WO2003105751A3 - Novel curcumin derivatives - Google Patents

Novel curcumin derivatives Download PDF

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Publication number
WO2003105751A3
WO2003105751A3 PCT/KR2002/001134 KR0201134W WO03105751A3 WO 2003105751 A3 WO2003105751 A3 WO 2003105751A3 KR 0201134 W KR0201134 W KR 0201134W WO 03105751 A3 WO03105751 A3 WO 03105751A3
Authority
WO
WIPO (PCT)
Prior art keywords
novel curcumin
curcumin derivatives
novel
pharmaceutical composition
curcumin derivative
Prior art date
Application number
PCT/KR2002/001134
Other languages
French (fr)
Other versions
WO2003105751A2 (en
Inventor
Ho-Jeong Kwon
Joong-Sup Shim
Jin-Hee Kim
Seung-Hoon Choi
Jong-Heon Shin
Jung-Rae Rho
Original Assignee
Ho-Jeong Kwon
Joong-Sup Shim
Jin-Hee Kim
Seung-Hoon Choi
Jong-Heon Shin
Jung-Rae Rho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ho-Jeong Kwon, Joong-Sup Shim, Jin-Hee Kim, Seung-Hoon Choi, Jong-Heon Shin, Jung-Rae Rho filed Critical Ho-Jeong Kwon
Priority to PCT/KR2002/001134 priority Critical patent/WO2003105751A2/en
Priority to AU2002314566A priority patent/AU2002314566A1/en
Publication of WO2003105751A2 publication Critical patent/WO2003105751A2/en
Publication of WO2003105751A3 publication Critical patent/WO2003105751A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • C07C251/34—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C251/36—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/40—Oximes with oxygen atoms of oxyimino groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with the carbon atoms of the oxyimino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to a novel curcumin derivative and a pharmaceutical composition, in particular to a novel curcumin derivative with anti-angiogenic activity and a pharmaceutical composition for treating or preventing a disease associated with unregulated angiogenesis.
PCT/KR2002/001134 2002-06-17 2002-06-17 Novel curcumin derivatives WO2003105751A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/KR2002/001134 WO2003105751A2 (en) 2002-06-17 2002-06-17 Novel curcumin derivatives
AU2002314566A AU2002314566A1 (en) 2002-06-17 2002-06-17 Novel curcumin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2002/001134 WO2003105751A2 (en) 2002-06-17 2002-06-17 Novel curcumin derivatives

Publications (2)

Publication Number Publication Date
WO2003105751A2 WO2003105751A2 (en) 2003-12-24
WO2003105751A3 true WO2003105751A3 (en) 2004-09-23

Family

ID=29728585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2002/001134 WO2003105751A2 (en) 2002-06-17 2002-06-17 Novel curcumin derivatives

Country Status (2)

Country Link
AU (1) AU2002314566A1 (en)
WO (1) WO2003105751A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070093457A1 (en) * 2004-02-11 2007-04-26 Nadir Arber Compositions for treatment of cancer and inflammation with curcumin and at least one nsaid
EP1797072A4 (en) * 2004-09-17 2009-09-09 Exelixis Inc Pyrazole kinase modulators and methods of use
WO2009073050A2 (en) * 2007-07-27 2009-06-11 Research Foundation Of City University Of New York Use of curcumin to block brain tumor formation in vivo
CN102575236B (en) * 2009-09-07 2014-10-01 贾瓦哈拉尔尼赫鲁高级科学研究中心 Inhibition of histone acetyltransferases by CTK7A and methods thereof
WO2012141228A1 (en) * 2011-04-11 2012-10-18 株式会社ファルマエイト Novel pyrazole derivative
JP6284158B2 (en) * 2012-10-10 2018-02-28 グリーン・テック株式会社 New pyrazole derivatives
CN103333140A (en) * 2013-06-27 2013-10-02 河南工业大学 Preparation method of curcumin derivatives, and antitumor drug
RU2695062C2 (en) * 2015-05-22 2019-07-19 Общество С Ограниченной Ответственностью "Отечественные Фармацевтические Технологии" Novel 3,5-divinyl-pyrazole derivatives for medical use
CN106800547B (en) * 2017-01-03 2019-07-23 中国人民解放军第二军医大学 A kind of disubstituted aryl class compound and its application
CN107519544A (en) * 2017-08-28 2017-12-29 武汉杨森生物技术有限公司 Compound anticoagulant heparin coating microballoon and preparation method and application
WO2021105137A1 (en) 2019-11-25 2021-06-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Trem-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease
JPWO2022186362A1 (en) * 2021-03-03 2022-09-09
WO2022189659A1 (en) 2021-03-12 2022-09-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Trem-1 inhibitors for the treatment of marfan syndrome
WO2023061946A1 (en) 2021-10-11 2023-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of trem-1 for predicting and preventing postoperative complications after cardiac surgery with cardiopulmonary by-pass

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2501220A1 (en) * 1975-01-14 1976-07-15 Heumann Ludwig & Co Gmbh 1,7-Diphenyl-5-hydroxy-1,4,6,-heptatriene-3-ones prepn. - in one step from beta-diketones and aromatic aldehydes
EP0245825A1 (en) * 1986-05-09 1987-11-19 Warner-Lambert Company Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
WO1997016403A1 (en) * 1995-11-03 1997-05-09 Geneprint, Inc. Process for the synthesis of curcumin-related compounds
WO2001000201A1 (en) * 1999-06-30 2001-01-04 Emory University Curcumin and curcuminoid inhibition of angiogenesis
US20030203933A1 (en) * 2002-04-17 2003-10-30 Kuo-Hsiung Lee Novel curcumin analogues and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2501220A1 (en) * 1975-01-14 1976-07-15 Heumann Ludwig & Co Gmbh 1,7-Diphenyl-5-hydroxy-1,4,6,-heptatriene-3-ones prepn. - in one step from beta-diketones and aromatic aldehydes
EP0245825A1 (en) * 1986-05-09 1987-11-19 Warner-Lambert Company Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them
WO1997016403A1 (en) * 1995-11-03 1997-05-09 Geneprint, Inc. Process for the synthesis of curcumin-related compounds
WO2001000201A1 (en) * 1999-06-30 2001-01-04 Emory University Curcumin and curcuminoid inhibition of angiogenesis
US20030203933A1 (en) * 2002-04-17 2003-10-30 Kuo-Hsiung Lee Novel curcumin analogues and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CD Rompp Chemie Lexikon-Version 1.0, Stuttgart/New York: Georg Thieme Verlag 1995 *
DATABASE CAPLUS [online] CHOWDHURY HEMANTA ET AL.: "Isolation, characterization and insect growth inhibitory activity of major turmeric constituents and their derivatives against Schistocerca gregaria (Forsk) and Dysdercus koenigii (Walk)", XP002903668, accession no. stn Database accession no. 2000:872086 *
PEST MANAGEMENT SCIENCE, vol. 56, no. 12, 2000, pages 1086 - 1092 *

Also Published As

Publication number Publication date
WO2003105751A2 (en) 2003-12-24
AU2002314566A1 (en) 2003-12-31
AU2002314566A8 (en) 2003-12-31

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