WO2004040016A3 - Genetic markers on chromosome 12 associated to bipolar or unipolar disorders - Google Patents

Genetic markers on chromosome 12 associated to bipolar or unipolar disorders Download PDF

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Publication number
WO2004040016A3
WO2004040016A3 PCT/GB2003/004684 GB0304684W WO2004040016A3 WO 2004040016 A3 WO2004040016 A3 WO 2004040016A3 GB 0304684 W GB0304684 W GB 0304684W WO 2004040016 A3 WO2004040016 A3 WO 2004040016A3
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WO
WIPO (PCT)
Prior art keywords
bipolar
chromosome
markers
disorders
affective disorders
Prior art date
Application number
PCT/GB2003/004684
Other languages
French (fr)
Other versions
WO2004040016A2 (en
Inventor
Gursharan Kalsi
Andrew Mcquillin
Hugh Malcolm Douglas Gurling
Birte Degn
Ole Mors
Torben Kruse
Henrik Di Ewald
Mikkel Dybro Lundorf
Original Assignee
Ucl Biomedica Plc
Gursharan Kalsi
Andrew Mcquillin
Hugh Malcolm Douglas Gurling
Birte Degn
Ole Mors
Torben Kruse
Ewald Marianne Varnich Hf
Mikkel Dybro Lundorf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucl Biomedica Plc, Gursharan Kalsi, Andrew Mcquillin, Hugh Malcolm Douglas Gurling, Birte Degn, Ole Mors, Torben Kruse, Ewald Marianne Varnich Hf, Mikkel Dybro Lundorf filed Critical Ucl Biomedica Plc
Priority to AU2003276427A priority Critical patent/AU2003276427A1/en
Publication of WO2004040016A2 publication Critical patent/WO2004040016A2/en
Publication of WO2004040016A3 publication Critical patent/WO2004040016A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention is concerned with the genetic causes for bipolar and genetically related unipolar affective disorders, providing markers and methods of treating and diagnosing bipolar and genetically related unipolar affective disorders and related neuropsychiatric disorders, and providing methods for identifying markers and compounds for use as part of therapeutic and/or diagnostic methods. The present inventors have identified and fine mapped a locus for bipolar disorder and related unipolar affective disorders on chromosome 12 for the first time and have been able to pin point several genes that are carrying mutations increasing susceptibility to bipolar disorder. The region identified is approximately two million base pairs of DNA in the chromosomal region 12q24.3 on the short arm of chromosome 12 between markers D12S2705 and D12S340.
PCT/GB2003/004684 2002-10-31 2003-10-31 Genetic markers on chromosome 12 associated to bipolar or unipolar disorders WO2004040016A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003276427A AU2003276427A1 (en) 2002-10-31 2003-10-31 Genetic markers on chromosome 12 associated to bipolar or unipolar disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0225360.7 2002-10-31
GBGB0225360.7A GB0225360D0 (en) 2002-10-31 2002-10-31 Genetic markers

Publications (2)

Publication Number Publication Date
WO2004040016A2 WO2004040016A2 (en) 2004-05-13
WO2004040016A3 true WO2004040016A3 (en) 2004-10-28

Family

ID=9946934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/004684 WO2004040016A2 (en) 2002-10-31 2003-10-31 Genetic markers on chromosome 12 associated to bipolar or unipolar disorders

Country Status (3)

Country Link
AU (1) AU2003276427A1 (en)
GB (1) GB0225360D0 (en)
WO (1) WO2004040016A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009205956B2 (en) 2008-01-18 2015-07-02 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
EP2596353A4 (en) 2010-07-23 2014-01-15 Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
MX361944B (en) 2010-07-23 2018-12-19 President And Fellows Of Harvard College Star Methods for detecting signatures of disease or conditions in bodily fluids.
SG10201505724SA (en) 2010-07-23 2015-09-29 Harvard College Methods of detecting diseases or conditions using phagocytic cells
KR20150035818A (en) 2012-06-15 2015-04-07 해리 스타일리 Methods of detecting diseases or conditions using circulating diseased cells
AU2013274002A1 (en) 2012-06-15 2015-02-05 Harry Stylli Methods of detecting diseases or conditions
EP2965086A4 (en) 2013-03-09 2017-02-08 Harry Stylli Methods of detecting prostate cancer
US10494675B2 (en) 2013-03-09 2019-12-03 Cell Mdx, Llc Methods of detecting cancer
WO2016040843A1 (en) 2014-09-11 2016-03-17 Harry Stylli Methods of detecting prostate cancer

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAWSON E ET AL: "Genetic association between alleles of pancreatic phospholipase A2 gene and bipolar affective disorder.", PSYCHIATRIC GENETICS. 1995 WINTER, vol. 5, no. 4, January 1995 (1995-01-01), pages 177 - 180, XP009026891, ISSN: 0955-8829 *
DEGN B ET AL: "Further evidence for a bipolar risk gene on chromosome 12q24 suggested by investigation of haplotype sharing and allelic association in patients from the Faroe Islands.", MOLECULAR PSYCHIATRY. JUL 2001, vol. 6, no. 4, July 2001 (2001-07-01), pages 450 - 455, XP009026917, ISSN: 1359-4184 *
EWALD H ET AL: "Significant linkage between bipolar affective disorder and chromosome 12q24.", PSYCHIATRIC GENETICS. 1998 AUTUMN, vol. 8, no. 3, October 1998 (1998-10-01), pages 131 - 140, XP009026909, ISSN: 0955-8829 *

Also Published As

Publication number Publication date
AU2003276427A1 (en) 2004-05-25
AU2003276427A8 (en) 2004-05-25
GB0225360D0 (en) 2002-12-11
WO2004040016A2 (en) 2004-05-13

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