WO2003070154A3 - Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same - Google Patents

Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same Download PDF

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Publication number
WO2003070154A3
WO2003070154A3 PCT/IN2003/000030 IN0300030W WO03070154A3 WO 2003070154 A3 WO2003070154 A3 WO 2003070154A3 IN 0300030 W IN0300030 W IN 0300030W WO 03070154 A3 WO03070154 A3 WO 03070154A3
Authority
WO
WIPO (PCT)
Prior art keywords
weight
formulation
preparing
expectorant
preferred
Prior art date
Application number
PCT/IN2003/000030
Other languages
French (fr)
Other versions
WO2003070154A2 (en
Inventor
Ramachandran Radhakrishnan
Nehru Babu Gaddipati
Original Assignee
Strides Arcolab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/096,709 external-priority patent/US20030158265A1/en
Application filed by Strides Arcolab Ltd filed Critical Strides Arcolab Ltd
Priority to AU2003230190A priority Critical patent/AU2003230190A1/en
Publication of WO2003070154A2 publication Critical patent/WO2003070154A2/en
Publication of WO2003070154A3 publication Critical patent/WO2003070154A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Disclosed are pharmaceutical formulations for oral administration through a soft gelatin capsule drug delivery device, wherein the pharmaceutical formulation, in a preferred embodiment, contains Pseudoephedrine HCl and an expectorant as the active ingredients. The active pharmaceutical ingredient is embedded into an oily matrix. The formulation also includes an expectorant; a surfactant; a suspending agent; and a suspension medium, wherein, in a preferred embodiment, the expectorant is guaifenesin, the surfactant is lecithin, the suspending agent is yellow beeswax, and the suspension medium is soybean oil. In a preferred embodiment, the formulation consists essentially of about 30.5 mg by weight of Pseudoephedrine HCI, about 200 mg by weight of guaifenesin, about 0.1- 5.0 mg by weight of yellow beeswax, about 10-15 mg by weight of lecithin; and about 200-300 mg by weight of soybean oil. Also disclosed is a process for preparing the formulation.
PCT/IN2003/000030 2002-02-20 2003-02-20 Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same WO2003070154A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003230190A AU2003230190A1 (en) 2002-02-20 2003-02-20 Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN127DE2002 2002-02-20
IN127/DEL/2002 2002-02-20
US10/096,709 2002-03-13
US10/096,709 US20030158265A1 (en) 2002-02-20 2002-03-13 Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same

Publications (2)

Publication Number Publication Date
WO2003070154A2 WO2003070154A2 (en) 2003-08-28
WO2003070154A3 true WO2003070154A3 (en) 2004-05-06

Family

ID=27758877

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2003/000030 WO2003070154A2 (en) 2002-02-20 2003-02-20 Orally administrable pharmaceutical formulation comprising pseudoephedrine hydrochloride and process for preparing the same

Country Status (2)

Country Link
AU (1) AU2003230190A1 (en)
WO (1) WO2003070154A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2412865A (en) * 2004-04-07 2005-10-12 Atulkumar Sumanbhai Patel Cough mixture comprising ipecacuanha and guaifenesin

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4716033A (en) * 1986-03-27 1987-12-29 Warner-Lambert Company Medicament adsorbates with surfactant and their preparation
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US5595758A (en) * 1993-06-18 1997-01-21 Smithkline Beecham Corporation Soft-shelled gelatin encapsulated particles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4716033A (en) * 1986-03-27 1987-12-29 Warner-Lambert Company Medicament adsorbates with surfactant and their preparation
US5595758A (en) * 1993-06-18 1997-01-21 Smithkline Beecham Corporation Soft-shelled gelatin encapsulated particles

Also Published As

Publication number Publication date
AU2003230190A1 (en) 2003-09-09
AU2003230190A8 (en) 2003-09-09
WO2003070154A2 (en) 2003-08-28

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