WO2003087328A3 - Method of generating non-naturally occuring protein models - Google Patents

Method of generating non-naturally occuring protein models Download PDF

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Publication number
WO2003087328A3
WO2003087328A3 PCT/US2003/011003 US0311003W WO03087328A3 WO 2003087328 A3 WO2003087328 A3 WO 2003087328A3 US 0311003 W US0311003 W US 0311003W WO 03087328 A3 WO03087328 A3 WO 03087328A3
Authority
WO
WIPO (PCT)
Prior art keywords
naturally occuring
generating non
protein models
occuring protein
stacks
Prior art date
Application number
PCT/US2003/011003
Other languages
French (fr)
Other versions
WO2003087328A2 (en
Inventor
Ned S Wingreen
Chao Tang
Eldon Emberly
Original Assignee
Ned S Wingreen
Chao Tang
Eldon Emberly
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ned S Wingreen, Chao Tang, Eldon Emberly filed Critical Ned S Wingreen
Priority to AU2003224914A priority Critical patent/AU2003224914A1/en
Publication of WO2003087328A2 publication Critical patent/WO2003087328A2/en
Publication of WO2003087328A3 publication Critical patent/WO2003087328A3/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/20—Protein or domain folding

Abstract

The invention provides new designable protein backbone configurations. The configurations are produced by a computer implemented method which includes the steps of: (a) specifying a fixed number of secondary structural elements having a set of dihedral angle pairs (b) generating a set of stacks having secondary structural elements; and (c) evaluating designability of the stacks.
PCT/US2003/011003 2002-04-11 2003-04-11 Method of generating non-naturally occuring protein models WO2003087328A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003224914A AU2003224914A1 (en) 2002-04-11 2003-04-11 Method of generating non-naturally occuring protein models

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37194702P 2002-04-11 2002-04-11
US60/371,947 2002-04-11

Publications (2)

Publication Number Publication Date
WO2003087328A2 WO2003087328A2 (en) 2003-10-23
WO2003087328A3 true WO2003087328A3 (en) 2004-01-22

Family

ID=29250762

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/011003 WO2003087328A2 (en) 2002-04-11 2003-04-11 Method of generating non-naturally occuring protein models

Country Status (2)

Country Link
AU (1) AU2003224914A1 (en)
WO (1) WO2003087328A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5878373A (en) * 1996-12-06 1999-03-02 Regents Of The University Of California System and method for determining three-dimensional structure of protein sequences
US5884230A (en) * 1993-04-28 1999-03-16 Immunex Corporation Method and system for protein modeling
US6256647B1 (en) * 1998-02-16 2001-07-03 Biomolecular Engineering Research Institute Method of searching database of three-dimensional protein structures

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5884230A (en) * 1993-04-28 1999-03-16 Immunex Corporation Method and system for protein modeling
US5878373A (en) * 1996-12-06 1999-03-02 Regents Of The University Of California System and method for determining three-dimensional structure of protein sequences
US6256647B1 (en) * 1998-02-16 2001-07-03 Biomolecular Engineering Research Institute Method of searching database of three-dimensional protein structures

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RANDIC ET AL.: "On a characterization of the folding of proteins", INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, vol. 75, 1999, pages 1017 - 1026, XP002969605 *
SKOLNICK ET AL.: "MONSSTER: a method for folding globular proteins with a small number of distance restraints", J. MOL. BIOL., vol. 265, 1997, pages 217 - 241, XP004462321 *

Also Published As

Publication number Publication date
AU2003224914A1 (en) 2003-10-27
WO2003087328A2 (en) 2003-10-23
AU2003224914A8 (en) 2003-10-27

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