WO2003090863A1 - Bobine de stimulation faisant appel a un miroir magnetique et son utilisation - Google Patents

Bobine de stimulation faisant appel a un miroir magnetique et son utilisation Download PDF

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Publication number
WO2003090863A1
WO2003090863A1 PCT/KR2003/000783 KR0300783W WO03090863A1 WO 2003090863 A1 WO2003090863 A1 WO 2003090863A1 KR 0300783 W KR0300783 W KR 0300783W WO 03090863 A1 WO03090863 A1 WO 03090863A1
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WO
WIPO (PCT)
Prior art keywords
magnetic
coil
stimulating
mirror
magnetic mirror
Prior art date
Application number
PCT/KR2003/000783
Other languages
English (en)
Inventor
Jung Hoe Kim
Soo Yeol Lee
Min Hyoung Cho
Original Assignee
Mcubetechnology Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcubetechnology Co., Ltd. filed Critical Mcubetechnology Co., Ltd.
Priority to AU2003222476A priority Critical patent/AU2003222476A1/en
Publication of WO2003090863A1 publication Critical patent/WO2003090863A1/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/008Magnetotherapy specially adapted for a specific therapy for pain treatment or analgesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/02Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/004Magnetotherapy specially adapted for a specific therapy
    • A61N2/006Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01FMAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F7/00Magnets
    • H01F7/06Electromagnets; Actuators including electromagnets

Definitions

  • the present invention relates to a magnetic stimulation coil in the diagnosis or treatment devices or health promoting devices which stimulate nerves or muscles in the human body by inducing electric field inside the nerves or muscles.
  • time varying magnetic field is applied to the human body.
  • the electric stimulation method was used to stimulate human brains. Since the electric stimulation method was very invasive in that electrodes have to be attached to the brain after opening the skull, the electric stimulation method has not been widely used in the brain stimulation. However, after the first publication about the brain stimulation using the magnetic stimulation coil, many researches on the magnetic stimulation of human nerves and muscles have been carried out. In 1991, R. Jalinous published a paper, "Technical and practical aspects of magnetic nerve stimulation” in Journal of Clinical Neurophysiology, vol.8, no.l, pp 10-25, in which many technical aspects of the magnetic stimulation technology were described in detail.
  • the magnetic stimulation technology consumes such a large power in the stimulation of the human body, the stimulation repetition frequency had been limited to l-2Hz in the past. Therefore, the magnetic stimulation technology had been used only for diagnosis of diseases in nervous system with few exceptional uses in treatments.
  • stimulating coil shapes suitable for urinary incontinence treatment were introduced in U.S. Patent Nos. 6,179,769 and 5,725,471
  • stimulating coil shapes suitable for stimulating brain and peripheral nerves were introduced in U.S. Patent Nos. 4,056,0974 and 4,994,015.
  • it is very essential to improve the coil efficiency and to use an efficient coil cooling method in the magnetic stimulation with the pulse repetition frequency of several tens of Hz for treatments .
  • the present invention is to solve the problems in current magnetic stimulation technology described above, and to provide a stimulating coil to increase the magnetic field strength per unit current fed to the stimulating coil while lowering the heat generation of the stimulating coil.
  • the stimulating coil according to the present invention comprising:
  • Fig. 1 is a diagram of a magnetic stimulation coil using a magnetic mirror according to an embodiment of the present invention
  • Fig. 2 is a diagram for explaining the operating principle of the magnetic mirror shown in Fig. 1;
  • Fig. 3 is a diagram for explaining the operating principle of the magnetic mirror shown in Fig. 1;
  • Fig. 4 is a diagram showing the magnetic mirror made of laminated ferromagnetic plates to reduce eddy currents;
  • Fig. 5 is a diagram for explaining the performance of a magnetic stimulation coil using the magnetic mirror according to an embodiment of the present invention
  • Fig. 6 is a diagram showing the performance comparison between the stimulating coils with and without the magnetic mirror effect
  • Fig. 7 is a diagram showing a shape of the magnetic mirror suitable for a 8-shaped stimulating coil
  • Fig. 8 is a diagram showing a shape of the magnetic mirror suitable for a curved stimulating coil
  • Fig. 9 is a diagram for explaining a method efficiently cooling the heat generated in the stimulating coil
  • Fig. 10 is a diagram showing a magnetic mirror and a stimulating coil which are applicable to an urinary incontinence treatment device
  • Fig. 11 is a diagram showing a magnetic mirror and a stimulating coil which are applicable to an physical therapy device .
  • the gist of the present invention is to improve the power consumption efficiency of a stimulating coil for stimulating nerves, muscles, and bones of the human body.
  • Fig. 1 a preferred stimulating coil shape is shown.
  • the stimulating coil consists of a coil 1 made of metallic conductor and a magnetic mirror 2 made of high magnetic permeability material.
  • the magnetic mirror has a circular shape, however, the magnetic mirror can have another shapes as described thereinafter. It is preferred that the coil 1 and the magnetic mirror 2 are positioned to meet as closely as possible. The more closely the coil 1 is positioned to the mirror 2, the larger the magnetic mirror effect and the smaller heat generation in the stimulating coil as described in hereinafter.
  • the magnetic stimulation coil consists of only a coil without a magnetic mirror.
  • Electric current I is fed to the stimulating coil from an external power supply. Since the peak amplitude of the current supplied to the stimulating coil is as large as several hundreds or several thousands of amperes, it is usual to use high voltage capacitors to charge electric charges supplied from the external power supply and discharge the charged electric charges to the stimulating coil instantaneously. In this case, the capacitor and the stimulating coil form a LC resonant circuit, and the resonant frequency is about several KHz .
  • electric current flows along the coil magnetic field is generated. The magnetic field can penetrate the tissues of the human body since most of biological tissues are magnetically transparent.
  • the stimulating coil can have various shapes. We have shown a circular coil, the most frequently used coil, in Fig. 1, the present invention applies to the coil with an arbitrary shape.
  • Fig. 2 basic principle of the present invention is illustrated.
  • the coil consists of an infinitely long wire 3.
  • the coil wire points perpendicularly to the paper.
  • Around the wire there is a magnetic material 4 parallel to the wire with the distance d.
  • the magnetic material has an semi-infinite shape.
  • magnetic material means the substance which as high magnetic permeability. That is, when an external magnetic field is applied to the magnetic material, strong magnetization appears inside the magnetic material making dense magnetic flux inside the material.
  • magnetic materials such as ferrite, silicon steel, permalloy, permendure, metallic glass, and powder iron.
  • Magnetic permeability of air is about 4 3.14X10 7 .
  • the magnetic permeability of ferrite is several hundred times larger than that of air, and the magnetic permeability of silicon steel is several thousand times larger than that of air.
  • the magnetic field around the wire can be calculated as if there is an imaginary wire 5 instead of the magnetic material carrying the same current as that of the wire.
  • the magnetic field calculation method in such a way is called image method or mirror method. The mirror method can be found in most electromagnetism texts.
  • Fig. 3 the principle of the mirror method is schematically illustrated. Only perpendicular magnetic field component exists on the surface of a magnetic material. That is, the magnetic flux vectors meet the magnetic material perpendicularly on its surface.
  • the left side of Fig. 3 shows such a shape using magnetic flux lines 6.
  • the shape of magnetic flux vectors generated around a wire with magnetic material is same as the shape of the magnetic flux vectors 7 of the case that there are a wire without magnetic material and another imaginary wire located at the distance 2d from the wire carrying the electric current of the same amplitude and direction. This is illustrated in the right side of Fig. 3.
  • the permeability of the magnetic material is not infinite, the shape and the position of the imaginary wire are changed.
  • Fig. 2 and Fig. 3 are regarded as stimulating coils, it can be found that there is additionally an imaginary stimulating coil inside the magnetic material. If the distance, d between the magnetic material and a coil is zero, a stimulating coil and a imaginary coil are overlapped each other, and the effect that the same shape of a magnetic field as that of a stimulating coil is added can be obtained. In other words, the effective strength of a magnetic field can be increased twice by using just one stimulating coil and a magnetic mirror.
  • the high permeablity and the ability to reduce an eddy current should be considered.
  • the fact that a imaginary coil is made inside the magnetic material requires the assumption that its electrical conductivity is zero, or the applied current is a direct current.
  • the current pulse of a few hundreds ⁇ sec is usually applied to a coil stimulating the human body. Therefore, if the electrical conductivity of the magnetic material is not zero, an eddy current is generated in magnetic material. Since the eddy current is generated in the opposite direction of the coil current, it reduces the magnetic field strength. Though ferrite has a very low conductivity, its permeablity is not high.
  • the saturation magnetic flux density of ferrite is 0.4-0.5 teslas and a stimulating coil makes magnetic flux density of 1-2 teslas
  • ferrite is not a proper material.
  • the present invention uses silicon steel, not ferrite. Silicon steel has some advantages of its low cost and high saturation magnetic flux density over 2.0 teslas. However, the high conductivity of silicon steel can make a large eddy current. To reduce a eddy current, the present invention uses laminated silicon steel plates as shown in Fig. 4. Since silicon steel plates are coated with an insulator, eddy currents cannot flow between plates, but can flow inside a plate. Therefore, the generation of eddy currents is restrained and the reduction of the magnetic field generated by a imaginary coil becomes very small.
  • Fig. 2 and Fig. 3 the infinite size of the magnetic material is assumed.
  • the model as shown in Fig. 5 is constructed.
  • the size of the magnetic material plate 11 with a circular shape is recommended to be a little bit larger than that of the circular coil 10 in Fig. 5.
  • the circle coil can be made of enameled wires.
  • FEM finite element method
  • Fig. 6 shows the simulation result.
  • the solid and dotted lines of Fig. 6 represent the strength of the magnetic flux density of the cases with and without a magnetic mirror, respectively.
  • the magnetic material was made of silicon steel mentioned in the above.
  • the inductance of the stimulating coil was assumed to be 50 ⁇ H. The performance comparison should be carried out under the condition of the same inductance value.
  • the current flowing along the coil is a shape of a damped sinusoidal wave and the its frequency depends on the inductance of the coil.
  • a stimulating coil with a magnetic mirror can have about twice larger inductance than the one without it. Therefore, inventors of the present invention designed the coil without a magnetic mirror so that its inductance is 50 ⁇ H.
  • the current flowing along the coil was 2,000A.
  • the result of Fig. 6 illustrates the values along the center axis of the parallel plane 5mm distant from the coil. This result shows that the magnetic flux density in the center of the coil increases from 0.92 teslas to 1.36 teslas by using a magnetic mirror. The increase rate of the magnetic field in this case is upto about 48%.
  • inventors of the present invention performed the practical experiment to verify the previously mentioned simulation result. All inductances of the used stimulating coils were adjusted to 50 ⁇ H. The inner and outer radii of the coil were 10mm and 60mm, respectively. And the thickness of the magnetic mirror was 15mm and its radius was 75mm. The magnetic mirror was made of laminated silicon steel plates. The thickness of silicon steel plates was 1mm. The plates were properly cut and stacked. When the current of 2,000A was fed to the stimulating coil, the measured result showed that the magnetic flux density in the center of the coil with the magnetic mirror was about 33% larger than that of the case without it. The difference between 48% increase of the simulation result and 33% of the experimental result is due to the eddy current generated inside the magnetic mirror.
  • the desirable conductivity of the magnetic mirror is ideally zero, that of a silicon steel plate is very high. Therefore, even the laminated magnetic mirror cannot remove all eddy currents. In order to reduce the effect of the eddy current as much as possible, the plate should be very thin.
  • the additional advantage of the magnetic mirror is to reduce the heat generated in the stimulating coil.
  • the magnetic mirror can reduce the number of coil turns and the proportional resistance, and finally the heat generated in the coil can be reduced.
  • Table 1 shows the measured temperature of the stimulating coil surface, when the pulse duration and the frequency of the applied current were 500 ⁇ sec and 50Hz, respectively.
  • the current pulse was a bipolar pulse and its amplitude was 2,000A.
  • the table 1 represents that the surface temperature of the stimulating coil can fall down by using the magnetic mirror. If the temperature rise of the coil is reduced, the higher frequency of the stimulating pulse can be used and the capacity of the cooler chilling the coil can be reduced.
  • the shape of the stimulation coil is not always circular.
  • Fig. 7 illustrates the 8-shaped coil 14 which is widely used. This 8-shaped coil is composed of two circular coils. It is widely used for selectively stimulating a specific area, since the magnetic flux can be focused at the place where two circles meet each other.
  • the magnetic mirror 15 can be also applied for this 8-shaped coil. In this case, the shape of the mirror may not be circular and a little bit larger size than that of the 8-shaped mirror is recommended.
  • the shape of the magnetic mirror can be varied according to the shape of the stimulating coils .
  • the circular shape of the mirror is the most desirable, a rectangle or a polygon larger than the coil can be used in consideration of manufacturing convenience.
  • the magnetic mirror can be applied to the coil with a curved surface, too. The curved surface had better be parallel to the coil surface.
  • Fig. 8 illustrates the curved surface of the magnetic mirror 17 which is suitable to stimulate a human brain.
  • Fig. 9 illustrates an uneven shape of the magnetic mirror 20 which is made by stacking magnetic material plates 18, 19 with different widths. This is an efficient structure to cool down the magnetic mirror.
  • Fig. 10 illustrates the shape of the stimulating coil and the magnetic mirror which are applicable to the treatment of urinary incontinence.
  • a patient is usually seated at a chair and the stimulating coil 21 and the magnetic mirror 22 are generally installed inside a seat 23.
  • Fig. 11 illustrates the shape of the stimulating coil and the magnetic mirror which are applicable to a physical therapy. Since the stimulating coil for a physical therapy are generally attached to the structure like an artificial arm, it is desirable to attach both of the coil and the magnetic mirror to an artificial arm 24.
  • the stimulating coil and the magnetic mirror can be closely adhered each other in the various ways using nonconductive glue, thread, ribbon, etc. And it is possible to insert the material with high thermal conductivity between the coil and the mirror in order to cool down the heat generated in the coil through the mirror.
  • the present invention can provide the stimulating coil with the magnetic mirror, which can reduce the required electric power and the heat generation by enhancing the efficiency of the stimulating coil.
  • the stimulating coil is used to stimulate the human body, magnetically for the function diagnosis of nerves and muscles, urinary incontinence treatment, physical therapy, the pain relief, obesity treatment, etc.

Abstract

L'invention concerne une bobine de stimulation magnétique faisant appel à l'effet de miroir magnétique pour stimuler des nerfs ou des muscles du corps humain, pour un diagnostic et pour une thérapie. L'invention concerne une bobine de stimulation magnétique constituée d'une bobine générant un champ magnétique au moyen d'un courant électrique fourni par une source d'alimentation, et d'un miroir magnétique générant un champ magnétique analogue à celui généré par la bobine. Dans ce cas, le miroir magnétique est constitué d'une matière ferromagnétique présentant une perméabilité magnétique élevée. Cette bobine de stimulation magnétique à effet de miroir magnétique présente plusieurs avantages par rapport à des techniques classiques en ce qu'elle présente une meilleure efficacité de puissance et une génération de chaleur moins importante. Ces avantages sont très importants dans des stimulateurs magnétiques utilisés pour un diagnostic et pour une thérapie à l'hôpital, ou pour des améliorations et des rééducations de fonctions altérées chez l'être humain. Par conséquent, cette bobine de stimulation magnétique peut être appliquée à des dispositifs de traitement variés, notamment pour le traitement de l'incontinence urinaire, pour une thérapie physique, pour le traitement de l'obésité, pour le traitement de l'arthrite, et pour des types variés de dispositifs destinés à améliorer la santé.
PCT/KR2003/000783 2002-04-24 2003-04-17 Bobine de stimulation faisant appel a un miroir magnetique et son utilisation WO2003090863A1 (fr)

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AU2003222476A AU2003222476A1 (en) 2002-04-24 2003-04-17 A stimulation coil using magnetic mirror and use thereof

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KR10-2002-0022447A KR100497500B1 (ko) 2002-04-24 2002-04-24 자기 거울을 이용한 자극 코일 및 그 용도
KR10-2002-0022447 2002-04-24

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FR2970655A1 (fr) * 2011-01-21 2012-07-27 Cosmosoft Dispositif pour la reduction des surcharges adipeuses
US9272157B2 (en) 2010-05-02 2016-03-01 Nervive, Inc. Modulating function of neural structures near the ear
US9339645B2 (en) 2010-05-02 2016-05-17 Nervive, Inc. Modulating function of the facial nerve system or related neural structures via the ear
US9586057B2 (en) 2015-07-01 2017-03-07 Btl Holdings Limited Magnetic stimulation methods and devices for therapeutic treatments
US9636519B2 (en) 2015-07-01 2017-05-02 Btl Holdings Limited Magnetic stimulation methods and devices for therapeutic treatments
US20180001106A1 (en) 2016-07-01 2018-01-04 Btl Holdings Limited Aesthetic method of biological structure treatment by magnetic field
US9919161B2 (en) 2015-07-01 2018-03-20 Btl Holdings Limited Method of neural structure stimulation by magnetic field
GB2554043A (en) * 2016-05-12 2018-03-28 The Magstim Company Ltd Magnetic Stimulation Coil Arrangement
US9937358B2 (en) 2015-07-01 2018-04-10 Btl Holdings Limited Aesthetic methods of biological structure treatment by magnetic field
US9974519B1 (en) 2015-07-01 2018-05-22 Btl Holdings Limited Aesthetic method of biologoical structure treatment by magnetic field
US10039929B1 (en) 2017-04-04 2018-08-07 BLT Holdings Limited Method and device for pelvic floor tissue treatment
US10065047B2 (en) 2013-05-20 2018-09-04 Nervive, Inc. Coordinating emergency treatment of cardiac dysfunction and non-cardiac neural dysfunction
US10124187B2 (en) 2015-04-28 2018-11-13 Btl Holdings Limited Combination of radiofrequency and magnetic treatment methods
US10245439B1 (en) 2015-07-01 2019-04-02 Medical Technologies Cz A.S. Aesthetic method of biological structure treatment by magnetic field
US10471269B1 (en) 2015-07-01 2019-11-12 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10478633B2 (en) 2015-07-01 2019-11-19 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10478634B2 (en) 2015-07-01 2019-11-19 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
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US10549110B1 (en) 2015-07-01 2020-02-04 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
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US10569094B2 (en) 2015-07-01 2020-02-25 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10632321B2 (en) 2016-07-01 2020-04-28 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US10695575B1 (en) 2016-05-10 2020-06-30 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
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GB2591692A (en) * 2016-05-12 2021-08-04 The Magstim Company Ltd Magnetic stimulation coil arrangement
US11185690B2 (en) 2016-05-23 2021-11-30 BTL Healthcare Technologies, a.s. Systems and methods for tissue treatment
US11247039B2 (en) 2016-05-03 2022-02-15 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11247063B2 (en) 2019-04-11 2022-02-15 Btl Healthcare Technologies A.S. Methods and devices for aesthetic treatment of biological structures by radiofrequency and magnetic energy
US11253718B2 (en) 2015-07-01 2022-02-22 Btl Healthcare Technologies A.S. High power time varying magnetic field therapy
US11253717B2 (en) 2015-10-29 2022-02-22 Btl Healthcare Technologies A.S. Aesthetic method of biological structure treatment by magnetic field
EP3974025A1 (fr) * 2014-01-15 2022-03-30 Neuronetics, Inc. Bobines de stimulation magnétique et composants ferromagnétiques pour une stimulation de surfaces réduite et une profondeur de traitement améliorée
US11464993B2 (en) 2016-05-03 2022-10-11 Btl Healthcare Technologies A.S. Device including RF source of energy and vacuum system
US11491329B2 (en) 2020-05-04 2022-11-08 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11534619B2 (en) 2016-05-10 2022-12-27 Btl Medical Solutions A.S. Aesthetic method of biological structure treatment by magnetic field
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
US11633596B2 (en) 2020-05-04 2023-04-25 Btl Healthcare Technologies A.S. Device and method for unattended treatment of a patient
US11896823B2 (en) 2017-04-04 2024-02-13 Btl Healthcare Technologies A.S. Method and device for pelvic floor tissue treatment
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Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9272157B2 (en) 2010-05-02 2016-03-01 Nervive, Inc. Modulating function of neural structures near the ear
US9339645B2 (en) 2010-05-02 2016-05-17 Nervive, Inc. Modulating function of the facial nerve system or related neural structures via the ear
US10105549B2 (en) 2010-05-02 2018-10-23 Nervive, Inc. Modulating function of neural structures near the ear
FR2970655A1 (fr) * 2011-01-21 2012-07-27 Cosmosoft Dispositif pour la reduction des surcharges adipeuses
US11612758B2 (en) 2012-07-05 2023-03-28 Btl Medical Solutions A.S. Device for repetitive nerve stimulation in order to break down fat tissue means of inductive magnetic fields
US10065047B2 (en) 2013-05-20 2018-09-04 Nervive, Inc. Coordinating emergency treatment of cardiac dysfunction and non-cardiac neural dysfunction
EP3974025A1 (fr) * 2014-01-15 2022-03-30 Neuronetics, Inc. Bobines de stimulation magnétique et composants ferromagnétiques pour une stimulation de surfaces réduite et une profondeur de traitement améliorée
US10124187B2 (en) 2015-04-28 2018-11-13 Btl Holdings Limited Combination of radiofrequency and magnetic treatment methods
US10245439B1 (en) 2015-07-01 2019-04-02 Medical Technologies Cz A.S. Aesthetic method of biological structure treatment by magnetic field
US10478634B2 (en) 2015-07-01 2019-11-19 Btl Medical Technologies S.R.O. Aesthetic method of biological structure treatment by magnetic field
US9937358B2 (en) 2015-07-01 2018-04-10 Btl Holdings Limited Aesthetic methods of biological structure treatment by magnetic field
US11491342B2 (en) 2015-07-01 2022-11-08 Btl Medical Solutions A.S. Magnetic stimulation methods and devices for therapeutic treatments
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