WO2003064452A3 - Method for the preparation of highly branched polypeptides - Google Patents

Method for the preparation of highly branched polypeptides Download PDF

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Publication number
WO2003064452A3
WO2003064452A3 PCT/EP2003/000899 EP0300899W WO03064452A3 WO 2003064452 A3 WO2003064452 A3 WO 2003064452A3 EP 0300899 W EP0300899 W EP 0300899W WO 03064452 A3 WO03064452 A3 WO 03064452A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
highly branched
polypeptides
branched polypeptides
carboxyanhydrides
Prior art date
Application number
PCT/EP2003/000899
Other languages
French (fr)
Other versions
WO2003064452A2 (en
Inventor
Harm-Anton Klok
Juan Rodriguez-Hernandez
Klaus Muellen
Original Assignee
Max Planck Gesellschaft
Harm-Anton Klok
Juan Rodriguez-Hernandez
Klaus Muellen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Harm-Anton Klok, Juan Rodriguez-Hernandez, Klaus Muellen filed Critical Max Planck Gesellschaft
Priority to AU2003205707A priority Critical patent/AU2003205707A1/en
Publication of WO2003064452A2 publication Critical patent/WO2003064452A2/en
Publication of WO2003064452A3 publication Critical patent/WO2003064452A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a method for the preparation of highly branched or dendritic graft polypeptides from alpha-amino acid N-carboxyanhydrides (NCA), to the polypeptides obtainable with said method and the use of the polypeptides as therapeutic or diagnostic agents.
PCT/EP2003/000899 2002-01-29 2003-01-29 Method for the preparation of highly branched polypeptides WO2003064452A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003205707A AU2003205707A1 (en) 2002-01-29 2003-01-29 Method for the preparation of highly branched polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02002204.2 2002-01-29
EP02002204 2002-01-29

Publications (2)

Publication Number Publication Date
WO2003064452A2 WO2003064452A2 (en) 2003-08-07
WO2003064452A3 true WO2003064452A3 (en) 2004-01-22

Family

ID=27635784

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/000899 WO2003064452A2 (en) 2002-01-29 2003-01-29 Method for the preparation of highly branched polypeptides

Country Status (2)

Country Link
AU (1) AU2003205707A1 (en)
WO (1) WO2003064452A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970881A (en) * 2019-03-01 2019-07-05 暨南大学 3D printing realizing controlled-release nitric oxide nano-bracket material and preparation method and application

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
FR2885130B1 (en) * 2005-04-28 2007-06-29 Centre Nat Rech Scient PROCESS FOR PREPARING POLYLYSIN DENDRIMERES GRAFTS
DE102005056592A1 (en) 2005-11-25 2007-05-31 Basf Ag Novel uncrosslinked, hyperbranched polylysines useful as e.g. adhesive aids, thixotropic agents or phase transfer agents are obtained by catalytic reaction of a salt of lysine with an acid and optionally with comonomers
CN102153654B (en) * 2009-12-31 2012-10-10 中国疾病预防控制中心病毒病预防控制所 Branched polypeptide using immune active peptide as vector and derivatives and application of branched polypeptide
CN102153742B (en) * 2011-01-21 2012-11-21 中国科学院长春应用化学研究所 Poly-amino acid grafted copolymer and method for preparing same
CN104524584B (en) * 2015-02-04 2017-06-23 中国科学院长春应用化学研究所 A kind of nano-carrier for responding step by step, its preparation method and its application
GB201821014D0 (en) 2018-12-21 2019-02-06 Royal College Surgeons Ireland Star polypeptides
US20240010837A1 (en) 2020-11-05 2024-01-11 Covestro (Netherlands) B.V. Compositions Suitable for Enhancing the Flexural Properties of Objects Containing Vegetable Fibers
WO2024008939A1 (en) 2022-07-08 2024-01-11 Covestro (Netherlands) B.V. Compositions for fibreboards with enhanced properties upon fast-curing at low temperature
WO2024008938A1 (en) 2022-07-08 2024-01-11 Covestro (Netherlands) B.V. Compositions for fibreboards with enhanced properties upon fast-curing at low temperature
WO2024008940A1 (en) 2022-07-08 2024-01-11 Covestro (Netherlands) B.V. Compositions for fibreboards with enhanced properties upon fast-curing at low temperature
WO2024038153A1 (en) 2022-08-19 2024-02-22 Covestro (Netherlands) B.V. Compositions for fibreboards with enhanced properties upon fast-curing at low temperature
WO2024038152A1 (en) 2022-08-19 2024-02-22 Covestro (Netherlands) B.V. Compositions for fibreboards with enhanced properties upon fast-curing at low temperature

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units

Non-Patent Citations (14)

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Title
HERNANDEZ JUAN RODRIGUEZ ET AL: "Synthesis and ring-opening (Co)polymerization of L-lysine N-carboxyanhydrides containing labile side-chain protective groups", J POLYM SCI PART A;JOURNAL OF POLYMER SCIENCE, PART A: POLYMER CHEMISTRY MAY 1 2003, vol. 41, no. 9, 1 May 2003 (2003-05-01), pages 1167 - 1187, XP002250743 *
JOON SIG CHOI ET AL: "Synthesis of a barbell-like triblock copolymer, poly(L-lysine) dendrimer-block-poly(ethylene glycol)-block-poly(L-lysine) dendrimer, and its self-assembly with plasmid DNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 122, no. 3, 26 January 2000 (2000-01-26), UNITED STATES, pages 474 - 480, XP002250768, ISSN: 0002-7863 *
KLOK H-A ET AL: "STAR-SHAPED FLUORESCENT POLYPEPTIDES", JOURNAL OF POLYMER SCIENCE, INTERSCIENCE PUBLISHERS, XX, vol. 39, no. 10, 2001, pages 1572 - 1582, XP001061864 *
KLOK HARM-ANTON ET AL: "Dendritic-graft polypeptides", MACROMOLECULES;MACROMOLECULES NOV 5 2002, vol. 35, no. 23, 5 November 2002 (2002-11-05), pages 8718 - 8723, XP002250744 *
RODRIGUEZ-HERNANDEZ JUAN ET AL: "Highly branched poly(L-lysine).", BIOMACROMOLECULES, vol. 4, no. 2, March 2003 (2003-03-01), pages 249 - 258, XP002250742, ISSN: 1525-7797 *
ROY R ET AL: "SOLID-PHASE SYNTHESIS OF DENDRITIC SIALOSIDE INHIBITORS OF INFLUENZA A VIRUS HAEMAGGLUTININ", JOURNAL OF THE CHEMICAL SOCIETY, CHEMICAL COMMUNICATIONS, CHEMICAL SOCIETY. LETCHWORTH, GB, no. 24, 21 December 1993 (1993-12-21), pages 1869 - 1872, XP000616525, ISSN: 0022-4936 *
SAKTHIVEL T ET AL: "Synthesis and physicochemical properties of lipophilic polyamide dendrimers.", PHARMACEUTICAL RESEARCH (NEW YORK), vol. 15, no. 5, May 1998 (1998-05-01), pages 776 - 782, XP009014408, ISSN: 0724-8741 *
SELA M ET AL.: "Multichain Polyamino acids", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 78, 20 February 1956 (1956-02-20), United States, pages 746 - 751, XP002250775 *
SELA M ET AL.: "Studies on the Chemical Basis of Antigenicity of Proteins", BIOCHEMICAL JOURNAL, vol. 85, 1962, pages 223 - 235, XP009015349 *
STIRIBA S-E ET AL: "DENDRITIC POLYMERS IN BIOMEDICAL APPLICATIONS: FROM POTENTIAL TO CLINICAL USE IN DIAGNOSTICS AND THERAPY", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 41, no. 8, 15 April 2002 (2002-04-15), pages 1329 - 1334, XP001111698, ISSN: 0570-0833 *
TAM J P: "Synthetic peptide vaccine design: Synthesis and properties of a high-density multiple antigenic peptide system", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 85, August 1988 (1988-08-01), pages 5409 - 5413, XP002131244, ISSN: 0027-8424 *
TOTH G K ET AL: "BRANCHED POLYPEPTIDES AS ANTIGENS FOR INFLUENZA VIRUS HEMAGGLUTININ AND T-CELL RECEPTOR SUBUNITS", PEPTIDE RESEARCH, NATICK, MA, US, vol. 6, no. 5, 1 September 1993 (1993-09-01), pages 272 - 280, XP000607497, ISSN: 1040-5704 *
VOYER NORMAND ET AL: "The use of peptidic frameworks for the construction of molecular receptors and devices.", TETRAHEDRON, vol. 51, no. 34, 21 August 1995 (1995-08-21), pages 9241 - 9284, XP002250745, ISSN: 0040-4020 *
WILDER R ET AL: "The use of triphosgene in the preparation of N-carboxy-alpha-amino acid anhydrides", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 57, no. 9, 24 April 1992 (1992-04-24), pages 2755 - 2756, XP002154840, ISSN: 0022-3263 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109970881A (en) * 2019-03-01 2019-07-05 暨南大学 3D printing realizing controlled-release nitric oxide nano-bracket material and preparation method and application
CN109970881B (en) * 2019-03-01 2021-06-11 暨南大学 3D printing controlled-release nitric oxide nano stent material, and preparation method and application thereof

Also Published As

Publication number Publication date
WO2003064452A2 (en) 2003-08-07
AU2003205707A1 (en) 2003-09-02

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