WO2004005220A3 - Method for asymmetric resolution of a racemic using diprogulic acid and use of said acid as asymmetric resolution agent - Google Patents

Method for asymmetric resolution of a racemic using diprogulic acid and use of said acid as asymmetric resolution agent Download PDF

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Publication number
WO2004005220A3
WO2004005220A3 PCT/FR2003/002086 FR0302086W WO2004005220A3 WO 2004005220 A3 WO2004005220 A3 WO 2004005220A3 FR 0302086 W FR0302086 W FR 0302086W WO 2004005220 A3 WO2004005220 A3 WO 2004005220A3
Authority
WO
WIPO (PCT)
Prior art keywords
acid
racemic
asymmetric resolution
diprogulic
asymmetric
Prior art date
Application number
PCT/FR2003/002086
Other languages
French (fr)
Other versions
WO2004005220A2 (en
Inventor
Sonia Roussiasse
Stephane Frein
Alain Burgos
Blandine Bertrand
Myriam Clementz
Aline Total
Original Assignee
Ppg Sipsy
Sonia Roussiasse
Stephane Frein
Alain Burgos
Blandine Bertrand
Myriam Clementz
Aline Total
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ppg Sipsy, Sonia Roussiasse, Stephane Frein, Alain Burgos, Blandine Bertrand, Myriam Clementz, Aline Total filed Critical Ppg Sipsy
Priority to AU2003263264A priority Critical patent/AU2003263264A1/en
Publication of WO2004005220A2 publication Critical patent/WO2004005220A2/en
Publication of WO2004005220A3 publication Critical patent/WO2004005220A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Abstract

The invention concerns a method for resolving a racemic to obtain its optically active isomer characterized in that it consists in reacting, with diprogulic acid or one of its salt, a racemic of general formula (I), wherein: Ar is a heteroaryl group; R1 is an alkyl group; R2 and R3, identical or different, represent each a hydrogen atom or an alkyl group; n is an integer ranging between 0 and 4.
PCT/FR2003/002086 2002-07-05 2003-07-04 Method for asymmetric resolution of a racemic using diprogulic acid and use of said acid as asymmetric resolution agent WO2004005220A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003263264A AU2003263264A1 (en) 2002-07-05 2003-07-04 Method for asymmetric resolution of a racemic using diprogulic acid and use of said acid as asymmetric resolution agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0208516A FR2841899A1 (en) 2002-07-05 2002-07-05 METHOD FOR ASYMMETRIC RESOLUTION OF A RACEMIC USING DIPROGULIC ACID AND USE OF SAID ACID AS AN ASYMMETRIC RESOLUTION AGENT
FR02/08516 2002-07-05

Publications (2)

Publication Number Publication Date
WO2004005220A2 WO2004005220A2 (en) 2004-01-15
WO2004005220A3 true WO2004005220A3 (en) 2004-04-15

Family

ID=29725239

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002086 WO2004005220A2 (en) 2002-07-05 2003-07-04 Method for asymmetric resolution of a racemic using diprogulic acid and use of said acid as asymmetric resolution agent

Country Status (3)

Country Link
AU (1) AU2003263264A1 (en)
FR (1) FR2841899A1 (en)
WO (1) WO2004005220A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7973182B2 (en) 2004-02-19 2011-07-05 Lonza Ltd. Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
CA2656128A1 (en) 2006-07-03 2008-01-10 Ranbaxy Laboratories Limited Process for the preparation of enantiomerically pure salts of n-methyl-3(1-naphthaleneoxy)-3-(2-thienyl)propanamine
US10012993B1 (en) 2016-12-09 2018-07-03 Zendrive, Inc. Method and system for risk modeling in autonomous vehicles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014772A1 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-ht1-like agonists
EP0650965A1 (en) * 1993-10-12 1995-05-03 Eli Lilly And Company Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994014772A1 (en) * 1992-12-21 1994-07-07 Smithkline Beecham Plc Enantiomers of carbazole derivatives as 5-ht1-like agonists
EP0650965A1 (en) * 1993-10-12 1995-05-03 Eli Lilly And Company Asymmetric synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine an intermediate in the preparation of duloxetine

Also Published As

Publication number Publication date
AU2003263264A8 (en) 2004-01-23
FR2841899A1 (en) 2004-01-09
WO2004005220A2 (en) 2004-01-15
AU2003263264A1 (en) 2004-01-23

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