WO2003074672A3 - Crebpas as modifiers of cell death pathways and methods of use - Google Patents

Crebpas as modifiers of cell death pathways and methods of use Download PDF

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Publication number
WO2003074672A3
WO2003074672A3 PCT/US2003/006361 US0306361W WO03074672A3 WO 2003074672 A3 WO2003074672 A3 WO 2003074672A3 US 0306361 W US0306361 W US 0306361W WO 03074672 A3 WO03074672 A3 WO 03074672A3
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WO
WIPO (PCT)
Prior art keywords
cell death
methods
crebpas
modifiers
death pathways
Prior art date
Application number
PCT/US2003/006361
Other languages
French (fr)
Other versions
WO2003074672A2 (en
Inventor
Michael A Costa
Dianne Parry
Changyou Chen
Original Assignee
Exelixis Inc
Michael A Costa
Dianne Parry
Changyou Chen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exelixis Inc, Michael A Costa, Dianne Parry, Changyou Chen filed Critical Exelixis Inc
Priority to AU2003213664A priority Critical patent/AU2003213664A1/en
Publication of WO2003074672A2 publication Critical patent/WO2003074672A2/en
Publication of WO2003074672A3 publication Critical patent/WO2003074672A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Human CREBPA genes are identified as modulators of the cell death pathway, and thus are therapeutic targets for disorders associated with defective cell death. Methods for identifying modulators of cell death, comprising screening for agents that modulate the activity of CREBPA are provided.
PCT/US2003/006361 2002-03-01 2003-02-28 Crebpas as modifiers of cell death pathways and methods of use WO2003074672A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003213664A AU2003213664A1 (en) 2002-03-01 2003-02-28 Crebpas as modifiers of cell death pathways and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36081002P 2002-03-01 2002-03-01
US60/360,810 2002-03-01

Publications (2)

Publication Number Publication Date
WO2003074672A2 WO2003074672A2 (en) 2003-09-12
WO2003074672A3 true WO2003074672A3 (en) 2005-04-14

Family

ID=27789029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/006361 WO2003074672A2 (en) 2002-03-01 2003-02-28 Crebpas as modifiers of cell death pathways and methods of use

Country Status (2)

Country Link
AU (1) AU2003213664A1 (en)
WO (1) WO2003074672A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814459A (en) * 1993-02-12 1998-09-29 The Salk Institute For Biological Studies Phosphospecific transcription factor antibodies
US6051559A (en) * 1994-10-07 2000-04-18 Cold Spring Harbor Laboratory Cloning and characterizing of genes associated with long-term memory
US6136596A (en) * 1995-05-19 2000-10-24 University Of Massachusetts Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5814459A (en) * 1993-02-12 1998-09-29 The Salk Institute For Biological Studies Phosphospecific transcription factor antibodies
US6051559A (en) * 1994-10-07 2000-04-18 Cold Spring Harbor Laboratory Cloning and characterizing of genes associated with long-term memory
US6136596A (en) * 1995-05-19 2000-10-24 University Of Massachusetts Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] ZU, ET AL.: "Regulation of trans-activating capacity of CRE-BPa by phorbol ester tumor promoter", XP002984557, Database accession no. NLM8378084 *
ONCOGENE, vol. 8, no. 10, October 1993 (1993-10-01), pages 2749 - 2758 *

Also Published As

Publication number Publication date
WO2003074672A2 (en) 2003-09-12
AU2003213664A1 (en) 2003-09-16
AU2003213664A8 (en) 2003-09-16

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