WO2004043274A1 - Method and device for application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum - Google Patents
Method and device for application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum Download PDFInfo
- Publication number
- WO2004043274A1 WO2004043274A1 PCT/IL2003/000949 IL0300949W WO2004043274A1 WO 2004043274 A1 WO2004043274 A1 WO 2004043274A1 IL 0300949 W IL0300949 W IL 0300949W WO 2004043274 A1 WO2004043274 A1 WO 2004043274A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aerosol
- cavity
- peritoneum
- vessel
- medical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M13/00—Insufflators for therapeutic or disinfectant purposes, i.e. devices for blowing a gas, powder or vapour into the body
- A61M13/003—Blowing gases other than for carrying powders, e.g. for inflating, dilating or rinsing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/34—Trocars; Puncturing needles
- A61B17/3474—Insufflating needles, e.g. Veress needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0225—Carbon oxides, e.g. Carbon dioxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/048—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/101—Pleural cavity
Definitions
- the present invention relates to the field of medicine and, more particularly, to application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum.
- the present invention may chiefly be used in anesthesia to reduce pain intensity during and after endoscopic procedures in visceral and artificial cavities.
- the object of the present invention is, therefore, the task of developing a method of application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum found in the thoracic or the abdominal cavity, respectively, wherein a medical preparation could be administered in a form ensuring the uniform application of the medical preparation over the whole surface of the pleura or the peritoneum, to increase the efficiency of the method, to prevent general intoxication and to reduce the irritative painful effect of carbon dioxide.
- the said task is fulfilled by dilation of the respective cavity allowing to expose a clear surface of the pleura or the peritoneum to apply a medical preparation thereto.
- the medical preparation is applied to the said clear surface by means of insufflation of its aerosol having a range of particle dimensions of 1-10 ⁇ m into the cavity.
- the device of the present invention for application of medical preparations comprises vessel 2 insulated from the environment, the said vessel having inlet pipe 4 to receive the vehicle gas and outlet pipe 6 to discharge an aerosol.
- the device also comprises insufflator 8, its outlet 10 connected to inlet pipe 4 of vessel 2.
- any other known pressure regulator having an outlet expanding gas pressure of 5 to 30 mm Hg may be used.
- Vessel 2 is equipped with a sealing member - membrane 12 - to pass a medical preparation into the vessel.
- Other structure, such as an end cap, may be used in the capacity of sealing member.
- the device of the present invention also comprises means 14 for preparing an aerosol of the medical preparation with a range of particle dimensions of 1 to 10 ⁇ m, the said means placed directly in the vessel and made in the form of an ultrasonic generator.
- Isufflator 8 is adjusted so as to have an expanding gas pressure of 5 to 30 mm Hg at its outlet 10.
- the proposed device is built into a l ⁇ iown system for insufflation of a gas into closed cavities. This system comprises carbon dioxide tank 16 connected through valve 18 with inlet 20 of insufflator 8, and connective pipe 22 with insufflation needle 24 or a troacar intended for insertion into abdominal cavity 26.
- An aqueous solution of a local anesthetic having a preset concentration is injected with a syringe (not shown) through membrane 12 into vessel 2.
- the amount of the anesthetic is determined by its maximal tolerance dose for the patient.
- sodium bicarbonate may be administered instead of or together with the anesthetic to prevent the acidic effect of carbon dioxide on the body tissue.
- ultrasonic generator 14 an aerosol of the anesthetic with a range of particle dimensions of 1 to 10 ⁇ m is created in vessel 2.
- the said range of particle dimensions is ensured by the shape of the vessel and by the frequency of the generator that are selected by the known design-and-experiment method.
- valve 18 of carbon dioxide tank 16 is opened and carbon dioxide is fed from tank 16 into insufflator 8 providing for a preset pressure in the range from 5 to 30 mm Hg, a preset gas flow, and for gas purification.
- the range of pressure values is determined by the possibility of dilation of the cavity to the required dimensions and by the patient's safety criteria.
- a specific pressure value within the said range is selected with regard to the compliance of the cavity.
- the gas is fed through inlet pipe 4 into vessel 2 where it is mixed with the anesthetic aerosol.
- Aerosol of the mixture of expanding gas, playing as well the role of driving gas, and anesthetic is passed to the abdominal cavity through outlet pipe 6, connective pipe 22 and insufflation needle 24 or a troacar.
- Dilation of abdominal cavity 26 caused by the aerosol exposes a clear peritoneal surface, and the aerosol is uniformly distributed over the whole volume of cavity 26.
- the said uniform distribution of the aerosol results in the uniform deposition of aerosol particles on the clear peritoneal surface and the formation of a uniform thin layer of anesthetic having a preset effective concentration.
- the cavity may be dilated by other known methods, for example, by gas-less techniques envisaging the use of mechamcal or vacuum devices.
- gas-less techniques envisaging the use of mechamcal or vacuum devices.
- the use of these devices is less advisable since mechanical devices may traumatize the peritoneum and vacuum ones bar the access to the operating field.
- Other embodiments of the present invention can be used in treatment for inflammatory diseases or in diagnostic procedures with the medical preparation being, respectively, an antibiotic or a diagnostic preparation, for example, a contrast medium intended to increase the contrast of organs' surfaces in X-ray, CT or MRI images or images obtained by other techniques.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003279504A AU2003279504A1 (en) | 2002-11-13 | 2003-11-12 | Method and device for application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL15281302A IL152813A0 (en) | 2002-11-13 | 2002-11-13 | Method and device for application of medical preparations to surfaces of the closed visceral cavities for example, to the pleura or the peritoneum |
IL152813 | 2002-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004043274A1 true WO2004043274A1 (en) | 2004-05-27 |
Family
ID=30011905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IL2003/000949 WO2004043274A1 (en) | 2002-11-13 | 2003-11-12 | Method and device for application of medical preparations to surfaces of the closed visceral cavities, for example, to the pleura or the peritoneum |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003279504A1 (en) |
IL (1) | IL152813A0 (en) |
WO (1) | WO2004043274A1 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006060301A2 (en) | 2004-11-30 | 2006-06-08 | Tissue Technologies, Llc | Starch derivatives and other derivatives, production processes therefor, and wound healing applications therefor |
WO2008117264A1 (en) * | 2007-03-28 | 2008-10-02 | Stamford Devices Limited | Insufflation of body cavities |
WO2011018777A1 (en) * | 2009-08-10 | 2011-02-17 | Aerosurgical Limited | An insufflation system |
WO2012163346A1 (en) * | 2011-05-27 | 2012-12-06 | Alexander Hetzel | Operating device for use in laparoscopy |
US8551036B2 (en) | 2009-08-10 | 2013-10-08 | Aerosurgical Limited | Insufflation system |
US9572596B2 (en) | 2011-06-30 | 2017-02-21 | Covidien Lp | Applicators for controlled in situ delivery of therapeutic compositions and implants, methods of fabrication and use |
WO2021092666A1 (en) * | 2019-11-12 | 2021-05-20 | Bhio Supply Indústria E Comércio De Equipamentos Médicos Ltda. | Ultrasonic aerosolization platform for the application of therapeutic substances to body cavities |
RU2794246C1 (en) * | 2022-11-22 | 2023-04-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Reusable trocar |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5558668A (en) * | 1994-10-11 | 1996-09-24 | Plc Medical Systems, Inc. | Medical laser treatment system and method |
US5964223A (en) * | 1994-06-17 | 1999-10-12 | Trudell Medical Limited | Nebulizing catheter system and methods of use and manufacture |
WO2001008573A2 (en) * | 1999-07-30 | 2001-02-08 | Ott Douglas E | Perforated trocar sleeve and method of use |
WO2002085444A1 (en) * | 2001-04-24 | 2002-10-31 | Northgate Technologies Inc. | Laparoscopic insertion device |
-
2002
- 2002-11-13 IL IL15281302A patent/IL152813A0/en unknown
-
2003
- 2003-11-12 WO PCT/IL2003/000949 patent/WO2004043274A1/en not_active Application Discontinuation
- 2003-11-12 AU AU2003279504A patent/AU2003279504A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5964223A (en) * | 1994-06-17 | 1999-10-12 | Trudell Medical Limited | Nebulizing catheter system and methods of use and manufacture |
US5558668A (en) * | 1994-10-11 | 1996-09-24 | Plc Medical Systems, Inc. | Medical laser treatment system and method |
WO2001008573A2 (en) * | 1999-07-30 | 2001-02-08 | Ott Douglas E | Perforated trocar sleeve and method of use |
WO2002085444A1 (en) * | 2001-04-24 | 2002-10-31 | Northgate Technologies Inc. | Laparoscopic insertion device |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006060301A2 (en) | 2004-11-30 | 2006-06-08 | Tissue Technologies, Llc | Starch derivatives and other derivatives, production processes therefor, and wound healing applications therefor |
WO2008117264A1 (en) * | 2007-03-28 | 2008-10-02 | Stamford Devices Limited | Insufflation of body cavities |
US10166348B2 (en) | 2009-08-10 | 2019-01-01 | Aerosurgical Limited | Insufflation system |
WO2011018777A1 (en) * | 2009-08-10 | 2011-02-17 | Aerosurgical Limited | An insufflation system |
US8551036B2 (en) | 2009-08-10 | 2013-10-08 | Aerosurgical Limited | Insufflation system |
US11738159B2 (en) | 2009-08-10 | 2023-08-29 | Aerosurgical Limited | Insufflation system |
US10888674B2 (en) | 2009-08-10 | 2021-01-12 | Aerosurgical Limited | Insufflation system |
US9629967B2 (en) | 2009-08-10 | 2017-04-25 | Aerosurgical Limited | Insufflation system |
WO2012163346A1 (en) * | 2011-05-27 | 2012-12-06 | Alexander Hetzel | Operating device for use in laparoscopy |
US9511197B2 (en) | 2011-05-27 | 2016-12-06 | Alexander Hetzel | Surgical device for use in laparoscopy |
US9572596B2 (en) | 2011-06-30 | 2017-02-21 | Covidien Lp | Applicators for controlled in situ delivery of therapeutic compositions and implants, methods of fabrication and use |
WO2021092666A1 (en) * | 2019-11-12 | 2021-05-20 | Bhio Supply Indústria E Comércio De Equipamentos Médicos Ltda. | Ultrasonic aerosolization platform for the application of therapeutic substances to body cavities |
RU2794246C1 (en) * | 2022-11-22 | 2023-04-13 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Reusable trocar |
Also Published As
Publication number | Publication date |
---|---|
AU2003279504A8 (en) | 2004-06-03 |
AU2003279504A1 (en) | 2004-06-03 |
IL152813A0 (en) | 2003-06-24 |
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