WO2004022564A3 - Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate - Google Patents
Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate Download PDFInfo
- Publication number
- WO2004022564A3 WO2004022564A3 PCT/GB2003/003805 GB0303805W WO2004022564A3 WO 2004022564 A3 WO2004022564 A3 WO 2004022564A3 GB 0303805 W GB0303805 W GB 0303805W WO 2004022564 A3 WO2004022564 A3 WO 2004022564A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- morphine
- converting
- under conditions
- conditions effective
- dihydrosinomenine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003263301A AU2003263301A1 (en) | 2002-09-03 | 2003-09-03 | Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0220385.9 | 2002-09-03 | ||
GB0220385A GB2392670A (en) | 2002-09-03 | 2002-09-03 | (+)-Morphine production |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004022564A2 WO2004022564A2 (en) | 2004-03-18 |
WO2004022564A3 true WO2004022564A3 (en) | 2004-07-01 |
Family
ID=9943367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2003/003805 WO2004022564A2 (en) | 2002-09-03 | 2003-09-03 | Alternative processes for the preparation of d- (+) -morphine, and d- (+) - morphine tartrate |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003263301A1 (en) |
GB (1) | GB2392670A (en) |
WO (1) | WO2004022564A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2610859C (en) | 2005-06-16 | 2013-11-12 | Peter Xianqi Wang | A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs |
EP2167505B1 (en) * | 2007-07-17 | 2012-11-28 | Mallinckrodt LLC | Preparation of n-alkylated opiates by reductive amination |
EP2328899B1 (en) | 2008-09-16 | 2018-01-24 | Mallinckrodt LLC | Processes for the synthesis of five and six membered heterocyclic rings |
WO2010065441A1 (en) * | 2008-12-02 | 2010-06-10 | Mallinckrodt Inc. | Process for preparing hydrocodone using a super acid |
US8946419B2 (en) | 2009-02-23 | 2015-02-03 | Mallinckrodt Llc | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
EP2398807A1 (en) * | 2009-02-23 | 2011-12-28 | Mallinckrodt LLC | (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives |
WO2010096790A1 (en) * | 2009-02-23 | 2010-08-26 | Mallinckrodt Inc. | (+)-morphinananium n-oxides and processes for their production |
US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
PL2453895T3 (en) * | 2009-07-16 | 2018-10-31 | Mallinckrodt Llc | (+) - morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
PL2593095T3 (en) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
CN104672142B (en) * | 2015-02-13 | 2017-08-04 | 江苏大学 | The preparation of diadactic structure Sinomenine derivate and medical usage |
CN109666030B (en) * | 2018-11-19 | 2021-04-27 | 兰州大学 | Method for catalyzing asymmetric synthesis of codeine and morphine |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4025520A (en) * | 1974-04-10 | 1977-05-24 | Macfarlan Smith Limited | Dehydrohalogenation of a 7-halodihydrocodeinone dialkyl ketal |
WO1991002485A1 (en) * | 1989-08-17 | 1991-03-07 | Research Foundation Of The City University Of New York | Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application |
-
2002
- 2002-09-03 GB GB0220385A patent/GB2392670A/en not_active Withdrawn
-
2003
- 2003-09-03 AU AU2003263301A patent/AU2003263301A1/en not_active Abandoned
- 2003-09-03 WO PCT/GB2003/003805 patent/WO2004022564A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4025520A (en) * | 1974-04-10 | 1977-05-24 | Macfarlan Smith Limited | Dehydrohalogenation of a 7-halodihydrocodeinone dialkyl ketal |
WO1991002485A1 (en) * | 1989-08-17 | 1991-03-07 | Research Foundation Of The City University Of New York | Microelectrodes and their use in a cathodic electrochemical current arrangement with telemetric application |
Non-Patent Citations (8)
Title |
---|
BRODERICK, P. A.: "In Vivo Electrochemical Studies of Rat Striatal Dopamine and Serotonine Release after Morphine", LIFE SCIENCES, vol. 36, 1985, pages 2269 - 2275, XP009022736 * |
GOTO, K.; YAMAMOTO, I.: "(+)-Codeine and (+)-Morphine from Sinomenine", PROC. JPN. ACAD., vol. 30, 1954, pages 769 - 773, XP009022637 * |
IIJIMA, I. ET AL.: "Studies in the (+)-Morphinan Series. 4. A Markedly Improved Synthesis of (+)-Morphine.", J. ORG. CHEM., vol. 43, no. 7, 1978, pages 1462 - 1463, XP001156547 * |
J .ORG. CHEM.,SUPPLEMENTAL PAGES, vol. 62, 1997, pages 1 - 13, XP002275946 * |
NICOLAOU K C ET AL: "A NEW METHOD FOR THE ONE-STEP SYNTHESIS OF A,BETA-UNSATURATED CARBONYL SYSTEMS FROM SATURATED ALCOHOLS COMPOUNDS", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, US, vol. 122, no. 31, 9 August 2000 (2000-08-09), pages 7596 - 7597, XP000937227, ISSN: 0002-7863 * |
NICOLAOU; K. C. ET AL.: "Modulation of the Reactivity Profile of IBX by Ligand Complexation ...", ANGEW. CHEM. INT. ED., vol. 41, no. 6, 15 March 2002 (2002-03-15), pages 993 - 996, XP002275169 * |
STRINGER, M. ET AL.: "d-Morphine, but not l-morphine, has low micromolar affinity for the non-competitive N-methyl-D-aspartate site in rat forebrain. ...", NEUROSCIENCE LETT., vol. 295, 2000, pages 21 - 24, XP002264370 * |
WHITE, J. D. ET AL.: "Asymmetric Synthesis of (+)-Morphine. The Phenanthrene Route Revisited.", J. ORG. CHEM., vol. 62, 1997, pages 5250 - 5251, XP002275168 * |
Also Published As
Publication number | Publication date |
---|---|
WO2004022564A2 (en) | 2004-03-18 |
AU2003263301A1 (en) | 2004-03-29 |
GB0220385D0 (en) | 2002-10-09 |
GB2392670A (en) | 2004-03-10 |
AU2003263301A8 (en) | 2004-03-29 |
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