WO2004041781A8 - Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones - Google Patents

Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones

Info

Publication number
WO2004041781A8
WO2004041781A8 PCT/IN2002/000226 IN0200226W WO2004041781A8 WO 2004041781 A8 WO2004041781 A8 WO 2004041781A8 IN 0200226 W IN0200226 W IN 0200226W WO 2004041781 A8 WO2004041781 A8 WO 2004041781A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
indole derivatives
phenylhydrazines
aminoketones
aminoalkyl
Prior art date
Application number
PCT/IN2002/000226
Other languages
French (fr)
Other versions
WO2004041781A1 (en
Inventor
Venkata Satya Niro Ramakrishna
Rama Sastri Kambhampati
Vikas Shreekrishna Shirsath
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Venkata Satya Niro Ramakrishna
Rama Sastri Kambhampati
Vikas Shreekrishna Shirsath
Venkateswarlu Jasti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd, Venkata Satya Niro Ramakrishna, Rama Sastri Kambhampati, Vikas Shreekrishna Shirsath, Venkateswarlu Jasti filed Critical Suven Life Sciences Ltd
Priority to AU2002356428A priority Critical patent/AU2002356428A1/en
Publication of WO2004041781A1 publication Critical patent/WO2004041781A1/en
Publication of WO2004041781A8 publication Critical patent/WO2004041781A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of indole derivatives, particularly those, which are useful as pharmaceutical intermediates. The process involves formation of hydrazone derivative between a phenyl hydrazine and a ketone amine, followed by cyclisation to give desired 2,3-substituted indole derivative in the presence of acid catalyst.
PCT/IN2002/000226 2002-11-07 2002-11-28 Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones WO2004041781A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002356428A AU2002356428A1 (en) 2002-11-07 2002-11-28 Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN817CH2002 2002-11-07
IN817/MAS/2002 2002-11-07

Publications (2)

Publication Number Publication Date
WO2004041781A1 WO2004041781A1 (en) 2004-05-21
WO2004041781A8 true WO2004041781A8 (en) 2004-09-16

Family

ID=32310094

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2002/000226 WO2004041781A1 (en) 2002-11-07 2002-11-28 Preparation of 3-aminoalkyl-substituted indole derivatives from phenylhydrazines and aminoketones

Country Status (1)

Country Link
WO (1) WO2004041781A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20010356A1 (en) * 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-HALOGEN TRIPTAMIN DERIVATIVES USEFUL AS LIGANDS OF THE 5-HT6 AND / OR 5-HT7 SEROTONIN RECEPTOR.
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US8013006B2 (en) 2004-07-14 2011-09-06 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
JP2008507518A (en) 2004-07-22 2008-03-13 ピーティーシー セラピューティクス，インコーポレーテッド Thienopyridine for treating hepatitis C
WO2009088402A2 (en) * 2007-10-01 2009-07-16 Princeton University Identification of bacterial autoinducer and use in treating bacterial pathogenicity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE548818C (en) * 1930-02-07 1932-04-20 I G Farbenindustrie Akt Ges Process for the preparation of substituted indoles
DE878802C (en) * 1943-07-13 1953-06-05 Hoechst Ag Process for the preparation of basic indoles
GB895430A (en) * 1958-04-07 1962-05-02 Sterling Drug Inc Tryptamine derivatives and acid addition salts thereof
US5942536A (en) * 1995-10-10 1999-08-24 Eli Lilly And Company N- 2-substituted-3-(2-aminoethyl)-1H-indol-5-YL!-Amides: new 5-HT1F agonists

Also Published As

Publication number Publication date
WO2004041781A1 (en) 2004-05-21

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