WO2003056378A1 - Appareillage d'imagerie confocale notamment pour endoscope - Google Patents
Appareillage d'imagerie confocale notamment pour endoscope Download PDFInfo
- Publication number
- WO2003056378A1 WO2003056378A1 PCT/FR2002/004481 FR0204481W WO03056378A1 WO 2003056378 A1 WO2003056378 A1 WO 2003056378A1 FR 0204481 W FR0204481 W FR 0204481W WO 03056378 A1 WO03056378 A1 WO 03056378A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- image guide
- lenses
- mirror
- optical
- signal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00188—Optical arrangements with focusing or zooming features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00165—Optical arrangements with light-conductive means, e.g. fibre optics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
- G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
- G02B23/2407—Optical details
- G02B23/2461—Illumination
- G02B23/2469—Illumination using optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/042—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances characterised by a proximal camera, e.g. a CCD camera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
Definitions
- the present invention relates to a confocal imaging apparatus in particular for an endoscope and of the type using a bundle of flexible optical fibers.
- the confocal character lies in the use of the same path to illumination and detection, and in the spatial filtration of the signal returning from the subsurface analysis plan.
- the fields of application of the invention are the analysis of biological tissues in vivo on humans or animals, external for example in the field of dermatology, or internal and accessible using a channel endoscope operator into which the flexible optical fiber bundle can be introduced, as well as the ex-vivo analysis of tissue samples from biopsy samples, and the in-vitro culture analysis in cell biology.
- the device can also be used to analyze the interior of a manufactured device.
- the apparatus according to the invention is of the type comprising a source emitting radiation at a given wavelength producing a parallel illumination beam.
- This beam of illumination is then separated for example by a separating blade in order to dissociate the illumination pathway and the detection pathway. It is then angularly deflected in two directions of space (scanning) by an optomechanical system of mirrors.
- An optical means picks up the angularly scanned beam and injects it into an image guide located in the focal plane of the latter and consisting of an ordered beam of several tens of thousands of flexible optical fibers.
- the optical fibers constituting the image guide are successively injected by angularly deflecting the beam by means of the mirrors, and this point by point for a given line, and line after line to constitute the image.
- the beam injected into the image guide (if necessary previously placed in (the endoscope operator canaf) is guided, emerges from it and is taken up by an optical means making it possible to illuminate point to point the site which is At any time, the spot illuminating the tissue is backscattered and follows the reverse path of the incident beam.
- This backscattered flux is therefore reinjected into the image guide, emerges from it, reaches the scanning system, is then returned to the detection channel by means of the separating plate, then focused in a filtering hole. It is then detected for example by a photomultiplier or an avalanche photodiode.
- the signal from the photodetector is then integrated, then digitized to be viewed on a screen .
- a device of this type is described in particular in international patent application WO 00/16151.
- the difficulties encountered are linked to the low ratio of the useful backscattered signal to the parasitic signal, which requires, for the image produced to be acceptable, a beam quality of the best possible illumination and preserved throughout the optical path, in particular in terms of the quality of the wavefront and the spatial distribution of the intensity of the focal spot which must be as close as possible to the diameter of the heart of a fiber.
- the degradation of the illumination beam both from an energy and spatial point of view is notably due to the parasitic reflections which operate at the input of the image guide and to optical transmission faults in the scanning systems and injection (field distortion, wavefront error).
- the scanning system comprises optomechanical and / or galvanometric resonant mirrors and the system for injecting into the image guide a focusing lens L4 or a microscope objective .
- the object of the present invention is to propose an apparatus whose quality of the illumination beam is improved at the entrance of the image guide and consequently the image quality is also improved. It also aims to propose a solution for this at low cost, simple to implement, miniaturizable and industrializable. It offers confocal imaging equipment, in particular for endoscopes, comprising an image guide made up of flexible optical fibers with:
- a source producing an illumination beam, means for angular scanning of said beam, means for injecting the deflected beam in turn into one of the fibers of the guide image, means for separating the illumination beam and the back-sent signal, means for spatial filtering, means for detecting said signal, electronic means for controlling, analyzing and digitally processing the detected signal and for displaying ; and - on the side of the distal end of the image guide: an optical head adapted to focus the illumination beam leaving the illuminated fiber,
- the invention is characterized in that the angular scanning means comprise a resonant line mirror and a galvanometric raster mirror with a variable frequency and two afocal optical systems adapted to combine the two mirrors first then the raster mirror and the injection means into the image guide in a second step, each optical system respecting the initial wavefront quality (WFE) and having a spatial distribution of the intensity of the focal spot (PSF) equal to the diameter of the core of a fiber.
- WFE initial wavefront quality
- PSF focal spot
- Each optical system can comprise either a set of standard lenses making it possible to carry out the scanning and the injection into the image guide coupled to additional custom-made lenses having the function of correcting the residual aberrations of the standard lenses, or a set of Very good quality custom lenses.
- an optical afocal system comprises four lenses including a correcting doublet placed symmetrically with respect to the image plane making it possible to correct the field curvature and to minimize the error of the wavefront.
- the means for injecting into the image guide comprise a set of lenses for transforming the angular scanning of the illumination beam into a translation scanning of the image guide which includes upstream a suitable doublet correcting the residual field curvature of said set of lenses.
- the electronic means for controlling, analyzing and digitally processing the detected signal and for viewing includes a synchronization card adapted in particular to synchronously control the movement of the line and frame mirrors and adapted to know at any time the position of the scanned illumination beam.
- FIG. 1 an apparatus for producing an image of a site situated at a given depth in a plane P of section XY perpendicular to the optical axis, said apparatus comprising an image guide 1 made up of several tens of thousands of flexible optical fibers with:
- a source 2 producing an illumination beam
- angular scanning means 3 of said beam means 4 for injecting the beam deflected in turn into one fibers of the image guide 1
- means 5 for separating the illumination beam and the back-emitted signal
- spatial filtering means 6 means for detecting said signal
- electronic means 8 for controlling, analyzing and digital processing of the detected signal and display;
- an optical head 9 adapted to focus the illumination beam leaving the illuminated fiber of the image guide at a focused point 10 in the plane P under the area of contact 1 1 of the optical head 9.
- the image guide 1 provides access to the subsurface analysis zone by shifting the source 2. If it is intended, with the optical head 9, to be inserted into the operating channel of the endoscope, it must have dimensions that are compatible (a few millimeters in diameter depending on the clinical application). It consists of an ordered bundle of flexible optical fibers surrounded by a sheath. Any guide with sufficient fiber and low inter-core spacing can be used to obtain good spatial resolution.
- the fibers are illuminated one by one in turn and in an addressed manner, thanks to the scanning means 3 and to the injection means 4.
- the useful diameter of the image guide therefore corresponds to the diameter of the heart of an illuminated fiber.
- the image guide 1 is equipped at its two ends with a glass slide (not shown in the figure) sufficiently thick to reject parasitic reflections outside the filtering means 6 for the reflection which occurs at entry of the fiber bundle, and outside of the illuminated optical fiber for the reflection which takes place at the exit of the image guide.
- the glass slides are anti-reflective treated to minimize the reflected light.
- Source 2 consists of a laser diode at 683 nm which must have a very good quality wavefront, less than or equal to ⁇ / 10. According to the invention, this diode is pulsed in order to dissociate by synchronous detection the useful signal from the stray reflection which takes place at the input of the image guide 1.
- a solid or gas laser it is possible to use a solid or gas laser, but the choice in wavelength in the 600-800 nm band where the absorption in the tissues is less, is less extensive; moreover, the cost at equivalent power is much higher.
- the means 5 for separating the illumination beam and the return signal here consist of a 50/50 separator cube for adjustment convenience. You can also use a 50/50 separator blade.
- the scanning means 3 have the function of reproducing a matrix of diodes of the same optical quality as the laser diode of the source 2 and which will be injected fiber to fiber. This requires a combination of non-standard optical means making it possible to correct the aberrations present in the transport and source duplication system in order to illuminate the signal guide fiber by fiber.
- the scanning system consists of two mirrors M1 and M2 and two optical systems.
- the mirror M1 is a “line” mirror resonating at a frequency of 4 kHz and the mirror M2 is a “frame” mirror, galvanometric with a variable frequency between 0 and 300 Hz.
- Each optical system is made up of four lenses, respectively, L1- L4 and L5-L8, allowing to combine the two mirrors at first, then the M2 mirror and the entry of the image guide.
- These optical systems must not present any aberrations which could: - broaden the spatial distribution of the intensity of the focal spot (FEP: Point Spreading Function or PSF: "Point Spread Function” in English) after the injection means 4 and thus degrade the coupling in the guide d 'image 1; - propagate the flux in the sheath of the image guide 1 which would degrade the PSF at the end of the guide and therefore the resolution of the image.
- FEP Point Spreading Function
- PSF Point Spread Function
- the lenses L2-L3 and L6-L7 are identical correcting doublets placed symmetrically with respect to the image plane. This makes it possible to homogenize the injection into the image guide by correcting the curvature of the field and minimizing the error of the wavefront due to the use of afocal systems outside the axes (L1-L4 and L5- L8).
- the injection means 4 They must have the minimum of aberrations and must not degrade the quality of the wavefront in order to achieve a focusing spot close to the diffraction limit, thereby achieving optimal coupling with the addressed fiber. (a PSF equal to the core diameter of a fiber). They include a custom-made doublet L9 and a standard triplet L10. The doublet L9 makes it possible to correct the residual aberrations of the triplet L10, namely the field curvature.
- the spatial filtering means 6 comprise a lens L1 1 and a filtering hole T making it possible to select only the illumination fiber and not the adjacent fibers which can generate a spurious signal.
- the size of the filtering hole is such that it corresponds to the diameter of the core of a fiber growing near the optical system between the entry of the fiber bundle and the filtering hole.
- the optical head 9 comprises several optical means making it possible to converge the beam emerging from the illuminated optical fiber and two glass slides, one is that described above at the output of the image guide and the other is a window adapted to come into contact with the site and carry out an index adaptation.
- the optical means have the following characteristics: - allow an analysis of the tissue at a depth of several tens to several hundred microns;
- the optical means include for example a lens system forming a custom-made objective.
- the detection means 7 comprise as signal detector an avalanche photodiode which acquires the signal continuously, the parasitic signal coming from the two ends of the signal guide being reduced to the same order of magnitude as the useful signal so as not to saturate the detector .
- the removal of the stray reflection residue at the input of the image guide is then carried out by digital time filtering.
- the electronic means 8 for controlling, analyzing and digitally processing the detected signal and for displaying includes the following cards: - a modulation card 20 of the laser source. This card allows the source to be modulated at a relatively high frequency (of the order of 100 MHz) in order to produce pulses (10 ns ⁇ T ⁇ 100 ns) at regular intervals (duty cycle of the order of 4). - A synchronization card 21 which has the following functions: - to synchronously control the scanning, that is to say the movement of the line M1 and frame M2 mirrors;
- a detector card 22 which includes an analog circuit which in particular performs an impedance adaptation and integration, an analog digital converter then a programmable logic component (for example an FGPA circuit) which formats the signal; a digital acquisition card 23 which makes it possible to process a stream of digital data at variable frequency and to display it on a screen 24;
- Image processing is done as follows.
- the raw information at the output of the detector card is formatted and processed in order to be visible and then interpretable.
- the method of acquiring images through the image guide made up of several tens of thousands of optical fibers and by scanning the latter induces specificities in the image and appropriate processing.
- the first group consists of signal processing methods aimed at calibrating the acquired signal. We can thus overcome the laser / guide coupling faults inherent in the acquisition process, as well as faults due to certain system noises. Calibration can take different forms depending on the precision of the sweep control and its stability over time. These treatments are essentially one-dimensional. 2.
- the second group improves the interpretation by integrating image processing (2D and 2D + time) specific to the opto-mechanical process. These treatments consist of a process of restoring images, followed by a rapid registration process allowing to overcome small movements. These treatments are fast compared to the acquisition time. These algorithms are fully automatic and adapt to the nature of the image. It goes without saying that alternative embodiments are possible, in particular with regard to the line mirror M1 which can resonate at another frequency, for example 8 kHz, the optical focal length systems which can be entirely made-to-measure or include other sets of suitable corrective lenses.
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE60205408T DE60205408T2 (de) | 2001-12-28 | 2002-12-20 | Konfokale abbildungsgeräte insbesondere für ein endoskop |
IL16270602A IL162706A0 (en) | 2001-12-28 | 2002-12-20 | Confocal imaging equipment in particular for endoscope |
BR0215371-8A BR0215371A (pt) | 2001-12-28 | 2002-12-20 | Equipamento de imagem confocal, em particular para endoscópio |
AU2002364671A AU2002364671B2 (en) | 2001-12-28 | 2002-12-20 | Confocal imaging equipment in particular for endoscope |
AT02805803T ATE301294T1 (de) | 2001-12-28 | 2002-12-20 | Konfokale abbildungsgeräte insbesondere für ein endoskop |
US10/500,160 US7285089B2 (en) | 2001-12-28 | 2002-12-20 | Confocal imaging equipment in particular for endoscope |
JP2003556843A JP4455059B2 (ja) | 2001-12-28 | 2002-12-20 | 特に内視鏡用の共焦点式イメージング装置 |
CA2471721A CA2471721C (fr) | 2001-12-28 | 2002-12-20 | Appareillage d'imagerie confocale notamment pour endoscope |
EP02805803A EP1468322B1 (fr) | 2001-12-28 | 2002-12-20 | Appareillage d imagerie confocale notamment pour endoscope |
IL162706A IL162706A (en) | 2001-12-28 | 2004-06-23 | Confocal imaging equipment in particular for endoscope |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0116980A FR2834349B1 (fr) | 2001-12-28 | 2001-12-28 | Appareillage d'imagerie confocale notamment pour endoscope |
FR01/16980 | 2001-12-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003056378A1 true WO2003056378A1 (fr) | 2003-07-10 |
Family
ID=8871053
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2002/004481 WO2003056378A1 (fr) | 2001-12-28 | 2002-12-20 | Appareillage d'imagerie confocale notamment pour endoscope |
Country Status (14)
Country | Link |
---|---|
US (1) | US7285089B2 (fr) |
EP (1) | EP1468322B1 (fr) |
JP (1) | JP4455059B2 (fr) |
CN (1) | CN1288473C (fr) |
AT (1) | ATE301294T1 (fr) |
AU (1) | AU2002364671B2 (fr) |
BR (1) | BR0215371A (fr) |
CA (1) | CA2471721C (fr) |
DE (1) | DE60205408T2 (fr) |
DK (1) | DK1468322T3 (fr) |
ES (1) | ES2247427T3 (fr) |
FR (1) | FR2834349B1 (fr) |
IL (2) | IL162706A0 (fr) |
WO (1) | WO2003056378A1 (fr) |
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WO2006051811A1 (fr) * | 2004-11-10 | 2006-05-18 | Olympus Corporation | Dispositif d'observation de corps biologique |
JP2006138928A (ja) * | 2004-11-10 | 2006-06-01 | Olympus Corp | 生体観察装置 |
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US8496579B2 (en) | 2006-09-28 | 2013-07-30 | Jenlab Gmbh | Method and arrangement for high-resolution microscope imaging or cutting in laser endoscopy |
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US5659642A (en) * | 1992-10-23 | 1997-08-19 | Optiscan Pty. Ltd. | Confocal microscope and endoscope |
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2001
- 2001-12-28 FR FR0116980A patent/FR2834349B1/fr not_active Expired - Fee Related
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2002
- 2002-12-20 ES ES02805803T patent/ES2247427T3/es not_active Expired - Lifetime
- 2002-12-20 DE DE60205408T patent/DE60205408T2/de not_active Expired - Lifetime
- 2002-12-20 AU AU2002364671A patent/AU2002364671B2/en not_active Ceased
- 2002-12-20 AT AT02805803T patent/ATE301294T1/de not_active IP Right Cessation
- 2002-12-20 IL IL16270602A patent/IL162706A0/xx unknown
- 2002-12-20 EP EP02805803A patent/EP1468322B1/fr not_active Expired - Lifetime
- 2002-12-20 CA CA2471721A patent/CA2471721C/fr not_active Expired - Lifetime
- 2002-12-20 US US10/500,160 patent/US7285089B2/en not_active Expired - Lifetime
- 2002-12-20 JP JP2003556843A patent/JP4455059B2/ja not_active Expired - Lifetime
- 2002-12-20 CN CNB028283228A patent/CN1288473C/zh not_active Expired - Fee Related
- 2002-12-20 BR BR0215371-8A patent/BR0215371A/pt not_active IP Right Cessation
- 2002-12-20 DK DK02805803T patent/DK1468322T3/da active
- 2002-12-20 WO PCT/FR2002/004481 patent/WO2003056378A1/fr active IP Right Grant
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2004
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Cited By (20)
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WO2006009754A1 (fr) * | 2004-06-17 | 2006-01-26 | Bayer Healthcare Llc | Tete de lecture coaxiale de reflectance diffuse |
US7724374B2 (en) | 2004-06-17 | 2010-05-25 | Bayer Healthcare Llc | Coaxial diffuse reflectance read head |
US7952716B2 (en) | 2004-06-17 | 2011-05-31 | Bayer Healthcare Llc | Coaxial diffuse reflectance read head |
WO2006051811A1 (fr) * | 2004-11-10 | 2006-05-18 | Olympus Corporation | Dispositif d'observation de corps biologique |
JP2006138928A (ja) * | 2004-11-10 | 2006-06-01 | Olympus Corp | 生体観察装置 |
US7609440B2 (en) | 2004-11-10 | 2009-10-27 | Olympus Corporation | In-vivo examination apparatus |
JP4652775B2 (ja) * | 2004-11-10 | 2011-03-16 | オリンパス株式会社 | 生体観察装置 |
JP2006204505A (ja) * | 2005-01-27 | 2006-08-10 | Olympus Corp | 生体観察装置 |
US8496579B2 (en) | 2006-09-28 | 2013-07-30 | Jenlab Gmbh | Method and arrangement for high-resolution microscope imaging or cutting in laser endoscopy |
US10335016B2 (en) | 2012-07-17 | 2019-07-02 | Ecole Polytechnique Federale De Lausanne (Epfl) | Reflective optical objective |
WO2014013412A1 (fr) | 2012-07-17 | 2014-01-23 | Ecole Polytechnique Federale De Lausanne (Epfl) | Objectif optique réfléchissant |
US11609186B2 (en) | 2015-03-31 | 2023-03-21 | Samantree Medical Sa | Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment |
US11828710B2 (en) | 2015-03-31 | 2023-11-28 | Samantree Medical Sa | Systems and methods for in-operating-theatre imaging of fresh tissue resected during surgery for pathology assessment |
US10539776B2 (en) | 2017-10-31 | 2020-01-21 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
US10816788B2 (en) | 2017-10-31 | 2020-10-27 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
US10928621B2 (en) | 2017-10-31 | 2021-02-23 | Samantree Medical Sa | Sample dishes for use in microscopy and methods of their use |
US11181728B2 (en) | 2017-10-31 | 2021-11-23 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
US11609416B2 (en) | 2017-10-31 | 2023-03-21 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
US11747603B2 (en) | 2017-10-31 | 2023-09-05 | Samantree Medical Sa | Imaging systems with micro optical element arrays and methods of specimen imaging |
US11966037B2 (en) | 2022-05-09 | 2024-04-23 | Samantree Medical Sa | Sample dishes for use in microscopy and methods of their use |
Also Published As
Publication number | Publication date |
---|---|
BR0215371A (pt) | 2004-12-07 |
CA2471721C (fr) | 2012-03-13 |
AU2002364671B2 (en) | 2007-06-14 |
DK1468322T3 (da) | 2005-12-05 |
ES2247427T3 (es) | 2006-03-01 |
JP4455059B2 (ja) | 2010-04-21 |
AU2002364671A1 (en) | 2003-07-15 |
US7285089B2 (en) | 2007-10-23 |
EP1468322B1 (fr) | 2005-08-03 |
DE60205408D1 (de) | 2005-09-08 |
CN1288473C (zh) | 2006-12-06 |
FR2834349B1 (fr) | 2004-04-09 |
JP2005512746A (ja) | 2005-05-12 |
IL162706A0 (en) | 2005-11-20 |
US20050078924A1 (en) | 2005-04-14 |
CN1620625A (zh) | 2005-05-25 |
IL162706A (en) | 2010-04-29 |
FR2834349A1 (fr) | 2003-07-04 |
CA2471721A1 (fr) | 2003-07-10 |
EP1468322A1 (fr) | 2004-10-20 |
DE60205408T2 (de) | 2006-06-01 |
ATE301294T1 (de) | 2005-08-15 |
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