WO2004024929A3 - Proximity-aided synthesis of templated molecules - Google Patents
Proximity-aided synthesis of templated molecules Download PDFInfo
- Publication number
- WO2004024929A3 WO2004024929A3 PCT/DK2003/000590 DK0300590W WO2004024929A3 WO 2004024929 A3 WO2004024929 A3 WO 2004024929A3 DK 0300590 W DK0300590 W DK 0300590W WO 2004024929 A3 WO2004024929 A3 WO 2004024929A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- template
- codon
- reactive group
- building block
- functional entity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Wind Motors (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003260291A AU2003260291A1 (en) | 2002-09-12 | 2003-09-12 | Proximity-aided synthesis of templated molecules |
EP03794823A EP1539953A2 (en) | 2002-09-12 | 2003-09-12 | Proximity-aided synthesis of templated molecules |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40996802P | 2002-09-12 | 2002-09-12 | |
DKPA200201347 | 2002-09-12 | ||
DKPA200201347 | 2002-09-12 | ||
US60/409,968 | 2002-09-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004024929A2 WO2004024929A2 (en) | 2004-03-25 |
WO2004024929A3 true WO2004024929A3 (en) | 2004-05-06 |
Family
ID=31995414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DK2003/000590 WO2004024929A2 (en) | 2002-09-12 | 2003-09-12 | Proximity-aided synthesis of templated molecules |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1539953A2 (en) |
AU (1) | AU2003260291A1 (en) |
WO (1) | WO2004024929A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
AU2011226815B2 (en) * | 2002-10-30 | 2014-09-25 | Nuevolution A/S | Enzymatic encoding |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
DE602004019764D1 (en) | 2003-03-20 | 2009-04-16 | Nuevolution As | LIGATION-RELATED CODING OF SMALL MOLECULES |
ATE447626T1 (en) | 2003-09-18 | 2009-11-15 | Nuevolution As | METHOD FOR OBTAINING STRUCTURAL INFORMATION FROM ENCODED MOLECULES AND FOR SELECTING COMPOUNDS |
RU2470077C2 (en) | 2003-12-17 | 2012-12-20 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Biologically active compound containing coding oligonucleotide (versions), method for synthesis thereof, library of compounds (versions), method for synthesis thereof, and method of searching for compound bound with biological target (versions) |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
US7704925B2 (en) | 2004-03-22 | 2010-04-27 | Nuevolution A/S | Ligational encoding using building block oligonucleotides |
EA024849B1 (en) * | 2004-11-08 | 2016-10-31 | Виперген Апс | Structure comprising a nucleic acid and a chemical compound, and method for creating same |
ATE462005T1 (en) | 2005-06-17 | 2010-04-15 | Harvard College | ITERATED BRANCHING PATHWAYS VIA NUCLEIC ACID-MEDIATED CHEMISTRY |
EP1940755A2 (en) | 2005-10-28 | 2008-07-09 | Praecis Pharmaceuticals Inc. | Methods for identifying compounds of interest using encoded libraries |
NZ594420A (en) | 2009-02-13 | 2013-06-28 | Chem Inc X | Methods of creating and screening dna-encoded libraries |
SI2558577T1 (en) | 2010-04-16 | 2019-05-31 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
AP2014007483A0 (en) | 2011-09-07 | 2014-03-31 | Chem Inc X | Methods for tagging DNA-encoded libraries |
IL236633B (en) | 2012-07-13 | 2022-07-01 | X Chem Inc | Dna-encoded libraries comprising a complex having a cross-linking oligonucleotide linkage |
EP3532613A4 (en) * | 2016-10-26 | 2020-05-06 | ModernaTX, Inc. | Methods and compositions for rna mapping |
US20210348212A1 (en) * | 2018-09-07 | 2021-11-11 | The Regents Of The University Of California | Hiv or hcv detection with crispr-cas13a |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020242A1 (en) * | 1992-03-30 | 1993-10-14 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003078625A2 (en) * | 2002-03-15 | 2003-09-25 | Nuevolution A/S | An improved method for synthesising templated molecules |
-
2003
- 2003-09-12 EP EP03794823A patent/EP1539953A2/en not_active Withdrawn
- 2003-09-12 WO PCT/DK2003/000590 patent/WO2004024929A2/en not_active Application Discontinuation
- 2003-09-12 AU AU2003260291A patent/AU2003260291A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020242A1 (en) * | 1992-03-30 | 1993-10-14 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
WO2000023458A1 (en) * | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
WO2002074929A2 (en) * | 2001-03-19 | 2002-09-26 | President And Fellows Of Harvard College | Evolving new molecular function |
Non-Patent Citations (3)
Title |
---|
GARTNER Z J ET AL: "Multistep small-molecule synthesis programmed by DNA templates", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 124, no. 35, 4 September 2002 (2002-09-04), pages 10304 - 10306, XP002265219, ISSN: 0002-7863 * |
GARTNER Z J ET AL: "THE GENERALITY OF DNA-TEMPLATED SYNTHESIS AS A BASIS FOR EVOLVING NON-NATURAL SMALL MOLECULES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 123, 2001, pages 6961 - 6963, XP001127054, ISSN: 0002-7863 * |
See also references of EP1539953A2 * |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8932992B2 (en) | 2001-06-20 | 2015-01-13 | Nuevolution A/S | Templated molecules and methods for using such molecules |
US8808984B2 (en) | 2002-03-15 | 2014-08-19 | Neuvolution A/S | Method for synthesising templated molecules |
US8206901B2 (en) | 2002-10-30 | 2012-06-26 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US8722583B2 (en) | 2002-10-30 | 2014-05-13 | Nuevolution A/S | Method for selecting a chemical entity from a tagged library |
US9109248B2 (en) | 2002-10-30 | 2015-08-18 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
US9284600B2 (en) | 2002-10-30 | 2016-03-15 | Neuvolution A/S | Method for the synthesis of a bifunctional complex |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
US9574189B2 (en) | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
Also Published As
Publication number | Publication date |
---|---|
WO2004024929A2 (en) | 2004-03-25 |
AU2003260291A8 (en) | 2004-04-30 |
EP1539953A2 (en) | 2005-06-15 |
AU2003260291A1 (en) | 2004-04-30 |
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