WO2003080097A3 - Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 7 (gpr7) - Google Patents

Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 7 (gpr7) Download PDF

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Publication number
WO2003080097A3
WO2003080097A3 PCT/EP2003/002404 EP0302404W WO03080097A3 WO 2003080097 A3 WO2003080097 A3 WO 2003080097A3 EP 0302404 W EP0302404 W EP 0302404W WO 03080097 A3 WO03080097 A3 WO 03080097A3
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WO
WIPO (PCT)
Prior art keywords
gpr7
therapeutics
diagnostics
protein
homo sapiens
Prior art date
Application number
PCT/EP2003/002404
Other languages
French (fr)
Other versions
WO2003080097A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003218713A priority Critical patent/AU2003218713A1/en
Publication of WO2003080097A2 publication Critical patent/WO2003080097A2/en
Publication of WO2003080097A3 publication Critical patent/WO2003080097A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a human GPR7 which is associated with the cardiovascular, hematological, peripheral and central nervous system diseases, COPD, asthma, inflammation, gastro-intestinal diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular, hematological, peripheral and central nervous system diseases, COPD, asthma, inflammation, gastro-intestinal diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR7 as well as pharmaceutical compositions comprising such compounds.
PCT/EP2003/002404 2002-03-22 2003-03-10 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 7 (gpr7) WO2003080097A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003218713A AU2003218713A1 (en) 2002-03-22 2003-03-10 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 7 (gpr7)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02006594 2002-03-22
EP02006594.2 2002-03-22

Publications (2)

Publication Number Publication Date
WO2003080097A2 WO2003080097A2 (en) 2003-10-02
WO2003080097A3 true WO2003080097A3 (en) 2004-03-11

Family

ID=28051728

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/002404 WO2003080097A2 (en) 2002-03-22 2003-03-10 Diagnostics and therapeutics for diseases associated with homo sapiens g - protein - coupled receptor 7 (gpr7)

Country Status (2)

Country Link
AU (1) AU2003218713A1 (en)
WO (1) WO2003080097A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004292444A (en) * 2003-03-13 2004-10-21 Takeda Chem Ind Ltd Preventing and treating agent for upper gastrointestinal tract disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591602A (en) * 1993-11-05 1997-01-07 O'dowd; Brian F. Nucleic acid encoding opioid receptor
WO2001059113A2 (en) * 2000-02-08 2001-08-16 Curagen Corporation G-protein coupled receptor proteins and nucleic acids encoding same
WO2002002637A2 (en) * 2000-06-30 2002-01-10 Curagen Corporation G-protein coupled receptors and nucleic acids encoding same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591602A (en) * 1993-11-05 1997-01-07 O'dowd; Brian F. Nucleic acid encoding opioid receptor
WO2001059113A2 (en) * 2000-02-08 2001-08-16 Curagen Corporation G-protein coupled receptor proteins and nucleic acids encoding same
WO2002002637A2 (en) * 2000-06-30 2002-01-10 Curagen Corporation G-protein coupled receptors and nucleic acids encoding same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZARATIN P F ET AL: "LOCALIZATION OF THE 7TM RECEPTOR GPR7 ON SCHWANN CELLS FROM PATIENTS WITH PERIPHERAL NEUROPATHIES", SOCIETY FOR NEUROSCIENCE ABSTRACTS, SOCIETY FOR NEUROSCIENCE, US, vol. 26, no. 1/2, 2000, pages 66812, XP001096386, ISSN: 0190-5295 *

Also Published As

Publication number Publication date
AU2003218713A8 (en) 2003-10-08
AU2003218713A1 (en) 2003-10-08
WO2003080097A2 (en) 2003-10-02

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