WO2003101452A8 - Process for the preparation of highly pure rabeprazole sodium salt - Google Patents

Process for the preparation of highly pure rabeprazole sodium salt

Info

Publication number
WO2003101452A8
WO2003101452A8 PCT/IN2003/000208 IN0300208W WO03101452A8 WO 2003101452 A8 WO2003101452 A8 WO 2003101452A8 IN 0300208 W IN0300208 W IN 0300208W WO 03101452 A8 WO03101452 A8 WO 03101452A8
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
highly pure
sodium salt
rabeprazole sodium
formula
Prior art date
Application number
PCT/IN2003/000208
Other languages
French (fr)
Other versions
WO2003101452A1 (en
Inventor
Dandala Ramesh
Sivakumaran Meenakshisunderam
K Ray U
Original Assignee
Aurobindo Pharma Ltd
Dandala Ramesh
Sivakumaran Meenakshisunderam
K Ray U
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aurobindo Pharma Ltd, Dandala Ramesh, Sivakumaran Meenakshisunderam, K Ray U filed Critical Aurobindo Pharma Ltd
Priority to AU2003237598A priority Critical patent/AU2003237598A1/en
Publication of WO2003101452A1 publication Critical patent/WO2003101452A1/en
Publication of WO2003101452A8 publication Critical patent/WO2003101452A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole

Abstract

A method for the preparation of (±)-sodium-2-[[[4-(3- methoxypropoxy)-3- methyl-pyridinyl]methyl]sulfinyl]-1H-benzimidazole(Rabeprazole sodium) of formula (I), which comprises dissolving Rabeprazole of Formula (II) in aqueous sodium hydroxide until complete dissolution has taken place and thereafter subjecting the so obtained solution to lyophilization to obtain highly pure Rabeprazole sodium of Formula (I) in dry form.
PCT/IN2003/000208 2002-06-03 2003-06-02 Process for the preparation of highly pure rabeprazole sodium salt WO2003101452A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003237598A AU2003237598A1 (en) 2002-06-03 2003-06-02 Process for the preparation of highly pure rabeprazole sodium salt

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN419/MAS/2002 2002-06-03
IN419CH2002 2002-06-03

Publications (2)

Publication Number Publication Date
WO2003101452A1 WO2003101452A1 (en) 2003-12-11
WO2003101452A8 true WO2003101452A8 (en) 2004-03-11

Family

ID=29596801

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2003/000208 WO2003101452A1 (en) 2002-06-03 2003-06-02 Process for the preparation of highly pure rabeprazole sodium salt

Country Status (2)

Country Link
AU (1) AU2003237598A1 (en)
WO (1) WO2003101452A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016225A2 (en) * 2003-08-18 2005-02-24 Bakulesh Mafatlal Khamar Stable pharmaceutical composition of rabeprazole
WO2006003946A1 (en) * 2004-06-30 2006-01-12 Eisai R & D Management Co., Ltd. Process for production of benzimidazole derivative salt precipitates
ITMI20042437A1 (en) * 2004-12-21 2005-03-21 Dipharma Spa CRYSTALLINE FORM OF RABEPRAZOLO SODICO
ITMI20062449A1 (en) 2006-12-19 2008-06-20 Dipharma Spa CRYSTALLINE FORM OF RABEPRAZOLO SODICO
WO2008155780A2 (en) 2007-06-21 2008-12-24 Matrix Laboratories Ltd Improved process for the preparation of pure rabeprazole
WO2011004281A1 (en) 2009-07-09 2011-01-13 Alembic Limited A process for the preparation of amorphous form of rabeprazole sodium
CN102949354B (en) * 2012-11-01 2014-02-26 江苏奥赛康药业股份有限公司 Sodium rabeprazole composition for injection
WO2014091450A1 (en) 2012-12-12 2014-06-19 Ranbaxy Laboratories Limited Process for the preparation of rabeprazole
CN104119315B (en) * 2014-05-21 2016-03-02 丽珠医药集团股份有限公司 A kind of preparation method of Sodium rabeprazole

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2166269B1 (en) * 1999-07-14 2003-04-01 Sint Quimica Sa NEW PROCEDURE FOR OBTAINING DERIVATIVES OF 2- (2-PIRIDINILMETILSULFINIL) -1H-BENZIMIDAZOL.
CA2419067C (en) * 2000-08-18 2008-12-23 Takeda Chemical Industries, Ltd. Injectable composition comprising benzimidazole compound and strong alkali

Also Published As

Publication number Publication date
AU2003237598A1 (en) 2003-12-19
WO2003101452A1 (en) 2003-12-11
AU2003237598A8 (en) 2003-12-19

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