WO2003069343A3 - Method for the detection of tumor markers cea, ca19.9, or ca72.4 in the stool, allowing diagnosis of gastrointestinal tumors - Google Patents

Method for the detection of tumor markers cea, ca19.9, or ca72.4 in the stool, allowing diagnosis of gastrointestinal tumors Download PDF

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Publication number
WO2003069343A3
WO2003069343A3 PCT/EP2003/001504 EP0301504W WO03069343A3 WO 2003069343 A3 WO2003069343 A3 WO 2003069343A3 EP 0301504 W EP0301504 W EP 0301504W WO 03069343 A3 WO03069343 A3 WO 03069343A3
Authority
WO
WIPO (PCT)
Prior art keywords
stool
tumor markers
detection
gastrointestinal tumors
allowing diagnosis
Prior art date
Application number
PCT/EP2003/001504
Other languages
German (de)
French (fr)
Other versions
WO2003069343A2 (en
Inventor
Hans Scheefers
Original Assignee
Schebo Biotech Ag
Hans Scheefers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schebo Biotech Ag, Hans Scheefers filed Critical Schebo Biotech Ag
Priority to AU2003210274A priority Critical patent/AU2003210274A1/en
Publication of WO2003069343A2 publication Critical patent/WO2003069343A2/en
Publication of WO2003069343A3 publication Critical patent/WO2003069343A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57446—Specifically defined cancers of stomach or intestine

Abstract

The invention relates to methods for the qualitative or/and quantitative detection of CEA, CA 19.9, CA72.4 or parts thereof as tumor markers in human or animal stool, by means of which a malignant activity in the gastrointestinal tract and the abdominal cavity (esophagus, stomach, small intestine, bile ducts, pancreas, and colon) can be diagnosed.
PCT/EP2003/001504 2002-02-14 2003-02-14 Method for the detection of tumor markers cea, ca19.9, or ca72.4 in the stool, allowing diagnosis of gastrointestinal tumors WO2003069343A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003210274A AU2003210274A1 (en) 2002-02-14 2003-02-14 Method for the detection of tumor markers cea, ca19.9, or ca72.4 in the stool, allowing diagnosis of gastrointestinal tumors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10206056.8 2002-02-14
DE10206056 2002-02-14

Publications (2)

Publication Number Publication Date
WO2003069343A2 WO2003069343A2 (en) 2003-08-21
WO2003069343A3 true WO2003069343A3 (en) 2004-12-23

Family

ID=27674624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/001504 WO2003069343A2 (en) 2002-02-14 2003-02-14 Method for the detection of tumor markers cea, ca19.9, or ca72.4 in the stool, allowing diagnosis of gastrointestinal tumors

Country Status (2)

Country Link
AU (1) AU2003210274A1 (en)
WO (1) WO2003069343A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2629071A1 (en) * 2005-12-21 2007-06-28 F. Hoffmann-La Roche Ag Method of assessing colorectal cancer by measuring hemoglobin and m2-pk in a stool sample
DE202012012084U1 (en) 2012-07-09 2013-04-15 Schebo Biotech Ag Test kit (combi rapid test) for the synchronous detection of biomarkers in stool for the detection of pathological changes in the gastrointestinal tract, especially in the intestine
DE102012013888A1 (en) 2012-07-09 2014-05-22 Schebo Biotech Ag Test kit (combi rapid test) for the synchronous detection of biomarkers in stool for the detection of pathological changes in the gastrointestinal tract, especially in the intestine
DE102016015060A1 (en) 2016-12-19 2018-03-29 Schebo Biotech Ag Method for the detection of tumor markers in the stool for the detection of gastrointestinal tumors
DE102018000815A1 (en) 2018-02-01 2019-08-01 Schebo Biotech Ag Method for the detection of biomarkers in the stool for the detection of diseases of the intestinal tract

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4467031A (en) * 1981-08-21 1984-08-21 Hoffmann-La Roche Inc. Enzyme-immunoassay for carcinoembryonic antigen
US4818709A (en) * 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
US5380647A (en) * 1991-02-05 1995-01-10 Farrokh Saidi Simple test for detecting carcinoembryonic antigen in stool
US6331402B1 (en) * 1998-06-26 2001-12-18 Roche Diagnostics Gmbh Reduction of interference of immunoassays by substances derived from the framework regions of antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4467031A (en) * 1981-08-21 1984-08-21 Hoffmann-La Roche Inc. Enzyme-immunoassay for carcinoembryonic antigen
US4818709A (en) * 1983-01-21 1989-04-04 Primus Frederick J CEA-family antigens, Anti-CEA antibodies and CEA immunoassay
US5380647A (en) * 1991-02-05 1995-01-10 Farrokh Saidi Simple test for detecting carcinoembryonic antigen in stool
US6331402B1 (en) * 1998-06-26 2001-12-18 Roche Diagnostics Gmbh Reduction of interference of immunoassays by substances derived from the framework regions of antibodies

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HENSLEE J G ET AL: "IDENTIFICATION AND CHARACTERIZATION OF NEW ANTIGENIC FRAGMENTS RELATED TO CARCINOEMBRYONIC ANTIGEN IN ADULT FECES", CANCER RESEARCH, vol. 52, no. 15, 1992, pages 4175 - 4182, XP001155542, ISSN: 0008-5472 *
KUROKI M ET AL: "REACTION PROFILES OF SEVEN ENZYME IMMUNOASSAY KITS FOR CARCINOEMBRYONIC ANTIGEN CEA ANALYZED WITH PURIFIED PREPARATIONS OF CEA AND RELATED NORMAL ANTIGENS", CLINICAL BIOCHEMISTRY, vol. 25, no. 1, 1992, pages 29 - 35, XP009018874, ISSN: 0009-9120 *
MEI YUAN ET AL: "Fecal detection of tumor-associated antigen S-Tn Tn and CEA in the diagnosis of gastric cancer", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 35, no. 0, 1994, 85th Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 10-13, 1994, 1994, pages 526, XP001155541, ISSN: 0197-016X *
NUNEZ GILDA ET AL: "Enzyme immunoassay to detect carcinoembryonic antigen in human fecal feces", BIOTECNOLOGIA APLICADA, vol. 11, no. 2, 1994, pages 180 - 184, XP009018884 *
STUBBS R S ET AL: "Faecal carcinoembryonic antigen in colorectal cancer patients.", GUT. ENGLAND AUG 1986, vol. 27, no. 8, August 1986 (1986-08-01), pages 901 - 905, XP009018889, ISSN: 0017-5749 *
SUGANO K ET AL: "DETECTION OF INCREASED STOOL CEA AND ITS CHARACTERIZATION AS A MEMBRANE-BOUND FORM IN COLORECTAL CARCINOMA AND OTHER GI TRACT DISORDERS", TUMOR BIOLOGY, vol. 11, no. 1-2, 1990, XVIITH MEETING OF THE INTERNATIONAL SOCIETY FOR ONCODEVELOPMENTAL BIOLOGY AND MEDICINE, FREIBURG, WE, pages 70, XP009018875, ISSN: 1010-4283 *

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Publication number Publication date
WO2003069343A2 (en) 2003-08-21
AU2003210274A1 (en) 2003-09-04

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