WO2003102170A8 - Souches de bordetella rendues deficientes par attenuation genetique - Google Patents

Souches de bordetella rendues deficientes par attenuation genetique

Info

Publication number
WO2003102170A8
WO2003102170A8 PCT/FR2003/001642 FR0301642W WO03102170A8 WO 2003102170 A8 WO2003102170 A8 WO 2003102170A8 FR 0301642 W FR0301642 W FR 0301642W WO 03102170 A8 WO03102170 A8 WO 03102170A8
Authority
WO
WIPO (PCT)
Prior art keywords
strains
bordetella
relates
gene
toxin
Prior art date
Application number
PCT/FR2003/001642
Other languages
English (en)
Other versions
WO2003102170A1 (fr
Inventor
Anne-Sophie Debrie
Camille Locht
Nathalie Mielcarek
Dominique Raze
Original Assignee
Pasteur Institut
Inst Nat Sante Rech Med
Anne-Sophie Debrie
Camille Locht
Nathalie Mielcarek
Dominique Raze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Inst Nat Sante Rech Med, Anne-Sophie Debrie, Camille Locht, Nathalie Mielcarek, Dominique Raze filed Critical Pasteur Institut
Priority to AU2003255618A priority Critical patent/AU2003255618A1/en
Publication of WO2003102170A1 publication Critical patent/WO2003102170A1/fr
Publication of WO2003102170A8 publication Critical patent/WO2003102170A8/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des souches vivantes de Bordetella rendues déficientes dans la production de la toxine de B. pertussis PTX et, le cas échéant, de la toxine dermonécrotique DNT, ainsi que dans la libération de la toxine cytotrachéale TCT, et ce, par atténuation génétique, en particulier par mutation ou délétion du gène ptx et, le cas échéant, du gène dnt, et par insertion d'un promoteur fort en amont du gène codant la protéine AmpG, laquelle est impliquée dans le recyclage de la toxine TCT. La présente invention a également pour objets des procédés d'obtention de ces souches, ainsi que leur utilisation pour la préparation de vaccins. Enfin, l'invention vise des compositions immunogènes comprenant de telles souches.
PCT/FR2003/001642 2002-05-30 2003-05-30 Souches de bordetella rendues deficientes par attenuation genetique WO2003102170A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003255618A AU2003255618A1 (en) 2002-05-30 2003-05-30 Strains of bordetella made deficient by means of genetic attenuation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR02/06666 2002-05-30
FR0206666A FR2840319B1 (fr) 2002-05-30 2002-05-30 Souches de bordetella rendues deficientes par attenuation genetique

Publications (2)

Publication Number Publication Date
WO2003102170A1 WO2003102170A1 (fr) 2003-12-11
WO2003102170A8 true WO2003102170A8 (fr) 2004-02-26

Family

ID=29558856

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/001642 WO2003102170A1 (fr) 2002-05-30 2003-05-30 Souches de bordetella rendues deficientes par attenuation genetique

Country Status (3)

Country Link
AU (1) AU2003255618A1 (fr)
FR (1) FR2840319B1 (fr)
WO (1) WO2003102170A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0707102B1 (pt) * 2006-03-10 2022-05-31 Institut Pasteur De Lille Composição imunogênica
US20120177688A1 (en) * 2009-04-28 2012-07-12 Institut Pasteur De Lille Vaccine for Prophylaxis or Treatment of an Allergen-Driven Airway Pathology
CA2765364C (fr) 2009-06-15 2015-05-26 National University Of Singapore Vaccin contre l'influenza, composition, et procedes d'utilisation
CN105412919A (zh) * 2009-06-15 2016-03-23 新加坡国立大学 流感疫苗、组合物及使用方法
CA2854110C (fr) 2011-11-02 2019-06-25 Institut Pasteur De Lille Effet d'une souche attenuee de bordetella sur une maladie allergique
EP2722338A1 (fr) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Nouvelles souches de bordetella de recombinaison
US9655959B2 (en) 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
JP6993984B2 (ja) 2016-03-29 2022-02-03 アンスティチュ パスツール ドゥ リール 変異ボルデテラ菌株および使用方法
WO2019077028A1 (fr) 2017-10-18 2019-04-25 Institut Pasteur De Lille Souches de bordetella exprimant des fimbriae de sérotype 3

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9407534D0 (en) * 1994-04-13 1994-06-08 Procter & Gamble Detergent compositions
FR2754543B1 (fr) * 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires

Also Published As

Publication number Publication date
AU2003255618A8 (en) 2003-12-19
FR2840319A1 (fr) 2003-12-05
AU2003255618A1 (en) 2003-12-19
FR2840319B1 (fr) 2004-08-20
WO2003102170A1 (fr) 2003-12-11

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