WO2003103666A3 - 4,5-dihydro-imidazo[4,5,1-j] quinolin-6-ones as parp inhibitors - Google Patents

4,5-dihydro-imidazo[4,5,1-j] quinolin-6-ones as parp inhibitors Download PDF

Info

Publication number
WO2003103666A3
WO2003103666A3 PCT/EP2003/005835 EP0305835W WO03103666A3 WO 2003103666 A3 WO2003103666 A3 WO 2003103666A3 EP 0305835 W EP0305835 W EP 0305835W WO 03103666 A3 WO03103666 A3 WO 03103666A3
Authority
WO
WIPO (PCT)
Prior art keywords
parp inhibitors
quinolin
imidazo
dihydro
ones
Prior art date
Application number
PCT/EP2003/005835
Other languages
French (fr)
Other versions
WO2003103666A2 (en
Inventor
Thomas Wagner
Steffen Weinbrenner
Rainer Boer
Frank Dullweber
Thomas Klein
Original Assignee
Altana Pharma Ag
Thomas Wagner
Steffen Weinbrenner
Rainer Boer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag, Thomas Wagner, Steffen Weinbrenner, Rainer Boer filed Critical Altana Pharma Ag
Priority to AU2003236686A priority Critical patent/AU2003236686A1/en
Publication of WO2003103666A2 publication Critical patent/WO2003103666A2/en
Publication of WO2003103666A3 publication Critical patent/WO2003103666A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The invention thus relates to compounds of formula (I), in which A is furanylene, thienylene, pyrrolylene, imidazolylene, pyrazolylene, oxazolylene, isoxazolylene, thiazolylene, isothiazolylene, oxadiazolylene, thiadiazolylene, phenylene, pyrindinylene, pyridazinylene, pyrimidinylene, pyrazinylene, pyrrolidinylene, pyrazolidinylene, piperidinylene, piperazinylene, imidazolidinylene or 3-7C-cycloalkylene and R1 and R2 have the meanings indicated in the description being PARP inhibitors.
PCT/EP2003/005835 2002-06-07 2003-06-04 Novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones WO2003103666A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003236686A AU2003236686A1 (en) 2002-06-07 2003-06-04 4,5-dihydro-imidazo(4,5,1-j) quinolin-6-ones as parp inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02012697.5 2002-06-07
EP02012697 2002-06-07

Publications (2)

Publication Number Publication Date
WO2003103666A2 WO2003103666A2 (en) 2003-12-18
WO2003103666A3 true WO2003103666A3 (en) 2004-04-01

Family

ID=29724380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/005835 WO2003103666A2 (en) 2002-06-07 2003-06-04 Novel 4,5-dihydro-imidazo[4,5,1-ij]quinolin-6-ones

Country Status (2)

Country Link
AU (1) AU2003236686A1 (en)
WO (1) WO2003103666A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101835750B (en) 2007-08-22 2013-07-17 阿斯利康(瑞典)有限公司 Cyclopropyl amide derivatives '978
TW201039825A (en) 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
US8497271B2 (en) * 2009-10-07 2013-07-30 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
US8304577B2 (en) 2009-10-09 2012-11-06 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
US8426414B2 (en) 2009-10-09 2013-04-23 Bristol-Myers Squibb Company Modulators of G protein-coupled receptor 88
BR112012020629A2 (en) 2010-02-18 2018-06-19 Astrazeneca Ab crystalline form and method for the therapy of a disorder
CN103130723B (en) 2011-11-30 2015-01-14 成都地奥制药集团有限公司 Poly (aenosine diphosphate glucose pyrophospheralase (ADP)-ribose) polymerase inhibitor

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016136A2 (en) * 1999-08-31 2001-03-08 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
WO2001023386A2 (en) * 1999-09-28 2001-04-05 Basf Aktiengesellschaft Benzodiazepin derivatives, the production and use thereof
WO2002012239A1 (en) * 2000-08-08 2002-02-14 Sanofi-Synthelabo Benzimidazole derivatives, preparation and therapeutic use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016136A2 (en) * 1999-08-31 2001-03-08 Agouron Pharmaceuticals, Inc. Tricyclic inhibitors of poly(adp-ribose) polymerases
WO2001023386A2 (en) * 1999-09-28 2001-04-05 Basf Aktiengesellschaft Benzodiazepin derivatives, the production and use thereof
WO2002012239A1 (en) * 2000-08-08 2002-02-14 Sanofi-Synthelabo Benzimidazole derivatives, preparation and therapeutic use thereof

Also Published As

Publication number Publication date
WO2003103666A2 (en) 2003-12-18
AU2003236686A1 (en) 2003-12-22
AU2003236686A8 (en) 2003-12-22

Similar Documents

Publication Publication Date Title
WO2003103666A3 (en) 4,5-dihydro-imidazo[4,5,1-j] quinolin-6-ones as parp inhibitors
EP1363348A4 (en) Metal oxide dispersion and photoactive electrode for dye-sensitized solar cell, and dye-sensitized solar cell
WO2002080825A3 (en) Device for pivotably connecting parts of an orthopaedic device
WO2000004862A3 (en) Bioenhanced formulations comprising eprosartan in oral solid dosage form
PA8586501A1 (en) AVAILABLE TABLETS THAT INCLUDE A BENZOIC ACID DERIVATIVE
WO2004091518A3 (en) Cxcr4 chemokine receptor binding compounds
DK1499607T3 (en) 4- (piperidyl and pyrrolidyl-alkyl-ureido) quinolines as urotensin II receptor antagonists
DE50012439D1 (en) Clamping gripper for loads to be gripped from above
CA2527561A1 (en) Solvent-containing compositions based on polychloroprene
BR0013708A (en) anode for electrolyte capacitors, electrolyte capacitor and anode manufacturing process
WO2002076434A3 (en) Nicotinic receptor agonists for the treatment of inflammatory diseases
EP0880961A3 (en) Composition comprising a derivative of cinnamic acid and a polyamino-polymer
MX9505192A (en) Utilization of p substance antagonist for preparing pharmaceutical compositions for the treatment of neurogenic cutaneous reddening.
DE60101486D1 (en) Use of polyamino acid derivatives as a preservative
WO2001004116A3 (en) Neurotrophic pyrrolidines and piperidines, and related compositions containing them
GB2350131B (en) Kit of structural building parts
WO2000063234A3 (en) Pyrrolidincarbonylamino cyclic disulfides as vcam-vla4 antagonists
WO2001029066A3 (en) Basic monocyclic compounds having nk2 antagonist action, processes for their preparation, and formulations containing them
EP1033129A4 (en) Antimicrobials
ITBO980496A1 (en) REVERSIBLE CLAMPING DEVICE.
ATE316376T1 (en) NEW PHARMACEUTICAL COMPOSITION AND ITS MANUFACTURING PROCESS
EP1542317A1 (en) Device for connecting an electrical wire
WO2003104133A3 (en) Single arm wheelchair lift
BG106368A (en) Pharmaceutical composition and its preparation
BR9811759A (en) Piperidinylmethyloxazolidinone derivative

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AU BA BR CA CN CO CU DZ EC GE HR ID IL IN IS JP KR LT LV MA MK MX NO NZ PH PL SG TN UA US VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP