WO2003067256A3 - Systems for analyzing microtissue arrays - Google Patents

Systems for analyzing microtissue arrays Download PDF

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Publication number
WO2003067256A3
WO2003067256A3 PCT/US2003/003565 US0303565W WO03067256A3 WO 2003067256 A3 WO2003067256 A3 WO 2003067256A3 US 0303565 W US0303565 W US 0303565W WO 03067256 A3 WO03067256 A3 WO 03067256A3
Authority
WO
WIPO (PCT)
Prior art keywords
images
microarray
analyze
tissue
samples
Prior art date
Application number
PCT/US2003/003565
Other languages
French (fr)
Other versions
WO2003067256A2 (en
Inventor
David J Foran
Wenjin Chen
Original Assignee
Univ New Jersey Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New Jersey Med filed Critical Univ New Jersey Med
Priority to AU2003209023A priority Critical patent/AU2003209023A1/en
Publication of WO2003067256A2 publication Critical patent/WO2003067256A2/en
Publication of WO2003067256A3 publication Critical patent/WO2003067256A3/en

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/70—Determining position or orientation of objects or cameras
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate

Landscapes

  • Engineering & Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Analysis (AREA)

Abstract

A tissue microarray imaging system autonomously images, analyzes, and stores data for samples in a tissue microarray. The system may include a tissue microarray, a robotic microscope, and an imaging workstation that executes software to automatically control operation of the microscope to capture images from the microarray and analyze image results. A low magnification may be used to register samples within the microarray and obtain coordinates for each tissue specimen. Progressively higher magnifications may be used to analyze images of each registered specimen. Where multiple dyes are used to stain specimens, color separation techniques may be applied to independently measure and analyze each staining intensity. Images and quantitative data from the images may then be stored in a relational database for subsequent review. The system may be local, or may be Web-based for distributed control and sharing of results.
PCT/US2003/003565 2002-02-05 2003-02-05 Systems for analyzing microtissue arrays WO2003067256A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209023A AU2003209023A1 (en) 2002-02-05 2003-02-05 Systems for analyzing microtissue arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/072,470 US7079673B2 (en) 2002-02-05 2002-02-05 Systems for analyzing microtissue arrays
US10/072,470 2002-02-05

Publications (2)

Publication Number Publication Date
WO2003067256A2 WO2003067256A2 (en) 2003-08-14
WO2003067256A3 true WO2003067256A3 (en) 2003-10-16

Family

ID=27659489

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003565 WO2003067256A2 (en) 2002-02-05 2003-02-05 Systems for analyzing microtissue arrays

Country Status (3)

Country Link
US (1) US7079673B2 (en)
AU (1) AU2003209023A1 (en)
WO (1) WO2003067256A2 (en)

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US20020150966A1 (en) * 2001-02-09 2002-10-17 Muraca Patrick J. Specimen-linked database
CN1306258C (en) * 2004-06-22 2007-03-21 浙江大学 Process for preparing tissue chips and apparatus thereof
US7858382B2 (en) * 2005-05-27 2010-12-28 Vidar Systems Corporation Sensing apparatus having rotating optical assembly
US7873193B2 (en) * 2005-06-21 2011-01-18 Carl Zeiss Microimaging Gmbh Serial section analysis for computer-controlled microscopic imaging
US7528374B2 (en) * 2006-03-03 2009-05-05 Vidar Systems Corporation Sensing apparatus having optical assembly that collimates emitted light for detection
GB0701201D0 (en) * 2007-01-22 2007-02-28 Cancer Rec Tech Ltd Cell mapping and tracking
US8131076B2 (en) * 2007-06-14 2012-03-06 Siemens Aktiengesellschaft Editing of pre-segmented images using seeds derived from contours
US20090238435A1 (en) * 2008-03-21 2009-09-24 Applied Imaging Corp. Multi-Exposure Imaging for Automated Fluorescent Microscope Slide Scanning
US8063385B2 (en) * 2009-05-29 2011-11-22 General Electric Company Method and apparatus for ultraviolet scan planning
WO2010148152A2 (en) * 2009-06-16 2010-12-23 Ikonisys, Inc. System and method for remote control of a microscope
WO2012107497A1 (en) * 2011-02-08 2012-08-16 Quentiq AG System, method and apparatus for the remote analysis of chemical compound microarrays
WO2013119838A1 (en) 2012-02-10 2013-08-15 Inscopix, Inc. Systems and methods for distributed video microscopy
WO2015157246A2 (en) * 2014-04-07 2015-10-15 Massachusetts Institute Of Technology Use of microparticle additives to simultaneously enable artifact-free image registration, auto-focusing, and chromatic aberration correction in microscopy

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US6272235B1 (en) * 1997-03-03 2001-08-07 Bacus Research Laboratories, Inc. Method and apparatus for creating a virtual microscope slide
WO1999030264A1 (en) * 1997-12-11 1999-06-17 Bellsouth Intellectual Property Corporation Digital telepathology imaging system programmed for identifying image regions of potential interest and anticipating sequence of image acquisition
WO1999044063A2 (en) * 1998-02-25 1999-09-02 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Tumor tissue microarrays for rapid molecular profiling

Also Published As

Publication number Publication date
AU2003209023A1 (en) 2003-09-02
US7079673B2 (en) 2006-07-18
US20030147552A1 (en) 2003-08-07
WO2003067256A2 (en) 2003-08-14

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