WO2004029262A3 - Production of 2 - keto - l - gulonic acd - Google Patents

Production of 2 - keto - l - gulonic acd Download PDF

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Publication number
WO2004029262A3
WO2004029262A3 PCT/EP2003/010490 EP0310490W WO2004029262A3 WO 2004029262 A3 WO2004029262 A3 WO 2004029262A3 EP 0310490 W EP0310490 W EP 0310490W WO 2004029262 A3 WO2004029262 A3 WO 2004029262A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
gulonic
acd
keto
microorganisms
Prior art date
Application number
PCT/EP2003/010490
Other languages
French (fr)
Other versions
WO2004029262A2 (en
Inventor
Tatsuo Hoshino
Teruhide Sugisawa
Yoshinori Takagi
Original Assignee
Dsm Ip Assets Bv
Tatsuo Hoshino
Teruhide Sugisawa
Yoshinori Takagi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Tatsuo Hoshino, Teruhide Sugisawa, Yoshinori Takagi filed Critical Dsm Ip Assets Bv
Priority to AU2003270233A priority Critical patent/AU2003270233A1/en
Publication of WO2004029262A2 publication Critical patent/WO2004029262A2/en
Publication of WO2004029262A3 publication Critical patent/WO2004029262A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/58—Aldonic, ketoaldonic or saccharic acids
    • C12P7/60—2-Ketogulonic acid

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to a process for the production of 2-KGA or a salt thereof from D-sorbitol by a multi-stage continuous or a single-stage semi-continuous fermentation mode using a mixed culture of microorganisms of the genus Gluconobacter or Acetobacter. One of the microorganisms is G. oxydans DSM 4025.
PCT/EP2003/010490 2002-09-27 2003-09-22 Production of 2 - keto - l - gulonic acd WO2004029262A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003270233A AU2003270233A1 (en) 2002-09-27 2003-09-22 Production of 2 - keto - l - gulonic acd

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02021598.4 2002-09-27
EP02021598 2002-09-27

Publications (2)

Publication Number Publication Date
WO2004029262A2 WO2004029262A2 (en) 2004-04-08
WO2004029262A3 true WO2004029262A3 (en) 2004-07-01

Family

ID=32039095

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/010490 WO2004029262A2 (en) 2002-09-27 2003-09-22 Production of 2 - keto - l - gulonic acd

Country Status (3)

Country Link
CN (1) CN100506995C (en)
AU (1) AU2003270233A1 (en)
WO (1) WO2004029262A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101348806B (en) * 2008-09-04 2010-11-10 江西省德兴市百勤异Vc钠有限公司 2-keto-D-gluconic acid semicontinuous fermentation process
CN101845475B (en) * 2010-04-30 2013-06-19 仪宏 Nutrition-enhanced culture medium for preparing 2-KGA through fermentation and method thereof for preparing 2-KGA
CN102424830A (en) * 2011-12-15 2012-04-25 江南大学 Method for enhancing 2-keto-L-gulonic acid (2-KLG) production intensity of Ketogulonigenium vulgare by adding reduced glutathione (GSH)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518136A2 (en) * 1991-06-13 1992-12-16 F. Hoffmann-La Roche Ag Fermentation process for producing 2-keto-L-gulonic acid
EP0972843A1 (en) * 1998-07-17 2000-01-19 F. Hoffmann-La Roche Ag Continuous fermentation process
WO2000049133A1 (en) * 1999-02-19 2000-08-24 Basf Aktiengesellschaft Method for producing l-sorbose
WO2000065066A1 (en) * 1999-04-22 2000-11-02 Korea Research Institute Of Bioscience And Biotechnology Gluconobacter suboxydans sorbitol dehydrogenase, genes and methods of use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1257127C (en) * 2004-06-11 2006-05-24 张忠和 Decorative boards

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0518136A2 (en) * 1991-06-13 1992-12-16 F. Hoffmann-La Roche Ag Fermentation process for producing 2-keto-L-gulonic acid
EP0972843A1 (en) * 1998-07-17 2000-01-19 F. Hoffmann-La Roche Ag Continuous fermentation process
WO2000049133A1 (en) * 1999-02-19 2000-08-24 Basf Aktiengesellschaft Method for producing l-sorbose
WO2000065066A1 (en) * 1999-04-22 2000-11-02 Korea Research Institute Of Bioscience And Biotechnology Gluconobacter suboxydans sorbitol dehydrogenase, genes and methods of use thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BOUDRANT J: "Microbial processes for ascorbic acid biosynthesis: a review.", ENZYME AND MICROBIAL TECHNOLOGY, vol. 12, no. 5, 1 May 1990 (1990-05-01), pages 322 - 329, XP000646789, ISSN: 0141-0229 *
GIRIDHAR R ET AL: "Fed-batch cultivation of Acetobacter suboxydans for the microbial oxidation of D-sorbitol to L-sorbose", BIOPROCESS ENGINEERING, vol. 23, no. 6, 2000, pages 575 - 577, XP008026575, ISSN: 0178-515X *
GUPTA A ET AL: "Gluconobacter oxydans: its biotechnological applications.", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY., vol. 3, no. 3, July 2001 (2001-07-01), pages 445 - 456, XP008026573, ISSN: 1464-1801 *
KÖLBLIN R ET AL: "Untersuchungen zur Umwandlung von Sorbit in Sorbose durch Acetobacter suboxydans. Researches to the conversion of sorbit into sorbose by Acetobacter suboxydans.", ZENTRALBLATT FUR BAKTERIOLOGIE, PARASITENKUNDE, INFEKTIONSKRANKHEITEN UND HYGIENE. ZWEITE NATURWISSENSCHAFTLICHE ABT., vol. 132, no. 3, 1977, pages 196 - 203, XP008026574, ISSN: 0044-4057 *
SRIVASTAVA A K ET AL: "Representation of culture transition states in A. suboxydans", JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, vol. 73, no. 1, 1998, pages 23 - 30, XP002267250, ISSN: 0268-2575 *

Also Published As

Publication number Publication date
AU2003270233A1 (en) 2004-04-19
CN1681933A (en) 2005-10-12
AU2003270233A8 (en) 2004-04-19
WO2004029262A2 (en) 2004-04-08
CN100506995C (en) 2009-07-01

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