alkyl, (C 3 -C 10 )cycloalkyl, (C 2 - C 6 )alkenyl, or (C 2 -C 6 )alkynyl wherein the alkyl, alkenyl and alkynyl groups are optionally substituted by deuterium, hydroxy, halogen, amino, trifluoromethyl, (d- C )alkoxy, (d-C 6 )alkylamino, ((CrC 6 )alkyl) 2 amino, (C 2 -C 6 )alkenyl, (C 2 -C 6 )alkynyl, trifluoromethyl(d-C 6 )alkyl, nitro, or nitro(C 1 -C 6 )alkyl.
- the present invention also relates to formation of the compound of the formula (lib) by reacting a compound having the formula (lllb)
- the reducing agent is lithium aluminum hydride.
- the present invention relates to formation of the compound of the formula (lllb) by hydrogenating a compound having the formula (IVb)
- the catalyst is Rh/alumina or Rh/C.
- the present invention also relates to formation of the compound of the formula (IVb) by reacting a compound having the formula (Vb)
- the present invention relates to the compounds herein described including compounds of the formula (la), (lb) and (lib).
- R is (d-C 6 )alkyl and n is one;
- R 2 and R 3 are each hydrogen or (CrC 6 )alkyl;
- R, is (C C 6 )alkyl; and/or
- R ⁇ 3 is (C 6 - C ⁇ o)aryl.
- the compound of formula (la) has the relative stereochemistry of formula (la-1 )
- the compound of formula (lb) has the relative stereochemistry of formula (lb-1 )
- alkyl and alkenyl groups referred to herein, as well as the alkyl moieties of other groups referred to herein may be linear or branched, and they may also be cyclic (e.g., cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl) or be linear or branched and contain cyclic moieties.
- alkyl and alkoxy groups may be substituted with one, two or three halogen and/or hydroxy atoms, preferably fluorine atoms.
- halogen and halide includes fluorine, chlorine, bromine, and iodine.
- (C 3 -C 10 )cycloalkyl when used herein refers to cycloalkyl groups containing zero to two levels of unsaturation such as cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, 1 ,3-cyclohexadiene, cycloheptyl, cycloheptenyl, bicyclo[3.2.1]octane, norbornanyl, and the like.
- (C 2 -C 9 )heterocycloalkyl when used herein refers to pyrrolidinyl, tetrahydrofuranyl, dihydrofuranyl, tetrahydropyranyl, pyranyl, thiopyranyl, aziridinyl, oxiranyl, methylenedioxyl, chromenyl, isoxazolidinyl, 1 ,3-oxazolidin-3-yl, isothiazolidinyl, 1 ,3-thiazolidin-3-yl, 1 ,2-pyrazolidin-2-yl, 1 ,3-pyrazolidin-1-yl, piperidinyl, thiomorpholinyl, 1 ,2-tetrahydrothiazin-2-yl, 1 ,3-tetrahydrothiazin-3-yl, tetrahydrothiadiazinyl, morpholinyl, 1 ,2-tetrahydrodiazin-2-yl, 1,3
- (C 2 -C 9 )heteroaryl when used herein refers to furyl, thienyl, thiazolyl, pyrazolyl, isothiazolyl, oxazolyl, isoxazolyl, pyrrolyl, triazolyl, tetrazolyl, imidazolyl, 1,3,5-oxadiazolyl, 1 ,2,4-oxadiazolyl, 1 ,2,3-oxadiazolyl, 1 ,3,5-thiadiazolyl, 1,2,3- thiadiazolyl, 1 ,2,4-thiadiazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, 1 ,2,4-triazinyl, 1 ,2,3-triazinyl, 1,3,5-triazinyl, pyrazolo[3,4-b]pyridinyl, cinnolinyl, pteri
- Aryl when used herein refers to phenyl or naphthyl.
- pharmaceutically acceptable is meant a material that is not biologically or otherwise undesirable, i.e., the material may be administered to an individual along with the selected compound without causing any undesirable biological effects or interacting in a deleterious manner with any of the other components of the pharmaceutical composition in which it is contained.
- the term "subject” is meant an individual.
- the subject is a mammal such as a primate, and more preferably, a human.
- the "subject” can include domesticated animals, livestock, and laboratory animals.
- "effective amount” or “effective dose” means the amount needed to achieve the desired result or results (treating or preventing the condition).
- an "effective amount” can vary for the various compounds used in the invention.
- numerical values described and claimed herein are approximate. Variation within the values may be attributed to equipment calibration, equipment errors, purity of the materials, among other factors. Additionally, variation may be possible, while still obtaining the same result
- step 1 of Scheme 1 the compound of formula (Via) is converted to the carbamate of formula (Va) by reaction with a compound of formula W-CO 2 Pv ⁇ in a solvent system.
- the solvent system preferably contains an amine, such as triethylamine, diisopropylethylamine, or other tertiary amine. Other solvents may also be used, including dichloromethane, tetrahydrofuran, and methyltetrahydrofuran.
- the mixture is then cooled to approximately -80° to 25°C and the W-CO ⁇ R, is slowly added to control the temperature. The mixture is allowed to stir until for at least one hour, preferably, four hours or more.
- step 2 of Scheme 1 the carbamate of formula (Va) is oxidized to form the oxidation product (IVa).
- the oxidation reaction produces a mixture of compounds having the formula (IVa).
- Any suitable oxidation conditions may be used. Preferred conditions include electrochemical oxidation, such as performing the oxidation reaction in an electrolytic solution in an electric cell and electrolyzing the cell.
- the electrolytic solution is a mixture of acetic acid and potassium acetate.
- the electrolytic solution includes acetic anhydride.
- the cathode and anode may be made of any suitable material, including platinum and niobium.
- the mixture is then electrolyzed at an appropriate current until the reaction is substantially complete.
- the temperature of the electrolytic solution may be maintained at a temperature lower than 60°C, preferably lower than 40°C.
- the temperature is preferably maintained at about 60°C to about 160°C; more preferably, the temperature is raised to about >100°C, more preferably to about >120°C.
- the mixture is allowed to stir for at least two hours, preferably 4 hours or more.
- step 4 of Scheme 1 the enamino acetate (Ilia) is converted to the ketopiperidine (lla) by reaction with a compound having the formula R t OH, water or RjNH 2 .
- this reaction is maintained at temperatures less than 20°C, more preferably less than 5°C.
- step 5 of Scheme 1 the ketopiperidine (lla) is converted to the aminopiperidine (la) by reaction with NHR 2 R 3 , N(CH 3 )R 2 R 3 , or N(CH 2 CH 3 )R 2 R 3 .
- the product of this reaction is reduced with a reducing agent to form the aminopiperidine (la).
- the reactions are typically conducted in a solvent, such as methanol, at ambient temperature for a time period between about 12 hours to about 18 hours.
- exemplary reducing agents include borohydrides, such as sodium cyanoborohydride and sodium borohydride.
- the temperature is maintained below 0°C.
- the reaction is substantially complete within minutes, usually within at least an hour.
- the carbamate (IVb) is hydrogenated to form the compound of formula (lllb).
- the hydrogenation also may lead to cis-trans isomers. Certain catalysts may be desired for the cis:trans selectivity.
- Exemplary hydrogentation catalysts include PtO 2 , Rh/C (several types), RuO 2 , Rh/AI 2 O 3 , Ru/C (several types), Lindlar's catalyst, and Wilkinson's catalyst.
- Exemplary solvents include acetic acid, propanol, ethanol, methanol/ammonium hydroxide, acetonitrile, tetrahydrofuran, cyclohexane, heptanes, toluene, dimethylformamide, water.
- the reactions are typically conducted in a solvent, such as methanol, at ambient temperature for a time period between about 12 hours to about 18 hours.
- exemplary reducing agents include borohydrides, such as sodium cyanoborohydride and sodium borohydride.
- the reducing agent is triacetoxyborohydride.
- step 4 of Scheme 2 the compound of formula (lib) is reduced to the compound of formula (lb).
- exemplary reducing agents include lithium aluminum hydride, Vitride (Red-AI), and borane.
- the reduction is carried out in a solvent such as tetrahydrofuran, diethylether, or methyltetrahydrofuran, preferably at temperatures of about -10°to about 100°C for about five minutes to about 48 hours.
- R' and R" are each independently selected from the group consisting of hydrogen, deuterium, amino, halo, hydoxy, nitro, carboxy, (C 2 -C 6 )alkenyl, (C 2 - C 6 )alkynyl, trifluoromethyl, trifluoromethoxy, (d-C 6 )alkyl, (C C 6 )alkoxy, (C 3 - C ⁇ o)cycloalkyl wherein the alkyl, alkoxy or cycloalkyl groups are optionally substittued by one to three groups selected from halo, hydroxy, carboxy, amino (C 1 -C 6 )alkylthio, (C C 6 )alkylamino, ((C C 6 )alkyl) 2 amino, (C 5 -C 9 )heteroaryl, (C 2 -C 9 )heterocycloalkyl, (C 3 -C 9 )cycloalkyl or (C
- R' is hydrogen or a protecting group
- R 4 -O-(C O)- or R 13 -(CH 2 )-.
- the coupling reaction is carried out in an alcohol solvent, such as tert-butanol, methanol or ethanol, or other high boiling organic solvents, such as dimethylformamide, triethylamine, 1 ,4-dioxane or 1 ,2-dichloroethane, at a temperature between about 60°C to about 120°C, preferably about 80°C. Typical reaction times are between about 2 hours to about 48 hours, preferably about 16 hours. If R'" is a protecting group, the protecting group may be removed in an additional step.
- an alcohol solvent such as tert-butanol, methanol or ethanol
- other high boiling organic solvents such as dimethylformamide, triethylamine, 1 ,4-dioxane or 1 ,2-dichloroethane
- removal of the protecting group, wherein R'" is benzenesulfonyl is carried out by treating the product of the coupling reaction A or B with an alkali base, such as sodium hydroxide or potassium hydroxide, in an alcohol solvent, such as methanol or ethanol, or mixed solvents, such as alcohol/tetrahydrofuran or alcohol/water.
- an alkali base such as sodium hydroxide or potassium hydroxide
- an alcohol solvent such as methanol or ethanol
- mixed solvents such as alcohol/tetrahydrofuran or alcohol/water.
- the reaction is carried out at room temperature for a time period between about 15 minutes to about 1 hour, preferably 30 minutes.
- Removal of the protecting group, wherein R is benzyl is conducted by treating the product of the coupling reaction A or B with sodium in ammonia at a temperature of about -78°C for a time period between about 15 minutes to about 1 hour.
- the pressure of each of the above reactions is not critical. Generally, the reactions are conducted at a pressure of about one to about three atmospheres, preferably at ambient pressure (about one atmosphere).
- the compounds of the formulas (la) and (lb) are capable of forming a wide variety of different salts with various inorganic and organic acids.
- the compounds of the present invention that are basic in nature are capable of forming a wide variety of different salts with various inorganic and organic acids. Although such salts must be pharmaceutically acceptable for administration to animals, it is often desirable in practice to initially isolate the compound of the present invention from the reaction mixture as a pharmaceutically unacceptable salt and then simply convert the latter back to the free base compound by treatment with an alkaline reagent and subsequently convert the latter free base to a pharmaceutically acceptable acid addition salt.
- the acid addition salts of the base compounds of this invention are readily prepared by treating the base compound with a substantially equivalent amount of the chosen mineral or organic acid in an aqueous solvent medium or in a suitable organic solvent, such as acetone, methanol or ethanol.
- the desired solid salt is readily obtained.
- the desired acid salt can also be precipitated from a solution of the free base in an organic solvent by adding to the solution an appropriate mineral or organic acid.
- Those compounds of the present invention that are acidic in nature are capable of forming base salts with various pharmacologically acceptable cations. Examples of such salts include the alkali metal or alkaline-earth metal salts and particularly, the calcium, sodium and potassium salts. These salts are all prepared by conventional techniques.
- the chemical bases which are used as reagents to prepare the pharmaceutically acceptable base salts of this invention are those which form non-toxic base salts with the acidic compounds of the present invention.
- Such non-toxic base salts include those derived from such pharmacologically acceptable cations as sodium, potassium calcium and magnesium, etc. These salts can easily be prepared by treating the corresponding acidic compounds with an aqueous solution containing the desired pharmacologically acceptable cations, and then evaporating the resulting solution to dryness, preferably under reduced pressure. Alternatively, they may also be prepared by mixing lower alkanolic solutions of the acidic compounds and the desired alkali metal alkoxide together, and then evaporating the resulting solution to dryness in the same manner as before. In either case, stoichiometric quantities of reagents are preferably employed in order to ensure completeness of reaction and maximum yields of the desired final product.
- the compounds of the formula I and its pharmaceutically acceptable salts are inhibitors of protein kinases, such as the enzyme Janus Kinase 3 (JAK3) and are therefore useful therapy as immunosuppressive agents for treating or preventing organ transplant rejection, xeno transplation, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukemia and other autoimmune diseases, acute and chronic organ transplant rejection, heart transplant rejection, lung transplant rejection, liver transplant rejection, kidney transplant rejection, pancreas transplant rejection, uterus transplant rejection, joints transplant rejection, islets transplant rejection, bone marrow transplant rejection, limb transplant rejection, cornea transplant rejection, skin transplant rejection, hepatocytes transplant rejection, hepatocytes cell transplant rejection, pancreatic beta-cells transplant rejection,
- JNK3 Janus Kinase 3
- the pharmaceutical compositions may take the form of, for example, tablets or capsules prepared by conventional means with pharmaceutically acceptable excipients such as binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose); fillers (e.g., lactose, microcrystalline cellulose or calcium phosphate); lubricants (e.g., magnesium stearate, talc or silica); disintegrants (e.g., potato starch or sodium starch glycolate); or wetting agents (e.g., sodium lauryl sulphate).
- binding agents e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose
- fillers e.g., lactose, microcrystalline cellulose or calcium phosphate
- lubricants e.g., magnesium stearate, talc or silica
- disintegrants e.g., potato starch or sodium
- Liquid preparations for oral administration may take the form of, for example, solutions, syrups or suspensions, or they may be presented as a dry product for constitution with water or other suitable vehicle before use.
- Such liquid preparations may be prepared by conventional means with pharmaceutically acceptable additives such as suspending agents (e.g., sorbitol syrup, methyl cellulose or hydrogenated edible fats); emulsifying agents (e.g., lecithin or acacia); non-aqueous vehicles (e.g., almond oil, oily esters or ethyl alcohol); and preservatives (e.g., methyl or propyl p-hydroxybenzoates or sorbic acid).
- suspending agents e.g., sorbitol syrup, methyl cellulose or hydrogenated edible fats
- emulsifying agents e.g., lecithin or acacia
- non-aqueous vehicles e.g., almond oil, oily esters or ethyl alcohol
- the composition may take the form of tablets or lozenges formulated in conventional manner.
- the active compounds of the invention may be formulated for parenteral administration by injection, including using conventional catheterization techniques or infusion.
- Formulations for injection may be presented in unit dosage form, e.g., in ampules or in multi-dose containers, with an added preservative.
- the compositions may take such forms as suspensions, solutions or emulsions in oily or aqueous vehicles, and may contain formulating agents such as suspending, stabilizing and/or dispersing agents.
- the active ingredient may be in powder form for reconstitution with a suitable vehicle, e.g., sterile pyrogen-free water, before use.
- the active compounds of the invention may also be formulated in rectal compositions such as suppositories or retention enemas, e L, containing conventional suppository bases such as cocoa butter or other glycerides.
- rectal compositions such as suppositories or retention enemas, e L, containing conventional suppository bases such as cocoa butter or other glycerides.
- the active compounds of the invention are conveniently delivered in the form of a solution or suspension from a pump spray container that is squeezed or pumped by the patient or as an aerosol spray presentation from a pressurized container or a nebulizer, with the use of a suitable propellant, e.g., dichlorodifluoromethane, tnchlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide or other suitable gas.
- a suitable propellant e.g., dichlorodifluoromethane, tnchlorofluoromethane,
- the dosage unit may be determined by providing a valve to deliver a metered amount.
- the pressurized container or nebulizer may contain a solution or suspension of the active compound.
- Capsules and cartridges made, for example, from gelatin) for use in an inhaler or insufflator may be formulated containing a powder mix of a compound of the invention and a suitable powder base such as lactose or starch.
- a proposed dose of the active compounds of the invention for oral, parenteral or buccal administration to the average adult human for the treatment of the conditions referred to above is 0.1 to 1000 mg of the active ingredient per unit dose which could be administered, for example, 1 to 4 times per day.
- Aerosol formulations for treatment of the conditions referred to above are preferably arranged so that each metered dose or "puff of aerosol contains 20 ⁇ g to 1000 ⁇ g of the compound of the invention.
- the overall daily dose with an aerosol will be within the range 0.1 mg to 1000 mg.
- Administration may be several times daily, for example 2, 3, 4 or 8 times, giving for example, 1 , 2 or 3 doses each time.
- the active compounds of formula (la-1 ) administered in a pharmaceutically acceptable form either alone or in combination with one or more additional agents which modulate a mammlian immune system or with antiinflammatory agents agents which may include but are not limited to cyclosporin A (e.g. Sandimmune ® or Neoral ® , rapamycin, FK-506 (tacrolimus), leflunomide, deoxyspergualin, mycophenolate (e.g. Cellcept ® , azathioprine (e.g. Imuran ® ), daclizumab (e.g. Zenapax ® ), OKT3 (e.g.
- Orthocolone ® AtGam, aspirin, acetaminophen, ibuprofen, naproxen, piroxicam, and antiinflmmatory steroids (e.g. prednisolone or dexamethasone),an EPO, FK 778, Sdz-rad, steroids, IVIG, COX-2 inhibitor, NSAIDS, FTY720, basiliximab, donor cells, enerolimus, anti-CD28/CTLA-41g, ISTA-TX-247, gancyclovir, interferon and alpha/rebif, septra, anti-TNFS, P38 inhibitors, CCRI antagonists, PDE4 antagonists, lipitor/statins, acyclovir, ribovikin, protease inhibitors/RTIs, insulin, rituximab, cetirizine or H1 blockers; and such agents may be administered as part of the same or separate dosage forms, via the same or different routes of administration, and on the same
- FK506 (Tacrolimus) is given orally at 0.10-0.15 mg/kg body weight, every 12 hours, within first 48 hours postoperative. Dose is monitored by serum Tacrolimus trough levels.
- Cyclosporin A (Sandimmune oral or intravenous formulation, or Neoral ® , oral solution or capsules) is given orally at 5 mg/kg body weight, every 12 hours within 48 hours postoperative. Dose is monitored by blood Cyclosporin A trough levels.
- the active agents can be formulated for sustained delivery according to methods well known to those of ordinary skill in the art. Examples of such formulations can be found in United States Patents 3,538,214, 4,060,598, 4,173,626, 3,119,742, and 3,492,397.
- JAK3 (JH1:GST) Enzymatic Assay
- the JAK3 kinase assay utilizes a protein expressed in baculovirus-infected SF9 cells (a fusion protein of GST and the catalytic domain of human JAK3) purified by affinity chromatography on glutathione-Sepaharose.
- the substrate for the reaction is poly-Glutamic acid-Tyrosine (PGT (4:1), Sigma catalog # P0275), coated onto Nunc Maxi Sorp plates at 100 ⁇ g/ml overnight at 37°C.
- This screen measures the inhibitory effect of compounds on IL-2 dependent T-Cell blast proliferation in vitro. Since signaling through the IL-2 receptor requires JAK-3, cell active inhibitors of JAK-3 should inhibit IL-2 dependent T-Cell blast proliferation.
- the cells for this assay are isolated from fresh human blood. After separation of the mononuclear cells using Accuspin System-Histopaque-1077 (Sigma # A7054), primary human T-Cells are isolated by negative selection using Lympho-Kwik T (One Lambda, Inc., Cat # LK-50T). T-Cells are cultured at 1-2 x 10 6 /ml in Media (RPMI + 10% heat-inactivated fetal calf serum (Hyclone Cat # A-1111 -L) + 1 %
- Penicillin/Streptomycin (Gibco) and induce to proliferate by the addition of 10ug/ml PHA (Murex Diagnostics, Cat # HA 16). After 3 days at 37°C in 5% CO 2 , cells are washed 3 times in Media, resuspended to a density of 1-2 x 10 6 cells/ml in Media plus 100 Units/ml of human recombinant IL-2 (R&D Systems, Cat # 202-IL). After 1 week the cells are IL-2 dependent and can be maintained for up to 3 weeks by feeding twice weekly with equal volumes of Media + 100 Units/ml of IL-2.
- IL-2 dependent cells are washed 3 times, resuspended in media and then plated (50,000 cells/well/0.1ml) in a Flat-bottom 96-well mierotiter plate (Falcon # 353075). From a10 mM stock of test compound in DMSO, serial 2-fold dilutions of compound are added in triplicate wells starting at 10 uM. After one hour, 10 Units/ml of IL-2 is added to each test well. Plates are then incubated at 37°C, 5% CO 2 for 72 hours.
- AA is amino acid
- Boc is t-butoxy carbonyl
- CDCI 3 is deuteriotrichloromethane
- DMF is N,N-dimethylformamide
- HCI hydrochloric acid
- HMDS hexamethyldisilazane
- IPE is isopropyl ether MeOH is methanol
- THF tetrahydrofuran g is grams
- M is molar ml is milliliter mmol is millimole
- N normal psi is pounds per square inch h is hours min is minutes sec is seconds mp is melting point
- HPLC high pressure liquid chromatography
- NMR nuclear magnetic resonance
- TLC thin layer chromatography
- the hydrogenation was carried out by charging 5 grams (1 equiv., 30.1 mmol) (4-methyl-pyridin-3-yl)-carbamic acid methyl ester, 50 ml ethanol (10 volumes), and 2.5 grams rhodium on alumina (0.5 wt. equivs.) to a bomb hydrogenator. The hydrogenation was performed under 100 psi hydrogen at 100°C for 24 hours to give only cis-(4-methyl-piperidin-3-yl)-carbamic acid methyl ester and its trans isomer (5:1 ratio) in quantitative yield.
- the reaction was worked up by quenching with 40 ml Rochelle Salt (20 volumes) to a temperature of 35°C and then extracting the product 2 times into 20 ml methylene chloride (10 volumes). The filtrate was then concentrated to a clear and colorless oil. (90 % yield). Note that the starting material needs to be clean in order for this reaction to proceed in high yield.
- Cis-(1 -Benzyl-4-methyl-piperidin-3-yl)-methyl-amine hvdrochloride salt The final salt formation was performed by charging 1.5 grams cis-(1-benzyl-4- methyl-piperidin-3-yl)-methyl-amine (1 equiv., 5.15 mmol) and 4.5 ml ethanol (3 volumes) to a reactor at 0°C. To the 0°C pot, was charged 0.93 ml 36 % HCI (0.625 volumes) so that the temperature stayed below 10°C. Next 3 mis ethanol (2 volumes) were concentrated from the reaction.
- the aqueous mixture was extracted with ethyl acetate (3 x 250 ml), the organic layers were combined and the ethyl acetate was removed under reduced pressure. Approximately 119.0 g of a thick brown oil material 5-acetoxy-4- methyl-3,4-dihydro-2H-pyridine-1 -carboxylic acid methyl ester was recovered.
- the TLC indicates conversion to product 5-acetoxy-4-methyl-3,4-dihydro-2H-pyridine-1- carboxylic acid methyl ester as the major component. The material was split evenly into two portions for separate hydrolysis reactions.
- the methylamine-ketone solution from above was diluted in absolute ethanol, and slowly added to the sodium borohydride solution with continued cooling in an ice bath. After addition was completed (ca. 1 hr), the mixture was allowed to warm to room temp. After 2 hours the flask was stored at 4 °C overnight. To the stirring solution was added 10 ml of water. After 20 minutes, concentrated hydrochloric acid was slowly added until the pH remained around 2. The mixture was then concentrated by rotary evaporation. The aqueous solution was made basic with sodium carbonate, and extracted three times with ethyl acetate. The organic layers were combined, dried over magnesium sulfate, filtered and concentrated by rotary evaporation.
Abstract
Description
Claims
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AU2003278529A AU2003278529A1 (en) | 2002-11-21 | 2003-11-10 | 3-amino-piperidine derivatives and processes for their preparation |
JP2004553003A JP2006508976A (en) | 2002-11-21 | 2003-11-10 | 3-Amino-piperazine derivatives and production method |
EP03769829A EP1572649A2 (en) | 2002-11-21 | 2003-11-10 | 3-amino-piperidine derivatives and processes for their preparation |
MXPA05005403A MXPA05005403A (en) | 2002-11-21 | 2003-11-10 | 3-amino-piperidine derivatives and processes for their preparation. |
BR0316470-5A BR0316470A (en) | 2002-11-21 | 2003-11-10 | 3-Amino-piperadine derivatives and preparation methods |
CA002506016A CA2506016C (en) | 2002-11-21 | 2003-11-10 | 3-amino-piperidine derivatives and processes for their preparation |
YUP-2005/0380A RS20050380A (en) | 2002-11-21 | 2003-11-10 | 3-amino piperidine derivatives and methods of manufacture |
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US (1) | US7084277B2 (en) |
EP (1) | EP1572649A2 (en) |
JP (1) | JP2006508976A (en) |
KR (2) | KR100678800B1 (en) |
CN (2) | CN1726192A (en) |
AU (1) | AU2003278529A1 (en) |
BR (1) | BR0316470A (en) |
CA (1) | CA2506016C (en) |
MX (1) | MXPA05005403A (en) |
PL (1) | PL377791A1 (en) |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2007098507A2 (en) | 2006-02-24 | 2007-08-30 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
WO2008049123A2 (en) | 2006-10-19 | 2008-04-24 | Rigel Pharmaceuticals, Inc. | 2,4-pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases |
US7655797B2 (en) | 2002-02-01 | 2010-02-02 | Rigel Pharmaceuticals, Inc. | Intermediates for making 2,4-pyrimidinediamine compounds |
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Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0111864A1 (en) * | 1982-12-21 | 1984-06-27 | Shionogi Seiyaku Kabushiki Kaisha | 1,4-Benzodiazepine derivatives |
US4725599A (en) * | 1986-09-08 | 1988-02-16 | Pfizer Inc. | Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents |
EP0302788A1 (en) * | 1987-08-07 | 1989-02-08 | Synthelabo | 2-[Methyl(4-piperidinyl)]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b] indole derivatives, their preparation and therapeutical use |
EP0478363A2 (en) * | 1990-09-27 | 1992-04-01 | Merck & Co. Inc. | Novel sulfonamide fibrinogen receptor antagonists |
EP0618196A1 (en) * | 1993-03-31 | 1994-10-05 | Eli Lilly And Company | Stereocontrolled synthesis of cis-bicyclic compounds |
US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
WO1998024446A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating movement disorders |
WO1999000368A1 (en) * | 1997-06-27 | 1999-01-07 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
WO2001070673A2 (en) * | 2000-03-17 | 2001-09-27 | Bristol-Myers Squibb Pharma Company | CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a) |
WO2001081347A2 (en) * | 2000-04-27 | 2001-11-01 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
US20010053782A1 (en) * | 1999-12-10 | 2001-12-20 | Blumenkopf Todd A. | Pyrrolo[2,3-d]pyrimidine compounds |
JP2002201192A (en) * | 2000-12-28 | 2002-07-16 | Japan Science & Technology Corp | New method for synthesizing febrifugine and febrifugine compound |
WO2002057244A1 (en) * | 2001-01-19 | 2002-07-25 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE640616A (en) | 1962-12-19 | |||
US3492397A (en) | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
US4060598A (en) | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
US3538214A (en) | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US4173626A (en) | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
JP4669607B2 (en) | 1997-09-15 | 2011-04-13 | ザ プロクター アンド ギャンブル カンパニー | Antimicrobial quinolones, compositions thereof and uses thereof |
JP4030164B2 (en) * | 1997-12-01 | 2008-01-09 | 株式会社トクヤマ | Tetrahydropyridine derivative and method for producing the same |
-
2003
- 2003-11-10 MX MXPA05005403A patent/MXPA05005403A/en active IP Right Grant
- 2003-11-10 RU RU2005115500/04A patent/RU2309147C9/en active
- 2003-11-10 KR KR1020057009058A patent/KR100678800B1/en not_active IP Right Cessation
- 2003-11-10 EP EP03769829A patent/EP1572649A2/en not_active Withdrawn
- 2003-11-10 KR KR1020067021730A patent/KR100742012B1/en not_active IP Right Cessation
- 2003-11-10 CN CNA2003801062274A patent/CN1726192A/en active Pending
- 2003-11-10 AU AU2003278529A patent/AU2003278529A1/en not_active Abandoned
- 2003-11-10 CN CNA2008101292567A patent/CN101353321A/en active Pending
- 2003-11-10 WO PCT/IB2003/005151 patent/WO2004046112A2/en active Application Filing
- 2003-11-10 CA CA002506016A patent/CA2506016C/en not_active Expired - Fee Related
- 2003-11-10 RS YUP-2005/0380A patent/RS20050380A/en unknown
- 2003-11-10 BR BR0316470-5A patent/BR0316470A/en not_active IP Right Cessation
- 2003-11-10 PL PL377791A patent/PL377791A1/en not_active Application Discontinuation
- 2003-11-10 JP JP2004553003A patent/JP2006508976A/en not_active Withdrawn
- 2003-11-20 US US10/717,958 patent/US7084277B2/en not_active Expired - Fee Related
-
2005
- 2005-05-19 ZA ZA200504068A patent/ZA200504068B/en unknown
-
2007
- 2007-04-28 RU RU2007116248/04A patent/RU2007116248A/en not_active Application Discontinuation
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0111864A1 (en) * | 1982-12-21 | 1984-06-27 | Shionogi Seiyaku Kabushiki Kaisha | 1,4-Benzodiazepine derivatives |
US4725599A (en) * | 1986-09-08 | 1988-02-16 | Pfizer Inc. | Heterocyclic ring fused pyrimidine-4 (3H)-ones as anticoccidial agents |
EP0302788A1 (en) * | 1987-08-07 | 1989-02-08 | Synthelabo | 2-[Methyl(4-piperidinyl)]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b] indole derivatives, their preparation and therapeutical use |
EP0478363A2 (en) * | 1990-09-27 | 1992-04-01 | Merck & Co. Inc. | Novel sulfonamide fibrinogen receptor antagonists |
EP0618196A1 (en) * | 1993-03-31 | 1994-10-05 | Eli Lilly And Company | Stereocontrolled synthesis of cis-bicyclic compounds |
US5559128A (en) * | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
WO1998024446A1 (en) * | 1996-12-02 | 1998-06-11 | Merck Sharp & Dohme Limited | Use of nk-1 receptor antagonists for treating movement disorders |
WO1999000368A1 (en) * | 1997-06-27 | 1999-01-07 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
US20010053782A1 (en) * | 1999-12-10 | 2001-12-20 | Blumenkopf Todd A. | Pyrrolo[2,3-d]pyrimidine compounds |
WO2001070673A2 (en) * | 2000-03-17 | 2001-09-27 | Bristol-Myers Squibb Pharma Company | CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a) |
WO2001081347A2 (en) * | 2000-04-27 | 2001-11-01 | Abbott Laboratories | Diazabicyclic central nervous system active agents |
JP2002201192A (en) * | 2000-12-28 | 2002-07-16 | Japan Science & Technology Corp | New method for synthesizing febrifugine and febrifugine compound |
WO2002057244A1 (en) * | 2001-01-19 | 2002-07-25 | Cytokinetics, Inc. | Phenothiazine kinesin inhibitors |
Non-Patent Citations (3)
Title |
---|
P. DUHAMEL ET AL.: "Synthesis of Bicyclic Aza-enones via a Lewis Acid Catalysed Michael-type Addition with Silyl Enol Ethers bearing a Nitrogen Atom" TETRAHEDRON LETTERS, vol. 34, no. 24, 1993, pages 3863-3866, XP002270973 * |
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 11, 30 September 1999 (1999-09-30) & JP 11 158147 A (TOKUYAMA CORP), 15 June 1999 (1999-06-15) * |
PATENT ABSTRACTS OF JAPAN vol. 2002, no. 11, 6 November 2002 (2002-11-06) & JP 2002 201192 A (JAPAN SCIENCE & TECHNOLOGY CORP), 16 July 2002 (2002-07-16) * |
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US10533001B2 (en) | 2008-04-16 | 2020-01-14 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8501944B2 (en) | 2008-04-16 | 2013-08-06 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US9868729B2 (en) | 2008-04-16 | 2018-01-16 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US11414410B2 (en) | 2008-04-16 | 2022-08-16 | Alexion Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8937070B2 (en) | 2008-04-16 | 2015-01-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8952027B2 (en) | 2008-04-16 | 2015-02-10 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
US9579320B2 (en) | 2008-04-16 | 2017-02-28 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8258144B2 (en) | 2008-04-22 | 2012-09-04 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US9139581B2 (en) | 2008-04-22 | 2015-09-22 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
US8299084B2 (en) | 2009-04-20 | 2012-10-30 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of Janus kinase 3 |
US8962638B2 (en) | 2009-04-20 | 2015-02-24 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of janus kinase 3 |
US9493469B2 (en) | 2009-04-20 | 2016-11-15 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of Janus kinase 3 |
US9856261B2 (en) | 2009-04-20 | 2018-01-02 | Auspex Pharmaceuticals, Inc. | Piperidine inhibitors of Janus kinase 3 |
WO2011045702A1 (en) | 2009-10-15 | 2011-04-21 | Pfizer Inc. | Pyrrolo[2,3-d] pyrimidine compounds |
US8633206B2 (en) | 2009-10-15 | 2014-01-21 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine compounds |
WO2011075334A1 (en) | 2009-12-18 | 2011-06-23 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
US8372854B2 (en) | 2009-12-18 | 2013-02-12 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine compounds |
WO2011097087A1 (en) | 2010-02-05 | 2011-08-11 | Pfizer Inc. | Pyrrolo [ 2, 3 - d] pyrimidine urea compounds as jak inhibitors |
US9102625B2 (en) | 2010-11-01 | 2015-08-11 | Portola Pharmaceuticals, Inc. | Nicotinamides as JAK kinase modulators |
WO2012061428A2 (en) | 2010-11-01 | 2012-05-10 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
EP2975027A1 (en) | 2010-11-01 | 2016-01-20 | Portola Pharmaceuticals, Inc. | Nicotinamides as jak kinase modulators |
US9359308B2 (en) | 2011-11-23 | 2016-06-07 | Portola Pharmaceuticals, Inc. | Pyrazine kinase inhibitors |
WO2014016338A1 (en) | 2012-07-25 | 2014-01-30 | Lek Pharmaceuticals D.D. | New synthetic route for the preparation of 3-amino-piperidine compounds |
US9676756B2 (en) | 2012-10-08 | 2017-06-13 | Portola Pharmaceuticals, Inc. | Substituted pyrimidinyl kinase inhibitors |
US9549929B2 (en) | 2013-02-22 | 2017-01-24 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine derivatives |
US9035074B2 (en) | 2013-02-22 | 2015-05-19 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine derivatives |
EP3290421A1 (en) | 2013-02-22 | 2018-03-07 | Pfizer Inc | Combination of pyrrolo [2, 3 -d]pyrimidine derivatives with one or more additional agents as inhibitors of janus- related kinases (jak) |
US9545405B2 (en) | 2013-02-22 | 2017-01-17 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine derivatives |
WO2014128591A1 (en) | 2013-02-22 | 2014-08-28 | Pfizer Inc. | Pyrrolo [2, 3 -d]pyrimidine derivatives as inhibitors of janus- related kinases (jak) |
WO2015083028A1 (en) | 2013-12-05 | 2015-06-11 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
US11111242B2 (en) | 2013-12-05 | 2021-09-07 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
US9617258B2 (en) | 2013-12-05 | 2017-04-11 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
EP3318565A1 (en) | 2013-12-05 | 2018-05-09 | Pfizer Inc | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyrrolo[2,3-d]pyridinyl acrylamides |
US10966980B2 (en) | 2014-08-12 | 2021-04-06 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives |
WO2016024185A1 (en) | 2014-08-12 | 2016-02-18 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
US10703756B2 (en) | 2015-05-01 | 2020-07-07 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidinyl, pyrrolo[2,3-B]pyrazinyl, pyrrolo[2,3-B]pyridinyl acrylamides and epoxides thereof |
WO2016178110A1 (en) | 2015-05-01 | 2016-11-10 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, pyrrolo[2,3-b]pyridinyl acrylamides and epoxides thereof |
WO2020198583A1 (en) | 2019-03-27 | 2020-10-01 | Insilico Medicine Ip Limited | Bicyclic jak inhibitors and uses thereof |
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RU2005115500A (en) | 2006-01-20 |
CN101353321A (en) | 2009-01-28 |
RS20050380A (en) | 2007-11-15 |
RU2309147C9 (en) | 2008-03-20 |
KR100678800B1 (en) | 2007-02-05 |
KR20050083905A (en) | 2005-08-26 |
JP2006508976A (en) | 2006-03-16 |
KR20060116873A (en) | 2006-11-15 |
WO2004046112A3 (en) | 2004-08-05 |
KR100742012B1 (en) | 2007-07-23 |
PL377791A1 (en) | 2006-02-20 |
CA2506016C (en) | 2009-03-17 |
US7084277B2 (en) | 2006-08-01 |
EP1572649A2 (en) | 2005-09-14 |
CN1726192A (en) | 2006-01-25 |
US20040102627A1 (en) | 2004-05-27 |
CA2506016A1 (en) | 2004-06-03 |
MXPA05005403A (en) | 2005-08-03 |
ZA200504068B (en) | 2006-08-30 |
RU2309147C2 (en) | 2007-10-27 |
AU2003278529A1 (en) | 2004-06-15 |
BR0316470A (en) | 2005-10-11 |
RU2007116248A (en) | 2008-11-10 |
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