WO2003099995A3 - Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene) - Google Patents

Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene) Download PDF

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Publication number
WO2003099995A3
WO2003099995A3 PCT/US2003/015741 US0315741W WO03099995A3 WO 2003099995 A3 WO2003099995 A3 WO 2003099995A3 US 0315741 W US0315741 W US 0315741W WO 03099995 A3 WO03099995 A3 WO 03099995A3
Authority
WO
WIPO (PCT)
Prior art keywords
disc1
human
acid sequence
schizophrenia
disrupted
Prior art date
Application number
PCT/US2003/015741
Other languages
English (en)
Other versions
WO2003099995A2 (fr
Inventor
Jill A Morris
Lei Ma
Yuan Liu
Original Assignee
Merck & Co Inc
Jill A Morris
Lei Ma
Yuan Liu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Jill A Morris, Lei Ma, Yuan Liu filed Critical Merck & Co Inc
Priority to US10/514,510 priority Critical patent/US20050171336A1/en
Priority to JP2004508237A priority patent/JP2005526516A/ja
Priority to CA002483201A priority patent/CA2483201A1/fr
Priority to EP03736650A priority patent/EP1549664A4/fr
Publication of WO2003099995A2 publication Critical patent/WO2003099995A2/fr
Publication of WO2003099995A3 publication Critical patent/WO2003099995A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des polypeptides de Disc-1, des acides nucléiques de Disc-1, ainsi que des souris transgéniques contenant le gène recombiné Disc-1. La séquence d'acides aminés de Disc-1 de SEQ ID NO :1 et la séquence d'acides nucléiques de SEQ ID NO :2 permettent d'obtenir l'orthologue murin des séquences humaines d'acides nucléiques et d'acides aminés de Disc-1.
PCT/US2003/015741 2002-05-24 2003-05-20 Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene) WO2003099995A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/514,510 US20050171336A1 (en) 2002-05-24 2003-05-20 Murine ortholog of the human disrupted-in-schizophrenia 1 gene
JP2004508237A JP2005526516A (ja) 2002-05-24 2003-05-20 ヒト精神分裂病における欠損遺伝子１のマウスオルソログ
CA002483201A CA2483201A1 (fr) 2002-05-24 2003-05-20 Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene)
EP03736650A EP1549664A4 (fr) 2002-05-24 2003-05-20 Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38319102P 2002-05-24 2002-05-24
US60/383,191 2002-05-24

Publications (2)

Publication Number Publication Date
WO2003099995A2 WO2003099995A2 (fr) 2003-12-04
WO2003099995A3 true WO2003099995A3 (fr) 2004-03-18

Family

ID=29584521

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/015741 WO2003099995A2 (fr) 2002-05-24 2003-05-20 Orthologue murin du gene humain de la proteine disc-1 (disrupted in schizophrenia 1 gene)

Country Status (5)

Country Link
US (1) US20050171336A1 (fr)
EP (1) EP1549664A4 (fr)
JP (1) JP2005526516A (fr)
CA (1) CA2483201A1 (fr)
WO (1) WO2003099995A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0813038D0 (en) * 2008-07-16 2008-08-20 Univ Aberdeen Disc1 transgenic rodent
DE102010018561B4 (de) * 2010-04-28 2012-04-12 Carsten Korth Quantitative Marker zur Bestimmung des mentalen Status eines Probanden

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1860601A (en) * 1999-12-01 2001-06-12 Akzo Nobel N.V. A novel gene, disrupted in schizophrenia

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DEVON R. ET AL.: "Identification of polymorphisms within disrupted in schizophrenia 1 and disrupted in schizophrenia 2 and an investigation of their association with schizophrenia and bipolar affective disorder", PSYCH. GENETICS, vol. 11, no. 2, 2001, pages 71 - 78, XP002952131 *
KATO T.: "Molecular genetics of bipolar disorder", NEUROSCI. RES., vol. 40, 2001, pages 105 - 113, XP002952130 *
MA L. ET AL.: "Cloning and characterization of DISC1, the mouse ortholog of DISC1 (Disrupted-In-Schizophrenia 1", GENOMICS, vol. 80, no. 6, 2002, pages 662 - 672, XP002970899 *
MILLAR J. ET AL.: "Disruption of two novel genes by a translocation co-segregating with schizophrenia", HUM. MOL. GEN., vol. 9, no. 9, 2000, pages 1415 - 1423, XP002952129 *
OZEKI Y. ET AL.: "Disrupted-in-schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth", PROC. NATL. ACAD. SCI. USA, vol. 100, no. 1, 2003, pages 289 - 294, XP002971601 *
See also references of EP1549664A4 *
TAYLOR M. ET AL.: "Evolutionary constraints on the disrupted in schizophrenia locus", GENOMICS, vol. 81, 2003, pages 67 - 77, XP002970900 *

Also Published As

Publication number Publication date
EP1549664A2 (fr) 2005-07-06
JP2005526516A (ja) 2005-09-08
WO2003099995A2 (fr) 2003-12-04
EP1549664A4 (fr) 2007-09-12
CA2483201A1 (fr) 2003-12-04
US20050171336A1 (en) 2005-08-04

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