WO2004026812A3 - Verfahren zur katalysator-freien herstellung von cyanophenolen aus methoxybenzonitrilen - Google Patents

Verfahren zur katalysator-freien herstellung von cyanophenolen aus methoxybenzonitrilen Download PDF

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Publication number
WO2004026812A3
WO2004026812A3 PCT/EP2003/009818 EP0309818W WO2004026812A3 WO 2004026812 A3 WO2004026812 A3 WO 2004026812A3 EP 0309818 W EP0309818 W EP 0309818W WO 2004026812 A3 WO2004026812 A3 WO 2004026812A3
Authority
WO
WIPO (PCT)
Prior art keywords
methoxybenzonitriles
cyanophenols
catalyst
free production
produced
Prior art date
Application number
PCT/EP2003/009818
Other languages
English (en)
French (fr)
Other versions
WO2004026812A2 (de
Inventor
Juergen Sans
Hans-Georg Erben
Franz Thalhammer
Andreu Mario Gomez
Original Assignee
Degussa
Juergen Sans
Hans-Georg Erben
Franz Thalhammer
Andreu Mario Gomez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa, Juergen Sans, Hans-Georg Erben, Franz Thalhammer, Andreu Mario Gomez filed Critical Degussa
Priority to US10/526,568 priority Critical patent/US20060173207A1/en
Priority to EP03797265A priority patent/EP1549610A2/de
Priority to JP2004536980A priority patent/JP2005538179A/ja
Publication of WO2004026812A2 publication Critical patent/WO2004026812A2/de
Publication of WO2004026812A3 publication Critical patent/WO2004026812A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Beim vorgeschlagenen Verfahren zur Katalysator-freien Herstellung von Cyanophenolen aus Methoxybenzonitrilen werden substituierte Methoxybenzonitrile der allgemeinen Formel (I) mit einem Alkalialkoholat bei Temperaturen zwischen 80 und 230 °C umgesetzt. Dieses Verfahren, das von einfachen, kostengünstigen und leicht zugänglichen Rohstoffen ausgeht und unter technisch leicht realisierbaren Bedingungen abläuft, ermöglicht die Herstellung von Cyanophenolen mit hohen und zum Teil sogar quantitativen Ausbeuten und garantiert geringen Abfallmengen. Als bevorzugtes Alkalialkoholat wird insbesondere Natriummethanolat bei bevorzugten Temperaturen zwischen 140 und 180 °C eingesetzt. Die Methoxybenzonitril-Komponente kann ggf. durch Ammonoxidation eines Methoxytoluols in Gegenwart von Ammoniak und (Luft-)Sauerstoff hergestellt und direkt weiter umgesetzt werden.
PCT/EP2003/009818 2002-09-11 2003-09-04 Verfahren zur katalysator-freien herstellung von cyanophenolen aus methoxybenzonitrilen WO2004026812A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/526,568 US20060173207A1 (en) 2002-09-11 2003-09-04 Method for catalyst-free production of cyanophenols from methoxybenzonitriles
EP03797265A EP1549610A2 (de) 2002-09-11 2003-09-04 Verfahren zur katalysator-freien herstellung von cyanophenolen aus methoxybenzonitrilen
JP2004536980A JP2005538179A (ja) 2002-09-11 2003-09-04 メトキシベンゾニトリルからのシアノフェノールの触媒不含の製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10242080.7 2002-09-11
DE10242080A DE10242080A1 (de) 2002-09-11 2002-09-11 Verfahren zur Katalysator-freien Herstellung von Cyanophenolen aus Methoxybenzonitrilen

Publications (2)

Publication Number Publication Date
WO2004026812A2 WO2004026812A2 (de) 2004-04-01
WO2004026812A3 true WO2004026812A3 (de) 2004-05-13

Family

ID=31895811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/009818 WO2004026812A2 (de) 2002-09-11 2003-09-04 Verfahren zur katalysator-freien herstellung von cyanophenolen aus methoxybenzonitrilen

Country Status (5)

Country Link
US (1) US20060173207A1 (de)
EP (1) EP1549610A2 (de)
JP (1) JP2005538179A (de)
DE (1) DE10242080A1 (de)
WO (1) WO2004026812A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102311364B (zh) * 2011-09-30 2014-07-09 江苏联化科技有限公司 一种邻(对)羟基苯甲腈的制备方法
WO2014186981A1 (zh) * 2013-05-24 2014-11-27 江苏联化科技有限公司 一种邻（对）羟基苯甲腈的制备方法
GB201419540D0 (en) * 2014-11-03 2014-12-17 Nanomerics Ltd Delivery of drugs
CN112745243A (zh) * 2019-10-31 2021-05-04 北京颖泰嘉和生物科技股份有限公司 水杨腈的制备方法
CN113024413B (zh) * 2019-12-25 2022-12-06 北京颖泰嘉和生物科技股份有限公司 水杨腈联产植物生长调节剂的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1065936A (en) * 1965-03-30 1967-04-19 Rhone Poulenc Sa Process for the preparation of 4-hydroxybenzonitrile
US3567758A (en) * 1967-05-05 1971-03-02 May & Baker Ltd Preparation of hydroxybenzonitriles
GB1442250A (en) * 1973-09-12 1976-07-14 Chinoin Gyogyszer Es Vegyeszet Preparation of 4-hydroxybenzonitrile derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1065936A (en) * 1965-03-30 1967-04-19 Rhone Poulenc Sa Process for the preparation of 4-hydroxybenzonitrile
US3567758A (en) * 1967-05-05 1971-03-02 May & Baker Ltd Preparation of hydroxybenzonitriles
GB1442250A (en) * 1973-09-12 1976-07-14 Chinoin Gyogyszer Es Vegyeszet Preparation of 4-hydroxybenzonitrile derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
L. TESTAFERRI ET AL: "The reaction of unactivated aryl halides with sodium methoxide in HMPA", TETRAHEDRON, vol. 39, no. 1, 1983, pages 193 - 197, XP002274200 *

Also Published As

Publication number Publication date
WO2004026812A2 (de) 2004-04-01
JP2005538179A (ja) 2005-12-15
EP1549610A2 (de) 2005-07-06
US20060173207A1 (en) 2006-08-03
DE10242080A1 (de) 2004-03-25

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