WO2003065045A3 - Diagnostics and therapeutics for diseases associated with the gpr65 receptor - Google Patents

Diagnostics and therapeutics for diseases associated with the gpr65 receptor Download PDF

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Publication number
WO2003065045A3
WO2003065045A3 PCT/EP2003/000477 EP0300477W WO03065045A3 WO 2003065045 A3 WO2003065045 A3 WO 2003065045A3 EP 0300477 W EP0300477 W EP 0300477W WO 03065045 A3 WO03065045 A3 WO 03065045A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
receptor
gpr65
genito
disorders
Prior art date
Application number
PCT/EP2003/000477
Other languages
French (fr)
Other versions
WO2003065045A2 (en
Inventor
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Original Assignee
Bayer Healthcare Ag
Stefan Golz
Ulf Brueggemeier
Andreas Geerts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Ag, Stefan Golz, Ulf Brueggemeier, Andreas Geerts filed Critical Bayer Healthcare Ag
Priority to AU2003206749A priority Critical patent/AU2003206749A1/en
Publication of WO2003065045A2 publication Critical patent/WO2003065045A2/en
Publication of WO2003065045A3 publication Critical patent/WO2003065045A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to a polynucleotide sequence of a novel G-Protein Coupled Receptor GPR65 receptor. The invention also provides the human GPR65 receptor associated with the hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, genito-urinary diseases, inflammation diseases and cancer. The invention also provides assays for the identification of compounds useful for the modulation of hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, genito-urinary diseases, inflammation diseases and cancer for treating or preventing hematological diseases, cardiovascular diseases, disorders of the peripheral and central nervous system, genito-urinary diseases, inflammation diseases and cancer associated with expression of the GPR65 receptor.
PCT/EP2003/000477 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with the gpr65 receptor WO2003065045A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003206749A AU2003206749A1 (en) 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with the gpr65 receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02001943 2002-02-01
EP02001943.6 2002-02-01

Publications (2)

Publication Number Publication Date
WO2003065045A2 WO2003065045A2 (en) 2003-08-07
WO2003065045A3 true WO2003065045A3 (en) 2004-02-19

Family

ID=27635781

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000477 WO2003065045A2 (en) 2002-02-01 2003-01-20 Diagnostics and therapeutics for diseases associated with the gpr65 receptor

Country Status (2)

Country Link
AU (1) AU2003206749A1 (en)
WO (1) WO2003065045A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005024057A1 (en) * 2003-09-10 2005-03-17 Galapagos Genomics N.V. Method of identifying a compound that changes the amyloid-beta precursor protein processing in a cell
WO2008101354A1 (en) * 2007-02-22 2008-08-28 Merck Frosst Canada Ltd Gpr65 as a therapeutic target in allergic airway inflammation
AU2015222944A1 (en) * 2014-02-27 2016-09-08 Massachusetts Institute Of Technology T cell balance gene expression, compositions of matters and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039442A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. G-protein receptor htnad29
WO1998032858A2 (en) * 1997-01-23 1998-07-30 Schering Corporation Mammalian chemokines; receptors; reagents; uses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039442A1 (en) * 1995-06-06 1996-12-12 Human Genome Sciences, Inc. G-protein receptor htnad29
WO1998032858A2 (en) * 1997-01-23 1998-07-30 Schering Corporation Mammalian chemokines; receptors; reagents; uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRALER M H ET AL: "Lysophospholipids and their G protein-coupled receptors in inflammation and immunity", BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS 23 MAY 2002 NETHERLANDS, vol. 1582, no. 1-3, 23 May 2002 (2002-05-23), pages 168 - 174, XP004366537, ISSN: 1388-1981 *
IM DONG-SOON ET AL: "Identification of a molecular target of psychosine and its role in globoid cell formation.", JOURNAL OF CELL BIOLOGY, vol. 153, no. 2, 16 April 2001 (2001-04-16), pages 429 - 434, XP002252776, ISSN: 0021-9525 *

Also Published As

Publication number Publication date
AU2003206749A1 (en) 2003-09-02
WO2003065045A2 (en) 2003-08-07

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