WO2003087375A8 - Cartilage differentiation regulating gene - Google Patents

Cartilage differentiation regulating gene

Info

Publication number
WO2003087375A8
WO2003087375A8 PCT/JP2003/004802 JP0304802W WO03087375A8 WO 2003087375 A8 WO2003087375 A8 WO 2003087375A8 JP 0304802 W JP0304802 W JP 0304802W WO 03087375 A8 WO03087375 A8 WO 03087375A8
Authority
WO
WIPO (PCT)
Prior art keywords
protein
promoting
collagen expression
dna
type
Prior art date
Application number
PCT/JP2003/004802
Other languages
French (fr)
Other versions
WO2003087375A1 (en
Inventor
Akio Matsuda
Goichi Honda
Shuji Muramatsu
Original Assignee
Asahi Kasei Pharma Corp
Akio Matsuda
Goichi Honda
Shuji Muramatsu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2002113908A external-priority patent/JP2006166703A/en
Application filed by Asahi Kasei Pharma Corp, Akio Matsuda, Goichi Honda, Shuji Muramatsu filed Critical Asahi Kasei Pharma Corp
Priority to AU2003223121A priority Critical patent/AU2003223121A1/en
Publication of WO2003087375A1 publication Critical patent/WO2003087375A1/en
Publication of WO2003087375A8 publication Critical patent/WO2003087375A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides the protein promoting type II collagen expression useful in diagnosis, therapy and prophylaxis of diseases associated with cartilage impairments. Using the plasmid CPE43, the cDNA encoding a protein capable of promoting type II collagen expression has been cloned from the cDNA library constructed from mouse cell line ATDC5 and human lung fibroblast, and the DNA sequence and the deduced amino acid sequence were determined. The protein, the DNA encoding the protein, a recombinant vector containing the DNA, and a transformant containing the recombinant vector are useful in screening for a substance inhibiting or promoting the type II collagen expression.
PCT/JP2003/004802 2002-04-16 2003-04-16 Cartilage differentiation regulating gene WO2003087375A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003223121A AU2003223121A1 (en) 2002-04-16 2003-04-16 Cartilage differentiation regulating gene

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JPNO.2002-113908 2002-04-16
JP2002113908A JP2006166703A (en) 2002-04-16 2002-04-16 Cartilage differentiation regulating gene
US37359402P 2002-04-19 2002-04-19
US60/373,594 2002-04-19

Publications (2)

Publication Number Publication Date
WO2003087375A1 WO2003087375A1 (en) 2003-10-23
WO2003087375A8 true WO2003087375A8 (en) 2005-06-02

Family

ID=29253565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/004802 WO2003087375A1 (en) 2002-04-16 2003-04-16 Cartilage differentiation regulating gene

Country Status (2)

Country Link
AU (1) AU2003223121A1 (en)
WO (1) WO2003087375A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013326A1 (en) * 2002-08-05 2004-02-12 Asahi Kasei Pharma Corporation Cartilage differentiation inhibiting gene

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2253249A1 (en) * 1996-04-23 1997-10-30 Sumitomo Pharmaceuticals Company, Limited Novel proteins c16 and c16n or genes encoding the same

Also Published As

Publication number Publication date
AU2003223121A1 (en) 2003-10-27
AU2003223121A8 (en) 2003-10-27
WO2003087375A1 (en) 2003-10-23

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121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
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Free format text: IN PCT GAZETTE 43/2003 UNDER (51) REPLACE THE EXISTING SYMBOLS BY "C12N 15/12, C07K 14/47, C12N 1/21, C12P 21/02, G01N 33/50, G01N 33/15, C07K 16/18, C12P 21/08, A61K 38/17, A61P 19/04 // (C12N 15/12, C12R 1:91), (C12P 21/08, C12R 1:91)"

122 Ep: pct application non-entry in european phase