WO2004034884A2 - Embolic filter frame having looped support strut elements - Google Patents
Embolic filter frame having looped support strut elements Download PDFInfo
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- WO2004034884A2 WO2004034884A2 PCT/US2003/032962 US0332962W WO2004034884A2 WO 2004034884 A2 WO2004034884 A2 WO 2004034884A2 US 0332962 W US0332962 W US 0332962W WO 2004034884 A2 WO2004034884 A2 WO 2004034884A2
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- WIPO (PCT)
- Prior art keywords
- filter
- support
- frame
- struts
- looped
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0105—Open ended, i.e. legs gathered only at one side
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P11/00—Connecting or disconnecting metal parts or objects by metal-working techniques not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/018—Filters implantable into blood vessels made from tubes or sheets of material, e.g. by etching or laser-cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0006—Rounded shapes, e.g. with rounded corners circular
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0067—Three-dimensional shapes conical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Definitions
- the invention relates to embolic filter devices for placement in the vasculature and in particular, self-expanding frames used to support embolic filter elements.
- Embolic protection is a concept of growing clinical importance directed at reducing the risk of embolic complications associated with interventional (i.e., transcatheter) and surgical procedures.
- interventional i.e., transcatheter
- embolic debris e.g., thrombus, clot, atheromatous plaque, etc.
- the therapeutic vascular procedures most commonly associated with adverse embolic complications include: carotid angioplasty with or without adjunctive stent placement; and revascularization of degenerated saphenous vein grafts.
- PTCA percutaneous transluminal coronary angioplasty
- surgical coronary artery bypass grafting percutaneous renal artery revascularization
- endovascular aortic aneurysm repair have also been associated with complications attributable to atheromatous embolization.
- embolic protection devices to capture and remove embolic debris, consequently, may improve patient outcomes by reducing the incidence of embolic complications.
- Embolic protection devices typically act as an intervening barrier between the source of the clot or plaque and the downstream vasculature.
- Numerous devices and methods of embolic protection have been used adjunctively with percutaneous interventional procedures. These techniques, although varied, have a number of desirable features including: intraluminal delivery; flexibility; trackability; small delivery profile to allow crossing of stenotic lesions; dimensional compatibility with conventional interventional implements; ability to minimize flow perturbations; thromboresistance; conformability of the barrier to the entire luminal cross section (even if irregular); and a means of safely removing the embolic protection device and trapped particulates.
- embolic protection There are two general strategies for achieving embolic protection: techniques that employ occlusion balloons; and techniques that employ an embolic filter.
- embolic filters is a desirable means of achieving embolic protection because they allow continuous perfusion of the vasculature downstream to the device.
- Occlusion balloon techniques have been taught by the prior art and involve devices in which blood flow to the vasculature distal to the lesion is blocked by the inflation of an occlusive balloon positioned downstream to the site of intervention. Following therapy, the intraluminal compartment between the lesion site and the occlusion balloon is aspirated to evacuate any thrombus or atheromatous debris that may have been liberated during the interventional procedure.
- the principle drawback of occlusion balloon techniques stems from the fact that during actuation, distal blood flow is completely inhibited, which can result in ischemic pain, distal stasis/thrombosis, and difficulties with fluoroscopic visualization due to contrast wash-out through the treated vascular segment.
- a prior system described in US Patent 4,723,549 to Wholey, et al. combines a therapeutic catheter (e.g., angioplasty balloon) and integral distal embolic filter.
- a therapeutic catheter e.g., angioplasty balloon
- integral distal embolic filter By incorporating a porous filter or embolus barrier at the distal end of a catheter, such as an angioplasty balloon catheter, particulates dislodged during an interventional procedure can be trapped and removed by same therapeutic device responsible for the embolization.
- One known device includes a collapsible filter device positioned distal to a dilating balloon on the end of the balloon catheter.
- the filter comprises a plurality of resilient ribs secured to circumference of the catheter that extend axially toward the dilating balloon. Filter material is secured to and between the ribs.
- the filter deploys as a filter balloon is inflated to form a cup-shaped trap.
- the filter does not necessarily seal around the interior vessel wall. Thus, particles can pass between the filter and the vessel wall.
- the device also lacks longitudinal compliance. Thus, inadvertent movement of the catheter results in longitudinal translation of the filter, which can cause damage to the vessel wall and liberate embolic debris.
- the embolic filters are incorporated directly into the distal end of a guide wire system for intravascular blood filtration. Given the current trends in both surgical and interventional practice, these devices are potentially the most versatile in their potential applications. These systems are typified by a filter frame that is attached to a guide wire that mechanically supports a porous filter element.
- the filter frame may include radially oriented struts, one or more circular hoops, or a pre-shaped basket configuration that deploys in the vessel.
- the filter element is typically comprised of a polymeric or metallic mesh net, which is attached to the filter frame and/or guide wire. In operation, blood flowing through the vessel is forced through the mesh filter element thereby capturing embolic material in the filter.
- Another example of a prior device uses an emboli capture device mounted on the distal end of a guide wire.
- the filter material is coupled to a distal portion of the guide wire and is expanded across the lumen of a vessel by a fluid activated expandable member in communication with a lumen running the length of the guide wire.
- a fluid activated expandable member in communication with a lumen running the length of the guide wire.
- filter material may interact with the clot to produce emboli.
- the device also lacks longitudinal compliance.
- Another device which is adapted for deployment in a body vessel for collecting floating debris and emboli in a filter, includes a collapsible proximally tapered frame to support the filter between a collapsed insertion profile and an expanded deployment profile.
- the tapered collapsible frame includes a mouth that is sized to extend to the walls of the body vessel in the expanded deployed profile and substantially longitudinal struts that attach and tether the filter frame to the support wire.
- This device also lacks substantial longitudinal compliance.
- This device has the additional drawback of having an extended length due to the longitudinally oriented strut configuration of the tapered frame. This extended length complicates the navigation and placement of the filter within tortuous anatomy.
- a further example of an embolic filter system involves a filter material fixed to cables or spines of a central guide wire.
- a movable core or fibers inside the guide wire can be utilized to transition the cables or spines from approximately parallel to the guide wire to approximately perpendicular the guide wire.
- the filter may not seal around the interior vessel wall. Thus, particles can pass between the filter and the entire vessel wall.
- This umbrella-type device is shallow when deployed so that, as it is being closed for removal, particles have the potential to escape.
- disadvantages associated with predicate devices include lack of longitudinal compliance, extended deployed length of the frame and associated tethering elements, and inadequate apposition and sealing against a vessel wall.
- longitudinal compliance Without longitudinal compliance, inadvertent movement of the filter catheter or support wire can displace the deployed filter and damage a vessel wall and/or introgenic vascular trauma, or, in extreme cases, result in the liberation of embolic debris.
- An extended deployed length aggravates proper filter deployment adjacent to vascular side branches or within tightly curved vessels. Inadequate filter apposition and sealing against a vessel wall has the undesirable effect of allowing emboli passage.
- the radial force exerted by the filter against the vessel wall should be optimized.
- Typical methods used to increase the radial force exerted by the filter include, for example, increasing the cross-sectional area (moment of inertia and therefore the stiffness) of the filter support frame and in particular the tethering elements of the frame.
- Enhanced radial force can also be achieved by incorporating additional support members or by enlarging the "relaxed" or deployed diameter of the filter frame relative to the diameter of the vessel into which it is deployed. These methods typically have the undesirable side effects of degrading the longitudinal compliance, adding to the compressed delivery profile, and, in some cases, increasing the deployed length.
- stiffer support frames Some methods used to increase the radial force (for example, stiffer support frames) have the additional drawback of requiring thicker-walled, larger profile, delivery catheters. To accommodate the increased pressure exerted by the stiff frame (constrained within the delivery catheter) a commensurately thicker catheter wall is required, compromising the delivery profile.
- the present invention is an improved embolic filter frame having looped support struts.
- the frame configuration of the present invention provides enhanced longitudinal compliance, improved sealing against a vessel wall, low profile delivery, and a short deployed length occupied by the frame and tethering elements.
- the present invention incorporates a filter support frame having "looped" support struts.
- the "looped" strut configuration enhances the radial force imparted onto a vessel wall without entailing the undesirable side effects previously described.
- the looped strut configuration also facilitates filter frame opposition when deployed in tortuous vascular anatomies.
- the looped support struts of the present invention assume an essentially longitudinal configuration and impart minimal radial force onto the catheter wall. The thickness of the catheter wall or radial constraint can therefore be minimized to increase flexibility, decrease the catheter profile, and enhance insertion trackabilty.
- the looped support struts assume a looped configuration. Once in the deployed, looped configuration, the support struts exert a high degree of radial force onto the vessel wall, enhancing apposition and sealing.
- the looped support struts also provide a high degree of longitudinal compliance relative to conventional designs.
- the full length of the looped support struts is positioned very close to the filter element, which minimizes the overall deployed length of the filter media support element.
- the deployed device of the present invention exhibits a low degree of "longitudinal" stiffness.
- the device in the deployed state, the device remains limp and compliant in the longitudinal direction. Consequently, minor longitudinal displacements of the support wire or catheter are not translated to the filter frame and vessel wall during guide wire manipulation.
- Another beneficial feature of the present invention is that the looped struts and the central collar connecting the support struts to the support wire of the present invention are positioned essentially within the plane of the filter opening and, if desired, can even be positioned within the filter frame element itself. This improves the utility of the embolic filter of the present invention by reducing the overall deployed length of the filter support frame and allowing the filter to be deployed very close to the treatment site.
- Figure 1 is a three-quarter isometric view of an embolic filter of the present invention, with a support frame having three looped support struts.
- Figure 2 is an enlarged partial view of the support frame of Figure 1.
- Figure 3A is an end view of the embolic filter of Figure 1 , depicting the support frame assuming an unconstrained diameter.
- Figure 3B is a partial side-view of a looped support strut of the present invention, defining a bend angle in the support strut.
- Figure 3C is a partial side-view of a looped support strut of the present invention, defining an "s" shape in the support strut.
- Figure 4 is a three-quarter isometric view of an embolic filter of the present invention as deployed into a vessel.
- Figure 5A is a partial three-quarter isometric view of an embolic filter of the present invention, defining the filter opening planes.
- Figures 5B through 5D are side views of an embolic filter of the present invention illustrating deployed diameters and various types of offset strut attachment points.
- Figures 6A and 6B are side views of an embolic filter of the present invention defining deployed diameters and overall lengths.
- Figures 6C and 6D are side views of an embolic filter frame of the present invention, defining deployed diameters and lengths.
- Figures 7A through 7C are side views of an embolic filter of the present invention, showing various stages of tensioning and elongation.
- Figure 7D is a side view of an embolic filter of the present invention constrained within a sheath.
- Figures 8A and 8B are, respectively, an end view and a side view of one embodiment of an embolic filter of the present invention, showing three support struts with loops, as viewed along two orthogonal axes.
- Figures 9A and 9B are, respectively, an end view and a side view of a further embodiment of an embolic filter of the present invention, showing three support struts with loops, as viewed along two orthogonal axes.
- Figures 10A and 10B are, respectively, an end view and a side view of another embodiment of an embolic filter of the present invention, showing three support struts with loops, as viewed along two orthogonal axes.
- Figures 11A and 11B are, respectively, an end view and a side view of still another embodiment of an embolic filter of the present invention, showing three support struts with loops, as viewed along two orthogonal axes.
- Figures 12A through 12F are end views of embolic filters embodiments of the present invention, showing, respectively, three, four, five, six, seven, and eight looped support struts.
- Figure 13 is a longitudinal cross-section view of an embolic filter frame of the present invention, depicting an enhanced radial force caused by vessel wall compression.
- Figure 14 is a side view of an embolic filter device of the present invention wherein the frame includes a truncated filter membrane support portion.
- Figure 15 is a three-quarter isometric view of a cut-out precursor tube used to fabricate a six-strut embolic filter frame of the present invention according to Example 1.
- Figure 16 is a three-quarter isometric view of the precursor tube of Figure 15 that has been expanded to form a six-strut embolic filter frame of the present invention.
- Figure 17 is a side view of an expanded and inverted precursor tube used to fabricate a six-strut embolic filter frame of the present invention according to Example 1.
- Figures 18A through 18C are longitudinal cross-section views of another embodiment of an embolic filter device of the present invention having a slidable attachment between the filter frame and the support wire.
- FIG. 1 Shown is an unconstrained, non-tensioned embolic filter assembly 30 of the present invention.
- the filter assembly 30 comprises a frame 31 having two distinct portions: a filter support portion 32 and a series of looped struts or tethers 34.
- Each looped strut 34 is affixed to a central collar 46, which is then attached to a support wire 36 at attachment point 38.
- Multiple struts 34 emanate radially outward and are attached to the frame's filter support portion 32.
- Attached to the filter support portion 32 is a filter element 40.
- a longitudinal axis 42 which is essentially coincident with the support wire 36.
- Embolic filter frames of the present invention can have 2, 3, 4, 5, 6, 7, 8 or more looped support struts.
- the number of support struts can effect the profile and shape of the filter membrane opening 60.
- the frame configuration in Figure 1 showing only three support struts for clarity, typically results in a filter opening having three "scallops" 41 which follow the profile of the filter support portion 32.
- additional support struts By incorporating additional support struts, the magnitude or size of each scallop 41 is reduced and the filter opening will more closely approximate a circle within a plane.
- six looped support struts are incorporated into a frame of the present invention.
- the filter element may be trimmed to match the contour of the scallops so to avoid deflecting or disrupting fluid flow or potentially allowing inadvertent passage of emboli.
- the distal end 35 of the filter element is preferably provided with a slidable attachment around the support wire 36 so as to allow the filter element to change position relative to the support wire 36 between compacted and deployed dimensions. Additionally, a slidable interface between the distal end 35 and the support element allows the filter element to remain fully extended in the vessel at all times, even when the filter assembly is undergoing longitudinal compliance, as described herein.
- the filter element may be formed from an elastic material that can accommodate different distal end positions relative to the position of the filter frame. Shown in Figure 2 is an enlarged view of the unconstrained looped support struts of an embolic filter 30 of the present invention. Shown is a frame 31 having filter support portions 32 and three looped support struts 34.
- FIG. 3A illustrates the unconstrained embolic filter assembly 30 from Figures 1 and 2. Shown are three preferred s-shaped, looped support struts 34 extending radially from the central collar 46. The support struts 34 extend from and are attached to a filter support portion 32. Attached to the filter support portion 32 is a filter element 40.
- attachment point 38 may comprise a rigidly secure fixation point between the support wire 36 and the centered collar 46, or it may comprise a slideable interface between the support wire 36 and central collar 46; thereby decoupling longitudinal or rotational motion of the support wire from the filter frame.
- the support struts 34 extend radially and are attached to a filter support portion 32. Attached to the filter support portion 32 is a filter element 40.
- a "filter support portion” is defined as that portion of a filter frame that is at least partially attached to a filter element 40.
- a “support strut” is defined as that portion of a filter frame that supports the filter support portion and generally is not attached directly to the filter element 40.
- a "looped support strut" is further illustrated in Figure 3B. Shown is the support strut 34 unattached to a filter element and constrained about a support wire or longitudinal axis 42.
- a reference axis 47 drawn through the support strut 34 as shown, approximates the magnitude of a bend or loop in the support strut.
- the axis 47 defines an angle 48 relative to the longitudinal axis 42 (also shown is a reference axis 49 which defines a 90 degree angle relative to the longitudinal axis 42). Shown is a looped support strut angle 48, which is greater than 90 degrees, relative to the longitudinal axis 42.
- a “looped strut” is therefore defined as a filter frame support strut, having a portion unattached to a filter element, wherein the strut has at least one bend equal to or greater than 90 degrees along the unattached portion.
- the looped angle can be viewed and measured about any axis.
- a looped, embolic filter frame support strut having an "s" shape is depicted in Figure 3C. Shown is the support strut 34 unattached to a filter element and constrained about a longitudinal axis 42. Also shown is an axis 37, which is parallel to the longitudinal axis 42. A reference axis 47, drawn through the support strut 34, as shown, approximates the magnitude of the bends or loops in the support strut. The axis 47 defines angles 48 relative to the longitudinal axis 42. Shown are two opposite bend angles 48, each of at least about 90 degrees.
- a "support strut having an 's' shape” is defined as a filter frame support strut having a portion unattached to a filter element, wherein the strut has at least two opposite bends greater than about 90 degrees along the unattached portion.
- the angles 48 can be viewed and measured about any axis.
- FIG. 4 Shown is an embolic filter assembly 30 of the present invention deployed within a compliant vessel 50 (shown in longitudinal cross-section).
- the vessel 50 defines an inner diameter which is slightly smaller, for example approximately 90%, than the unconstrained diameter of the device. This is shown as diameter 44 in Figure 3A.
- the "under-sized” vessel therefore imparts a radial constraint to the deployed filter, which prevents the filter from expanding to a full, unconstrained diameter. In this process, an interference fit between the filter and vessel wall is achieved.
- the looped support struts 34 when constrained by a vessel therefore exert a radial or expansive force 52 onto the vessel wall 50, forming a seal region 54.
- This radial, expansive force 52 can also be referred to as the "hoop stress” or "radial force” applied to the vessel wall.
- unconstrained diameter As the term “unconstrained diameter” is used herein, it is intended to describe the device of the present invention as it self-deploys on a tabletop. In this form it is both unconstrained and untensioned. This state is also referred to herein as being “not in tension” or in a “non-tensioned” state.
- the support wire 36 when rigidly fixed at or about the central collar, can be slightly displaced along the longitudinal axis 42 in directions 56 or 58 without significantly disrupting or translating to the seal region 54.
- the looped support struts 34 therefore provide a degree of "longitudinal compliance" which effectively isolates the filter element from small support wire displacements.
- Devices of the presents invention having unconstrained diameters of about 6mm (0.24") can tolerate support wire displacements in directions 56 or 58 of about +/- 0.8mm (+/-0.03") or more, without causing a significant disruption or translation to the seal region 54.
- the support wire therefore has a "maximum total displacement" before causing a disruption to the seal region 54.
- Longitudinal compliance can be alternately expressed as a ratio of unconstrained diameter divided by the maximum total support wire displacement when rigidly fixed to the support wire (without disrupting or translating the seal region against the vessel wall).
- a device of the present invention can be deployed within a transparent elastic tube having a diameter of about 80% of the filter's unconstrained diameter. The maximum total support wire displacement (without disrupting or moving the seal region) can then be approximated.
- Devices of the present invention display ratios of unconstrained diameter divided by the maximum total displacement of the support wire of about 6 or less.
- the embolic filter of the present invention has a ratio of unconstrained diameter to maximum support wire displacement of about 5, about 4, about 3, about 2.5, about 2, about 1.5, about 1.2, or about 1.
- a relatively easy test to quantify longitudinal compliance in the present invention is to deploy the filter apparatus within a silicone tube (such as that available from JAMAK Healthcare Technologies, Weatherford, TX) having a thin wall thickness of approximately 0.25 mm (0.01") and having an internal diameter of approximately 80% that of the unconstrained filter apparatus. It should be noted that the use of an 80% constrained diameter is preferred since a 20% interference fit between the device and the vessel will prevent device migration and provide adequate sealing.
- the support wire to which the apparatus is attached may be longitudinally manipulated. The maximum distance the support wire can be displaced (in a longitudinal direction) without moving the filter frame in relation to the silicone tubing is recorded as "longitudinal compliance.”
- the present invention also has the beneficial feature of a short deployed length, as depicted in Figures 5A through 5D.
- the short deployed length of the present invention is a result of the looped struts and the central collar connecting the support struts to the support wire being positioned essentially within the plane of the filter opening.
- the looped struts can be engineered to deploy to be directly within the plane of the opening to the filter element, slightly upstream of the opening, or even slightly downstream of the opening so as to orient within the filter frame element itself.
- Shown in Figure 5A is an embolic filter 30 of the present invention in an unconstrained state having a proximal end 43 and a distal end 45.
- the filter element 40 has a filter "opening" 60, which defines a plane having an x-axis 62 and an y-axis 64.
- the opening axis 62 and 64 are positioned at the most proximal ends of the scallops 41.
- the opening plane shown is orthogonal to the support wire 36 and the longitudinal axis 42.
- the two axes 62, 64 therefore define the plane of the filter opening 60.
- Looped struts 34, of the present invention are joined onto a central collar 46, which is attached to the support wire 36 at attachment point 38 via either rigidly fixed or slideable means.
- FIG. 5B Shown in Figure 5B is a filter element 40 having a filter opening 60, an y-axis 64, and a longitudinal axis 42.
- the axis 64 is an "edge-view" of the plane of the filter opening. Axes 42 and 64 intersect at point 70. Point 70 is therefore on the plane of the filter opening.
- a point or location on the longitudinal axis 42 is considered to be “offset distally” from the plane of the filter opening if the point lies within the filter element in the longitudinal direction labeled 72.
- a point or location on the longitudinal axis 42 is considered to be “offset proximally” from the plane of the filter opening if the point lies outside of the filter element in the longitudinal direction labeled 74.
- Figure 5C illustrates a looped support strut 34 and central collar 46 of the present invention having a support wire attachment point 38 which is rigidly fixed to the support wire and off-set distally from the plane of the filter opening 64. Shown is a support wire attachment point 38 positioned inside the filter element 40 in the distal direction 72. The magnitude of the attachment point offset is shown as element 80.
- Figure 5D illustrates a looped support strut 34 and central collar 46 of the present invention having a support wire attachment point 38 which is rigidly fixed to the support wire and off-set proximally from the plane of the filter opening 64. Shown is a support wire attachment point 38, positioned outside of the filter element 40, in the proximal direction 74. The magnitude of the attachment point offset is shown as item 82.
- the relative magnitude of any off-set, along with the direction of the off-set between a support wire attachment point and the plane of the filter opening 64, can be expressed by an "offset ratio" of the strut attachment point off-set divided by the unconstrained diameter 44.
- an "offset ratio" of the strut attachment point off-set divided by the unconstrained diameter 44 For example, a filter having a strut attachment point offset of 4mm and an unconstrained diameter of 10mm, would have a ratio of 0.4. This ratio can be applied to strut to support wire attachment points that are offset distally or proximally to the plane of the filter opening. A ratio of "zero" would reflect no offset, or in other words an attachment point lying in the plane of the filter opening.
- Embolic filters of the present invention can have distally offset ratios (of the attachment point off-set divided the unconstrained diameter) ranging from about 0 to about 1 , with a preferred range of about 0 to about 0.7, with a most preferred range of about 0.2 to about 0.5. These distally offset ratios reflect strut/collar to support wire attachments positioned within the filter element. Similarly, embolic filter of the present invention can have proximally offset ratios, reflecting strut/collar to support wire attachments positioned outside of the filter element. In these configurations, embolic filters of the present invention can have offset ratios (attachment point offset divided by the unconstrained diameter) ranging from about 0 to about 1.
- Devices of the present invention can be configured to have a strut to central collar attachment points that are significantly different than the central collar to support wire attachment points. For these configurations, both attachment points are then approximated by a point on the support wire that is in closest proximity to the strut.
- the looped support struts of the present invention allow a short deployed length that enhances navigation within tortuous vessels and allows deployment near vascular side-branches.
- a device should be defined by at least one of the five ratios defined below.
- the deployed length of a filter can be expressed by a first ratio of the deployed length divided by the unconstrained diameter of the filter.
- Shown in Figure 6A is an embolic filter 30 of the present invention having a filter element 40, looped struts 34, strut/collar to support wire attachment point 38 (lying outside of the filter element), and a unconstrained diameter 44.
- an embolic filter 30 of the present invention having a filter element 40, looped struts 34a, strut/collar to support wire attachment point 38 (lying within the filter element), and a unconstrained diameter 44. Shown is a deployed length 86, which is referenced from the opposing ends of the filter element, and does not include the looped struts 34a or the attachment point 38.
- Embolic filters of the present invention can have ratios of the deployed length 84, 86 divided by the filter unconstrained diameter 44, ranging from about 0.5 to about 7, with a preferred range of about 1 to about 5, with a most preferred range of about 2 to about 4.
- a similar expression of a filter deployed length or footprint is a second ratio of the deployed length of the frame (not including a filter element) divided by the frame unconstrained diameter.
- Shown in Figure 6C is an embolic filter frame of the present invention having filter support portions 32 and looped struts 34, strut/collar to support wire attachment point 38 (lying outside of the filter element 40), and a unconstrained frame diameter 44. Shown is a frame deployed length 87, which does not include the filter element 40.
- FIG. 6D Shown in Figure 6D is an embolic filter frame of the present invention having filter support portions 32 and looped struts 34, strut/collar to support wire attachment point 38 (lying within the filter element 40), and a unconstrained diameter 44. Shown is a frame deployed length 88, which does not include the filter element 40.
- Embolic filters of the present invention can have ratios of the frame deployed length 87, 88 divided by the frame unconstrained diameter 44, ranging from about 0.1 to about 7, with a preferred range of about 0.3 to about 2, with a most preferred range of about 0.5 to about 1. Additional benefits of the looped struts of the present invention relate to the delivery aspects of the embolic filter as shown in Figures 7A through 7D.
- the looped support struts of the present invention when tensioned elongate and assume a compacted and essentially linear form. While constrained in this linear state by a delivery catheter or other constraint means, the support struts exert relatively little force onto the radial constraint means, which permits the radial constraint means to be very thin and/or delicate.
- the overall delivery profile and stiffness are therefore reduced over those required for prior embolic filter devices.
- the struts of the present invention spontaneously open and assume a looped configuration, which exert a high degree of force onto the vessel wall, creating an enhanced filter to vessel wall seal.
- FIG. 7A Shown in Figure 7A is an embolic filter 30 of the present invention having looped struts 34 attached to a central collar 46.
- the central collar is attached to a support wire 36.
- the support struts emanate radially outward and are integral to (or joined to) a frame having a filter support portion 32.
- a filter element 40 is attached to the filter support portion 32.
- the low force applied to the delivery catheter by the elongated looped strut facilitates use of a relatively thin catheter wall 94.
- the looped struts of the present invention spontaneously open and assume the configuration shown in Figures 4 and 7A, either spontaneously or through manipulation of the support wire and/or delivery catheter.
- struts 34 of an embolic filter of the present invention are constrained in an "essentially linear" form, as shown in Figure 7D. While in this essentially linear form, the central support collar 46 (or strut to support wire attachment point 38) is positioned outside of the filter element 40.
- the central support collar 46 is also separated from the filter element 40 by the elongated and essentially linear support struts 34. Once properly deployed, however, the central support collar 46 (or strut to support wire attachment point 38) lies within the filter element 40, as shown in Figure 7A. The central support collar 46 (or strut to support wire attachment point 38) therefore moves or translates relative to the filter element during deployment. Typical filters of the present invention undergo a relative translation (support collar to filter element) equal to at least 1/2 of the length of the constrained filter element 96 (as is shown in Figure 7D).
- a total constrained delivery length 97 of an embolic filter of the present invention Embolic filters of the present invention can have a third ratio of the total constrained delivery length 97 divided by the unconstrained length. For the present invention, this third ratio may be about 1, about 2, about 2.5, about 3, about 3.5, or greater.
- the unconstrained length is defined by length 84 ( Figure 6A) or by length 86 ( Figure 6B).
- embolic filters of the present invention can have a fourth ratio of the total constrained frame delivery length 98 divided by the unconstrained frame length. For the present invention, this fourth ratio may be about 2, about 2.5, about 3, about 3.5, or greater.
- the unconstrained frame length is defined by length 87 (Figure 6C) or by length 88 ( Figure 6D).
- a fifth ratio relating to the short deployed length is the strut constrained delivery length divided by the strut unconstrained deployed length.
- the strut constrained delivery length is defined as the length of a strut portion 34 of the frame, not including the filter support portion 32, as shown in Figure 7D.
- the strut constrained delivery length is therefore a portion of the total frame length 98 in Figure 7D.
- the strut unconstrained length is defined as the length of a unconstrained strut 34a as shown in Figures 6C and 6D, not including the length of a filter support portion 32.
- Filter frames of the present invention can have ratios of the strut constrained delivery length divided by the strut unconstrained deployed length of about 2, of about 3, of about 4, of about 5, of about 6, or about 7, or more. Filter frames of the present invention preferably have ratios of the strut constrained delivery length divided by the strut unconstrained deployed length of about 3, of about 3.5, of about 4, of about 4.5, or about 5 or more. Most preferred ratios of strut constrained delivery length divided by the strut unconstrained deployed length are about 3, about 3.3, of about 3.6, or about 4, or more.
- Embolic filters of the present invention can be produced using a variety of common methods and processes.
- an embolic filter frame with looped struts can be fabricated from any biocompatible material having adequate resilience and stiffness.
- nitinol, stainless steel, titanium, and polymers may be employed as applicable materials.
- a precursor frame having looped struts may be fabricated in a planar sheet form and rolled and attached to itself to form a frame of the present invention.
- a cylindrical tube can be cut and expanded or cut and compressed to form a frame of the present invention.
- Cutting processes can include lasers, stampings, etching, mill-cutting, water-jets, electrical discharge machining, or any other suitable process.
- Filter elements or members used in conjunction with the looped struts of the present invention, can be produced using a variety of common materials, methods and processes.
- Suitable biocompatible materials include, but are not limited to, metallic foilsor meshes, or sheets or meshes formed from various polymers, including fluoropolymers such as polytetrafluoroethylene.
- Filter members can be molded, cast, formed, or otherwise fabricated by joining various suitable materials.
- Figures 8 through 12 illustrate (but do not limit) various alternate embodiments of looped struts of the present invention.
- Shown in Figures 8A and 8B is an embolic filter 30 having a preferred looped strut configuration 34.
- a preferred strut 34 of the present invention can have a looped shape or profile when viewed along two orthogonal axes. The struts 34 therefore project a looped configuration in two orthogonal views.
- Alternate strut configurations of the present invention can have looped shapes when viewed along different combinations of axes or along a single axis.
- Figures 9A and 9B are similar views to those of 8A and 8B, showing an alternate looped strut configuration wherein the alternate strut 34 has an essentially looped shape only when viewed along a single axis. Shown is a strut 34 having a looped shape in an end view ( Figure 9A) and an essentially linear shape in a side view ( Figure 9B).
- a strut of the present invention can have an essentially linear shape when viewed on end, while having a looped shape when viewed, for example from the side.
- This configuration is illustrated in Figures 10A and 10B, which show an alternate strut 34 having an essentially linear shape when viewed from the end ( Figure 10A), while having a looped configuration when viewed from the side ( Figure 10B).
- Looped support struts of the present invention can be configured with bends greater than about 90 degrees (as defined by Figure 3C), greater than about 120 degrees, greater than about 180 degrees, greater than about 240 degrees, or more.
- a looped strut of the present invention having a bend greater than about 200 degrees is depicted in Figure 11 A.
- the struts 34 also have a looped configuration when viewed from another axis, in this case a side view, as shown in Figure 11 B. Looped support struts of the present invention can therefore have different "loop" configurations when projected onto different viewing planes.
- embolic filters Shown in all Figures 8 through 11 are embolic filters having three, looped support struts with support wire attachment points 38 and central support collars 46, lying essentially within the filter element, as previously described in Figures 5A and 5B.
- Embolic filter frames of the present invention can have 2, 3, 4, 5, 6, 7, 8, or more looped support struts.
- Various multiple strut configurations are depicted in Figures 12A through 12F.
- Figure 12A shows an end view of an embolic filter of the present invention having 3 looped struts 34.
- Figure 12B shows an end view of an embolic filter of the present invention having 4 looped struts 34.
- Figure 12C shows an end view of an embolic filter of the present invention having 5 looped struts 34.
- Figure 12D shows an end view of an embolic filter of the present invention having 6 looped struts 34.
- Figure 12E shows an end view of an embolic filter of the present invention having 7 looped struts 34.
- Figure 12F shows an end view of an embolic filter of the present invention having 8 looped struts 34.
- FIG. 13 An additional functional aspect of embolic filter frames of the present invention is shown in Figure 13. Shown is an embolic filter 30 having looped support struts 34, filter element 40 attached to the filter element support 32, central collar 46, and support wire 36.
- a compressive load 100 is applied to the frame, which counteracts the radial force applied by the frame to the vessel.
- the compressive load 100 causes a frame portion, in this case the filter element support portion 32, to deflect outwardly, as shown by item 102.
- the deflection 102 can improve the sealing between the filter element 40 and the vessel wall, further reducing the advertent passage of emboli.
- the additional loading onto the vessel wall can also reduce the possibility of "vascular trauma" caused by relative motion between the filter and the vessel, and opposition when deployed in curved vascular segments.
- Shown in Figure 14 is an alternate configuration of a frame having looped struts 34 and having a simplified filter support portion (in contrast to the elongated filter support portions 32 shown in Figure 2). Shown are a support wire 36 and a filter element 40 attached directly to the ends of the six looped support struts 34 of the present invention.
- the support struts 34 attach to the filter element 40 at attachment points 103. It should be appreciated that the length and shape of the struts 34 in this embodiment may be varied to accommodate bonding of struts 34 to different points on the filter element or to bond the filter element 40 along a partial length of the struts 34.
- An additional feature of a filter frame of the present invention relates to the looped strut "spontaneous" transformation from a constrained linear state to a "locked” and inverted state, similar to that of "locking pliers" or an "off-center locking clamp". Once inverted, the looped struts maintain a stable, short length, looped configuration and must be tensioned to revert back to the constrained linear state.
- support wire as referred to and relating to the present invention, (for example, element 36 in Figure 1 ) can include a solid or hollow support wire or can include any other tubular article with at least one continuous lumen running therethrough.
- a suitable support wire for use with the present invention may include, but is not limited to, a guide wire.
- Filters of the present invention can be configured for deployment within a variety of articles, including, but not limited to, filtering applications within animal vessels, catheters, pipes, ducts, fluid conduits, tubes, hoses, material transfer conduits, storage containers, pumps, valves and other fluid containers.
- Filterable fluids include gasses, liquids, plasma and flowable solids or particulate mixtures. Fluids can flow across the filters of the present invention, or the filters can be dragged or otherwise transported through a fluid.
- Filters of the present invention are not limited to generally circular profiles (when viewed on end) and can have, when deployed an oval, triangular, square, polygon, or other profile.
- Filters of the present invention can also be combined, "ganged,” or used in conjunction with other devices such as diagnostic, visualization, therapeutic instruments, or other filters.
- the strut configurations of the present invention can also be incorporated into non-filtering devices, such as vessel occluders, indwelling diagnostic instruments, therapeutic instruments, or visualization devices.
- the device and the method of production of the present invention may be better understood by referring to the following example.
- a 0.9 mm nitinol tube 104 with a wall thickness of approximately 0.09mm (obtained from SMA Inc, San Jose, CA) was laser cut by Laserage Technologies Inc, Waukegan, IL, to form a frame configuration of a single, undulating, integral, 6 apex ring.
- the frame included radiopaque marker housings 106 at each distal apex and tether or strut elements 34 extending from each proximal apex 108 and converging at the opposite end in a "collar" 46 of uncut parent material.
- This frame was then lightly grit blasted at 30 psi with 20-micron silicon carbide media in a grit blasting machine (Model MB1000 available from Comco Inc, Burbank, CA). The frame was then gently slid up a tapered mandrel until it achieved a functional size of approximately 6mm. The frame and mandrel were then subjected to an initial thermal treatment to set the geometry in an initial, tapered (conical) configuration in an air convection oven (Carbolite Corporation, Sheffield, England). The frame was quenched in ambient temperature water and removed from the mandrel, resulting in a non-inverted frame.
- FIG. 16 Shown in Figure 16 is the non-inverted frame 110 having support struts 34, a central collar 46, apexes 108, and radiopaque marker housings 106.
- the frame portion distal to the apexes 108 form a filter element support portion 32.
- the frame was then placed on a second mandrel, designed to constrain the outside of the frame while allowing the inversion of the tether elements back upon themselves. Once constrained in the proper configuration, the tooling and frame were subjected to a second thermal treatment to set the final frame geometry and to set the nitinol transition to an appropriate temperature.
- the resulting inverted frame is depicted in Figure 17.
- FIG. 17 Shown in Figure 17 is an inverted frame 112 having six looped support struts 34a, apexes 108, radiopaque housings 106, and an integral central collar 46.
- the frame portion distal to the apexes 108 form a filter element support portion 32.
- the frame (now at functional size and preferred geometry) was then lightly coated with fluorinated ethylene propylene (FEP) powder (e.g., FEP 5101.available from DuPont Corp, Wilmington, DE) by first stirring the powder in a kitchen blender (Hamilton Beach Blendmaster) after the powder was mixed into a "cloud,” the frame was lowered into the blender for approximately 5 seconds (enough time for FEP to build up onto the surface of the frame).
- FEP powder fluorinated ethylene propylene
- the frame, coated with FEP powder was placed in an air convection oven (Grieve Oven, The Grieve Corporation, Round Lake, IL) set at 320°C for approximately one minute followed by air cooling to room temperature.
- a typical filtering media was made by laser perforating one layer of a thin, polytetrafluoroethylene (PTFE) membrane using a 10-watt C0 2 laser.
- the membrane thickness measured about 0.0002" (0.005 mm) and had tensile strengths of about 49,000 psi (about 340 KPa) in a first direction and of about 17,000 psi (about 120 KPa) in a second direction (perpendicular to the first direction).
- the tensile measurements were performed at 200mm/min. load rate with a 1" (2.5 cm) jaw spacing.
- the membrane had a density of about 2.14g/cm 3 .
- the laser power and shutter time parameters were adjusted to allow the laser to consistently create uniform 0.004" (0.1 mm) diameter holes in the membrane.
- the hole pattern geometry was then adjusted to create a pattern with uniform hole size, uniform hole spacing, and uniform strength throughout the pattern.
- This perforated pattern was then folded on itself and heat-sealed using a local heat source (Weber soldering iron, EC2002M, (available through McMaster Carr, Santa Fe Springs, CA)) into a pattern which would result in a conical shape.
- the conical flat pattern was then trimmed with scissors, inverted, and mounted upon the FEP powder coated NiTi frame and attached though the application of localized heat (the heat causing the FEP coating on the frame to re-melt and flow onto the surface of the filter sack thus providing a biocompatable thermoplastic adhesive).
- a guide wire component was then inserted into the collar end of the frame and a small amount of instant adhesive (Loctite 401 , Loctitie Corp, Rocky Hill, CT) was applied and dried to adhere and create a smooth transition from the guide wire to the outer diameter (OD) of the frame collar.
- a small amount of instant adhesive Loctite 401 , Loctitie Corp, Rocky Hill, CT
- attachment of the filter to the guide wire could be accomplished by adhesion, welding, soldering, brazing, a combination of these, or a number of other methods.
- the filter assembly 30 includes a frame 31 that is slidably mounted to the support wire 36. This attachment may be accomplished through a variety of means, including by providing a collar 46 that is sized slightly larger than the support wire 36 to allow the collar to move relative to the support wire when in use. Stops 114a, 114b are provided on the support wire 36 to limit the range of relative movement between the filter assembly 30 and the support wire 36. Constructed in this manner, the filter assembly 30 has exceptional longitudinal compliance relative to the support wire in that the support wire can freely move between the stops 114 without translating longitudinal or rotational movement to the filter assembly. The full range of proximal and distal movement of the filter assembly 30 relative to the stops 114 is shown in Figures 18B and 18C.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2004545447A JP4620465B2 (en) | 2002-10-17 | 2003-10-16 | An embolic filter frame with looped support strut elements |
CA2502225A CA2502225C (en) | 2002-10-17 | 2003-10-16 | Embolic filter frame having looped support strut elements |
EP20030809115 EP1558325B1 (en) | 2002-10-17 | 2003-10-16 | Embolic filter frame having looped support strut elements |
AU2003301259A AU2003301259A1 (en) | 2002-10-17 | 2003-10-16 | Embolic filter frame having looped support strut elements |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US10/273,859 US20040093012A1 (en) | 2002-10-17 | 2002-10-17 | Embolic filter frame having looped support strut elements |
US10/273,859 | 2002-10-17 |
Publications (2)
Publication Number | Publication Date |
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WO2004034884A2 true WO2004034884A2 (en) | 2004-04-29 |
WO2004034884A3 WO2004034884A3 (en) | 2004-06-03 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2003/032962 WO2004034884A2 (en) | 2002-10-17 | 2003-10-16 | Embolic filter frame having looped support strut elements |
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US (6) | US20040093012A1 (en) |
EP (6) | EP2626106B8 (en) |
JP (4) | JP4620465B2 (en) |
AT (1) | ATE519519T1 (en) |
AU (1) | AU2003301259A1 (en) |
CA (1) | CA2502225C (en) |
ES (2) | ES2369241T3 (en) |
HK (1) | HK1188166A1 (en) |
WO (1) | WO2004034884A2 (en) |
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