WO2003074704A1 - Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation - Google Patents

Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation Download PDF

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Publication number
WO2003074704A1
WO2003074704A1 PCT/JP2003/002311 JP0302311W WO03074704A1 WO 2003074704 A1 WO2003074704 A1 WO 2003074704A1 JP 0302311 W JP0302311 W JP 0302311W WO 03074704 A1 WO03074704 A1 WO 03074704A1
Authority
WO
WIPO (PCT)
Prior art keywords
sex hormones
female sex
binding
antigen
tolerance
Prior art date
Application number
PCT/JP2003/002311
Other languages
English (en)
French (fr)
Inventor
Masanao Katagiri
Shigeru Fujimoto
Yasuhiro Goda
Original Assignee
Japan Envirochemicals, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Envirochemicals, Ltd. filed Critical Japan Envirochemicals, Ltd.
Priority to EP03707172A priority Critical patent/EP1486566A4/en
Priority to AU2003211337A priority patent/AU2003211337A1/en
Priority to US10/506,063 priority patent/US20060110771A1/en
Publication of WO2003074704A1 publication Critical patent/WO2003074704A1/ja
Priority to NO20044169A priority patent/NO20044169L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PCT/JP2003/002311 2002-03-01 2003-02-28 Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation WO2003074704A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP03707172A EP1486566A4 (en) 2002-03-01 2003-02-28 FOR BINDING TO FEMALE SEXUAL HORMONES, PROTEINS AND METHOD FOR THE PRODUCTION THEREOF
AU2003211337A AU2003211337A1 (en) 2002-03-01 2003-02-28 Proteins capable of binding to female sex hormones and process for producing the same
US10/506,063 US20060110771A1 (en) 2002-03-01 2003-02-28 Proteins capable of binding to female sex hormones and process for producing the same
NO20044169A NO20044169L (no) 2002-03-01 2004-09-30 Proteiner i stand til a binde kvinnelige kjonnshormoner og fremgangsmate for a produsere de samme

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-55669 2002-03-01
JP2002055669 2002-03-01

Publications (1)

Publication Number Publication Date
WO2003074704A1 true WO2003074704A1 (fr) 2003-09-12

Family

ID=27784617

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/002311 WO2003074704A1 (fr) 2002-03-01 2003-02-28 Proteines capables de se lier aux hormones sexuelles feminines et procede de preparation

Country Status (5)

Country Link
US (1) US20060110771A1 (ja)
EP (1) EP1486566A4 (ja)
AU (1) AU2003211337A1 (ja)
NO (1) NO20044169L (ja)
WO (1) WO2003074704A1 (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL303569A (en) 2010-02-24 2023-08-01 Immunogen Inc Folate receptor 1 antibodies and immunoconjugates and uses thereof
CA2831426C (en) 2011-04-01 2023-02-21 Immunogen, Inc. Methods for increasing efficacy of folr1 cancer therapy
IL299620A (en) 2012-08-31 2023-03-01 Immunogen Inc Tests and diagnostic kits for the detection of folate receptor 1
WO2015031815A2 (en) 2013-08-30 2015-03-05 Immunogen, Inc. Antibodies and assays for detection of folate receptor 1
IL298438A (en) 2015-09-17 2023-01-01 Immunogen Inc Medical combinations containing anti-folr1 immune conjugates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10309198A (ja) * 1997-05-12 1998-11-24 Tosoh Corp 抗体、遺伝子及びキメラ抗体の製法
EP1258729A2 (en) * 2001-05-18 2002-11-20 Takeda Chemical Industries, Ltd. A method of selecting an antibody, a hybridoma, a monoclonal antibody and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI913434A (fi) * 1990-07-16 1992-01-17 Technical Research Centre F Finland Rekombinanta fusionsproteiner vilka utsoendras.
US5342760A (en) * 1992-06-10 1994-08-30 Abbott Laboratories Determination of estradiol by competitive immunoassay
JP3525221B2 (ja) * 1993-02-17 2004-05-10 味の素株式会社 免疫抑制剤
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
IL111748A0 (en) * 1993-12-03 1995-01-24 Zeneca Ltd Proteins
AU5752696A (en) * 1995-05-18 1996-11-29 Regents Of The University Of Michigan, The Dna binding antibodies
US5977319A (en) * 1996-10-21 1999-11-02 Cambridge Antibody Technology Limited Specific binding members for estradiol; materials and methods
US6824780B1 (en) * 1999-10-29 2004-11-30 Genentech, Inc. Anti-tumor antibody compositions and methods of use
EP1514597A1 (en) * 2002-05-31 2005-03-16 Japan Envirochemicals, Ltd. Isolation material for hormone disrupting substance, method of concentrating and method of clean-up

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10309198A (ja) * 1997-05-12 1998-11-24 Tosoh Corp 抗体、遺伝子及びキメラ抗体の製法
EP1258729A2 (en) * 2001-05-18 2002-11-20 Takeda Chemical Industries, Ltd. A method of selecting an antibody, a hybridoma, a monoclonal antibody and use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
AGASAN A.L. ET AL.: "Development of a monoclonal antibody for use in radioimmunoassay of ethynylestradiol", STEROIDS, vol. 47, no. 4-5, April 1986 (1986-04-01) - May 1986 (1986-05-01), pages 295 - 306, XP002969453 *
CUILLERON C.Y. ET AL.: "Specific photoaffinity-labeling of Tyr-50 on the heavy chain and of Tyr-32 on the light chain in the steroid combining site of a mouse monoclonal anti-estradiol antibody using C3-, C6- and C7-linked 5-azido-2-nitrobenzoylamidoestradiol photoreagents", BIOCHEMISTRY, vol. 40, no. 49, 11 December 2001 (2001-12-11), pages 14907 - 14920, XP002969450 *
MASATO HIROBE ET AL.: "Estrone teiryo-yo ELISA no kaihatsu", JAPAN SOCIETY ON WATER ENVIRONMENT NENKAN KOENSHU, 14 March 2002 (2002-03-14), pages 433, XP002969456 *
MONNET C. ET AL.: "Highly specific anti-estradiol antibodies: structural characterization and binding diversity", J. MOL. BIOL., vol. 315, no. 4, 25 January 2002 (2002-01-25), pages 699 - 712, XP002969451 *
NAOHIRO FUJITA ET AL.: "Ko estrogen kotai no kozo to hannosei no kento", SEIKAGAKU, vol. 74, no. 8, 25 August 2002 (2002-08-25), pages 945, XP002969457 *
PAJUNEN M. ET AL.: "Cloning, sequencing, expression and characterization of three anti-estradiol-17beta Fab fragments", BIOCHEM. BIOPHYS. ACTA, vol. 1351, no. 1-2, 20 March 1997 (1997-03-20), pages 192 - 202, XP002969452 *
TAUSSIG M.J. ET AL.: "Blot-sequencing of antibodies: application to analysis of V gene usage among anti-steroid monoclonal atibodies", IMMUNOLOGY, vol. 72, no. 4, April 1991 (1991-04-01), pages 471 - 480, XP002969454 *
YASUHIRO GODA ET AL.: "Josei hormone-yo ELISA shiryo no maeshori-ho kento", GESUIDO KENKYU HAPPYOKAI KOENSHU, vol. 38, 5 June 2001 (2001-06-05), pages 903 - 905, XP002969455 *

Also Published As

Publication number Publication date
AU2003211337A1 (en) 2003-09-16
EP1486566A4 (en) 2005-10-12
EP1486566A1 (en) 2004-12-15
US20060110771A1 (en) 2006-05-25
NO20044169L (no) 2004-11-16

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