WO2003066067A3 - Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases - Google Patents
Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases Download PDFInfo
- Publication number
- WO2003066067A3 WO2003066067A3 PCT/IB2003/000932 IB0300932W WO03066067A3 WO 2003066067 A3 WO2003066067 A3 WO 2003066067A3 IB 0300932 W IB0300932 W IB 0300932W WO 03066067 A3 WO03066067 A3 WO 03066067A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- releasing compounds
- treatment
- medicament
- manufacture
- inflammatory diseases
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 2
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 229940124599 anti-inflammatory drug Drugs 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/603—Salicylic acid; Derivatives thereof having further aromatic rings, e.g. diflunisal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
- C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0307420A BR0307420A (en) | 2002-02-04 | 2003-02-03 | Compounds, pharmaceutical compositions and methods for preventing and / or treating mammalian disease |
JP2003565491A JP2005519928A (en) | 2002-02-04 | 2003-02-03 | Method for treating mammals by administration of a compound having CO releasing ability, compound having CO releasing ability and pharmaceutical composition thereof |
AU2003208525A AU2003208525B9 (en) | 2002-02-04 | 2003-02-03 | Amend the invention title to read Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof |
NZ534912A NZ534912A (en) | 2002-02-04 | 2003-02-03 | supramolecule aggregate comprising CO containing organometallic or transition metal complex and anti-inflammatory agent or biphosphonate phosphonate derivative |
CA 2475209 CA2475209A1 (en) | 2002-02-04 | 2003-02-03 | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
EP03706818A EP1476168A2 (en) | 2002-02-04 | 2003-02-03 | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35323302P | 2002-02-04 | 2002-02-04 | |
US60/353,233 | 2002-02-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003066067A2 WO2003066067A2 (en) | 2003-08-14 |
WO2003066067A3 true WO2003066067A3 (en) | 2004-02-05 |
Family
ID=27734286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2003/000932 WO2003066067A2 (en) | 2002-02-04 | 2003-02-03 | Use of co-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
Country Status (11)
Country | Link |
---|---|
US (4) | US7011854B2 (en) |
EP (3) | EP2319518A1 (en) |
JP (1) | JP2005519928A (en) |
CN (1) | CN1646140A (en) |
AU (2) | AU2003208525B9 (en) |
BR (1) | BR0307420A (en) |
CA (1) | CA2475209A1 (en) |
NZ (1) | NZ534912A (en) |
RU (1) | RU2004126950A (en) |
WO (1) | WO2003066067A2 (en) |
ZA (1) | ZA200406711B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9023402B2 (en) | 2002-02-04 | 2015-05-05 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for treating a mammal by administration of a compound having the ability to release CO |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8128963B2 (en) * | 1996-09-27 | 2012-03-06 | The Trustees Of Columbia University In The City Of New York | Methods for treating ischemic disorders using carbon monoxide |
US7678390B2 (en) * | 1999-04-01 | 2010-03-16 | Yale University | Carbon monoxide as a biomarker and therapeutic agent |
US20040014099A1 (en) * | 2001-03-19 | 2004-01-22 | Decode Genetics Ehf. | Susceptibility gene for human stroke; methods of treatment |
GB0111872D0 (en) * | 2001-05-15 | 2001-07-04 | Northwick Park Inst For Medica | Therapeutic agents and methods |
ES2316583T3 (en) * | 2001-06-21 | 2009-04-16 | Beth Israel Deaconess Medical Center, Inc. | CARBON MONOXIDE IMPROVES RESULTS OF TISSUE AND ORGAN TRANSPLANTS AND SUPPRESSES ADOPTOSIS. |
US7968605B2 (en) * | 2002-02-04 | 2011-06-28 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
US20080026984A1 (en) * | 2002-02-04 | 2008-01-31 | Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
EP1480658B1 (en) * | 2002-02-13 | 2017-01-25 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating vascular disease |
RS91104A (en) | 2002-04-15 | 2007-02-05 | University Of Pittsburgh Of The Commonwealth System Of Higher Education, | Methods of treating necrotizing enterocolitis |
ES2546280T3 (en) * | 2002-04-15 | 2015-09-22 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Carbon monoxide for use in a method to treat ileus |
US8097585B2 (en) | 2002-04-15 | 2012-01-17 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating inflammation by administration of heme oxygenase-1 and products of heme degradation |
RS99304A (en) * | 2002-05-17 | 2007-04-10 | Yale University, | Methods of treating hepatitis |
EP1509237A4 (en) * | 2002-06-05 | 2006-07-12 | Univ Yale | Methods of treating angiogenesis, tumor growth, and metastasis |
US20040228930A1 (en) * | 2002-11-07 | 2004-11-18 | Billiar Timothy R. | Treatment for hemorrhagic shock |
GB2395432B (en) * | 2002-11-20 | 2005-09-14 | Northwick Park Inst For Medica | Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs |
EP1445886B1 (en) | 2003-01-31 | 2015-05-20 | Ntt Docomo, Inc. | Multiple-output multiple-input (MIMO) communication system, MIMO receiver and MIMO receiving method |
JP2007501209A (en) * | 2003-08-04 | 2007-01-25 | ノースウィック パーク インスティテュート フォー メディカル リサーチ | Use of boranocarbonate for the release of carbon monoxide for therapeutic purposes |
US7462405B2 (en) * | 2003-12-05 | 2008-12-09 | Eastman Kodak Company | Organic element for electroluminescent devices |
US20050196868A1 (en) * | 2004-03-03 | 2005-09-08 | The Charlotte-Mecklenburg Hospital Authority | Use of free hemoglobin and its surrogate markers to detect and monitor pulmonary hypertension |
US20080311189A1 (en) * | 2004-03-18 | 2008-12-18 | Matos Marta R P Norton | Compositions Comprising Organometallic Molybdenum Compounds For Treating Cancer |
WO2007073225A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda. | Molybdenum carbonyl complexes for treating rheumatoid arthritis and other inflammatory diseases |
WO2007073226A1 (en) * | 2005-12-20 | 2007-06-28 | Alfama - Investigação E Desenvolvimento De Produtos Farmacêuticos Lda | Method for treating a mammal by administration of a compound having the ability to release co |
GB0601394D0 (en) * | 2006-01-24 | 2006-03-01 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
DE102006020492A1 (en) * | 2006-04-21 | 2007-10-25 | Novalung Gmbh | Use of acetylsalicylic acid (ASA) when using a membrane lung |
GB0613362D0 (en) * | 2006-07-05 | 2006-08-16 | Hemocorm Ltd | Therapeutic delivery of carbon monoxide |
AU2007328549A1 (en) * | 2006-12-06 | 2008-06-12 | Alfama - Investigacao E Desenvolvimento De Produtos Farmaceuticos Lda | Methods for treating inflammatory disease by administering aldehydes and derivatives thereof |
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US8927750B2 (en) | 2011-02-04 | 2015-01-06 | Universitaet Zu Koeln | Acyloxy- and phosphoryloxy-butadiene-Fe(CO)3 complexes as enzyme-triggered co-releasing molecules |
KR101398368B1 (en) | 2011-03-16 | 2014-05-22 | 울산대학교 산학협력단 | Composition comprising carbon monoxide or carbon monoxide donor for preventing or treating menopausal syndrome |
EP2734235B1 (en) | 2011-07-21 | 2017-03-22 | Alfama, Inc. | Ruthenium carbon monoxide releasing molecules and uses thereof |
CN102850403B (en) * | 2012-05-29 | 2015-01-14 | 嘉兴学院 | Water-soluble iron carbonyl compound, and preparation method and application thereof |
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US10300069B2 (en) | 2014-06-09 | 2019-05-28 | Georgia State University Research Foundation, Inc. | Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using thereof |
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CN107625954A (en) * | 2016-07-19 | 2018-01-26 | 上海本素医药科技有限公司 | Homopure containing carbon monoxide and its application in anti-inflammatory |
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US10500217B2 (en) | 2018-04-30 | 2019-12-10 | Leslie Ray Matthews, M.D., Llc | Vitamin D3, heat shock proteins, and glutathione for the treatment of chronic inflammation and chronic diseases |
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CN113620983B (en) * | 2021-09-02 | 2022-05-27 | 山西大学 | Light-operated organic CO donor molecule and preparation method and application thereof |
CN115010939B (en) * | 2022-04-22 | 2023-04-28 | 深圳先进技术研究院 | Carbonyl siderophore capable of responding to release of carbon monoxide and preparation method and application thereof |
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US5882674A (en) * | 1994-06-18 | 1999-03-16 | Lts Lohmann Therapie-Systeme Gmbh | Transdermal therapeutic system comprising active substances representing carbon monoxide sources |
WO2002092075A2 (en) * | 2001-05-15 | 2002-11-21 | Northwick Park Institute For Medical Research | Therapeutic delivery of carbon monoxide |
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- 2003-02-03 US US10/356,738 patent/US7011854B2/en not_active Expired - Fee Related
- 2003-02-03 CA CA 2475209 patent/CA2475209A1/en not_active Abandoned
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US9023402B2 (en) | 2002-02-04 | 2015-05-05 | ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. | Method for treating a mammal by administration of a compound having the ability to release CO |
US9163044B2 (en) | 2011-04-19 | 2015-10-20 | Alfama, Inc. | Carbon monoxide releasing molecules and uses thereof |
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EP2042181A1 (en) | 2009-04-01 |
US20040067261A1 (en) | 2004-04-08 |
US20060233890A1 (en) | 2006-10-19 |
WO2003066067A2 (en) | 2003-08-14 |
US20060148900A1 (en) | 2006-07-06 |
NZ534912A (en) | 2007-08-31 |
BR0307420A (en) | 2004-12-21 |
CA2475209A1 (en) | 2003-08-14 |
US7011854B2 (en) | 2006-03-14 |
US20110237546A1 (en) | 2011-09-29 |
US7964220B2 (en) | 2011-06-21 |
AU2009202682A1 (en) | 2009-07-23 |
EP1476168A2 (en) | 2004-11-17 |
AU2003208525B2 (en) | 2009-04-02 |
AU2003208525A1 (en) | 2003-09-02 |
US9023402B2 (en) | 2015-05-05 |
AU2003208525B9 (en) | 2009-08-27 |
EP2319518A1 (en) | 2011-05-11 |
ZA200406711B (en) | 2006-05-31 |
RU2004126950A (en) | 2005-06-27 |
JP2005519928A (en) | 2005-07-07 |
CN1646140A (en) | 2005-07-27 |
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