WO2004032830A3 - Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same - Google Patents

Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same Download PDF

Info

Publication number
WO2004032830A3
WO2004032830A3 PCT/US2003/025750 US0325750W WO2004032830A3 WO 2004032830 A3 WO2004032830 A3 WO 2004032830A3 US 0325750 W US0325750 W US 0325750W WO 2004032830 A3 WO2004032830 A3 WO 2004032830A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymer grafting
making
methods
same
glycosaminoglycan polymers
Prior art date
Application number
PCT/US2003/025750
Other languages
French (fr)
Other versions
WO2004032830A2 (en
Inventor
Paul L Deangelis
Wei Jing
Original Assignee
Univ Oklahoma
Paul L Deangelis
Wei Jing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Oklahoma, Paul L Deangelis, Wei Jing filed Critical Univ Oklahoma
Priority to CA2536016A priority Critical patent/CA2536016C/en
Priority to EP03808063A priority patent/EP1575622A2/en
Priority to AU2003296894A priority patent/AU2003296894A1/en
Publication of WO2004032830A2 publication Critical patent/WO2004032830A2/en
Publication of WO2004032830A3 publication Critical patent/WO2004032830A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Surgery (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The present invention relates to methodology for polymer grafting by a polysaccharide synthase and, more particularly, polymer grafting using the hyaluronate or chondroitin or heparin/heparosan synthases from Pasteurella, in order to create a variety of glycosaminoglycan oligosaccharides having a natural or chimeric or hybrid sugar structure with a targeted size that are substantially monodisperse in size.
PCT/US2003/025750 2002-08-16 2003-08-14 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same WO2004032830A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA2536016A CA2536016C (en) 2002-08-16 2003-08-14 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
EP03808063A EP1575622A2 (en) 2002-08-16 2003-08-14 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
AU2003296894A AU2003296894A1 (en) 2002-08-16 2003-08-14 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40435602P 2002-08-16 2002-08-16
US60/404,356 2002-08-16
US47943203P 2003-06-18 2003-06-18
US60/479,432 2003-06-18
US49136203P 2003-07-31 2003-07-31

Publications (2)

Publication Number Publication Date
WO2004032830A2 WO2004032830A2 (en) 2004-04-22
WO2004032830A3 true WO2004032830A3 (en) 2006-02-09

Family

ID=35788527

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/025750 WO2004032830A2 (en) 2002-08-16 2003-08-14 Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same

Country Status (2)

Country Link
AU (1) AU2003296894A1 (en)
WO (1) WO2004032830A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006033693A2 (en) * 2004-06-30 2006-03-30 Deangelis Paul L Methods of selectively treating diseases with specific glycosaminoglycan polymers
US7351423B2 (en) 2004-09-01 2008-04-01 Depuy Spine, Inc. Musculo-skeletal implant having a bioactive gradient
FR2949042B1 (en) * 2009-08-11 2011-11-04 Tbf Genie Tissulaire PROCESS FOR TREATING CARTILAGE-LIKE TISSUE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000027437A2 (en) * 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000027437A2 (en) * 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DEANGELIS P L: "Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses.", CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS. 15 NOV 1999, vol. 56, no. 7-8, 15 November 1999 (1999-11-15), pages 670 - 682, XP002357143, ISSN: 1420-682X *
DEANGELIS P L: "MOLECULAR DIRECTIONALITY OF POLYSACCHARIDE POLYMERIZATION BY THE PASTEURELLA MULTOCIDA HYALURONAN SYNTHASE", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 274, no. 37, 1999, pages 26557 - 26562, XP001100688, ISSN: 0021-9258 *
HELDERMON C ET AL: "STREPTOCOCCAL HYALURONAN SYNTHASES AND THE SYNTHESIS OF DESIGNER HYALURONAN", INTERNATIONAL CONGRESS SERIES, EXCERPTA MEDICA, AMSTERDAM, NL, 2000, pages 41 - 50, XP009047179, ISSN: 0531-5131 *
JING WEI ET AL: "Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM,, US, vol. 279, no. 40, 1 October 2004 (2004-10-01), pages 42345 - 42349, XP002312311, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2003296894A1 (en) 2004-05-04
WO2004032830A2 (en) 2004-04-22
AU2003296894A8 (en) 2004-05-04

Similar Documents

Publication Publication Date Title
WO2002089742A3 (en) Heparin/heparosan synthase and methods of making and using same
Lindahl et al. Heparin or heparan sulfate-what is the difference?
WO2000027437A3 (en) Polymer grafting by polysaccharide synthases
Nahain et al. Heparin mimetics with anticoagulant activity
Campa et al. Biochemical analysis of the processive mechanism for epimerization of alginate by mannuronan C-5 epimerase AlgE4
Ciancia et al. Overview of anticoagulant activity of sulfated polysaccharides from seaweeds in relation to their structures, focusing on those of green seaweeds
TNSN05101A1 (en) MIXTURES OF POLYSACCHARIDES DERIVED FROM HEPARIN PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
Martinou et al. Mode of action of chitin deacetylase from Mucor rouxii on partially N-acetylated chitosans
MY166801A (en) Glucosyltransferase enzymes for production of glucan polymers
WO2007140231A3 (en) Low molecular weight heparin composition and uses thereof
WO2006047755A3 (en) Method and medicament for sulfated polysaccharide treatment of heparin-induced thrombocytopenia (hit) syndrome
Yapo Pectin rhamnogalacturonan II: On the “Small Stem with Four Branches” in the primary cell walls of plants
WO2005012364A3 (en) Complex matrix for biomedical use
WO2008057697A3 (en) Cross-linked polymer particles
AU2003209240A1 (en) Alkali-swellable associative polymers, methods and compositions
WO2006122187A3 (en) Treating and evaluating inflammatory disorders
WO2003029261A3 (en) Glycosaminoglycan polymers and methods of making and using same
HK1118174A1 (en) Dietary fiber composition comprising glucomannan, xanthan gum, and alginate
WO2006040091A3 (en) Chitosan-containing cosmetic formulation
ASPINALL Classification of polysaccharides
WO2004017910A3 (en) Total synthesis of heparin
HK1095706A1 (en) High soluble fiber fermented foods
SG179471A1 (en) Arborescent polymers and process for making same
WO2001080810A3 (en) Chondroitin synthase gene and methods of making and using same
WO2004032830A3 (en) Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2003808063

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2003808063

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2536016

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP