WO2024019606A1 - Cutting catheter - Google Patents

Cutting catheter Download PDF

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Publication number
WO2024019606A1
WO2024019606A1 PCT/KZ2022/000009 KZ2022000009W WO2024019606A1 WO 2024019606 A1 WO2024019606 A1 WO 2024019606A1 KZ 2022000009 W KZ2022000009 W KZ 2022000009W WO 2024019606 A1 WO2024019606 A1 WO 2024019606A1
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WO
WIPO (PCT)
Prior art keywords
ring
cutting
nylon
shaped
catheter
Prior art date
Application number
PCT/KZ2022/000009
Other languages
French (fr)
Russian (ru)
Inventor
Нурлан Токтаганович ИСМАИЛОВ
Болатбек Бимендеевич БАЙМАХАНОВ
Сабит Бексеитович ПАЗИЛОВ
Нуридин Егенбердиевич АМИТОВ
Турганбай МАХАНОВ
Нариман Болтаевич ТАБЫНБАЕВ
Марат Асанович АРИПОВ
Жанабай Ибраевич РЫСБАЕВ
Алмас Әбдіғаппарұлы ӘБІЛПАТТА
Берик Русланович ДАУТБАЕВ
Азамат Кошербаевич КОЖАХМЕТОВ
Нурбол Сабитович БАЗАРБАЕВ
Нұрлыхан Төреханұлы ҚАСЫМОВ
Кенесары Айтуганович БАСПАЕВ
Канат Акмаганбетович НАБДИНОВ
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Нурлан Токтаганович ИСМАИЛОВ
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Application filed by Нурлан Токтаганович ИСМАИЛОВ filed Critical Нурлан Токтаганович ИСМАИЛОВ
Publication of WO2024019606A1 publication Critical patent/WO2024019606A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/3205Excision instruments
    • A61B17/3207Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes

Definitions

  • the invention relates to medical equipment, namely cutting catheters, and can be used for thromboextraction and expansion of passages in vessels (artery, vein), destroying the elastic and fibrous part of the plaques for further stenting of the vessel.
  • Atherosclerotic cardiovascular disease caused by the formation of lesions or plaques on the inner walls of blood vessels.
  • various lesions may be associated with atherosclerosis, including lesions of the aortic ostium.
  • Lesions of the aortic orifice lead to lesions of the orifices of the great vessels branching from the aorta. This can lead to partial or even complete blockage of the artery.
  • Thrombosis is a dangerous condition in which a blood clot forms in a vessel.
  • a blood clot can grow and clog a vessel (artery, vein) until it completely blocks. Under certain conditions it can cause it to “break off”, becoming a thromboembolus. Due to the dangers associated with such blockages, various methods and procedures have been developed to treat vascular blockages.
  • the closest analogue in technical essence to the claimed invention is a radiopaque balloon catheter with a cutting tool, which contains a catheter and a guide for delivering the balloon to the treated area.
  • the catheter has a shaft containing a balloon with a pair of first radiopaque markers located at a distance from each other in the longitudinal direction to indicate the ends of the cylindrical portion of the balloon.
  • the cylindrical section is located between the conical sections of the cylinder and provides a working surface.
  • the conductor for delivering the balloon to the treatment area includes at least one pair of second radiopaque markers, and at least one pair of second radiopaque markers corresponds in location to a pair of first radiopaque markers on the balloon, so that one of the first radiopaque markers on the balloon is aligned with one of the second radiopaque markers on the conductor and another of the first radiopaque markers on the balloon is combined with another of the second radiopaque markers on the conductor /RU 2663072 C2, publ. 08/01/2018/.
  • the disadvantages of this analogue include the rigidity of the cutting cylinders. This limits the flexibility and ease of delivery of the balloon as it moves through the tortuous paths of a vessel or other body lumen.
  • cylinders equipped with cutting blades and edges may be more difficult to deflate and fold. This may make it more difficult to remove balloons from the vascular system.
  • the objective of the invention is to create a new, improved design of a cutting catheter with improved technical characteristics.
  • the technical result is to improve flexibility, increase safety and ensure effective removal and treatment of fibrotic lesions.
  • the cutting catheter including a conductor and a cutting tool, according to the invention, is equipped with two conductors connected at one end to a cylindrical connector, and at the other to a ring-shaped device, in which the outer part of the ring-shaped device is a nylon bag with a hydrophilic coating, and the inner part is a ring-shaped microsurgical blade, wherein the ring-shaped microsurgical blade is equipped with at least three protective inserts made of atraumatic nylon, and the nylon bag with a hydrophilic coating has multiple holes.
  • the ring-shaped microsurgical blade is made by combining two cutting tools in the shape of a semicircle, and the conductors are made with the ability to set the ring-shaped microsurgical blade in motion.
  • FIGS. 1 - 2 show a visual diagram of the cutting catheter (general view and front view), on which the following elements are indicated:
  • 1 - cylindrical connector 1 - cylindrical connector; 2 - protective inserts made of atraumatic nylon; 3 - nylon bag with hydrophilic coating; 4 - conductors driving the ring-shaped blade; 5 - ring-shaped microsurgical blade; 6 - holes.
  • the cutting catheter is equipped with two conductors (4), connected at one end to a cylindrical connector (1), and at the other to a bag made of nylon with a hydrophilic coating (3) by means of a ring-shaped microsurgical blade (5), and the ring-shaped microsurgical blade (5) is equipped with , at least three protective inserts made of atraumatic nylon (2), and a nylon bag with a hydrophilic coating (3) has multiple holes (6).
  • the ring-shaped microsurgical blade (5) is made by combining two cutting tools in the shape of a semicircle, and the conductors (4) are made with the ability to set the ring-shaped microsurgical blade (5) in motion.
  • the invention works as follows.
  • a cutting catheter is used before stenting the blocked artery.
  • the catheter is advanced using fluoroscopy along the guide wire so that the microsurgical blade is distal to the stenosis.
  • tightening the catheter atheromatous plaques are removed (excised) with a microsurgical blade, and the removed plaques are collected in the bag.
  • the claimed solutions use a bag with a microsurgical blade, which is designed to excise the stenosis during the procedure.
  • the distal part of the catheter is nylon with a hydrophilic coating. Tapered distal tip of the shaft, 4 mm long. The distal part of the shaft is nylon, the proximal part of the shaft is stainless steel. Hydrophilic coating throughout the shaft.
  • X-ray contrast recessed markers on a ring-shaped device 2 pcs. (in the distal and proximal parts) from an alloy of platinum and iridium.
  • the working length of the shaft is 140 cm, compatible with a 0.014" guidewire, 6 F guiding catheter. Compatible with 6, 7 F introducers.
  • the catheter tube has two lumens, one lumen is designed to open the ring-shaped device, the second is the lumen for the guidewire.
  • a cutting ring-shaped device which has a proximal and distal end. Diameter when opened is 1.25-12.0 mm, when assembled - no more than 1 mm. The length of the device is 5-40 mm.
  • the ring-shaped device is attached by two conductors. The material of the conductor of the supporting inner rod and the proximal part is stainless steel coated with duraglide, the transition part is duraglide, the distal part is platinum. Outer diameter no more than 0.014”. At a distance of 5 mm, it connects and passes through the connector, enters the catheter channel.
  • the ring-shaped device consists of two parts.
  • Outer part material - atraumatic nylon with hydrophilic coating, inner part - microsurgical blades.
  • the inner part protrudes by 0.5-1 mm.
  • the ring-shaped part of the device is connected to the bag (distal end, material: nylon with hydrophilic coating).
  • the bag has 6-8 holes, round shape d - 1000 microns (1 mm).

Abstract

The invention relates to medical equipment, and more particularly to cutting catheters, and can be used for thrombus extraction and for widening passageways in vessels (arteries, veins) by breaking down the elastic and fibrous portion of plaques for subsequent stenting of the vessel. The technical result is that of providing improved flexibility and increased safety and allowing effective removal and treatment of fibrotic lesions. This is achieved in that the claimed cutting catheter comprising a guidewire and a cutting instrument is provided with two guide members connected at one end to a cylindrical connector and at the other end to an annular device, wherein the outer part of said annular device is a bag made of hydrophilically coated nylon, and the inner part is an annular microsurgical blade, said annular microsurgical blade being provided with at least three protective inserts made of atraumatic nylon, and said hydrophilically coated nylon bag having a plurality of holes.

Description

Режущий катетер Cutting catheter
Изобретение относится к медицинской технике, а именно к режущим катетерам, и может быть использовано для тромбоэкстракции и расширения проходов в сосудах (артерия, вена), разрушая эластическую и фиброзную часть бляшек для дальнейшего стентирования сосуда. The invention relates to medical equipment, namely cutting catheters, and can be used for thromboextraction and expansion of passages in vessels (artery, vein), destroying the elastic and fibrous part of the plaques for further stenting of the vessel.
Одними из наиболее распространенных заболеваний сердца являются атеросклеротические сердечно-сосудистые заболевания, вызванные образованием поражений или бляшек на внутренних стенках кровеносных сосудов. Например, различные поражения могут быть связаны с атеросклерозом, в том числе поражения устья аорты. Поражения устья аорты приводят к поражениям устьев магистральных сосудов, ответвляющихся от аорты. Это может привести к частичной или даже полной закупорке артерии. One of the most common heart diseases is atherosclerotic cardiovascular disease, caused by the formation of lesions or plaques on the inner walls of blood vessels. For example, various lesions may be associated with atherosclerosis, including lesions of the aortic ostium. Lesions of the aortic orifice lead to lesions of the orifices of the great vessels branching from the aorta. This can lead to partial or even complete blockage of the artery.
Тромбоз - опасное состояние, при котором в сосуде образуется кровяной сгусток. Такой тромб может расти и закупоривая сосуд (артерия, вена) вплоть до полного перекрытия. При определенных условиях может привести «оторваться», становясь тромбоэмболом. Вследствие опасности, связанной с такой закупоркой, были разработаны различные методы и процедуры для лечения сосудистых закупорок. Thrombosis is a dangerous condition in which a blood clot forms in a vessel. Such a blood clot can grow and clog a vessel (artery, vein) until it completely blocks. Under certain conditions it can cause it to “break off”, becoming a thromboembolus. Due to the dangers associated with such blockages, various methods and procedures have been developed to treat vascular blockages.
Наиболее близким аналогом по технической сущности к заявленному изобретению является рентгеноконтрастный баллонный катетер с режущим инструментом, который содержит катетер и проводник для доставки баллона в обрабатываемую зону. Катетер имеет шахту, содержащую баллон с парой первых рентгеноконтрастных маркеров, расположенных на расстоянии друг от друга в продольном направлении для обозначения концов цилиндрического участка баллона. Цилиндрический участок расположен между коническими участками баллона и обеспечивает рабочую поверхность. Проводник для доставки баллона в обрабатываемую зону включает по меньшей мере одну пару вторых рентгеноконтрастных маркеров, причем по меньшей мере одна пара вторых рентгеноконтрастных маркеров соответствует по местоположению паре первых рентгеноконтрастных маркеров на баллоне, так что один из первых рентгеноконтрастных маркеров на баллоне совмещается с одним из вторых рентгеноконтрастных маркеров на проводнике и другой из первых рентгеноконтрастных маркеров на баллоне совмещается с другим из вторых рентгеноконтрастных маркеров на проводнике /RU 2663072 С2, опубл. 01.08.2018 г./. The closest analogue in technical essence to the claimed invention is a radiopaque balloon catheter with a cutting tool, which contains a catheter and a guide for delivering the balloon to the treated area. The catheter has a shaft containing a balloon with a pair of first radiopaque markers located at a distance from each other in the longitudinal direction to indicate the ends of the cylindrical portion of the balloon. The cylindrical section is located between the conical sections of the cylinder and provides a working surface. The conductor for delivering the balloon to the treatment area includes at least one pair of second radiopaque markers, and at least one pair of second radiopaque markers corresponds in location to a pair of first radiopaque markers on the balloon, so that one of the first radiopaque markers on the balloon is aligned with one of the second radiopaque markers on the conductor and another of the first radiopaque markers on the balloon is combined with another of the second radiopaque markers on the conductor /RU 2663072 C2, publ. 08/01/2018/.
К недостаткам данного аналога относятся жесткость режущих баллонов. Это ограничивает гибкость и легкость подачи баллона, когда он продвигается через извилистые пути сосуда или иного просвета тела. Кроме того, баллоны, оснащенные режущими лезвиями и кромками, может быть труднее сдувать и складывать. Это может привести к тому, что удаление баллонов из сосудистой системы будет сложнее. Задачей изобретения является создание новой усовершенствованной конструкции режущего катетера с улучшенными техническими характеристиками. The disadvantages of this analogue include the rigidity of the cutting cylinders. This limits the flexibility and ease of delivery of the balloon as it moves through the tortuous paths of a vessel or other body lumen. In addition, cylinders equipped with cutting blades and edges may be more difficult to deflate and fold. This may make it more difficult to remove balloons from the vascular system. The objective of the invention is to create a new, improved design of a cutting catheter with improved technical characteristics.
Техническим результатом является улучшение гибкости, повышение безопасности и обеспечение эффективного удаления и лечения фиброзных поражений. The technical result is to improve flexibility, increase safety and ensure effective removal and treatment of fibrotic lesions.
Это достигается тем, что режущий катетер, включающий проводник и режущий инструмент, согласно изобретению, снабжен двумя проводниками, соединенными на одном конце с цилиндрическим коннектором, а на другом - с кольцеобразным устройством, при котором наружная часть кольцеобразного устройства представляет собой мешок из нейлона с гидрофильным покрытием, а внутренняя часть - кольцеобразное микрохирургическое лезвие, причем кольцеобразное микрохирургическое лезвие снабжено, по меньшей мере, тремя защитными вставками из атравмичного нейлона, а мешок из нейлона с гидрофильным покрытием имеет множественные отверстия. This is achieved by the fact that the cutting catheter, including a conductor and a cutting tool, according to the invention, is equipped with two conductors connected at one end to a cylindrical connector, and at the other to a ring-shaped device, in which the outer part of the ring-shaped device is a nylon bag with a hydrophilic coating, and the inner part is a ring-shaped microsurgical blade, wherein the ring-shaped microsurgical blade is equipped with at least three protective inserts made of atraumatic nylon, and the nylon bag with a hydrophilic coating has multiple holes.
Кольцеобразное микрохирургическое лезвие выполнено посредством совмещения двух режущих инструментов в форме полуокружности, а проводники выполнены с возможностью приведения кольцеобразного микрохирургического лезвия в движение. The ring-shaped microsurgical blade is made by combining two cutting tools in the shape of a semicircle, and the conductors are made with the ability to set the ring-shaped microsurgical blade in motion.
На фигурах 1 -2 изображена наглядная схема режущего катетера (общий вид и вид спереди), на которых обозначены следующие элементы: Figures 1 - 2 show a visual diagram of the cutting catheter (general view and front view), on which the following elements are indicated:
1 - цилиндрический коннектор; 2 - защитные вставки из атравмичного нейлона; 3 - мешок из нейлона с гидрофильным покрытием; 4 - проводники, приводящее в движение кольцеобразное лезвие; 5 - кольцеобразное микрохирургическое лезвие; 6 - отверстия. 1 - cylindrical connector; 2 - protective inserts made of atraumatic nylon; 3 - nylon bag with hydrophilic coating; 4 - conductors driving the ring-shaped blade; 5 - ring-shaped microsurgical blade; 6 - holes.
Режущий катетер снабжен двумя проводниками (4), соединенными на одном конце с цилиндрическим коннектором (1), а на другом - с мешком из нейлона с гидрофильным покрытием (3) посредством кольцеобразного микрохирургического лезвия (5), причем кольцеобразное микрохирургическое лезвие (5) снабжено, по меньшей мере, тремя защитными вставками из атравмичного нейлона (2), а мешок из нейлона с гидрофильным покрытием (3) имеет множественные отверстия (6). The cutting catheter is equipped with two conductors (4), connected at one end to a cylindrical connector (1), and at the other to a bag made of nylon with a hydrophilic coating (3) by means of a ring-shaped microsurgical blade (5), and the ring-shaped microsurgical blade (5) is equipped with , at least three protective inserts made of atraumatic nylon (2), and a nylon bag with a hydrophilic coating (3) has multiple holes (6).
Кольцеобразное микрохирургическое лезвие (5) выполнено посредством совмещения двух режущих инструментов в форме полуокружности, а проводники (4) выполнены с возможностью приведения кольцеобразного микрохирургического лезвия (5) в движение. The ring-shaped microsurgical blade (5) is made by combining two cutting tools in the shape of a semicircle, and the conductors (4) are made with the ability to set the ring-shaped microsurgical blade (5) in motion.
Изобретение работает следующим образом. The invention works as follows.
Пример. Example.
Перед стентированием закупоренной артерии используется режущий катетер. Катетер продвигают с применением рентгеноскопии по проволочной направляющей, так чтобы микрохирургическое лезвие оказался дистальнее стеноза. Далее подтягивая катетер, микрохирургическим лезвием удаляются (иссекаются) атероматозные бляшки, в мешке собираются удаленные бляшки. Соответственно, в заявленном решений используют мешок с микрохирургическим лезвием, который предназначен для иссечения стеноза в ходе процедуры. A cutting catheter is used before stenting the blocked artery. The catheter is advanced using fluoroscopy along the guide wire so that the microsurgical blade is distal to the stenosis. Next, tightening the catheter, atheromatous plaques are removed (excised) with a microsurgical blade, and the removed plaques are collected in the bag. Accordingly, the claimed solutions use a bag with a microsurgical blade, which is designed to excise the stenosis during the procedure.
Технические характеристики режущего катетера. Technical characteristics of the cutting catheter.
Материал: дистальная часть катетера - нейлон с гидрофильным покрытием. Конусообразный дистальный кончик шафта длиной 4 мм. Дистальная часть шафта - нейлон, проксимальная часть шафта - нержавеющая сталь. Гидрофильное покрытие на всем протяжении шафта. Рентгенконтрастные утопленные маркеры на кольцеобразном устройстве: 2 шт. (в дистальной и проксимальной части) из сплава платины и иридия. Рабочая длина шафта - 140 см, совместим с проводником 0,014", проводниковым катетером 6 F. Совместим с интродьюсерами 6, 7 F. Трубка катетера имеет два просвета, один просвет предназначен для открытия кольцеобразного устройства, второй - это просвет для проводника. Material: the distal part of the catheter is nylon with a hydrophilic coating. Tapered distal tip of the shaft, 4 mm long. The distal part of the shaft is nylon, the proximal part of the shaft is stainless steel. Hydrophilic coating throughout the shaft. X-ray contrast recessed markers on a ring-shaped device: 2 pcs. (in the distal and proximal parts) from an alloy of platinum and iridium. The working length of the shaft is 140 cm, compatible with a 0.014" guidewire, 6 F guiding catheter. Compatible with 6, 7 F introducers. The catheter tube has two lumens, one lumen is designed to open the ring-shaped device, the second is the lumen for the guidewire.
На дистальном конце катетера имеется режущее кольцеобразное устройство, имеет проксимальный и дистальный конец. Диаметр при открытии 1,25-12,0 мм, в собранном виде - не более 1 мм. Длина устройства - 5-40 мм. Кольцеобразное устройство прикреплена двумя проводниками. Материал проводника поддерживающего внутреннего стержня и проксимальная часть - нержавеющая сталь, покрытая дюраглид, переходная часть - дюраглид, дистальная часть - платина. Наружный диаметр не более 0.014”. На расстоянии 5 мм соединяется и проходят через коннектор, входит в канал катетера. Кольцеобразное устройство состоит из двух частей. Наружная часть: материал - атравматичный нейлон с гидрофильным покрытием, внутренняя часть - микрохирургические лезвия. Внутренняя часть выступает на 0,5-1 мм. Кольцеобразная часть устройства соединена с мешком (дистальный конец, материал: нейлон с гидрофильным покрытием). Мешок имеет 6-8 отверстий, круглой формы d - 1000 мкм (1 мм). At the distal end of the catheter there is a cutting ring-shaped device, which has a proximal and distal end. Diameter when opened is 1.25-12.0 mm, when assembled - no more than 1 mm. The length of the device is 5-40 mm. The ring-shaped device is attached by two conductors. The material of the conductor of the supporting inner rod and the proximal part is stainless steel coated with duraglide, the transition part is duraglide, the distal part is platinum. Outer diameter no more than 0.014”. At a distance of 5 mm, it connects and passes through the connector, enters the catheter channel. The ring-shaped device consists of two parts. Outer part: material - atraumatic nylon with hydrophilic coating, inner part - microsurgical blades. The inner part protrudes by 0.5-1 mm. The ring-shaped part of the device is connected to the bag (distal end, material: nylon with hydrophilic coating). The bag has 6-8 holes, round shape d - 1000 microns (1 mm).

Claims

Формула изобретения Claim
1. Режущий катетер, включающий проводник и режущий инструмент, отличающийся тем, что снабжен двумя проводниками, соединенными на одном конце с цилиндрическим коннектором, а на другом - с кольцеобразным устройством, при котором наружная часть кольцеобразного устройства представляет собой мешок из нейлона с гидрофильным покрытием, а внутренняя часть - кольцеобразное микрохирургическое лезвие, причем кольцеобразное микрохирургическое лезвие снабжено, по меньшей мере, тремя защитными вставками из атравмичного нейлона, а мешок из нейлона с гидрофильным покрытием имеет множественные отверстия. 1. A cutting catheter, including a conductor and a cutting tool, characterized in that it is equipped with two conductors connected at one end to a cylindrical connector, and at the other to a ring-shaped device, in which the outer part of the ring-shaped device is a bag made of nylon with a hydrophilic coating, and the inner part is a ring-shaped microsurgical blade, wherein the ring-shaped microsurgical blade is equipped with at least three protective inserts made of atraumatic nylon, and the nylon bag with a hydrophilic coating has multiple holes.
2. Катетер по п.1, отличающийся тем, что кольцеобразное микрохирургическое лезвие выполнено посредством совмещения двух режущих инструментов в форме полуокружности. 2. The catheter according to claim 1, characterized in that the ring-shaped microsurgical blade is made by combining two cutting tools in the shape of a semicircle.
3. Катетер по п.1, отличающийся тем, что проводники выполнены с возможностью приведения кольцеобразного микрохирургического лезвия в движение. 3. The catheter according to claim 1, characterized in that the conductors are designed to set the ring-shaped microsurgical blade in motion.
4 4
PCT/KZ2022/000009 2022-07-18 2022-07-29 Cutting catheter WO2024019606A1 (en)

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KZ20220442 2022-07-18
KZ2022/0442.1 2022-07-18

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187495A1 (en) * 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
WO2004034884A2 (en) * 2002-10-17 2004-04-29 Gore Enterprise Holdings, Inc. Embolic filter frame having looped support strut elements
US20110040314A1 (en) * 1999-10-22 2011-02-17 Mcguckin Jr James F Rotational Thrombectomy Wire With Blocking Device
WO2014028260A1 (en) * 2012-08-14 2014-02-20 W. L. Gore & Associates, Inc. Devices and systems for thrombus treatment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110040314A1 (en) * 1999-10-22 2011-02-17 Mcguckin Jr James F Rotational Thrombectomy Wire With Blocking Device
US20030187495A1 (en) * 2002-04-01 2003-10-02 Cully Edward H. Endoluminal devices, embolic filters, methods of manufacture and use
WO2004034884A2 (en) * 2002-10-17 2004-04-29 Gore Enterprise Holdings, Inc. Embolic filter frame having looped support strut elements
WO2014028260A1 (en) * 2012-08-14 2014-02-20 W. L. Gore & Associates, Inc. Devices and systems for thrombus treatment

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