WO2003087756A3 - Chemical analysis of samples - Google Patents

Chemical analysis of samples Download PDF

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Publication number
WO2003087756A3
WO2003087756A3 PCT/IB2003/001407 IB0301407W WO03087756A3 WO 2003087756 A3 WO2003087756 A3 WO 2003087756A3 IB 0301407 W IB0301407 W IB 0301407W WO 03087756 A3 WO03087756 A3 WO 03087756A3
Authority
WO
WIPO (PCT)
Prior art keywords
chromatographic column
sample
eluent fraction
pressure
fluid flow
Prior art date
Application number
PCT/IB2003/001407
Other languages
French (fr)
Other versions
WO2003087756A2 (en
Inventor
Egmont Richard Rohwer
Andre Venter
Original Assignee
Univ Pretoria
Egmont Richard Rohwer
Andre Venter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pretoria, Egmont Richard Rohwer, Andre Venter filed Critical Univ Pretoria
Priority to AU2003219362A priority Critical patent/AU2003219362A1/en
Publication of WO2003087756A2 publication Critical patent/WO2003087756A2/en
Publication of WO2003087756A3 publication Critical patent/WO2003087756A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/462—Flow patterns using more than one column with serial coupling of separation columns with different eluents or with eluents in different states
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/025—Gas chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/383—Flow patterns flow switching in a single column by using auxiliary fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N2030/382—Flow patterns flow switching in a single column
    • G01N2030/385—Flow patterns flow switching in a single column by switching valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography

Abstract

The invention relates to a method of analyzing a sample, and to an apparatus for such analysis. The method includes subjecting a liquid sample to high pressure fluid chromatography in a first chromatographic column (12) operating at a first temperature in order to effect partial analysis of the sample. The eluent fraction produced by the first separation is then passed through a pressure-reducing zone in fluid flow connection with the first chromatographic column, after which the eluent fraction is fed through a second chromatographic column (48) which is in fluid flow connection with the pressure-reducing zone. The temperature of the second chromatographic column (48) is then ramped independently of the first chromatographic column (12) in order to effect fast gas chromatographic separation of the eluent fraction into further fractions of differing volatilities.
PCT/IB2003/001407 2002-04-16 2003-04-15 Chemical analysis of samples WO2003087756A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003219362A AU2003219362A1 (en) 2002-04-16 2003-04-15 Chemical analysis of samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA2002/3002 2002-04-16
ZA200203002 2002-04-16

Publications (2)

Publication Number Publication Date
WO2003087756A2 WO2003087756A2 (en) 2003-10-23
WO2003087756A3 true WO2003087756A3 (en) 2004-07-01

Family

ID=29251515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2003/001407 WO2003087756A2 (en) 2002-04-16 2003-04-15 Chemical analysis of samples

Country Status (2)

Country Link
AU (1) AU2003219362A1 (en)
WO (1) WO2003087756A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITVE20070039A1 (en) * 2007-06-18 2008-12-19 Dani Instr Spa FOCUSING APPARATUS FOR GAS CHROMATOGRAPHY.-
CN103018380A (en) * 2012-11-27 2013-04-03 张勇 Voltage-adjustable directly-heated type chromatographic column
DE102013212540A1 (en) 2013-06-27 2014-12-31 Agilent Technologies Inc. Conditioning a subsequent sample packet in a sample separation stage while processing a previous sample package in a sample processing stage
WO2015198096A1 (en) * 2014-06-25 2015-12-30 Agilent Technologies, Inc. Secondary stage fluid separation device detachably connectable with primary stage fluid separation device
CN109073611B (en) * 2016-04-20 2021-08-10 沃特世科技公司 Method and apparatus for flame ionization detection for chromatography
CN105974026B (en) * 2016-06-15 2018-05-15 华南理工大学 Can overall process ultralow pressure shunting arrhea type two-dimensional liquid chromatography and application thereof
CN106053668B (en) * 2016-07-13 2018-06-19 华南理工大学 What bidimensional analysis was carried out at the same time arrheas type two-dimensional liquid chromatography and its application
WO2019229697A1 (en) * 2018-05-31 2019-12-05 Waters Technologies Corporation High resolution and semi-preparative recycling chromatography system for isolation and preparation of unknown trace impurities in pharmaceutical products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1151825A (en) * 1997-08-08 1999-02-26 Asahi Chem Ind Co Ltd Method for continuously analyzing composition of high-pressure mixed fluid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1151825A (en) * 1997-08-08 1999-02-26 Asahi Chem Ind Co Ltd Method for continuously analyzing composition of high-pressure mixed fluid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; AN 1999-218314(19) *
DATABASE WPI Derwent World Patents Index; AN 2003-505536(47) *

Also Published As

Publication number Publication date
AU2003219362A8 (en) 2003-10-27
AU2003219362A1 (en) 2003-10-27
WO2003087756A2 (en) 2003-10-23

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