WO2004039839A3 - Modified voltage-gated calcium channels - Google Patents

Modified voltage-gated calcium channels Download PDF

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Publication number
WO2004039839A3
WO2004039839A3 PCT/EP2003/008938 EP0308938W WO2004039839A3 WO 2004039839 A3 WO2004039839 A3 WO 2004039839A3 EP 0308938 W EP0308938 W EP 0308938W WO 2004039839 A3 WO2004039839 A3 WO 2004039839A3
Authority
WO
WIPO (PCT)
Prior art keywords
cav
channels
modified
gated calcium
calcium channels
Prior art date
Application number
PCT/EP2003/008938
Other languages
French (fr)
Other versions
WO2004039839A2 (en
Inventor
Cord-Michael Becker
Julia Brill
Kristina Becker
Original Assignee
Friedrich Alexander Uni Versit
Cord-Michael Becker
Julia Brill
Kristina Becker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich Alexander Uni Versit, Cord-Michael Becker, Julia Brill, Kristina Becker filed Critical Friedrich Alexander Uni Versit
Priority to AU2003281999A priority Critical patent/AU2003281999A1/en
Publication of WO2004039839A2 publication Critical patent/WO2004039839A2/en
Publication of WO2004039839A3 publication Critical patent/WO2004039839A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to modified voltage-gated calcium (CaV ) channels. Furthermore, the invention provides nucleic acid sequences to generate modified CaV channels as well as isolated CaV channel proteins or subunits. The present invention further provides cells or animal models expressing the modified CaV channels. The invention further relates to methods using modified Cav channels or animals expressing Cav channels in diagnostic and clinical assays. The methods of using modified Cav channels are particularly interesting for the identification and activity testing of chemical or pharmaceutical compounds, which may have the capacity of modulating the activity of Cav channels.
PCT/EP2003/008938 2002-10-31 2003-08-12 Modified voltage-gated calcium channels WO2004039839A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003281999A AU2003281999A1 (en) 2002-10-31 2003-08-12 Modified voltage-gated calcium channels

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10252213.8 2002-10-31
DE10252213 2002-10-31

Publications (2)

Publication Number Publication Date
WO2004039839A2 WO2004039839A2 (en) 2004-05-13
WO2004039839A3 true WO2004039839A3 (en) 2004-06-24

Family

ID=32185420

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/008938 WO2004039839A2 (en) 2002-10-31 2003-08-12 Modified voltage-gated calcium channels

Country Status (2)

Country Link
AU (1) AU2003281999A1 (en)
WO (1) WO2004039839A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE, 6 November 2002 (2002-11-06), pages abs No 619.3, XP001180943 *
DATABASE EMBL [online] 12 September 2001 (2001-09-12), XP002277629, Database accession no. AF247141 *
DATABASE EMBL [online] 21 April 2002 (2002-04-21), XP002277628, Database accession no. AL731803 *
DATABASE EMBL [online] 21 February 2002 (2002-02-21), XP002277627, Database accession no. AL672219 *
DATABASE EMBL [online] 8 January 2001 (2001-01-08), XP002277630, Database accession no. AF247139 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 279, no. 8, 20 February 2004 (2004-02-20), pages 7322 - 7330, XP001180843 *

Also Published As

Publication number Publication date
WO2004039839A2 (en) 2004-05-13
AU2003281999A1 (en) 2004-05-25
AU2003281999A8 (en) 2004-05-25

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