WO2002053176A3 - An autologous anti-cancer vaccine - Google Patents

An autologous anti-cancer vaccine Download PDF

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Publication number
WO2002053176A3
WO2002053176A3 PCT/IL2002/000012 IL0200012W WO02053176A3 WO 2002053176 A3 WO2002053176 A3 WO 2002053176A3 IL 0200012 W IL0200012 W IL 0200012W WO 02053176 A3 WO02053176 A3 WO 02053176A3
Authority
WO
WIPO (PCT)
Prior art keywords
composition
mixture
loaded
apc
antigen presenting
Prior art date
Application number
PCT/IL2002/000012
Other languages
French (fr)
Other versions
WO2002053176A2 (en
Inventor
Michal Lotem
Tamar Peretz
Eitan Shiloni
Olga Drize
Shoshana Frankenburg
Original Assignee
Hadasit Med Res Service
Michal Lotem
Tamar Peretz
Eitan Shiloni
Olga Drize
Shoshana Frankenburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hadasit Med Res Service, Michal Lotem, Tamar Peretz, Eitan Shiloni, Olga Drize, Shoshana Frankenburg filed Critical Hadasit Med Res Service
Priority to AU2002219485A priority Critical patent/AU2002219485A1/en
Publication of WO2002053176A2 publication Critical patent/WO2002053176A2/en
Publication of WO2002053176A3 publication Critical patent/WO2002053176A3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00119Melanoma antigens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0639Dendritic cells, e.g. Langherhans cells in the epidermis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001156Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00119Melanoma antigens
    • A61K39/001191Melan-A/MART
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/00119Melanoma antigens
    • A61K39/001192Glycoprotein 100 [Gp100]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4615Dendritic cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4622Antigen presenting cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/46449Melanoma antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/4644Cancer antigens
    • A61K39/464499Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55522Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/02Compounds of the arachidonic acid pathway, e.g. prostaglandins, leukotrienes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/05Adjuvants
    • C12N2501/056Immunostimulating oligonucleotides, e.g. CpG
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
    • C12N2501/25Tumour necrosing factors [TNF]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a pharmaceutical composition for inducing an immune response directed against malignancies in a mammalian subject. The composition comprises as active ingredients autologous antigen presenting cell (APC) which were loaded with mixture of at least two allogenic tumor cell line lysates. Optionally, the composition of the invention may further comprise an IL-2 adjuvant. The invention further relates to a method for conferring immunity against a malignancy, in a mammalian subject in need, by administering an autologous antigen presenting cells (APC) loaded with a mixture of allogeneic cell lysates mixture, or a composition comprising the same to said subject. The invention further relates to the use of these loaded APC cells in the preparation of pharmaceutical composition for the treatment of malignant disorders, particularly, melanoma.
PCT/IL2002/000012 2001-01-08 2002-01-06 An autologous anti-cancer vaccine WO2002053176A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002219485A AU2002219485A1 (en) 2001-01-08 2002-01-06 An autologous anti-cancer vaccine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL140796 2001-01-08
IL14079601A IL140796A0 (en) 2001-01-08 2001-01-08 An autologous anti-cancer vaccine

Publications (2)

Publication Number Publication Date
WO2002053176A2 WO2002053176A2 (en) 2002-07-11
WO2002053176A3 true WO2002053176A3 (en) 2002-12-19

Family

ID=11075015

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2002/000012 WO2002053176A2 (en) 2001-01-08 2002-01-06 An autologous anti-cancer vaccine

Country Status (3)

Country Link
AU (1) AU2002219485A1 (en)
IL (1) IL140796A0 (en)
WO (1) WO2002053176A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008121461A2 (en) * 2007-02-26 2008-10-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Vaccine for activating helper function of cd8+ tcells
EA009325B1 (en) 2007-03-07 2007-12-28 Петр Генриевич ЛОХОВ Antitumor vaccine, method for preparing thereof and method for using antitumor immunotherapy
AR060424A1 (en) * 2007-04-11 2008-06-18 Consejo Nac Invest Cient Tec CELLULAR LINES, COMPOSITIONS FOR THE TREATMENT OF MELANOMS THAT UNDERSTAND PROCEDURES TO PREPARE COMPOSITIONS AND TREATMENT METHODS
CL2007002825A1 (en) 2007-09-28 2008-05-30 Univ De Chile Oncobiomed METHOD FOR GENERATING VACCINES THAT STIMULATE THE IMMUNE SYSTEM THAT INCLUDES INDUCTING PERIPHERAL BLOOD MONONUCLEAR CELLS TO BE DIFFERENTIATED FROM APC, THEN, SEPARATE SUCH APC AND MIX THEM WITH ADJUVANTS; EXTRACT OF TUMOR CELLS; AND COMP
WO2012156969A1 (en) * 2011-05-17 2012-11-22 Hadasit Medical Research Services And Development Ltd. Allogeneic tumor cell vaccination
CN104540937A (en) * 2012-02-02 2015-04-22 新干细胞肿瘤学有限责任公司 Pluripotent germ layer origin antigen presenting cancer vaccine
CN103372203B (en) * 2012-04-17 2015-05-06 国家纳米科学中心 Antigen composition, preparation method and application of antigen composition and tumour vaccine
CN109876137A (en) * 2012-11-15 2019-06-14 厦门鹭佳生物科技有限公司 A kind of preparation method and applications of autologous tumor vaccine
CN106456730A (en) * 2014-03-17 2017-02-22 德意志联邦共和国代表主席罗伯特·科赫研究所 A medicament for use in a method of inducing or extending a cellular cytotoxic immune response
CN106795492A (en) * 2015-06-17 2017-05-31 深圳市达科为生物工程有限公司 A kind of preparation method of tumor-specific CTL

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033612A1 (en) * 1996-03-15 1997-09-18 Immunotherapy, Inc. Dialdehydes as immunostimulatory adjuvants and cross-linkers for producing immunogenic preparations and generating pressure and cross-link treated cells for enhancing and augmenting the immune response against cancers, tumors and pathogenic diseases
WO2000040701A2 (en) * 1998-12-31 2000-07-13 Hadasit Medical Research Services And Development Ltd. Non-myeloablative tolerogenic treatment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997033612A1 (en) * 1996-03-15 1997-09-18 Immunotherapy, Inc. Dialdehydes as immunostimulatory adjuvants and cross-linkers for producing immunogenic preparations and generating pressure and cross-link treated cells for enhancing and augmenting the immune response against cancers, tumors and pathogenic diseases
WO2000040701A2 (en) * 1998-12-31 2000-07-13 Hadasit Medical Research Services And Development Ltd. Non-myeloablative tolerogenic treatment

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAKRABORTY N. ET AL.: "Melanoma cell lysate loaded autologous antigen presenting cell (APC) as a vaccine in melanoma", PROC. AM. ASS. CANCER RES., vol. 38, pages 400, XP001080013 *
HERR W. ET AL.: "Mature dendritic cells pulsed with freeze-thaw cell lysates define an effective in vitro vaccine designed to elicit EBY-specific CD4+ and CD8+ T lymphocyte responses", IMMUNOBIOLOGY, vol. 96, no. 5, 2000, pages 1857 - 1864, XP002203121 *
NESTLE F O ET AL: "Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells", NATURE MEDICINE, NATURE PUBLISHING, CO, US, vol. 4, no. 3, March 1998 (1998-03-01), pages 328 - 332, XP002122868, ISSN: 1078-8956 *

Also Published As

Publication number Publication date
AU2002219485A1 (en) 2002-07-16
WO2002053176A2 (en) 2002-07-11
IL140796A0 (en) 2002-02-10

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