WO2003074562A3 - Vanilloid receptor (trpv) fusion proteins - Google Patents

Vanilloid receptor (trpv) fusion proteins Download PDF

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Publication number
WO2003074562A3
WO2003074562A3 PCT/GB2003/000895 GB0300895W WO03074562A3 WO 2003074562 A3 WO2003074562 A3 WO 2003074562A3 GB 0300895 W GB0300895 W GB 0300895W WO 03074562 A3 WO03074562 A3 WO 03074562A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptides
vanilloid receptor
vrl3
compounds
ion channel
Prior art date
Application number
PCT/GB2003/000895
Other languages
French (fr)
Other versions
WO2003074562A2 (en
Inventor
John Beresford Davis
Graham Duncan Smith
Original Assignee
Glaxo Group Ltd
John Beresford Davis
Graham Duncan Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0205124A external-priority patent/GB0205124D0/en
Priority claimed from GB0214258A external-priority patent/GB0214258D0/en
Application filed by Glaxo Group Ltd, John Beresford Davis, Graham Duncan Smith filed Critical Glaxo Group Ltd
Priority to AU2003212512A priority Critical patent/AU2003212512A1/en
Publication of WO2003074562A2 publication Critical patent/WO2003074562A2/en
Publication of WO2003074562A3 publication Critical patent/WO2003074562A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention relates to a method of screening for compounds which interact with a heteromeric ion channel comprising an association of Vanilloid receptor 1 (VR1) ion channel subunits and Vanilloid receptor like 3 (VRL3) ion channel subunits. The invention also relates to an isolated heteromeric protein or polypeptide comprising an association of VR1 and VRL3 sequences, to fusion proteins comprising amino acid sequences of VR1 and VRL3 and to the use of such proteins and polypeptides in screening for compounds which activate the polypeptides (activators, agonists or channel openers), inhibit the activity of the polypeptides (inhibitors, antagonists or channel blockers) or which enhance or diminish the binding interactions of the polypeptides with other molecules, e.g. accessory proteins, ligands or co-factors. Such compounds will show utility in therapy, including prophylaxis, of various types of pain or the pain associated with certain diseases.
PCT/GB2003/000895 2002-03-05 2003-03-04 Vanilloid receptor (trpv) fusion proteins WO2003074562A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003212512A AU2003212512A1 (en) 2002-03-05 2003-03-04 Vanilloid receptor (trpv) fusion proteins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0205124A GB0205124D0 (en) 2002-03-05 2002-03-05 Noxious heat receptor
GB0205124.1 2002-03-05
GB0214258A GB0214258D0 (en) 2002-06-20 2002-06-20 Noxious heat receptor
GB0214258.6 2002-06-20

Publications (2)

Publication Number Publication Date
WO2003074562A2 WO2003074562A2 (en) 2003-09-12
WO2003074562A3 true WO2003074562A3 (en) 2003-12-11

Family

ID=27790182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2003/000895 WO2003074562A2 (en) 2002-03-05 2003-03-04 Vanilloid receptor (trpv) fusion proteins

Country Status (2)

Country Link
AU (1) AU2003212512A1 (en)
WO (1) WO2003074562A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037675A1 (en) * 1998-01-22 1999-07-29 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptors
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
WO2000032766A1 (en) * 1998-12-01 2000-06-08 Glaxo Group Limited Human vanilloid receptors and their uses
WO2002000722A2 (en) * 2000-06-26 2002-01-03 Millennium Pharmaceuticals, Inc. Human calcium channels (48000; 52920) and uses thereof
GB2372993A (en) * 2000-11-03 2002-09-11 Smithkline Beecham Plc Vanilloid Receptor 6

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037675A1 (en) * 1998-01-22 1999-07-29 The Regents Of The University Of California Nucleic acid sequences encoding capsaicin receptors
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
WO2000032766A1 (en) * 1998-12-01 2000-06-08 Glaxo Group Limited Human vanilloid receptors and their uses
WO2002000722A2 (en) * 2000-06-26 2002-01-03 Millennium Pharmaceuticals, Inc. Human calcium channels (48000; 52920) and uses thereof
GB2372993A (en) * 2000-11-03 2002-09-11 Smithkline Beecham Plc Vanilloid Receptor 6

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CATERINA M J ET AL: "THE CAPSAICIN RECEPTOR: A HEAT-ACTIVATED ION CHANNEL IN THE PAIN PATHWAY", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 389, 23 October 1997 (1997-10-23), pages 816 - 824, XP002075020, ISSN: 0028-0836 *
JERMAN J C ET AL: "CHARACTERIZATION USING FLIPR OF RAT VANILLOID RECEPTOR (RVR1) PHARMACOLOGY", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 130, no. 4, 2000, pages 916 - 922, XP001064386, ISSN: 0007-1188 *
MONTELL C ET AL: "A unified nomenclature for the superfamily of TRP cation channels", MOLECULAR CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 9, no. 2, February 2002 (2002-02-01), pages 229 - 231, XP002239402, ISSN: 1097-2765 *
SMITH G D ET AL: "TRPV3 is a temperature-sensitive vanilloid receptor-like protein", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 418, no. 6894, 2002, pages 186 - 190, XP002240353, ISSN: 0028-0836 *

Also Published As

Publication number Publication date
AU2003212512A8 (en) 2003-09-16
AU2003212512A1 (en) 2003-09-16
WO2003074562A2 (en) 2003-09-12

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