WO2003076907A1 - Vorrichtung zur bestimmung der physikalischen und chemischen parameter von aerosol-formulierungen aus dosieraerosolen - Google Patents
Vorrichtung zur bestimmung der physikalischen und chemischen parameter von aerosol-formulierungen aus dosieraerosolen Download PDFInfo
- Publication number
- WO2003076907A1 WO2003076907A1 PCT/EP2003/001205 EP0301205W WO03076907A1 WO 2003076907 A1 WO2003076907 A1 WO 2003076907A1 EP 0301205 W EP0301205 W EP 0301205W WO 03076907 A1 WO03076907 A1 WO 03076907A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- measuring
- physical
- determining
- chemical parameters
- aerosol
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/22—Devices for withdrawing samples in the gaseous state
- G01N1/2202—Devices for withdrawing samples in the gaseous state involving separation of sample components during sampling
- G01N2001/222—Other features
- G01N2001/2223—Other features aerosol sampling devices
Definitions
- the invention relates to a device for determining the physical and chemical parameters of aerosol formulations from metered dose aerosols (MDI).
- MDI metered dose aerosols
- Dosage aerosols have been shown to prolong the life of medication for patients suffering from asthma, chronic bronchitis or pulmonary emphysema.
- the handy, easy-to-use MDIs are used to deliver a precisely measured dose of the ate pathogen-expanding medication directly to the lungs in acute situations.
- the delivery of an active ingredient by means of metered dose aerosols is not limited to the indicated indications, but is continuously expanded, as is known from research reports.
- These MDIs consist of a metal cartridge, usually an aluminum container, with a metering chamber and valve system and a holder with a mouthpiece.
- blowing agents are required that release the active substances under constant pressure as a finely divided spray, the aerosol.
- the complete formulations contain as Blowing agents fluorinated hydrocarbons, preferably HFKW227ea, HFKWl34a or mixtures thereof.
- the object of the invention is to provide a device with which it is possible to fill the pressurized aerosol formulation without loss into a measuring container, where the physical and chemical parameters can be determined directly by means of inserted probes.
- the device according to the invention comprises
- stirrer at the bottom of the measuring chamber (e.g. magnetic stirrer)
- the MDI opening mechanism includes
- This sleeve is detachably or non-detachably connected to the housing, whereby a connection to the measuring chamber is guaranteed,
- An actuator (6) preferably a screw head for pressing the cartridge onto the needle or the mandrel.
- the cartridge (5) is pressed against the needle (7) by the screw head (6) and thus opened.
- the complete formulation reaches the measuring chamber through an opening connected to the needle.
- a further connection between the sleeve and the measuring chamber can be arranged.
- a measuring electrode (2) e.g. B. to determine the pH.
- the measuring electrode can e.g. B. can also be a conductivity measuring cell, a moisture measuring cell or an ion sensitive electrode.
- the measuring chamber is made of chemical resistant material, e.g. B. stainless steel. It is also within the scope of the invention to provide the measuring chamber with a viewing window.
- the device according to the invention makes it possible to transfer the contents of the cartridge into the measuring chamber without changing the composition of the metered dose aerosol formulation.
- GC gas chromatographs
- hygrometers X-ray spectrometers
- mass spectrometers mass spectrometers
- polarimeters crystal structure analyzers
- calorimeters calorimeters
- refractometers HPLC devices
- NMR devices electrophoresis devices
- devices for measuring the TIC and TOC content devices for recording adsorption in the area of infrared (IR), " ultraviolet (UV), Fourier transformed infrared (FTIR) or measuring arrangements for determining the solubility of the permeation behavior, the thermal conductivity, the contents of individual components (eg by means of AAS) and couplings thereof (e.g. GC-MS, GC-IR, GC-FTIR).
- measuring a GMP-compliant statistical number of samples e.g. reactions which change the homogeneity or pH, as in the example of insulin, e.g. by destroying the insulin.
- the measuring chamber can also be equipped with other sensors or complete measuring systems, the range of changes to be measured, physical and chemical, can be expanded to include these measuring systems.
- a decrease in an aliquot of the total amount is easier to achieve by the apparatus according to the invention than by taking a larger sample through the metering valve.
- the filled metal cartridge was inserted into the sleeve and pressed against the mandrel by means of the actuator, so that the contents of the cartridge thus opened were placed in the measuring chamber was transferred.
- the pH was measured using a pressure-stable measuring electrode. To ensure a homogeneous distribution, the measuring apparatus was moved on a vibrating bench. The measurements were carried out when the apparatus was at a standstill.
- Figure 1 shows a simplified embodiment of the device.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003206858A AU2003206858A1 (en) | 2002-03-13 | 2003-02-07 | Device for determining the physical and chemical parameters of aerosol formulations discharged from metered dosed inhalers |
EP03704566A EP1485695A1 (de) | 2002-03-13 | 2003-02-07 | Vorrichtung zur bestimmung der physikalischen und chemischen parameter von aerosol-formulierungen aus dosieraerosolen |
CA002460767A CA2460767A1 (en) | 2002-03-13 | 2003-02-07 | Device for determining the physical and chemical parameters of aerosol formulations discharged from metered dosed inhalers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE20203999.4 | 2002-03-13 | ||
DE20203999U DE20203999U1 (de) | 2002-03-13 | 2002-03-13 | Vorrichtung zur Bestimmung der physikalischen und chemischen Parameter von Aerosol-Formulierungen aus Dosieraerosolen |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003076907A1 true WO2003076907A1 (de) | 2003-09-18 |
Family
ID=7968891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/001205 WO2003076907A1 (de) | 2002-03-13 | 2003-02-07 | Vorrichtung zur bestimmung der physikalischen und chemischen parameter von aerosol-formulierungen aus dosieraerosolen |
Country Status (6)
Country | Link |
---|---|
US (1) | US20040031486A1 (de) |
EP (1) | EP1485695A1 (de) |
AU (1) | AU2003206858A1 (de) |
CA (1) | CA2460767A1 (de) |
DE (1) | DE20203999U1 (de) |
WO (1) | WO2003076907A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2604995A1 (de) | 2011-12-16 | 2013-06-19 | Deva Holding Anonim Sirketi | Inhaltextraktor für Dosierinhalator |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0320171D0 (en) * | 2003-08-28 | 2003-10-01 | Optinose As | Delivery devices |
SE0303030D0 (sv) * | 2003-11-14 | 2003-11-14 | Astrazeneca Ab | Canister piercer |
WO2008088270A1 (en) * | 2007-01-16 | 2008-07-24 | Astrazeneca Ab | Method and system for analysing a dose formulation of a metered dose device |
EP2561333B1 (de) * | 2010-04-19 | 2015-11-25 | Battelle Memorial Institute | Elektrohydrodynamisches sprühen |
EA039832B1 (ru) * | 2020-12-25 | 2022-03-17 | Общество С Ограниченной Ответственностью "Научно-Производственный Инновационный Внедренческий Центр" Ооо "Нп Ивц" | Модуль генерации аэрозоля ингаляционного устройства |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU546812A1 (ru) * | 1974-08-23 | 1977-02-15 | Предприятие П/Я Р-6900 | Аэрозольно-оптический газоанализатор |
DE19824744A1 (de) * | 1998-06-03 | 1999-03-18 | Schmidt Ott Andreas Prof Dr | Vorrichtung zur Messung des Staubgehalts in Gasen |
US6055052A (en) * | 1998-01-26 | 2000-04-25 | Mie Corporation | System for, and method of, monitoring airborne particulate, including particulate of the PM2.5 class |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2298099A1 (fr) * | 1975-01-15 | 1976-08-13 | Aquitaine Petrole | Dispositif pour la mesure de la masse des particules d'un aerosol par unite de volume |
FR2773884B1 (fr) * | 1998-01-22 | 2000-03-24 | Proengin | Appareil combinant la spectrophotometrie et la detection de l'ionisation d'une flamme, pour l'analyse d'une composition gazeuse |
US6397838B1 (en) * | 1998-12-23 | 2002-06-04 | Battelle Pulmonary Therapeutics, Inc. | Pulmonary aerosol delivery device and method |
-
2002
- 2002-03-13 DE DE20203999U patent/DE20203999U1/de not_active Expired - Lifetime
-
2003
- 2003-02-07 CA CA002460767A patent/CA2460767A1/en not_active Abandoned
- 2003-02-07 AU AU2003206858A patent/AU2003206858A1/en not_active Abandoned
- 2003-02-07 EP EP03704566A patent/EP1485695A1/de not_active Withdrawn
- 2003-02-07 WO PCT/EP2003/001205 patent/WO2003076907A1/de not_active Application Discontinuation
- 2003-03-13 US US10/386,947 patent/US20040031486A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SU546812A1 (ru) * | 1974-08-23 | 1977-02-15 | Предприятие П/Я Р-6900 | Аэрозольно-оптический газоанализатор |
US6055052A (en) * | 1998-01-26 | 2000-04-25 | Mie Corporation | System for, and method of, monitoring airborne particulate, including particulate of the PM2.5 class |
DE19824744A1 (de) * | 1998-06-03 | 1999-03-18 | Schmidt Ott Andreas Prof Dr | Vorrichtung zur Messung des Staubgehalts in Gasen |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch Week 197804, Derwent World Patents Index; Class J04, AN 1978-07901A, XP002245171 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2604995A1 (de) | 2011-12-16 | 2013-06-19 | Deva Holding Anonim Sirketi | Inhaltextraktor für Dosierinhalator |
WO2013087853A1 (en) | 2011-12-16 | 2013-06-20 | Deva Holding Anonim Sirketi | Content extractor for metered dose inhalers |
Also Published As
Publication number | Publication date |
---|---|
DE20203999U1 (de) | 2002-08-22 |
AU2003206858A1 (en) | 2003-09-22 |
US20040031486A1 (en) | 2004-02-19 |
CA2460767A1 (en) | 2003-09-18 |
EP1485695A1 (de) | 2004-12-15 |
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