WO2003055879A3 - Tropane derivative, chelation product comprising this tropane derivative and a metal or a metal complex, and radiopharmaceutical - Google Patents

Tropane derivative, chelation product comprising this tropane derivative and a metal or a metal complex, and radiopharmaceutical Download PDF

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Publication number
WO2003055879A3
WO2003055879A3 PCT/IB2002/005357 IB0205357W WO03055879A3 WO 2003055879 A3 WO2003055879 A3 WO 2003055879A3 IB 0205357 W IB0205357 W IB 0205357W WO 03055879 A3 WO03055879 A3 WO 03055879A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal
tropane derivative
radiopharmaceutical
metal complex
group
Prior art date
Application number
PCT/IB2002/005357
Other languages
French (fr)
Other versions
WO2003055879A2 (en
Inventor
Frederic Turpin
Laurent Mauclaire
Fadi Masri
Francoise Riche
Moulinet D Hardemare Amaury Du
Original Assignee
Schering Ag
Frederic Turpin
Laurent Mauclaire
Fadi Masri
Francoise Riche
Moulinet D Hardemare Amaury Du
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Frederic Turpin, Laurent Mauclaire, Fadi Masri, Francoise Riche, Moulinet D Hardemare Amaury Du filed Critical Schering Ag
Priority to AU2002367114A priority Critical patent/AU2002367114A1/en
Publication of WO2003055879A2 publication Critical patent/WO2003055879A2/en
Publication of WO2003055879A3 publication Critical patent/WO2003055879A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention relates to a tropane derivative, to a chelation product composed of this tropane derivative and of a metal or of a metal complex, and to a radiopharmaceutical comprising the said product. The tropane derivative of the present invention is of following formula (I), in which X represents a compound for chelation of a metal or of a metal complex, the 6 and 7 carbons being bonded to one another or not being bonded to one another, in which: R1 is an alkyl or alkenyl, R2 is of the form -COOZ with Z chosen from H or an alkyl group, R3 represents a phenyl group; a phenylalkyl or phenylalkenyl group; a benzoate group or an oxo group, and in which the bond between the 2 and 3 carbons is a single or double bond.
PCT/IB2002/005357 2001-12-26 2002-12-13 Tropane derivative, chelation product comprising this tropane derivative and a metal or a metal complex, and radiopharmaceutical WO2003055879A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002367114A AU2002367114A1 (en) 2001-12-26 2002-12-13 Tropane derivative, chelation product comprising this tropane derivative and a metal or a metal complex, and radiopharmaceutical

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116867 2001-12-26
FR0116867A FR2833952B1 (en) 2001-12-26 2001-12-26 TROPANE DERIVATIVE, CHELATION PRODUCT COMPRISING THIS TROPANE DERIVATIVE AND A METAL OR A METAL AND RADIOPHARMACEUTICAL COMPLEX

Publications (2)

Publication Number Publication Date
WO2003055879A2 WO2003055879A2 (en) 2003-07-10
WO2003055879A3 true WO2003055879A3 (en) 2004-06-17

Family

ID=8870988

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/005357 WO2003055879A2 (en) 2001-12-26 2002-12-13 Tropane derivative, chelation product comprising this tropane derivative and a metal or a metal complex, and radiopharmaceutical

Country Status (3)

Country Link
AU (1) AU2002367114A1 (en)
FR (1) FR2833952B1 (en)
WO (1) WO2003055879A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1444990A1 (en) 2003-02-07 2004-08-11 Amersham plc Improved Radiometal Complex Compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014445A1 (en) * 1995-10-19 1997-04-24 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
EP1051980A2 (en) * 1999-05-12 2000-11-15 President And Fellows Of Harvard College Dopamine transporter imaging agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014445A1 (en) * 1995-10-19 1997-04-24 The Trustees Of The University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents
EP1051980A2 (en) * 1999-05-12 2000-11-15 President And Fellows Of Harvard College Dopamine transporter imaging agents

Also Published As

Publication number Publication date
AU2002367114A1 (en) 2003-07-15
FR2833952A1 (en) 2003-06-27
WO2003055879A2 (en) 2003-07-10
FR2833952B1 (en) 2004-03-26

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