WO2003082834A3 - Morpholine derivatives and intermediates therefor - Google Patents

Morpholine derivatives and intermediates therefor Download PDF

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Publication number
WO2003082834A3
WO2003082834A3 PCT/EP2003/003338 EP0303338W WO03082834A3 WO 2003082834 A3 WO2003082834 A3 WO 2003082834A3 EP 0303338 W EP0303338 W EP 0303338W WO 03082834 A3 WO03082834 A3 WO 03082834A3
Authority
WO
WIPO (PCT)
Prior art keywords
morpholine derivatives
intermediates therefor
amino
methyl
intermediates
Prior art date
Application number
PCT/EP2003/003338
Other languages
French (fr)
Other versions
WO2003082834A2 (en
Inventor
Rachael Ann Ancliff
Caroline Mary Cook
Colin David Eldred
Paul Martin Gore
Lee Andrew Harrison
Martin Alistair Hayes
Simon Teanby Hodgson
Duncan Bruce Judd
Suzanne Elaine Keeling
Xiao Qing Lewell
Gail Mills
Graeme Michael Robertson
Stephen Swanson
Andrew John Walker
Mark Wilkinson
Original Assignee
Glaxo Group Ltd
Rachael Ann Ancliff
Caroline Mary Cook
Colin David Eldred
Paul Martin Gore
Lee Andrew Harrison
Martin Alistair Hayes
Simon Teanby Hodgson
Duncan Bruce Judd
Suzanne Elaine Keeling
Xiao Qing Lewell
Gail Mills
Graeme Michael Robertson
Stephen Swanson
Andrew John Walker
Mark Wilkinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Rachael Ann Ancliff, Caroline Mary Cook, Colin David Eldred, Paul Martin Gore, Lee Andrew Harrison, Martin Alistair Hayes, Simon Teanby Hodgson, Duncan Bruce Judd, Suzanne Elaine Keeling, Xiao Qing Lewell, Gail Mills, Graeme Michael Robertson, Stephen Swanson, Andrew John Walker, Mark Wilkinson filed Critical Glaxo Group Ltd
Priority to JP2003580302A priority Critical patent/JP2006504626A/en
Priority to EP03745295A priority patent/EP1490345A2/en
Priority to AU2003226758A priority patent/AU2003226758A1/en
Publication of WO2003082834A2 publication Critical patent/WO2003082834A2/en
Publication of WO2003082834A3 publication Critical patent/WO2003082834A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compound of formula (I); which is;3-({[({[(2S)-4-(3,4-dichlorobenzyl)morpholin-2-yl]methyl}amino)carbonyl]--amino}methyl)-N-ethylbenzamide;and salts and solvates thereof, a process for its preparation, pharmaceutical formulations containing it and its use in therapy.
PCT/EP2003/003338 2002-03-28 2003-03-27 Morpholine derivatives and intermediates therefor WO2003082834A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2003580302A JP2006504626A (en) 2002-03-28 2003-03-27 Morpholine derivatives and intermediates thereof
EP03745295A EP1490345A2 (en) 2002-03-28 2003-03-27 Novel compound
AU2003226758A AU2003226758A1 (en) 2002-03-28 2003-03-27 Morpholine derivatives and intermediates therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0207447.4 2002-03-28
GBGB0207447.4A GB0207447D0 (en) 2002-03-28 2002-03-28 Novel compounds

Publications (2)

Publication Number Publication Date
WO2003082834A2 WO2003082834A2 (en) 2003-10-09
WO2003082834A3 true WO2003082834A3 (en) 2004-03-25

Family

ID=9933997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/003338 WO2003082834A2 (en) 2002-03-28 2003-03-27 Morpholine derivatives and intermediates therefor

Country Status (7)

Country Link
EP (1) EP1490345A2 (en)
JP (1) JP2006504626A (en)
AR (1) AR039176A1 (en)
AU (1) AU2003226758A1 (en)
GB (1) GB0207447D0 (en)
TW (1) TW200401771A (en)
WO (1) WO2003082834A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243959A1 (en) * 1986-04-30 1987-11-04 Dainippon Pharmaceutical Co., Ltd. Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
WO1995031431A1 (en) * 1994-05-18 1995-11-23 Nisshin Flour Milling Co., Ltd. Novel diaminomethylidene derivative
WO1995031442A1 (en) * 1994-05-18 1995-11-23 Nisshin Flour Milling Co., Ltd. Novel pyrimidine derivative
WO1998056771A2 (en) * 1997-06-12 1998-12-17 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
WO2002026723A1 (en) * 2000-09-29 2002-04-04 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0243959A1 (en) * 1986-04-30 1987-11-04 Dainippon Pharmaceutical Co., Ltd. Substituted benzamide derivatives, processes for the preparation thereof, and pharmaceutical compositions containing the same
WO1995031431A1 (en) * 1994-05-18 1995-11-23 Nisshin Flour Milling Co., Ltd. Novel diaminomethylidene derivative
WO1995031442A1 (en) * 1994-05-18 1995-11-23 Nisshin Flour Milling Co., Ltd. Novel pyrimidine derivative
WO1998056771A2 (en) * 1997-06-12 1998-12-17 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
WO2002026723A1 (en) * 2000-09-29 2002-04-04 Glaxo Group Limited Compounds useful in the treatment of inflammatory diseases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SARTORI E ET AL: "SYNTHESIS AND ACTIVITIES OF NET ARYLSULFONAMIDO THROMBOXANE A2 RECEPTOR ANTAGONISTS", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 28, no. 7/8, 1993, pages 625 - 632, XP000396678, ISSN: 0223-5234 *

Also Published As

Publication number Publication date
JP2006504626A (en) 2006-02-09
TW200401771A (en) 2004-02-01
AR039176A1 (en) 2005-02-09
AU2003226758A1 (en) 2003-10-13
GB0207447D0 (en) 2002-05-08
EP1490345A2 (en) 2004-12-29
WO2003082834A2 (en) 2003-10-09
AU2003226758A8 (en) 2003-10-13

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