WO2003101379A3 - Pyranoindazoles and their use for the treatment of glaucoma - Google Patents

Pyranoindazoles and their use for the treatment of glaucoma Download PDF

Info

Publication number
WO2003101379A3
WO2003101379A3 PCT/US2002/039666 US0239666W WO03101379A3 WO 2003101379 A3 WO2003101379 A3 WO 2003101379A3 US 0239666 W US0239666 W US 0239666W WO 03101379 A3 WO03101379 A3 WO 03101379A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyranoindazoles
glaucoma
treatment
disclosed
lowering
Prior art date
Application number
PCT/US2002/039666
Other languages
French (fr)
Other versions
WO2003101379A2 (en
Inventor
Hwang-Hsing Chen
Jesse A May
Bryon S Severns
Original Assignee
Alcon Inc
Hwang-Hsing Chen
Jesse A May
Bryon S Severns
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc, Hwang-Hsing Chen, Jesse A May, Bryon S Severns filed Critical Alcon Inc
Priority to MXPA04011791A priority Critical patent/MXPA04011791A/en
Priority to EP02790099A priority patent/EP1513521A2/en
Priority to BR0215752-7A priority patent/BR0215752A/en
Priority to AU2002353122A priority patent/AU2002353122B2/en
Priority to JP2004508737A priority patent/JP2005532337A/en
Priority to CA002486832A priority patent/CA2486832A1/en
Publication of WO2003101379A2 publication Critical patent/WO2003101379A2/en
Publication of WO2003101379A3 publication Critical patent/WO2003101379A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Pyranoindazoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of glaucoma using compositions containing one or more of the compounds of the present invention.
PCT/US2002/039666 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma WO2003101379A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
MXPA04011791A MXPA04011791A (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma.
EP02790099A EP1513521A2 (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma
BR0215752-7A BR0215752A (en) 2002-05-30 2002-12-11 Pyanoindazoles and their use in the treatment of glaucoma
AU2002353122A AU2002353122B2 (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma
JP2004508737A JP2005532337A (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma
CA002486832A CA2486832A1 (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1686102A 2002-05-30 2002-05-30
US02/016,861 2002-05-30

Publications (2)

Publication Number Publication Date
WO2003101379A2 WO2003101379A2 (en) 2003-12-11
WO2003101379A3 true WO2003101379A3 (en) 2004-03-04

Family

ID=29709135

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/039666 WO2003101379A2 (en) 2002-05-30 2002-12-11 Pyranoindazoles and their use for the treatment of glaucoma

Country Status (7)

Country Link
EP (1) EP1513521A2 (en)
JP (1) JP2005532337A (en)
AU (1) AU2002353122B2 (en)
BR (1) BR0215752A (en)
CA (1) CA2486832A1 (en)
MX (1) MXPA04011791A (en)
WO (1) WO2003101379A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR046890A1 (en) 2003-12-15 2005-12-28 Alcon Inc [1,4] OXAZINO [2,3-G] SUBSTITUTED INDAZOLS FOR THE TREATMENT OF GLAUCOMA.
WO2006062839A1 (en) * 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
TWI667233B (en) 2013-12-19 2019-08-01 德商拜耳製藥公司 Novel indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their use for producing medicaments

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098860A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098860A1 (en) * 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma

Also Published As

Publication number Publication date
MXPA04011791A (en) 2005-07-26
EP1513521A2 (en) 2005-03-16
BR0215752A (en) 2005-03-29
JP2005532337A (en) 2005-10-27
WO2003101379A2 (en) 2003-12-11
CA2486832A1 (en) 2003-12-11
AU2002353122B2 (en) 2008-01-31
AU2002353122A1 (en) 2003-12-19

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