WO2003104394A3 - Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon - Google Patents

Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon Download PDF

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Publication number
WO2003104394A3
WO2003104394A3 PCT/US2003/016181 US0316181W WO03104394A3 WO 2003104394 A3 WO2003104394 A3 WO 2003104394A3 US 0316181 W US0316181 W US 0316181W WO 03104394 A3 WO03104394 A3 WO 03104394A3
Authority
WO
WIPO (PCT)
Prior art keywords
serine protease
nucleic acid
acid molecules
methods based
molecules encoding
Prior art date
Application number
PCT/US2003/016181
Other languages
French (fr)
Other versions
WO2003104394A2 (en
Inventor
Edwin L Madison
Edgar O Ong
Original Assignee
Dendreon Corp
Edwin L Madison
Edgar O Ong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dendreon Corp, Edwin L Madison, Edgar O Ong filed Critical Dendreon Corp
Priority to AU2003269880A priority Critical patent/AU2003269880A1/en
Publication of WO2003104394A2 publication Critical patent/WO2003104394A2/en
Publication of WO2003104394A3 publication Critical patent/WO2003104394A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Provided herein are type II transmembrane serine protease 12 (MTSP12) polypeptides. Zymogen and activated forms of these polypeptides, including single and two chain forms of each protease domain and multi-chain forms containing a plurality of protease domains also are provided. Multi-chain forms of the MTSP12 containing two, three, four or more chains are provided as are molecules containing one, two or three of the protease domains, in any order, and as single or multiple chains are provided. Methods using the polypeptides to identify compounds that modulate the protease activity of an MTSP12 are provided.
PCT/US2003/016181 2002-05-21 2003-05-21 Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon WO2003104394A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003269880A AU2003269880A1 (en) 2002-05-21 2003-05-21 Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38285102P 2002-05-21 2002-05-21
US60/382,851 2002-05-21

Publications (2)

Publication Number Publication Date
WO2003104394A2 WO2003104394A2 (en) 2003-12-18
WO2003104394A3 true WO2003104394A3 (en) 2005-04-21

Family

ID=29736084

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/016181 WO2003104394A2 (en) 2002-05-21 2003-05-21 Nucleic acid molecules encoding a transmembrane serine protease 12, the encoded polypeptides and methods based thereon

Country Status (2)

Country Link
AU (1) AU2003269880A1 (en)
WO (1) WO2003104394A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290757B2 (en) 2006-07-05 2016-03-22 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby
US9476037B2 (en) 2008-04-11 2016-10-25 Catalyst Biosciences, Inc. Factor VII polypeptides that are modified and uses thereof

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002095007A2 (en) * 2001-05-23 2002-11-28 Dendreon San Diego Llc Conjugates activated by cell surface proteases and therapeutic uses thereof
WO2006090389A2 (en) 2005-02-24 2006-08-31 Compugen Ltd. Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
AU2006304804B2 (en) 2005-10-21 2011-06-02 Vertex Pharmaceuticals Incorporated Modified proteases that inhibit complement activation
SG11201912071QA (en) 2017-06-22 2020-01-30 Catalyst Biosciences Inc Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
US20210069306A1 (en) 2019-08-15 2021-03-11 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration and on-demand treatment
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
CN117159748B (en) * 2023-09-12 2024-05-28 中国农业大学 Application of TMPRSS12 gene in preparation of medicines for preventing or treating novel coronavirus infection

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001027624A2 (en) * 1999-10-08 2001-04-19 Superarray, Inc. Compositions and methods for detecting protein modification and enzymatic activity
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
WO2002008392A2 (en) * 2000-07-25 2002-01-31 Bayer Aktiengesellschaft Regulation of human matriptase-like serine protease
US20020019006A1 (en) * 1999-02-05 2002-02-14 Alphagene,Inc. Proteomic interaction arrays
WO2002038744A2 (en) * 2000-10-18 2002-05-16 Incyte Genomics, Inc. Proteases
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020019006A1 (en) * 1999-02-05 2002-02-14 Alphagene,Inc. Proteomic interaction arrays
WO2001027624A2 (en) * 1999-10-08 2001-04-19 Superarray, Inc. Compositions and methods for detecting protein modification and enzymatic activity
WO2002000860A2 (en) * 2000-06-26 2002-01-03 Sugen, Inc. Novel proteases
WO2002008392A2 (en) * 2000-07-25 2002-01-31 Bayer Aktiengesellschaft Regulation of human matriptase-like serine protease
WO2002038744A2 (en) * 2000-10-18 2002-05-16 Incyte Genomics, Inc. Proteases
WO2002068579A2 (en) * 2001-01-10 2002-09-06 Pe Corporation (Ny) Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAL S. ET AL.: "Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single transaltion product", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 100, no. 20, 5 August 2003 (2003-08-05), USA, pages 9185 - 9190, XP002985506 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9290757B2 (en) 2006-07-05 2016-03-22 Catalyst Biosciences, Inc. Protease screening methods and proteases identified thereby
US9476037B2 (en) 2008-04-11 2016-10-25 Catalyst Biosciences, Inc. Factor VII polypeptides that are modified and uses thereof

Also Published As

Publication number Publication date
AU2003269880A1 (en) 2003-12-22
WO2003104394A2 (en) 2003-12-18
AU2003269880A8 (en) 2003-12-22

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