WO2003064587A3 - Hif-1 alpha proteins mutated in the c-terminal transactivation domain - Google Patents

Hif-1 alpha proteins mutated in the c-terminal transactivation domain Download PDF

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Publication number
WO2003064587A3
WO2003064587A3 PCT/SE2003/000030 SE0300030W WO03064587A3 WO 2003064587 A3 WO2003064587 A3 WO 2003064587A3 SE 0300030 W SE0300030 W SE 0300030W WO 03064587 A3 WO03064587 A3 WO 03064587A3
Authority
WO
WIPO (PCT)
Prior art keywords
hif
alpha
transactivation
transactivation domain
terminal transactivation
Prior art date
Application number
PCT/SE2003/000030
Other languages
French (fr)
Other versions
WO2003064587A2 (en
Inventor
Jorge L Ruas
Lorenz Poellinger
Teresa Pereira
Original Assignee
Angio Genetics Sweden Ab
Jorge L Ruas
Lorenz Poellinger
Teresa Pereira
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angio Genetics Sweden Ab, Jorge L Ruas, Lorenz Poellinger, Teresa Pereira filed Critical Angio Genetics Sweden Ab
Priority to AU2003201798A priority Critical patent/AU2003201798A1/en
Publication of WO2003064587A2 publication Critical patent/WO2003064587A2/en
Publication of WO2003064587A3 publication Critical patent/WO2003064587A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

D-leucine repeats in the C-terminal transactivation domain (C-TAD) of hypoxia-inducible factor-1 alpha (HIF-1 alpha) are critical for transactivation, coactivator interaction and intranuclear trafficking. Further, CBP regulates the intranuclear distribution of HIF-1 alpha and SRC-1. These findings provide new ways to increase HIF-1 alpha transactivation capacity, inhibit HIF-1 alpha activity, and screen substances that may be capable of altering the HIF-1 alpha transactivation response. Further, they provide novel methods and products that can be used to cause substances to be hypoxia-inducible when in their native state they are not.
PCT/SE2003/000030 2002-01-11 2003-01-13 Hif-1 alpha proteins mutated in the c-terminal transactivation domain WO2003064587A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003201798A AU2003201798A1 (en) 2002-01-11 2003-01-13 Hif-1 alpha proteins mutated in the c-terminal transactivation domain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34697602P 2002-01-11 2002-01-11
US60/346,976 2002-01-11

Publications (2)

Publication Number Publication Date
WO2003064587A2 WO2003064587A2 (en) 2003-08-07
WO2003064587A3 true WO2003064587A3 (en) 2003-11-13

Family

ID=27662960

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2003/000030 WO2003064587A2 (en) 2002-01-11 2003-01-13 Hif-1 alpha proteins mutated in the c-terminal transactivation domain

Country Status (2)

Country Link
AU (1) AU2003201798A1 (en)
WO (1) WO2003064587A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106366173A (en) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 Chromatin peptide for controlling expression of anoxic reaction gene through combining hypoxic response element

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029437A1 (en) * 1998-11-13 2000-05-25 Pharmacia Ab HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS
WO2000074725A1 (en) * 1999-06-04 2000-12-14 Dana-Farber Cancer Institute, Inc. Identification of compounds that modify transcriptional responses to hypoxia

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029437A1 (en) * 1998-11-13 2000-05-25 Pharmacia Ab HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS
WO2000074725A1 (en) * 1999-06-04 2000-12-14 Dana-Farber Cancer Institute, Inc. Identification of compounds that modify transcriptional responses to hypoxia

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JIE GU ET AL.: "Molecular mechanism of hypoxia-inducible factor 1alpha-p300 interaction", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 5, 2001, pages 3550 - 3554 *
JORGE L. ET AL.: "Functional analysis of hypoxia-inducible factor-1alpha-mediated transactivation", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 41, October 2002 (2002-10-01), pages 38723 - 38730, XP055016537, DOI: doi:10.1074/jbc.M205051200 *
O'ROURKE JOHN F. ET AL.: "Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1alpha", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 4, 1999, pages 2060 - 2071, XP002304818, DOI: doi:10.1074/jbc.274.4.2060 *
PILAR CARRERO ET AL.: "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 1, 2000, pages 402 - 415 *

Also Published As

Publication number Publication date
AU2003201798A1 (en) 2003-09-02
WO2003064587A2 (en) 2003-08-07

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