WO2004032880A3 - Method for inhibiting angiogenesis with ship-1 inhibitors - Google Patents

Method for inhibiting angiogenesis with ship-1 inhibitors Download PDF

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Publication number
WO2004032880A3
WO2004032880A3 PCT/US2003/032494 US0332494W WO2004032880A3 WO 2004032880 A3 WO2004032880 A3 WO 2004032880A3 US 0332494 W US0332494 W US 0332494W WO 2004032880 A3 WO2004032880 A3 WO 2004032880A3
Authority
WO
WIPO (PCT)
Prior art keywords
ship
inhibitors
inhibiting angiogenesis
methods
angiogenesis
Prior art date
Application number
PCT/US2003/032494
Other languages
French (fr)
Other versions
WO2004032880A2 (en
Inventor
Eric G Marcusson
Nicholas M Dean
Original Assignee
Isis Pharmaceuticals Inc
Eric G Marcusson
Nicholas M Dean
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc, Eric G Marcusson, Nicholas M Dean filed Critical Isis Pharmaceuticals Inc
Priority to AU2003284140A priority Critical patent/AU2003284140A1/en
Publication of WO2004032880A2 publication Critical patent/WO2004032880A2/en
Publication of WO2004032880A3 publication Critical patent/WO2004032880A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03056—Inositol-polyphosphate 5-phosphatase (3.1.3.56)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Methods for inhibiting angiogenesis using inhibitors of Ship-1 are provided. The net result is prevention, reduction or treatment of angiogenesis. Methods of treating angiogenic diseases and conditions and conditions associated with aberrant or excessive blood vessel growth are provided. Ship-1 inhibitors of the present invention include small molecules, antibodies, peptides (including dominant negative peptides) and antisense compounds, including ribozymes, inhibitory RNA molecules including siRNA molecules and antisense oligonucleotides.
PCT/US2003/032494 2002-10-11 2003-10-14 Method for inhibiting angiogenesis with ship-1 inhibitors WO2004032880A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003284140A AU2003284140A1 (en) 2002-10-11 2003-10-14 Method for inhibiting angiogenesis with ship-1 inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41839302P 2002-10-11 2002-10-11
US60/418,393 2002-10-11

Publications (2)

Publication Number Publication Date
WO2004032880A2 WO2004032880A2 (en) 2004-04-22
WO2004032880A3 true WO2004032880A3 (en) 2004-08-12

Family

ID=32094161

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/032494 WO2004032880A2 (en) 2002-10-11 2003-10-14 Method for inhibiting angiogenesis with ship-1 inhibitors

Country Status (2)

Country Link
AU (1) AU2003284140A1 (en)
WO (1) WO2004032880A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008022468A1 (en) * 2006-08-24 2008-02-28 British Columbia Cancer Agency Branch Compositions and methods for treating myelosuppression
US8956824B2 (en) 2006-12-04 2015-02-17 British Columbia Cancer Agency Branch Methods for identifying allosteric modulators of ship polypeptides
EP3581563B1 (en) 2010-04-09 2023-06-28 The Research Foundation of the State University of New York Ship inhibitors and uses thereof
CA2953917C (en) * 2013-07-01 2021-10-19 The Research Foundation For The State University Of New York Ship inhibition to combat obesity
WO2015195812A1 (en) 2014-06-17 2015-12-23 The Research Foundation For The State University Of New York Ship inhibition to induce activation of natural killer cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010252A1 (en) * 1995-09-14 1997-03-20 Fred Hutchinson Cancer Research Center Dna encoding an sh2-inositol phosphatase, an shc-binding protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997010252A1 (en) * 1995-09-14 1997-03-20 Fred Hutchinson Cancer Research Center Dna encoding an sh2-inositol phosphatase, an shc-binding protein

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHAVAKIS E, ET AL: "REGULATION OF ENDOTHELIAL CELL SURVIVAL AND APOPTOSIS DURING ANGIOGENESIS", ARTERIOSCLER THROMB VASC BIOL, vol. 22, no. 6, 1 June 2002 (2002-06-01), pages 887 - 893, XP002977223 *
DAMEN J E, ET AL: "MULTIPLE FORMS OF THE SH2-CONTAINING INOSITOL PHOSPHATASE, SHIP, ARE GENERATED BY C-TERMINAL TRUNCATION", BLOOD, vol. 92, no. 4, 15 August 1998 (1998-08-15), pages 1199 - 1205, XP002977222 *
GERBER, ET AL: "VASCULAR ENDOTHELIAL GROWTH FACTOR REGULATES ENDOTHELIAL CELLS SURVIVAL THROUGH THE PHOSPHATIDYLINOSITOL 3'-KINASE/AKT SIGNAL TRANSDUCTION PATHWAY. REQUIREMENT FOR FLK-1/KDR ACTIVATION", J. BIOL. CHEM., vol. 273, no. 46, 13 November 1998 (1998-11-13), pages 30336 - 30343, XP002155564 *
LIU L, ET AL: "THE SRC HOMOLOGY 2 (SH2) DOMAIN OF SH2-CONTAINING INOSITOL PHOSPHATASE (SHIP) IS ESSENTIAL FOR TYROSINE PHOSPHORYLATION OF SHIP, ITS ASSOCIATION WITH SHC, AND ITS INDUCTION OF APOPTOSIS", J. BIOL. CHEM., vol. 272, no. 14, 4 April 1997 (1997-04-04), pages 8983 - 8988, XP002977221 *
STEFAN M, ET AL: "SRC HOMOLOGY 2-CONTAINING INOSITOL 5-PHOSPHATASE 1 BINDS TO THE MULTIFUNCTIONAL DOCKING SITE OF C-MET AND POTENTIATES HEPATOCYTE GROWTH FACTOR-INDUCED BRANCHING TUBULOGENESIS", J. BIO. CHEM., vol. 276, no. 5, 2 February 2001 (2001-02-02), pages 3017 - 3023, XP002977224 *

Also Published As

Publication number Publication date
AU2003284140A1 (en) 2004-05-04
WO2004032880A2 (en) 2004-04-22
AU2003284140A8 (en) 2004-05-04

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