WO2003080111A3 - Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof - Google Patents

Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof Download PDF

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Publication number
WO2003080111A3
WO2003080111A3 PCT/CA2003/000434 CA0300434W WO03080111A3 WO 2003080111 A3 WO2003080111 A3 WO 2003080111A3 CA 0300434 W CA0300434 W CA 0300434W WO 03080111 A3 WO03080111 A3 WO 03080111A3
Authority
WO
WIPO (PCT)
Prior art keywords
cancer vaccine
chemotherapeutic agents
therapeutic methods
vaccine adjuvants
tumor growth
Prior art date
Application number
PCT/CA2003/000434
Other languages
French (fr)
Other versions
WO2003080111A2 (en
Inventor
Eric Simard
Philippe Goyette
Pierre Lemieux
Original Assignee
Technologies Biolactis Inc
Eric Simard
Philippe Goyette
Pierre Lemieux
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technologies Biolactis Inc, Eric Simard, Philippe Goyette, Pierre Lemieux filed Critical Technologies Biolactis Inc
Priority to AU2003212170A priority Critical patent/AU2003212170A1/en
Priority to CA002479528A priority patent/CA2479528A1/en
Priority to EP03707982A priority patent/EP1490098B1/en
Priority to US10/508,738 priority patent/US20060051354A1/en
Priority to DE60331725T priority patent/DE60331725D1/en
Priority to AT03707982T priority patent/ATE460943T1/en
Publication of WO2003080111A2 publication Critical patent/WO2003080111A2/en
Publication of WO2003080111A3 publication Critical patent/WO2003080111A3/en
Priority to US12/753,173 priority patent/US20100272676A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to an anti-cancer vaccine composition comprising an antigen in association with an effective amount of at least one immunomodulator chemotherapeutic adjuvant eliciting an immune response in a patient and a pharmaceutically acceptable carrier. It also relates to method of preventing tumor growth and reducing tumor growth using the anti-cancer vaccine composition of the present invention.
PCT/CA2003/000434 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof WO2003080111A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2003212170A AU2003212170A1 (en) 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof
CA002479528A CA2479528A1 (en) 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof
EP03707982A EP1490098B1 (en) 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof
US10/508,738 US20060051354A1 (en) 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof
DE60331725T DE60331725D1 (en) 2002-03-25 2003-03-25 THERAPEUTIC AGENTS AS ANTICROBLE VACCINE ADJUVANTIES AND THEIR THERAPEUTIC PROCEDURES
AT03707982T ATE460943T1 (en) 2002-03-25 2003-03-25 THERAPEUTIC AGENTS AS ANTI-CANCER VACCINE ADJUVANTS AND THERAPEUTIC METHODS
US12/753,173 US20100272676A1 (en) 2002-03-25 2010-04-02 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36653102P 2002-03-25 2002-03-25
US60/366,531 2002-03-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/753,173 Continuation US20100272676A1 (en) 2002-03-25 2010-04-02 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof

Publications (2)

Publication Number Publication Date
WO2003080111A2 WO2003080111A2 (en) 2003-10-02
WO2003080111A3 true WO2003080111A3 (en) 2003-11-13

Family

ID=28454811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2003/000434 WO2003080111A2 (en) 2002-03-25 2003-03-25 Chemotherapeutic agents as anti-cancer vaccine adjuvants and therapeutic methods thereof

Country Status (7)

Country Link
US (2) US20060051354A1 (en)
EP (1) EP1490098B1 (en)
AT (1) ATE460943T1 (en)
AU (1) AU2003212170A1 (en)
CA (1) CA2479528A1 (en)
DE (1) DE60331725D1 (en)
WO (1) WO2003080111A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8128922B2 (en) 1999-10-20 2012-03-06 Johns Hopkins University Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen
US9701725B2 (en) 2003-05-05 2017-07-11 The Johns Hopkins University Anti-cancer DNA vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein
CA2594040A1 (en) 2005-01-06 2006-07-13 The Johns Hopkins University Rna interference that blocks expression of pro-apoptotic proteins potentiates immunity induced by dna and transfected dendritic cell vaccines
GB0519303D0 (en) * 2005-09-21 2005-11-02 Oxford Biomedica Ltd Chemo-immunotherapy method
NZ567837A (en) * 2005-11-02 2011-11-25 Univ Texas Concurrent chemotherapy and immunotherapy with EGFRvIII peptide and temozolomide
WO2007060918A1 (en) * 2005-11-24 2007-05-31 Dainippon Sumitomo Pharma Co., Ltd. Novel memory ctl induction potentiator
US20100330105A1 (en) * 2006-08-22 2010-12-30 John Hopkins University Anticancer Combination Therapies
US7655216B2 (en) * 2007-02-26 2010-02-02 University of Pittsburgh - of the Commonwealth of Higher Education Vaccine for activating helper function of CD8+ Tcells
US9085638B2 (en) 2007-03-07 2015-07-21 The Johns Hopkins University DNA vaccine enhancement with MHC class II activators
US20090004213A1 (en) 2007-03-26 2009-01-01 Immatics Biotechnologies Gmbh Combination therapy using active immunotherapy
CN101766815B (en) * 2009-12-31 2012-04-25 胡松华 Application of taxol and taxotere
WO2012054425A2 (en) * 2010-10-18 2012-04-26 University Of Iowa Research Foundation Biodegradable particulate formulations
ES2702622T3 (en) * 2013-03-27 2019-03-04 Immunovaccine Technologies Inc Method to improve the effectiveness of a survivin vaccine in the treatment of cancer
JP6813258B2 (en) * 2014-12-11 2021-01-13 リティックス バイオファーマ エイエス Chemotherapy combination
WO2016168361A1 (en) * 2015-04-14 2016-10-20 Polynoma, Llc Polyvalent vaccines and combination therapy for the treatment of melanoma
WO2021051066A1 (en) * 2019-09-13 2021-03-18 H. Lee Moffitt Cancer Center And Research Institute, Inc. Her3 pulsed dc1 therapy
CN111518169B (en) * 2020-04-29 2021-07-06 潍坊医学院 Polypeptide, polypeptide nano drug-loaded carrier and application of polypeptide and polypeptide nano drug-loaded carrier

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016246A1 (en) * 1996-10-16 1998-04-23 Johns Hopkins University Cytokine enhanced immunotherapy for brain tumors
US20010038841A1 (en) * 1996-07-25 2001-11-08 Hiserodt John C. Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5717092A (en) * 1996-03-29 1998-02-10 Vertex Pharmaceuticals Inc. Compounds with improved multi-drug resistance activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010038841A1 (en) * 1996-07-25 2001-11-08 Hiserodt John C. Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
WO1998016246A1 (en) * 1996-10-16 1998-04-23 Johns Hopkins University Cytokine enhanced immunotherapy for brain tumors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 96, no. 11 Part 1, 16 November 2000 (2000-11-16), 42ND ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; SAN FRANCISCO, CALIFORNIA, USA; DECEMBER 01-05, 2000, pages 844a, ISSN: 0006-4971 *
CURRENT OPINION IN MOLECULAR THERAPEUTICS. FEB 2001, vol. 3, no. 1, February 2001 (2001-02-01), pages 77 - 84, ISSN: 1464-8431 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2000 (2000-11-16), REECE D E ET AL: "Use of the anti-idiotype (ID) antibody (AB) vaccine 11D10 (TRIAB) in patients (PTS) with metastatic breast cancer (MBC) undergoing autologous stem cell transplantation (ASCT).", XP002254170, Database accession no. PREV200100317653 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; February 2001 (2001-02-01), EMENS L A ET AL: "Chemotherapy: friend or foe to cancer vaccines?", XP002254169, Database accession no. NLM11249735 *
RADCLIFF FIONA J ET AL: "Mobilization of dendritic cells in cancer patients treated with granulocyte colony-stimulating factor and chemotherapy.", BRITISH JOURNAL OF HAEMATOLOGY OCTOBER, 2002, vol. 119, no. 1, October 2002 (2002-10-01), &, pages 204 - 211, XP002254168, ISSN: 0007-1048 *

Also Published As

Publication number Publication date
US20100272676A1 (en) 2010-10-28
US20060051354A1 (en) 2006-03-09
DE60331725D1 (en) 2010-04-29
WO2003080111A2 (en) 2003-10-02
EP1490098A2 (en) 2004-12-29
CA2479528A1 (en) 2003-10-02
AU2003212170A1 (en) 2003-10-08
EP1490098B1 (en) 2010-03-17
AU2003212170A8 (en) 2003-10-08
ATE460943T1 (en) 2010-04-15

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