GB2412865A

GB2412865A - Cough mixture comprising ipecacuanha and guaifenesin

Info

Publication number: GB2412865A
Application number: GB0407954A
Authority: GB
Inventors: Atulkumar Sumanbhai Patel
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-04-07
Filing date: 2004-04-07
Publication date: 2005-10-12
Also published as: GB0407954D0

Abstract

A cough mixture comprising ipecacuanha tincture BP and guaifenesin Ph Eur. The mixture may further comprise menthol, liquorice extract and anise oil and may include pseudoephedrine hydrochloride. The mixture may include a sugar-free base syrup and a preservative. In particular the mixture is useful for a person needing to expectorate.

Description

24 1 2865

A COUGH MIXTURE

This invention relates to a cough mixture and, more especially, this invention relates to a cough mixture for a person requiring to expectorate, for example cough up phlegm.

There are various different types of coughs such for example as coughs which are known as dry coughs, coughs which are known as night time coughs, and coughs which require a person to expectorate. There are many different types of known cough mixtures for each type of cough.

Some of the known cough mixtures are more effective than others.

It is an aim of the present invention to provide a new cough mixture which is for a person requiring to expectorate and which is effective.

Accordingly, in one non-limiting embodiment of the present invention there is provided a cough mixture comprising ipecacuanha tincture BP and gualfenesin Ph Eur. The cough mixture of the present invention is especially advantageous for persons having coughs requiring them to expectorate.

The cough mixture may include menthol and/or liquorish extract and/or anise oil.

The cough mixture may comprise per 5ml of total solution: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml such a cough mixture is suitable for a person with a cough requiring the person to expectorate.

For a cough mixture for a person that requires an expectorant and also a decongestant, then the cough mixture may advantageously include pseudophedrine Hcl.

When the pseudophedrine Hcl is present, then the cough mixture may comprise: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml pseudophedrine Hcl 60mg The cough mixtures of the present invention may include at least one sugar-free base syrup.

Two typical sugar-free base syrups are as follows: 1. Malititol syrup Ploysorbate 80 Saccharin Sodium Citric Acid Monohydrate Strawberry Flavouring Purified Water 2. Maltitol Sorbitol Glycerol Cellulose Colouring The cough mixture may include at least one preservative.

The preservative may be included in the sugar-free base syrup.

Thus, for example, the above sugar-free base syrup No. 1 may include sodium methylhydroxybenzoate and sodium propylhydroxybenzoate, and the above sugar-free base syrup No. 2 may include ethyl parahydroxybenzoate, methyl parahydroxybenzoate and propyl parahyd roxybenzoate.

The cough mixture of the present invention is intended for adults and it is not normally intended for children.

Embodiments of the invention will now be described with reference to the accompanying non-limiting Examples.

EXAMPLE I

There was formulated a cough mixture which was for an adult with a cough requiring expectoration. The cough mixture comprised per 5ml of total solution: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml a sugar-free base syrup a preservative The adult was treated with the cough mixture for a period of days until the cough and the need for expectoration disappeared. During the treatment, the cough was kept under control to the benefit of the adult.

EXAMPLE II

There was formulated a cough mixture which was for an adult with a cough requiring expectoration and also decongestion. The cough mixture comprised per 5ml of total solution: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml pseudophedrine Hcl 60mg a sugar-free base syrup a preservative s The adult was treated with the cough mixture for a period of days until the cough and the need for expectoration and decongestion disappeared.

During the treatment, the cough was kept under control to the benefit of the adult.

In Examples I and 11 above, the sugar-free base syrup and the preservative may be combined as one of the following two formulations: 1. Malititol syrup Ploysorbate 80 Saccharin Sodium Citric Acid Monohydrate Sodium Methylhydroxybenzoate Sodium Propylhydroxybenzoate Strawberry Flavouring Purified Water 2. Maltitol Sorbitol Glycerol Cellulose Ethyl Parahydroxybenzoate Methyl Parahydroxybenzoate Propyl Parahydroxybenzoate Colouring A typical formula is as follows: Ascorbic Acid BP 29 Raspberry Flavour 1.5ml Mycasin 804-55 300ml Ethanol BP 25ml Benzoic Acid BP 0.69 Purified Water BP 175ml It is to be appreciated that the embodiments of the invention described above with reference to the accompanying Examples have been given by way of example only and that modifications may be effected. Thus, for example, because the cough mixtures of Examples I and 11 are intended for adults, they do not comprise flavourings. However, flavourings can be added if desired, as indicated by the strawberry flavouring in formulation No. 1 above. Any suitable and appropriate flavourings may be employed such for example as lemon or peppermint as alternatives to strawberry. f

Claims

1. A cough mixture comprising ipecacuanha tincture BP and guaifenesin Ph Eur.

2. A cough mixture according to claim 1 and including menthol.

3. A cough mixture according to claim 1 or claim 2 and including liquorish extract.

A cough mixture according to any one of the preceding claims and including anise oil.

5. A cough mixture according to any one of the preceding claims and comprising per 5ml of total solution: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml

6. A cough mixture according to any one of the preceding claims and including pseudophedrine Hcl.

7. A cough mixture according to claim 6 and comprising per 5ml of total solution: ipecacuanha tincture BP 0.1 ml gualfenesin Ph Eur 100mg menthol 2.5mg liquorish extract 0.25ml anise oil 0.05ml pseudophedrine Hcl 60mg

8. A cough mixture according to any one of the preceding claims and including at least one sugar-free base syrup.

9. A cough mixture according to any one of the preceding claims and including at least one preservative.

10. A cough mixture substantially as herein described with reference to the accompanying Examples.