WO2004020666A3 - Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases - Google Patents

Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases Download PDF

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Publication number
WO2004020666A3
WO2004020666A3 PCT/EP2003/009536 EP0309536W WO2004020666A3 WO 2004020666 A3 WO2004020666 A3 WO 2004020666A3 EP 0309536 W EP0309536 W EP 0309536W WO 2004020666 A3 WO2004020666 A3 WO 2004020666A3
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WO
WIPO (PCT)
Prior art keywords
disease
alzheimer
binding protein
thyroid hormone
neurodegenerative diseases
Prior art date
Application number
PCT/EP2003/009536
Other languages
French (fr)
Other versions
WO2004020666A2 (en
Inventor
Der Kammer Heinz Von
Johannes Pohlner
Original Assignee
Evotec Neurosciences Gmbh
Der Kammer Heinz Von
Johannes Pohlner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Neurosciences Gmbh, Der Kammer Heinz Von, Johannes Pohlner filed Critical Evotec Neurosciences Gmbh
Priority to EP03753364A priority Critical patent/EP1534856A2/en
Priority to AU2003271568A priority patent/AU2003271568A1/en
Publication of WO2004020666A2 publication Critical patent/WO2004020666A2/en
Publication of WO2004020666A3 publication Critical patent/WO2004020666A3/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention discloses the differential expression of the gene coding for THBP, thyroid hormone binding protein, in specific brain regions of Alzheimer's disease patients. Based on this finding, the invention provides a method for diagnosing or prognosticating Alzheimer's disease in a subject, or for determining whether a subject is at increased risk of developing Alzheimer's disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the gene coding for THBP. A method of screening for modulating agents of neurodegenerative diseases is also disclosed.
PCT/EP2003/009536 2002-09-02 2003-08-28 Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases WO2004020666A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP03753364A EP1534856A2 (en) 2002-09-02 2003-08-28 Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases
AU2003271568A AU2003271568A1 (en) 2002-09-02 2003-08-28 Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP02019557.4 2002-09-02
EP02019557 2002-09-02
US40724902P 2002-09-03 2002-09-03
US60/407,249 2002-09-03

Publications (2)

Publication Number Publication Date
WO2004020666A2 WO2004020666A2 (en) 2004-03-11
WO2004020666A3 true WO2004020666A3 (en) 2004-09-02

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/009536 WO2004020666A2 (en) 2002-09-02 2003-08-28 Diagnostic and therapeutic use of thyroid hormone binding protein for neurodegenerative diseases

Country Status (3)

Country Link
EP (1) EP1534856A2 (en)
AU (1) AU2003271568A1 (en)
WO (1) WO2004020666A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
WO2000067033A1 (en) * 1999-05-03 2000-11-09 Evotec Biosystems Ag Methods of diagnosing or treating alzheimer's disease
WO2002016636A2 (en) * 2000-08-24 2002-02-28 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
WO2002022867A2 (en) * 2000-09-13 2002-03-21 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a phosphoprotein enriched in astrocytes for alzheimer's disease and related neurodegenerative disorders
WO2002057496A2 (en) * 2001-01-18 2002-07-25 Socratech L.L.C. Gene expression profiling of endothelium in alzheimer's disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980281A (en) * 1988-02-10 1990-12-25 Housey Gerard M Method of screening for protein inhibitors and activators
WO2000067033A1 (en) * 1999-05-03 2000-11-09 Evotec Biosystems Ag Methods of diagnosing or treating alzheimer's disease
WO2002016636A2 (en) * 2000-08-24 2002-02-28 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a caveolae-associated integral membrane protein for alzheimer's disease and related neurodegenerative disorders
WO2002022867A2 (en) * 2000-09-13 2002-03-21 Evotec Neurosciences Gmbh Diagnostic and therapeutic use of a phosphoprotein enriched in astrocytes for alzheimer's disease and related neurodegenerative disorders
WO2002057496A2 (en) * 2001-01-18 2002-07-25 Socratech L.L.C. Gene expression profiling of endothelium in alzheimer's disease

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
"Consensus report of the Working Group on: "Molecular and Biochemical Markers of Alzheimer's Disease". The Ronald and Nancy Reagan Research Institute of the Alzheimer's Association and the National Institute on Aging Working Group.", NEUROBIOLOGY OF AGING. UNITED STATES 1998 MAR-APR, vol. 19, no. 2, March 1998 (1998-03-01), pages 109 - 116, XP002243838, ISSN: 0197-4580 *
BROWN VANESSA M ET AL: "High-throughput imaging of brain gene expression.", GENOME RESEARCH. UNITED STATES FEB 2002, vol. 12, no. 2, February 2002 (2002-02-01), pages 244 - 254, XP002231816, ISSN: 1088-9051 *
CALLAHAN L M ET AL: "Analysis of message expression in single neurons of Alzheimer's disease brain.", NEUROBIOLOGY OF AGING. UNITED STATES 1998 JAN-FEB, vol. 19, no. 1 Suppl, January 1998 (1998-01-01), pages S99 - 105, XP002243837, ISSN: 0197-4580 *
CHOW N ET AL: "Expression profiles of multiple genes in single neurons of Alzheimer's disease.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 4 AUG 1998, vol. 95, no. 16, 4 August 1998 (1998-08-04), pages 9620 - 9625, XP002243836, ISSN: 0027-8424 *
DATABASE EMBL GENBANK [online] XP002231826, Database accession no. BC018061 *
DATABASE EMBL GENBANK [online] XP002231827, Database accession no. BC008398 *
DATABASE EMBL GENBANK [online] XP002231828, Database accession no. L02950 *
DATABASE EMBL GENBANK [online] XP002231830, Database accession no. U85772 *
DATABASE NCBI GENBANK [online] XP002275538, Database accession no. Q14894 *
DATABASE WPI Section Ch Week 199311, Derwent World Patents Index; Class B04, AN 1993-093573, XP002243840 *
DATABASE WPI Section Ch Week 199319, Derwent World Patents Index; Class B04, AN 1993-159482, XP002243839 *
DOYU M ET AL: "Gene expression profile in Alzheimer's brain screened by molecular indexing.", BRAIN RESEARCH. MOLECULAR BRAIN RESEARCH. NETHERLANDS 19 FEB 2001, vol. 87, no. 1, 19 February 2001 (2001-02-19), pages 1 - 11, XP002231818, ISSN: 0169-328X *
GINSBERG S D ET AL: "Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons.", ANNALS OF NEUROLOGY. UNITED STATES JUL 2000, vol. 48, no. 1, July 2000 (2000-07-01), pages 77 - 87, XP008008699, ISSN: 0364-5134 *
HATA R ET AL: "Up-regulation of calcineurin Abeta mRNA in the Alzheimer's disease brain: assessment by cDNA microarray.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. UNITED STATES 8 JUN 2001, vol. 284, no. 2, 8 June 2001 (2001-06-08), pages 310 - 316, XP002231817, ISSN: 0006-291X *
KIM R Y ET AL: "mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 1 OCT 1992, vol. 89, no. 19, 1 October 1992 (1992-10-01), pages 9292 - 9296, XP002231825, ISSN: 0027-8424 *
LORING J F ET AL: "A gene expression profile of Alzheimer's disease.", DNA AND CELL BIOLOGY. UNITED STATES NOV 2001, vol. 20, no. 11, November 2001 (2001-11-01), pages 683 - 695, XP001083747, ISSN: 1044-5498 *
PASINETTI G M ET AL: "FROM CDNA MICROARRAYS TO HIGH-THROUGHPUT PROTEOMICS. IMPLICATIONS IN THE SEARCH FOR PREVENTIVE INITIATIVES TO SLOW THE CLINICAL PROGRESSION OF ALZHEIMER'S DISEASE DEMENTIA", RESTORATIVE NEUROLOGY AND NEUROSCIENCE, XX, XX, vol. 18, no. 2/3, 2001, pages 137 - 142, XP009006184 *
PASINETTI G M: "Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia.", JOURNAL OF NEUROSCIENCE RESEARCH. UNITED STATES 15 SEP 2001, vol. 65, no. 6, 15 September 2001 (2001-09-15), pages 471 - 476, XP002231820, ISSN: 0360-4012 *
RYAN M ET AL: "Indexing-based differential display--studies on post-mortem Alzheimer's brains.", BRAIN RESEARCH. MOLECULAR BRAIN RESEARCH. NETHERLANDS 31 MAR 2001, vol. 88, no. 1-2, 31 March 2001 (2001-03-31), pages 199 - 202, XP002231819, ISSN: 0169-328X *
SCHONBERGER S J ET AL: "PROTEOMIC ANALYSIS OF THE BRAIN IN ALZHEIMER'S DISEASE: MOLECULAR PHENOTYPE OF A COMPLEX DISEASE PROCESS", PROTEOMICS, XX, XX, vol. 1, no. 12, December 2001 (2001-12-01), pages 1519 - 1528, XP009006180 *
TSUJI T ET AL: "ANALYSIS OF THE PROTEOMIC PROFILING OF BRAIN TISSUE IN ALZHEIMER'S DISEASE", DISEASE MARKERS, WILEY, CHICHESTER, GB, vol. 17, no. 4, 2001, pages 247 - 257, XP009006179, ISSN: 0278-0240 *
VAN LEUVEN F: "Single and multiple transgenic mice as models for Alzheimer's disease.", PROGRESS IN NEUROBIOLOGY. ENGLAND JUN 2000, vol. 61, no. 3, June 2000 (2000-06-01), pages 305 - 312, XP001023899, ISSN: 0301-0082 *
VIÉ M P ET AL: "Purification, molecular cloning, and functional expression of the human nicodinamide-adenine dinucleotide phosphate-regulated thyroid hormone-binding protein.", MOLECULAR ENDOCRINOLOGY (BALTIMORE, MD.) UNITED STATES OCT 1997, vol. 11, no. 11, October 1997 (1997-10-01), pages 1728 - 1736, XP002231823, ISSN: 0888-8809 *
WELLS J M: "FUTURE DIRECTIONS IN THE ANALYSIS OF GENE EXPRESSION IN ALZHEIMER DISEASE", ALZHEIMER DISEASE AND ASSOCIATED DISORDERS, RAVEN PRESS, NEW YORK, NY, US, vol. 13, no. SUPPL 1, April 1999 (1999-04-01), pages S78 - S81, XP009006178, ISSN: 0893-0341 *

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Publication number Publication date
EP1534856A2 (en) 2005-06-01
AU2003271568A1 (en) 2004-03-19
WO2004020666A2 (en) 2004-03-11

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