WO2003074042A1 - Uncoupling protein expression promoter - Google Patents

Uncoupling protein expression promoter Download PDF

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Publication number
WO2003074042A1
WO2003074042A1 PCT/JP2003/002441 JP0302441W WO03074042A1 WO 2003074042 A1 WO2003074042 A1 WO 2003074042A1 JP 0302441 W JP0302441 W JP 0302441W WO 03074042 A1 WO03074042 A1 WO 03074042A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein expression
expression promoter
uncoupling protein
fatty acid
medium
Prior art date
Application number
PCT/JP2003/002441
Other languages
French (fr)
Japanese (ja)
Inventor
Hisami Shinohara
Osamu Noguchi
Fumie Asami
Hatsumi Shimada
Toshiyuki Inui
Original Assignee
The Nisshin Oillio Group, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Nisshin Oillio Group, Ltd. filed Critical The Nisshin Oillio Group, Ltd.
Priority to AU2003211635A priority Critical patent/AU2003211635A1/en
Priority to JP2003572560A priority patent/JPWO2003074042A1/en
Publication of WO2003074042A1 publication Critical patent/WO2003074042A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

It is intended to provide an uncoupling protein expression promoter and foods and drinks containing the uncoupling protein expression promoter. Namely, an uncoupling protein expression promoter containing a medium-chain fatty acid and/or a glycerol fatty acid ester containing a medium-chain fatty acid (preferably a medium-chain fatty acid triglycerol fatty acid ester) as the active ingredient and foods and drinks containing the uncoupling protein expression promoter.
PCT/JP2003/002441 2002-03-04 2003-03-03 Uncoupling protein expression promoter WO2003074042A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003211635A AU2003211635A1 (en) 2002-03-04 2003-03-03 Uncoupling protein expression promoter
JP2003572560A JPWO2003074042A1 (en) 2002-03-04 2003-03-03 Uncoupling protein expression enhancer

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2002-057981 2002-03-04
JP2002057981 2002-03-04
JP2002-260508 2002-09-05
JP2002260508 2002-09-05

Publications (1)

Publication Number Publication Date
WO2003074042A1 true WO2003074042A1 (en) 2003-09-12

Family

ID=27790953

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/002441 WO2003074042A1 (en) 2002-03-04 2003-03-03 Uncoupling protein expression promoter

Country Status (4)

Country Link
JP (1) JPWO2003074042A1 (en)
AU (1) AU2003211635A1 (en)
TW (1) TW200408388A (en)
WO (1) WO2003074042A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007297395A (en) * 2006-05-05 2007-11-15 Softgel Formulators Inc Highly absorbable coenzyme q10 composition and method for producing the same
WO2011135107A1 (en) * 2010-04-26 2011-11-03 Angel Manuel Gago De Santos Compositions for the symptomatic relief of stomach pain or gastro-oesophageal reflux

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502010A (en) * 1987-09-03 1990-07-05 ニュー　イングランド　ディーコネス　ホスピタル　コーポレイション Food Alternatives Utilizing Omega-3 and Intermediate Chain Triglyceride Mixtures
JPH03220123A (en) * 1990-01-22 1991-09-27 Fuji Oil Co Ltd Appetite supressant and food containing the same suppressant
JPH0860180A (en) * 1994-08-25 1996-03-05 Kao Corp Oil and fat composition and food containing the same
JP2001064171A (en) * 1999-08-26 2001-03-13 Kao Corp Deconjugate protein expression inducing agent
JP2002180082A (en) * 2000-12-11 2002-06-26 Maruha Corp Intake material
JP2002188096A (en) * 2000-10-12 2002-07-05 Kanegafuchi Chem Ind Co Ltd New glyceride, method for producing the same and its use
WO2003005836A2 (en) * 2001-07-10 2003-01-23 Trustees Of Boston University Modified-fat nutritional products useful for preventing or treating obesity

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02502010A (en) * 1987-09-03 1990-07-05 ニュー　イングランド　ディーコネス　ホスピタル　コーポレイション Food Alternatives Utilizing Omega-3 and Intermediate Chain Triglyceride Mixtures
JPH03220123A (en) * 1990-01-22 1991-09-27 Fuji Oil Co Ltd Appetite supressant and food containing the same suppressant
JPH0860180A (en) * 1994-08-25 1996-03-05 Kao Corp Oil and fat composition and food containing the same
JP2001064171A (en) * 1999-08-26 2001-03-13 Kao Corp Deconjugate protein expression inducing agent
JP2002188096A (en) * 2000-10-12 2002-07-05 Kanegafuchi Chem Ind Co Ltd New glyceride, method for producing the same and its use
JP2002180082A (en) * 2000-12-11 2002-06-26 Maruha Corp Intake material
WO2003005836A2 (en) * 2001-07-10 2003-01-23 Trustees Of Boston University Modified-fat nutritional products useful for preventing or treating obesity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BABAYAN VIGEN K.: "Medium chain length fatty acid esters and their medical and nutritional applications", JOURNAL OF THE AMERICAN OIL CHEMISTS' SOCIETY, vol. 58, no. 1, 1981, pages 49A - 51A, XP002975356 *
BACH ANDRE C. ET AL.: "The usefulness of dietary medium-chain triglycerides in body weight control: fact or fancy?", JOURNAL OF LIPID RESEARCH, vol. 37, no. 4, 1996, pages 708 - 726, XP002975355 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007297395A (en) * 2006-05-05 2007-11-15 Softgel Formulators Inc Highly absorbable coenzyme q10 composition and method for producing the same
WO2011135107A1 (en) * 2010-04-26 2011-11-03 Angel Manuel Gago De Santos Compositions for the symptomatic relief of stomach pain or gastro-oesophageal reflux

Also Published As

Publication number Publication date
TW200408388A (en) 2004-06-01
JPWO2003074042A1 (en) 2005-06-23
AU2003211635A1 (en) 2003-09-16

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