WO2003070213A3 - Liquid mucoadhesive pharmaceutical composition - Google Patents
Liquid mucoadhesive pharmaceutical composition Download PDFInfo
- Publication number
- WO2003070213A3 WO2003070213A3 PCT/BG2003/000005 BG0300005W WO03070213A3 WO 2003070213 A3 WO2003070213 A3 WO 2003070213A3 BG 0300005 W BG0300005 W BG 0300005W WO 03070213 A3 WO03070213 A3 WO 03070213A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pharmaceutical composition
- composition
- liquid
- prolonged
- mucoadhesive pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Otolaryngology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to liquid mucoadhesive pharmaceutical composition to be applied to the mucosal epithelia with prolonged and improved coating and protection effect. The composition can be used in the medical practice as oral, ocular, nasal, rectal, vaginal and periodontal pharmaceutical preparations. The liquid pharmaceutical composition comprises xylomethazoline.HCl about 0.10 wt.% to 10.00 wt.%, hydroxypropyl methycellulose from 0.01 wt.% to 10 wt.%, disodium ethylenediamine tetraacetate from 0.01 wt.% to 10.00 wt.%, phosphate buffer to 100 wt. % with pH about 5 to 7, the relative viscosity of the solution is about 70.00 to 90.00, and the relative adhesive capacity is 105.0 % to 120.0 %. The composition according to the invention can be applied easilly and has a prolonged contact to the mucosal surface. In this way the composition provides a good therapeutic effect at lower does and has a good bioavailability.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003205460A AU2003205460A1 (en) | 2002-02-22 | 2003-02-18 | Liquid mucoadhesive pharmaceutical composition |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG106430A BG65734B1 (en) | 2002-02-22 | 2002-02-22 | Liquid mucoadhesive pharmaceutical composition |
| BG106430 | 2002-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2003070213A2 WO2003070213A2 (en) | 2003-08-28 |
| WO2003070213A3 true WO2003070213A3 (en) | 2004-03-25 |
Family
ID=27739965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/BG2003/000005 WO2003070213A2 (en) | 2002-02-22 | 2003-02-18 | Liquid mucoadhesive pharmaceutical composition |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2003205460A1 (en) |
| BG (1) | BG65734B1 (en) |
| WO (1) | WO2003070213A2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2423711B (en) | 2005-10-24 | 2007-02-14 | Fortune Apex Dev Ltd | Method for preparing a pharmaceutical composition with enhanced mucoadhesion |
| KR20100017435A (en) | 2007-05-09 | 2010-02-16 | 파마코포어, 인크. | Therapeutic compounds |
| US9539077B1 (en) | 2011-12-05 | 2017-01-10 | Daniel A. Dopps | Method for alternatively resisting and permitting menstrual flow |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603131A (en) * | 1982-04-26 | 1986-07-29 | Bernstein Joel E | Method and composition for treating and preventing irritation of the mucous membranes of the nose |
| EP0550921A1 (en) * | 1991-11-27 | 1993-07-14 | ZAMBON GROUP S.p.A. | Pharmaceutical composition for ophthalmic use comprising a nonsteroidal anti-inflammatory and a decongestant drug |
| US5814655A (en) * | 1996-11-14 | 1998-09-29 | Insite Vision Incorporated | Non-steroidal ophthalmic mixtures |
| WO1999038492A1 (en) * | 1998-01-30 | 1999-08-05 | Novartis Consumer Health S.A. | Nasal solutions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1250421B (en) * | 1991-05-30 | 1995-04-07 | Recordati Chem Pharm | CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH BIO-ADHESIVE PROPERTIES. |
| US5458879A (en) * | 1994-03-03 | 1995-10-17 | The Procter & Gamble Company | Oral vehicle compositions |
| US5976573A (en) * | 1996-07-03 | 1999-11-02 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
| US6319513B1 (en) * | 1998-08-24 | 2001-11-20 | The Procter & Gamble Company | Oral liquid mucoadhesive compounds |
-
2002
- 2002-02-22 BG BG106430A patent/BG65734B1/en unknown
-
2003
- 2003-02-18 WO PCT/BG2003/000005 patent/WO2003070213A2/en not_active Application Discontinuation
- 2003-02-18 AU AU2003205460A patent/AU2003205460A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4603131A (en) * | 1982-04-26 | 1986-07-29 | Bernstein Joel E | Method and composition for treating and preventing irritation of the mucous membranes of the nose |
| EP0550921A1 (en) * | 1991-11-27 | 1993-07-14 | ZAMBON GROUP S.p.A. | Pharmaceutical composition for ophthalmic use comprising a nonsteroidal anti-inflammatory and a decongestant drug |
| US5814655A (en) * | 1996-11-14 | 1998-09-29 | Insite Vision Incorporated | Non-steroidal ophthalmic mixtures |
| WO1999038492A1 (en) * | 1998-01-30 | 1999-08-05 | Novartis Consumer Health S.A. | Nasal solutions |
Also Published As
| Publication number | Publication date |
|---|---|
| BG106430A (en) | 2003-08-29 |
| BG65734B1 (en) | 2009-09-30 |
| WO2003070213A2 (en) | 2003-08-28 |
| AU2003205460A1 (en) | 2003-09-09 |
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