AU2001253765A1 - Method of treating dry eye disease with nicotinic acetylcholine receptor agonists - Google Patents

Method of treating dry eye disease with nicotinic acetylcholine receptor agonists

Info

Publication number
AU2001253765A1
AU2001253765A1 AU2001253765A AU5376501A AU2001253765A1 AU 2001253765 A1 AU2001253765 A1 AU 2001253765A1 AU 2001253765 A AU2001253765 A AU 2001253765A AU 5376501 A AU5376501 A AU 5376501A AU 2001253765 A1 AU2001253765 A1 AU 2001253765A1
Authority
AU
Australia
Prior art keywords
receptor agonists
dry eye
acetylcholine receptor
eye disease
nicotinic acetylcholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001253765A
Inventor
Mathew Cowlen
Ward M. Peterson
Benjamin R. Yerxa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inspire Pharmaceuticals Inc
Original Assignee
Inspire Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inspire Pharmaceuticals Inc filed Critical Inspire Pharmaceuticals Inc
Publication of AU2001253765A1 publication Critical patent/AU2001253765A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AU2001253765A 2000-04-21 2001-04-19 Method of treating dry eye disease with nicotinic acetylcholine receptor agonists Abandoned AU2001253765A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09557059 2000-04-21
US09/557,059 US6277855B1 (en) 2000-04-21 2000-04-21 Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
PCT/US2001/013034 WO2001080844A2 (en) 2000-04-21 2001-04-19 Method of treating dry eye disease with nicotinic acetylcholine receptor agonists

Publications (1)

Publication Number Publication Date
AU2001253765A1 true AU2001253765A1 (en) 2001-11-07

Family

ID=24223897

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001253765A Abandoned AU2001253765A1 (en) 2000-04-21 2001-04-19 Method of treating dry eye disease with nicotinic acetylcholine receptor agonists

Country Status (8)

Country Link
US (1) US6277855B1 (en)
EP (1) EP1214062B1 (en)
JP (1) JP2003531168A (en)
AR (1) AR028026A1 (en)
AT (1) ATE253912T1 (en)
AU (1) AU2001253765A1 (en)
DE (1) DE60101201D1 (en)
WO (1) WO2001080844A2 (en)

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596725B2 (en) * 1997-02-10 2003-07-22 Inspire Pharmaceuticals, Inc. Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema
US7223744B2 (en) * 1997-02-10 2007-05-29 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising dinucleoside polyphosphates and salts thereof
US6818629B2 (en) 1997-02-10 2004-11-16 Inspire Pharmaceuticals, Inc. Pharmaceutical formulation comprising P1-(2'-deoxycytidine 5'-)P4-(uridine 5'-) tetraphosphate
US7078391B2 (en) * 1997-02-10 2006-07-18 Inspire Pharmaceuticals, Inc. Method of treating edematous retinal disorders
US6455554B1 (en) * 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
US6576224B1 (en) 1999-07-06 2003-06-10 Sinuspharma, Inc. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
US20020061281A1 (en) * 1999-07-06 2002-05-23 Osbakken Robert S. Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis
ES2425114T3 (en) * 2000-03-16 2013-10-11 The Mclean Hospital Corporation CDP-choline and uridine for the treatment of alcohol abuse
CA2359813C (en) * 2000-10-24 2008-04-22 Richard L. Jones Nicotine mucosal spray
GB2381750A (en) * 2001-10-10 2003-05-14 Inspire Pharmaceuticals Inc Treatment for enhancing joint lubrication
US6852741B2 (en) * 2001-12-31 2005-02-08 University Of Florida Compositions and methods for treatment of neurological disorders
US6659985B2 (en) 2002-01-30 2003-12-09 Southern College Of Optometry Method to use transdermal administration of androgens to the adnexa of the eye
US7069084B2 (en) * 2002-06-14 2006-06-27 Seefit Incorporated Method and apparatus for preventing and treating eyelid problems
WO2004012674A2 (en) * 2002-08-02 2004-02-12 Nutraceutical Development Corporation Development of muscle mass in a mammal
US7179481B2 (en) * 2002-09-19 2007-02-20 Kimberly-Clark Worldwide, Inc. Vaginal health products
US20060035811A1 (en) * 2002-10-18 2006-02-16 Luis Molina Methods of treating dry eye disease with lantibiotics
CA2503286C (en) * 2002-11-08 2011-08-30 The Mclean Hospital Corporation Compounds for the treatment of tobacco dependence and withdrawal
US7056889B2 (en) 2002-12-16 2006-06-06 Kimberly-Clark, Worldwide, Inc. Compounds that bind P2Y2 or P2Y1 receptors
US7098189B2 (en) * 2002-12-16 2006-08-29 Kimberly-Clark Worldwide, Inc. Wound and skin care compositions
JP4717444B2 (en) * 2002-12-20 2011-07-06 ザ マクレーン ホスピタル コーポレーション Compounds for normalization of sleep / wake cycles
KR20120035220A (en) 2003-01-22 2012-04-13 센주 세이야꾸 가부시키가이샤 Percutaneous absorption preparation for treating ophthalmic disease, use thereof and method for migration of ophthalmic remedy into topical tissue in eye
US20050013806A1 (en) * 2003-04-04 2005-01-20 Chang Min S. Use of contact lens for corneal cell transplant
US20050208102A1 (en) * 2003-04-09 2005-09-22 Schultz Clyde L Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US9216106B2 (en) * 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
US20050074497A1 (en) * 2003-04-09 2005-04-07 Schultz Clyde L. Hydrogels used to deliver medicaments to the eye for the treatment of posterior segment diseases
US20050255144A1 (en) * 2003-04-09 2005-11-17 Directcontact Llc Methods and articles for the delivery of medicaments to the eye for the treatment of posterior segment diseases
US6984628B2 (en) * 2003-07-15 2006-01-10 Allergan, Inc. Ophthalmic compositions comprising trefoil factor family peptides
EP1727554A4 (en) * 2003-10-08 2009-09-30 Mclean Hospital Corp Methods of treating psychiatric, substance abuse, and other disorders using combinations containing omega-3 fatty acids
WO2005034874A2 (en) * 2003-10-08 2005-04-21 The Mclean Hospital Corporation Enhanced efficacy of omega-3 fatty acid therapy in the treatment of psychiatric disorders and other indications
WO2005060984A1 (en) * 2003-12-12 2005-07-07 Yee Richard W Method and apparatus for preventing and treating eyelid problems
US20060270592A1 (en) * 2004-03-19 2006-11-30 Ophthalmic Research Associates, Inc. Use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
US7479481B2 (en) * 2004-05-06 2009-01-20 Molichem Medicines, Inc. Treatment of ocular diseases and disorders using lantibiotic compositions
EP1750740A4 (en) * 2004-05-06 2009-06-10 Molichem Medicines Inc Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
DE602005019724D1 (en) * 2004-05-21 2010-04-15 Senju Pharma Co OPHTHALMOLOGIC PERCUTANEOUS ABSORBENT PREPARATION CONTAINING A MUSCARIN RECEPTOR AGONIST
ES2553953T3 (en) 2004-06-03 2015-12-15 Senju Pharmaceutical Co., Ltd. Drug for the recovery of corneal perception that contains an amide compound
WO2005123097A1 (en) * 2004-06-10 2005-12-29 Mclean Hospital Corporation Pyrimidines, such as cytidine, in treatments for patients with bipolar disorder
WO2005122767A1 (en) * 2004-06-10 2005-12-29 Mclean Hospital Corporation Pyrimidines, such as uridine, in treatments for patients with bipolar disorder
US7485666B2 (en) * 2004-06-17 2009-02-03 Kimberly-Clark Worldwide, Inc. Vaginal health products
EP1784199A4 (en) * 2004-08-11 2010-06-23 Mclean Hospital Corp Compounds for the treatment of marihuana dependence, withdrawal, and usage
EP1848541A4 (en) * 2005-02-07 2013-01-16 Pharmalight Inc Method and device for ophthalmic administration of active pharmaceutical ingredients
JPWO2007013661A1 (en) * 2005-07-26 2009-02-12 千寿製薬株式会社 Ophthalmic transdermal preparation
FR2889847B1 (en) 2005-08-18 2007-10-05 Sanofi Aventis Sa DERIVATIVES OF 5-PYRIDAZINYL-1-AZABICYCLO [3.2.1] OCTAVE, THEIR PREPARATION IN THERAPEUTICS.
US8187639B2 (en) 2005-09-27 2012-05-29 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
US8182841B2 (en) 2005-09-27 2012-05-22 Tissue Tech, Inc. Amniotic membrane preparations and purified compositions and anti-inflammation methods
US9726673B2 (en) 2005-11-23 2017-08-08 Genentech, Inc. Methods and compositions related to B cell assays
US20070231360A1 (en) * 2006-03-28 2007-10-04 Minu, L.L.C. Neural conduit agent dissemination
US20070237797A1 (en) * 2006-03-28 2007-10-11 Gholam A. Peyman Neural Conduit Agent Dissemination
US20070297991A1 (en) * 2006-06-23 2007-12-27 Minu, L.L.C. Neural conduit agent dissemination for smoking cessation and other applications
US20080107713A1 (en) * 2006-11-08 2008-05-08 Orilla Werhner C Contact lens as a sustained drug delivery implant
US20080317819A1 (en) * 2007-06-21 2008-12-25 Orilla Werhner C Iop lowering drug combination or non-combination loaded contact lens with zonal drug delivery areas
US20090004244A1 (en) * 2007-06-27 2009-01-01 Orilla Werhner C Iris design as a drug depot for zonal drug delivery by contact lens
US20090004245A1 (en) * 2007-06-28 2009-01-01 Orilla Werhner C Use of an iris simulated layer to allow aesthetic appearance drug loaded contact lens
DE102007055046A1 (en) * 2007-11-19 2009-05-28 Fluoron Gmbh infusion
GB0724558D0 (en) * 2007-12-15 2008-01-30 Sharma Anant Optical correction
RU2464023C2 (en) * 2008-05-16 2012-10-20 АКСИС, Инс Therapeutic agent for treating fibromyalgia
US20100041621A1 (en) * 2008-08-15 2010-02-18 Perry Renshaw Methods and compositions for improving cognitive performance
KR20110091501A (en) * 2008-10-14 2011-08-11 싸이코제닉스 아이엔씨. Nicotinic acetylcholine receptor ligands and the uses thereof
WO2010091649A2 (en) * 2009-02-11 2010-08-19 Heglund, A.S. A composition for buccal absorption of nicotine for the purpose of smoking cessation
TWI455722B (en) 2010-06-04 2014-10-11 Pfizer Vaccines Llc Conjugates for the prevention or treatment of nicotine addiction
WO2012068247A1 (en) 2010-11-16 2012-05-24 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for treatment of dry eye
US9821159B2 (en) 2010-11-16 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Stimulation devices and methods
US9993444B2 (en) * 2011-01-10 2018-06-12 Invion, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
US9682044B2 (en) 2011-06-10 2017-06-20 Tissuetech, Inc. Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
US9931423B2 (en) 2011-08-26 2018-04-03 Tissuetech, Inc. Methods of sterilizing fetal support tissues
US9132193B2 (en) 2012-11-05 2015-09-15 University of Pittsburgh—of the Commonwealth System of Higher Education Use of Slurp1 as an imunomodulatory molecule in the ocular surface
RU2510701C1 (en) * 2012-12-19 2014-04-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт глазных болезней" Российской академии медицинских наук (ФГБУ "НИИГБ" РАМН) Method of treating blepharoconjunctival form of dry eye syndrome
WO2014138709A1 (en) * 2013-03-08 2014-09-12 Oculeve, Inc. Devices and methods for treating dry eye in animals
WO2014165124A1 (en) 2013-03-12 2014-10-09 Oculeve, Inc. Implant delivery devices, systems, and methods
JP6795975B2 (en) 2013-04-19 2020-12-02 オキュリーブ， インコーポレイテッド Nasal stimulation devices and methods
JP6604963B2 (en) 2014-02-25 2019-11-20 オキュリーブ， インコーポレイテッド Polymer formulations for nasolacrimal gland stimulation
US9303013B2 (en) 2014-05-16 2016-04-05 Pfizer Inc. Conjugates and associated methods of producing them for the prevention or treatment of nicotine addiction
CA2956176A1 (en) 2014-07-25 2016-01-28 Oculeve, Inc. Stimulation patterns for treating dry eye
PT3209295T (en) * 2014-10-20 2021-02-05 Oyster Point Pharma Inc Methods of treating ocular conditions
CA2965186A1 (en) 2014-10-22 2016-04-28 Oculeve, Inc. Stimulation devices and methods for treating dry eye
CA2965514A1 (en) 2014-10-22 2016-04-28 Oculeve, Inc. Contact lens for increasing tear production
AU2015335774B2 (en) 2014-10-22 2020-07-16 Oculeve, Inc. Implantable nasal stimulator systems and methods
US20160120912A1 (en) * 2014-11-05 2016-05-05 Tissuetech, Inc. Compositions and method for promoting nerve growth and regeneration
CN113208809A (en) 2014-12-31 2021-08-06 迈克罗欧普提克斯股份有限公司 Glaucoma treatment device and method
BR112017024805B1 (en) * 2015-05-21 2021-09-14 Ophtalmis Monaco COMBINATION OF LIPOIC ACID AND TAURINE AS OSMOPROTECTIVE AGENT
JP2017052723A (en) * 2015-09-10 2017-03-16 株式会社Ｌｔｔバイオファーマ Dry eye improver
JP6892693B2 (en) 2015-09-30 2021-06-23 マイクロオプティクス インコーポレイテッド Dry eye treatment equipment and methods
US10426958B2 (en) 2015-12-04 2019-10-01 Oculeve, Inc. Intranasal stimulation for enhanced release of ocular mucins and other tear proteins
US10252048B2 (en) 2016-02-19 2019-04-09 Oculeve, Inc. Nasal stimulation for rhinitis, nasal congestion, and ocular allergies
WO2017177024A1 (en) * 2016-04-07 2017-10-12 Oyster Point Pharma, Inc. Methods of treating ocular conditions
KR102199560B1 (en) 2016-04-12 2021-01-07 아르투로 솔리스 헤레라 Composition and method for treating sinus mucosa disease with nicotinic acetylcholine receptor agonist
AU2017260237A1 (en) 2016-05-02 2018-11-22 Oculeve, Inc. Intranasal stimulation for treatment of meibomian gland disease and blepharitis
WO2018102535A1 (en) 2016-12-02 2018-06-07 Oculeve, Inc. Apparatus and method for dry eye forecast and treatment recommendation
TW202019424A (en) * 2018-07-10 2020-06-01 美商奧伊斯特普安生物製藥公司 Methods of treating ocular conditions
WO2023279162A1 (en) * 2021-07-07 2023-01-12 University Of Canberra Methods of treatment and inhibition

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753945A (en) 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
US4868154A (en) 1986-02-19 1989-09-19 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with melanocyte stimulating hormones
WO1994005288A1 (en) 1992-08-31 1994-03-17 University Of Florida Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
US5817679A (en) 1993-04-01 1998-10-06 University Of Virginia 7-Azabicyclo 2.2.1!-heptane and -heptene derivatives as cholinergic receptor ligands
US5723477A (en) 1994-11-10 1998-03-03 Sibia Neurosciences, Inc. Modulators of acetylcholine receptors
US5583140A (en) 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
US5900407A (en) 1997-02-06 1999-05-04 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with uridine triphosphates and related compounds
US5629325A (en) 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission
DE19626373A1 (en) * 1996-07-02 1998-01-08 Boehringer Ingelheim Kg Novel use of active ingredients that affect the function of non-neuronal acetylcholine
US5830904A (en) 1997-02-05 1998-11-03 University Of Kentucky Research Foundation Lobeline compounds as a treatment for psychostimulant abuse and withdrawal, and for eating disorders
US5861423A (en) 1997-02-21 1999-01-19 Caldwell; William Scott Pharmaceutical compositions incorporating aryl substituted olefinic amine compounds

Also Published As

Publication number Publication date
US6277855B1 (en) 2001-08-21
EP1214062B1 (en) 2003-11-12
ATE253912T1 (en) 2003-11-15
AR028026A1 (en) 2003-04-23
WO2001080844A3 (en) 2002-03-28
DE60101201D1 (en) 2003-12-18
EP1214062A2 (en) 2002-06-19
JP2003531168A (en) 2003-10-21
WO2001080844A2 (en) 2001-11-01

Similar Documents

Publication Publication Date Title
AU2001253765A1 (en) Method of treating dry eye disease with nicotinic acetylcholine receptor agonists
WO2000038663A3 (en) Ep4 receptor agonists for treatment of dry eye
AU2001261835A1 (en) Method of treating vaginal dryness with nicotinic acetylcholine receptor agonists
AU2500900A (en) Apparatus and methods for treating congestive heart disease
AU2001227837A1 (en) Novel treatment for eye disease
AU2001231104A1 (en) Methods for treating diabetes
AU1948901A (en) Illuminating device for treating eye disease
IL152511A0 (en) Apparatus and methods for treating congestive heart disease
AU2001269799A1 (en) Methods for treating various eye disorders
AU2001238665A1 (en) Method of identifying partial agonists of the a2a receptor
AU2002232919A1 (en) Method for treating fibrotic diseases or other indications
AU2001289684A1 (en) Glass-ceramics, process for their preparation and use
AU2001294794A1 (en) Method and apparatus for spectrophotometry of the eye
EP1167607A3 (en) Method for the wet treatment of laundry
AU2001259775A1 (en) Method for treating retinal degeneration with purinergic receptor agonists
AU5977501A (en) Method for treating retinal degeneration with purinergic receptor agonists
AU2001237939A1 (en) Methods for treating glaucoma
AU2002246490A1 (en) Method of treating parkinson's disease
AU2002241670A1 (en) Method for treating glaucoma IB
AU2000254308A1 (en) Pyrazolopyrimidinone derivatives, process for their preparation and their use
AU2002227189A1 (en) Method and device for treating gastroesophageal reflux disease
AU2001258827A1 (en) Method for examining WT1-related disease
AU2001294983A1 (en) Methods for treating joints using viscoelastic collagen solutions
AU3747800A (en) Method for treating dry eye
AU2001274552A1 (en) Method of fundamentally treating common cold