WO2003069309A3 - Dosage immunocapteur et fonctionnel pour complexe i mitochondrial - Google Patents

Dosage immunocapteur et fonctionnel pour complexe i mitochondrial Download PDF

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Publication number
WO2003069309A3
WO2003069309A3 PCT/US2003/004567 US0304567W WO03069309A3 WO 2003069309 A3 WO2003069309 A3 WO 2003069309A3 US 0304567 W US0304567 W US 0304567W WO 03069309 A3 WO03069309 A3 WO 03069309A3
Authority
WO
WIPO (PCT)
Prior art keywords
complex
diseases
screening
activity
immunocapture
Prior art date
Application number
PCT/US2003/004567
Other languages
English (en)
Other versions
WO2003069309A2 (fr
Inventor
Michael F Marusich
Roderick A Capaldi
Devin Oglesbee
Original Assignee
Oregon State
Michael F Marusich
Roderick A Capaldi
Devin Oglesbee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon State, Michael F Marusich, Roderick A Capaldi, Devin Oglesbee filed Critical Oregon State
Priority to AU2003211083A priority Critical patent/AU2003211083A1/en
Publication of WO2003069309A2 publication Critical patent/WO2003069309A2/fr
Publication of WO2003069309A3 publication Critical patent/WO2003069309A3/fr
Priority to US10/997,819 priority patent/US20050153381A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Des anomalies du complexe I sont l'une des causes les plus fréquentes de maladies et de troubles associés à des troubles de la chaîne respiratoire mitochondriale, notamment des maladies génétiquement associées, et des maladies neurodégénératives à début tardif. L'invention concerne des méthodes d'utilisation d'anticorps monoclonaux qui réagissent aux sous-unités du complexe I de 39, 30, 20, 18, 15, et 8-kDa de façon à aider à diagnostiquer les carences de complexe I. Ces procédés consistent à effectuer un criblage rapide permettant de détecter le début d'une variété de maladies ou la phase dans laquelle elle se trouve. L'invention concerne en outre des procédés de criblage d'agents, tels que des médicaments, pour déterminer leur effet sur l'activité du complexe I et des procédés de dépistage de patients dont l'activité du complexe I est altérée et de patients suspects d'avoir une maladie à début tardif associée à la modification post-translationnelle d'au moins une sous-unité du complexe I.
PCT/US2003/004567 2002-02-14 2003-02-14 Dosage immunocapteur et fonctionnel pour complexe i mitochondrial WO2003069309A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2003211083A AU2003211083A1 (en) 2002-02-14 2003-02-14 Immunocapture and functional assay for mitochondrial complex i
US10/997,819 US20050153381A1 (en) 2002-02-14 2004-11-24 Immunocapture of mitochondrial protein complexes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35744102P 2002-02-14 2002-02-14
US60/357,441 2002-02-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US91725404A Continuation 2002-02-14 2004-08-11

Publications (2)

Publication Number Publication Date
WO2003069309A2 WO2003069309A2 (fr) 2003-08-21
WO2003069309A3 true WO2003069309A3 (fr) 2003-12-31

Family

ID=27734751

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/004567 WO2003069309A2 (fr) 2002-02-14 2003-02-14 Dosage immunocapteur et fonctionnel pour complexe i mitochondrial

Country Status (2)

Country Link
AU (1) AU2003211083A1 (fr)
WO (1) WO2003069309A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005976A1 (fr) * 1987-12-22 1989-06-29 Pharmacia Ab Procede de diagnostic de la cirrhose bilaire primaire et anticorps adaptes pour etre utilises dans ledit procede
US5888498A (en) * 1995-03-03 1999-03-30 Mitokor Cellular and animal models for diseases associated with mitochondrial defects

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989005976A1 (fr) * 1987-12-22 1989-06-29 Pharmacia Ab Procede de diagnostic de la cirrhose bilaire primaire et anticorps adaptes pour etre utilises dans ledit procede
US5888498A (en) * 1995-03-03 1999-03-30 Mitokor Cellular and animal models for diseases associated with mitochondrial defects

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FANG ET AL.: "Isolation and characterization of complex I, rotenone-sensitive NADH:ubiquinone oxidoreductase, from the procyclic forms of trypanosoma brucei", EUR. J. BIOCHEM., vol. 268, 2001, pages 3075 - 3082, XP002967161 *
PETTUS ET AL.: "Immunocytochemical characterization of the mitochondrially encoded ND1 subunit of complex I (NADH;Ubiquinone oxidoreductase) in rat brain", JOURNAL OF NEUROCHEMISTRY, vol. 75, no. 1, 2000, pages 383 - 392, XP002967160 *
WILLIAMS ET AL.: "Immunological phenotyping of fibroblast cultures from patients with a mitochondrial respiratory chain deficit", LABORATORY INVESTIGATION, vol. 81, 2001, pages 1069 - 1077, XP002967159 *

Also Published As

Publication number Publication date
AU2003211083A1 (en) 2003-09-04
AU2003211083A8 (en) 2003-09-04
WO2003069309A2 (fr) 2003-08-21

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